Câncer e Estatística: Mortalidade Por Câncer nas Capitais Brasileiras no Decurso de 1942 a 1952; Mortalidade Por Câncer no Distrito Federal Por Grupos de Idade, Sexo e Côr no Quinquênio 1948-1952

Trabalho apresentado ao 6° Congresso Internacional realizado em São Paulo em julho de 1954, sobre estatísticas de mortalidade por câncer nas capitais brasileiras e no Distrito Federal

Joint power loading of data and pilots in OFDM using imperfect channel state information at the transmitter

Abstract- The search for optimality in the design of channel precoders and training symbols in block processing communication systems is one of paramount importance. Finding the best tradeoff in terms of power distribution between information and pilot symbols for frequency selective channels, when channel estimation via feedback is available, however, has not been fully addressed. In this paper, we solve the problem of finding the optimal power distribution between pilots and data symbols in the mean-square-error (MSE) sense when a delayless error-free channel feedback path is available to the transmitter. The novel approach adaptively designs the optimal precoders and training vectors based on the frequency domain estimates of the channel

Estabilidade de ácido ascórbico e antocianinas em néctar de camu-camu (Myrciaria dubia (H. B. K.) McVaugh)

Camu-camu is a fruit with a remarkable nutritional potential due to its high ascorbic acid content. Hence, the aim of the present study is to evaluate the stability of ascorbic acid and pigments present in camu-camu nectar stored under different light and temperature conditions. Fruits were depulped and assessed as to their physico-chemical characteristics. Nectar obtained from the pulp was placed in plastic bottles and stored at room temperature and refrigerated, with and without light, and were assessed for 120 days as to stability of the ascorbic acid and anthocyanins. The ascorbic acid content in nectar stored under light did not differ statistically from that protected from it. It was found that this vitamin in nectar stored for 120 days at a chilled temperature presented good stability. Concerning the anthocyanins, room temperature contributed negatively bringing about a more accelerated degradation, yet, exposure to light had no effect. According to trial conditions used in the present study, it was concluded that the light factor had little influence on the ascorbic acid and anthocyanins in the camu-camu nectar and that the temperature of storing it in the open shows it had a negative factor on the stability of these pigments

El comportamiento de la lactatemia y frecuencia cardiaca durante esfuerzos con intensidades de competencias en la carrera a pie de los triatletas de la Selección Nacional de Cuba / The behavior of lactatemia and heart rate during efforts with intensities

Las exigencias competitivas en el deporte de alto rendimiento se incrementan como resultado de la imposición constante de nuevos récords, el aprovechamiento de la ciencia y la tecnología será unos de los factores protagonistas de este proceso. Al respecto se impone utilizar medios, métodos y procedimientos más efectivos para superar los niveles de rendimiento. La investigación contó con un diseño preexperimento de control mínimo para un solo grupo con pretest - postest de naturaleza cuantitativa y cualitativa. Se trabajó con una muestra de 6 triatletas con un promedio de edad de 23 años, con más de 7 años de experiencia que representan el 100 % de la población de la Pre Selección Nacional de Cuba. Se aplicó un sistema de test con cargas incrementales que permite conocer el comportamiento de los niveles de lactato y frecuencia cardiaca en la carrera de los triatletas de la selección nacional de Cuba para su mejor desempeño en la preparación competitiva. Se utilizaron métodos del nivel teórico, empírico y estadístico los cuales posibilitaron constatar su veracidad durante todo el proceso de investigación. Existió una mejora significativa en la tolerancia al lactato en los triatletas, por lo que existió un incremento en el rendimiento de la carrera corroborado por los resultados en los Juegos Centroamericanos y del Caribe Veracruz 2014. Abstract  The competitive demands in high performance sport are increased as a result of the constant imposition of new records, the use of science and technology will be one of the main factors of this process. In this regard, it is necessary to use more effective means, methods and procedures to overcome performance levels. The research had a minimum control preexperiment design for a single group with pretest - posttest of quantitative and qualitative nature. We worked with a sample of 6 triathletes with an average age of 23 years, with more than 7 years of experience that represented 100% of the population of the Pre National Selection of Cuba. We applied a test system with incremental loads that allows us to know the behavior of lactate levels and heart rate in the triathletes of the national team of Cuba for their best performance in competitive preparation. Methods of the theoretical, empirical and statistical level were used, which made it possible to verify their veracity throughout the research process. There was a significant improvement in lactation tolerance in the triathletes, so there was an increase in the performance of the race corroborated by the results in the Central American and Caribbean Games Veracruz 2014

GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions

The contribution of intimal cell proliferation to the formation of early atherosclerotic lesions is poorly understood. We combined 5-bromo-2′-deoxyuridine pulse labeling with sensitive en face immunoconfocal microscopy analysis, and quantified intimal cell proliferation and Ly-6Chigh monocyte recruitment in low density lipoprotein receptor–null mice. Cell proliferation begins in nascent lesions preferentially at their periphery, and proliferating cells accumulate in lesions over time. Although intimal cell proliferation increases in parallel to monocyte recruitment as lesions grow, proliferation continues when monocyte recruitment is inhibited. The majority of proliferating intimal cells are dendritic cells expressing CD11c and major histocompatibility complex class II and 33D1, but not CD11b. Systemic injection of granulocyte/macrophage colony-stimulating factor (GM-CSF) markedly increased cell proliferation in early lesions, whereas function-blocking anti–GM-CSF antibody inhibited proliferation. These findings establish GM-CSF as a key regulator of intimal cell proliferation in lesions, and demonstrate that both proliferation and monocyte recruitment contribute to the inception of atherosclerosis

Noise Cancellation using Selectable Adaptive Algorithm for Speech in Variable Noise Environment

Some of the teething problems associated in the use of two-sensor noise cancellation systems are the nature of the noise signals—a problem that imposes the use of highly complex algorithms in reducing the noise. The usage of such methods can be impractical for many real time applications, where speed of convergence and processing time are critical. At the same time, the existing approaches are based on using a single, often complex adaptive filter to minimize noise, which has been determined to be inadequate and ineffective. In this paper, a new mechanism is proposed to reduce background noise from speech communications. The procedure is based on a two-sensor adaptive noise canceller that is capable of assigning an appropriate filter adapting to properties of the noise. The criterion to achieve this is based on measuring the eigenvalue spread based on the autocorrelation of the input noise. The proposed noise canceller (INC) applies an adaptive algorithm according to the characteristics of the input signal. Various experiments based on this technique using real-world signals are conducted to gauge the effectiveness of the approach. Initial results illustrated the system capabilities in executing noise cancellation under different types of environmental noise. The results based on the INC technique indicate fast convergence rates; improvements up to 30 dB in signal-to-noise ratio and at the same time shows 65% reduction of computational power compared to conventional method

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

The endogenous cellular and molecular mechanisms that control acute inflammation and its resolution are of wide interest. Using self-resolving inflammatory exudates and lipidomics, we have identified a new pathway involving biosynthesis of potent antiinflammatory and proresolving mediators from the essential fatty acid docosahexaenoic acid (DHA) by macrophages (MΦs). During the resolution of mouse peritonitis, exudates accumulated both 17-hydroxydocosahexaenoic acid, a known marker of 17S-D series resolvin (Rv) and protectin biosynthesis, and 14S-hydroxydocosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid from endogenous DHA. Addition of either DHA or 14S-hydroperoxydocosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid to activated MΦs converted these substrates to novel dihydroxy-containing products that possessed potent antiinflammatory and proresolving activity with a potency similar to resolvin E1, 5S,12R,18R-trihydroxyeicosa-6Z,8E,10E,14Z,16E-pentaenoic acid, and protectin D1, 10R,17S-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid. Stable isotope incorporation, intermediate trapping, and characterization of physical and biological properties of the products demonstrated a novel 14-lipoxygenase pathway, generating bioactive 7,14-dihydroxydocosa-4Z,8,10,12,16Z,19Z-hexaenoic acid, coined MΦ mediator in resolving inflammation (maresin), which enhances resolution. These findings suggest that maresins and this new metabolome may be involved in some of the beneficial actions of DHA and MΦs in tissue homeostasis, inflammation resolution, wound healing, and host defense

QUANTIFICAÇÃO DE COMPOSTOS BIOATIVOS E POTENCIAL ANTIOXIDANTE TOTAL DE FRUTEIRAS NATIVAS DE ALAGOAS

O objetivo do presente trabalho foi quantificar os teores de antocianinas e flavonoides e avaliar o potencial antioxidante das seguintes frutas nativas: araçá-boi (Eugenia stipitata McVaugh), araçá-pera (Psidium acutangulum DC.), murici (Byrsonima verbascifolia L. Rich), maçaranduba (Manilkara salzmanii Lam.) e trapiá (Crateva tapia L). Os teores de antocianinas e flavonoides foram determinados segundo a metodologia desenvolvida por Francis (1982), utilizando-se 1 g de polpa para cada espécie frutífera e solvente extrator solução de Etanol-HCl (85:15%), sendo os resultados expressos em mg 100 g-1 de polpa. O potencial antioxidante foi avaliado pelo método do DPPH, que tem por base a redução da absorbância na região visível do comprimento de 515 nm na presença de antioxidante, sendo realizado em triplicata e os resultados expressos em EC50. Para a análise dos dados foi realizada uma estatística descritiva, onde foram obtidos os valores médios e o desvio-padrão da média. Observaram-se quantidades expressivas de antocianinas totais nos frutos estudados, porém, os frutos de maçaranduba e trapiá apresentaram os maiores teores, com valores médios de 12,57 ± 2,28 mg 100 g-1 e 5,32 ± 0,41 mg 100 g-1, respectivamente. Os maiores teores de flavonoides totais foram observados nos frutos de murici e trapiá, com médias de 33,43 ± 0,64 mg 100 g-1 e 31,19 ± 0,95 mg 100 g-1, respectivamente. O fruto de araçá-boi foi o que apresentou maior potencial antioxidante com EC50 médio de 0,07 g DPPH/g fruto. As espécies constituem fontes potenciais de compostos bioativos e apresentam alto potencial antioxidante, podendo fazer parte da dieta da população como alimento funcional, bem como viabilizar a agregação de valor aos frutos produzidos na região