Semiparametric estimate of the efficiency of imperfect maintenance actions for a gamma deteriorating system

International audienceA system is considered, which is deteriorating over time according to a non homogeneous gamma process with unknown parameters. The system is subject to periodic and instantaneous imperfect maintenance actions (repairs). Each imperfect repair removes a proportion ρ of the accumulated degradation since the previous repair. The parameter ρ hence appears as a measure for the maintenance efficiency. This model is called arithmetic reduction of degradation of order 1. The system is inspected right before each maintenance action, thus providing some multivariate measurement of the successively observed deterioration levels. Based on these data, a semiparametric estimator of ρ is proposed, considering the parameters of the underlying gamma process as nuisance parameters. This estimator is mainly based on the range of admissible ρ's, which depends on the data. Under technical assumptions, consistency results are obtained, with surprisingly high convergence rates (up to exponential). The case where several i.i.d. systems are observed is next envisioned. Consistency results are obtained for the efficiency estimator, as the number of systems tends to infinity, with a convergence rate that can be higher or lower than the classical square root rate. Finally, the performances of the estimators are illustrated on a few numerical examples

A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule

The distal parts of the renal tubule play a critical role in maintaining homeostasis of extracellular fluids. In this review, we present an in-depth analysis of microarray-based gene expression profiles available for microdissected mouse distal nephron segments, i.e., the distal convoluted tubule (DCT) and the connecting tubule (CNT), and for the cortical portion of the collecting duct (CCD; Zuber et al., Proc Natl Acad Sci USA 106:16523-16528, 2009). Classification of expressed transcripts in 14 major functional gene categories demonstrated that all principal proteins involved in maintaining the salt and water balance are represented by highly abundant transcripts. However, a significant number of transcripts belonging, for instance, to categories of G-protein-coupled receptors or serine/threonine kinases exhibit high expression levels but remain unassigned to a specific renal function. We also established a list of genes differentially expressed between the DCT/CNT and the CCD. This list is enriched by genes related to segment-specific transport functions and by transcription factors directing the development of the distal nephron or collecting ducts. Collectively, this in silico analysis provides comprehensive information about relative abundance and tissue specificity of the DCT/CNT and the CCD expressed transcripts and identifies new candidate genes for renal homeostasi

Semi-Transparent Image Sensors for Eye-Tracking Applications

Image sensors hold a pivotal role in society due to their ability to capture vast amounts of information. Traditionally, image sensors are opaque due to light absorption in both the pixels and the read-out electronics that are stacked on top of each other. Making image sensors visibly transparent would have a far-reaching impact in numerous areas such as human-computer interfaces, smart displays, and both augmented and virtual reality. In this paper, we present the development and analysis of the first semi-transparent image sensor and its applicability as an eye-tracking device. The device consists of an 8x8 array of semi-transparent photodetectors and electrodes disposed on a fully transparent substrate. Each pixel of the array has a size of 60 x 140 {\mu}m and an optical transparency of 85-95%. Pixels have a high sensitivity, with more than 90% of them showing a noise equivalent irradiance < 10-4 W/m2 for wavelengths of 637 nm. As the semi-transparent photodetectors have a large amount of built-in gain, the opaque read-out electronics can be placed far away from the detector array to ensure maximum transparency and fill factor. Indeed, the operation and appearance of transparent image sensors present a fundamental shift in how we think about cameras and imaging, as these devices can be concealed in plain sight

Frontal and tilted PDV proves for measuring velocity history of laser-shock induced calibrated particles

Author Institution: Commissariat à l'énergie atomique et aux énergies alternatives (France)Slides presented at the 7th Annual Photonic Doppler Velocimetry (PDV) Workshop held at Sandia National Laboratory, Albuquerque, New Mexico, October 22-23, 2012

Dynamic fragmentation of graphite under laser-driven shocks: Identification of four damage regimes

This study presents the results of a large experimental campaign conducted on the Luli2000 laser facility. Thin targets of a commercial grade of porous graphite were submitted to high-power laser-driven shocks leading to their fragmentation. Many diagnostics were used such as high-speed time- and space-resolved imaging systems (shadowgraphy and photography), laser velocimetry (PDV and VISAR), debris collection and post-mortem X-ray tomography. They provided the loading levels into the targets, the spall strength of the material, the shape and size of debris and the localization of the subsurface cracks. The crossed data reduction of all the records showed their reliability and allowed to get a better insight into the damage phenomena at play in graphite. Thereby, four damage regimes, ranked according to their severity and loading level, were identified. It confirms that laser shocks are very complementary to classical impact tests (plates and spheres) since they ally two-dimensional loadings to the possibility of using both, in-situ and post-mortem diagnostics. Finally, the campaign shall be able to provide large and consistent data to develop and adjust reliable models for shock wave propagation and damage into porous graphite

Landscape evolution and geodynamic controls in the Gulf of Cadiz (Huelva coast, SW Spain) during the Late Quaternary

The coastal evolution of the El Abalario area (Huelva, southern Spain) during the Late Pleistocene and Holocene is reinterpreted after a refinement of the available geochronology by means of optically stimulated luminescence (OSL) dating. New data come from the analysis of soft sediment deformation, palaeosols, geomorphological mapping, and published seismic surveys on the onshore and offshore Gulf of Cadiz. The present structure of El Abalario dome resulted from the complex interaction of littoral-catchment processes and sea-level changes upon an emergent coastal plain, conditioned by the upwarping of the underlying Pliocene - Pleistocene prograding deltaic sequence. Upwarping is probably related to escape of over-pressurized fluids, accompanied by dewatering, prior to (?) and during OIS (Oxygen Isotopic Stage) 5. Continued upwarping produced the large NW - SE gravitational fault of Torre del Loro (TLF) in the southwestern flank of the dome, roughly parallel to the present coastline during OIS 5 - OIS 4. The resulting escarpment favoured the accumulation of aeolian sand dunes (units U1, U2, and U3) from OIS 5 to early OIS 1. Unit U1 (OIS 5) ends upwards in a supersurface with a thick weathering profile that suggests moist and temperate climatic conditions. Unit U2 accumulated mainly during OIS 4 and OIS 3 with prevailing W/E winds. The supersurface between U2 and U3 records a part of OIS 2, with relative low sea level. Sedimentation of unit U3 took place during the Last Deglaciation (radiocarbon and OSL ages) with prevailing W/SW winds, under a temperate moist climate, that became more arid towards the top (Holocene). A major supersurface with an iron crust-like layer (SsFe) developed during the Holocene Climatic Optimum (OIS 1) under wetter and more temperate conditions than before, fossilizing the TLF. The supersurface is covered by younger aeolian dunes (U4, U5, U6, and U7) transported by W - SW winds since the Late Neolithic - Chalcolithic cultural period (̃5.0 ky cal BP).Financial support from Spanish Projects BTE2002-1065 and BTE2002-1691. This is a contribution to IGCP 495 and to the INQUA “Coastal and Marine Processes Commission”

Coastal zones recording sea level and dimatic changes during and since the Last Deglaciation: Atlantic-Mediterranean region, Spain. Abstracts

The Late Quaternary climatic oscillations caused important changes in coastal system in the Mediterranean area. Sea level changes mark a series of geomorphological and environmental variations. Macrophyte and Charophyte plant remains from coastal lake cores, are useful tools studying these environment for their specific sensibility to ecological changes (depth, salinity, temperature, energy, susbstrate, Ph, etc..). The study sites are two ancient coastal lake systems (Lago Battaglia, now dry; Laghi Alimini) and a wetland area (Ariscianne), along the Adriatic coast of Apulia (southern Italy). The chronology, provided by AMS radiocarbon date, ascribes the cores to middle and late Holocene. Data collected show a diversification in local vegetation pattern along the successions, outlining transformations in sedimentation basins through time, related to sea-level changes and geomorphological coastal processes according to other proxy available for the same cores (i.e. pollen and faunal analysis, magnetic susceptivity, loss on ignition). The relationship between limnic and telmatic species gives also information about both local and regional lake-level fluctuations

Twenty-year follow-up of kangaroo mother care versus traditional care

Q1Q1e20162063BACKGROUND AND OBJECTIVES: Kangaroo mother care (KMC) is a multifaceted intervention for preterm and low birth weight infants and their parents. Short- and mid-term benefits of KMC on survival, neurodevelopment, breastfeeding, and the quality of mother–infant bonding were documented in a randomized controlled trial (RCT) conducted in Colombia from 1993 to 1996. The aim of the present study was to evaluate the persistence of these results in young adulthood. METHODS: From 2012 to 2014, a total of 494 (69%) of the 716 participants of the original RCT known to be alive were identified; 441 (62% of the participants in the original RCT) were re-enrolled, and results for the 264 participants weighing ≤1800 g at birth were analyzed. The KMC and control groups were compared for health status and neurologic, cognitive, and social functioning with the use of neuroimaging, neurophysiological, and behavioral tests. RESULTS: The effects of KMC at 1 year on IQ and home environment were still present 20 years later in the most fragile individuals, and KMC parents were more protective and nurturing, reflected by reduced school absenteeism and reduced hyperactivity, aggressiveness, externalization, and socio-deviant conduct of young adults. Neuroimaging showed larger volume of the left caudate nucleus in the KMC group. CONCLUSIONS: This study indicates that KMC had significant, long-lasting social and behavioral protective effects 20 years after the intervention. Coverage with this efficient and scientifically based health care intervention should be extended to the 18 million infants born each year who are candidates for the method