Buenas prácticas de innovación docente en la Universidad de Córdoba

El programa se basa en el uso de un nuevo soporte para impartir la asignatura de Nutrición y Genética en el grado de Enfermería, que no es otro que el foro. Con su puesta en marcha se propugna la generación de temas de debate entre el alumnado, se facilita el autoaprendizaje y el trabajo en equipo, además de fomentar un estilo de vida saludable, basado en una dieta equilibrada, el ejercicio físico y el abandono de hábitos tóxicos

The earliest basketry in southern Europe: Hunter- gatherer and farmer plant-based technology in Cueva de los Murciélagos (Albuñol)

This work was supported by the project “De los museos al territorio: actualizando el estudio de la Cueva de los Murciélagos de Albuñol (Granada)” (MUTERMUR) (Referencia CM/JIN/2021-009) financed by the program of Young Researchers of Comunidad de Madrid (directed by F.M.-S. as the principal investigator). J.S. is funded by Ramon y Cajal fellowship (RYC2019-028346) by the Spanish Ministry of Science and Innovation (MCIN). M.C. is funded by a Ramón y Cajal fellowship (RYC2019-026697-I) and by the Spanish Ministry of Science and Innovation (MCIN). R.P.H., M.H.-O., and A.P.P. are members of the research group 2021-SGR 00190 funded by the AGAUR. R.P.H. is an ICREA academia researcher. M.M.-S. was funded by the Beatriz Galindo program as Junior Distinguished Researcher (BG20/00076).Supplementary TextPlant material culture can offer unique insights into the ways of life of prehistoric societies; however, its perishable nature has prevented a thorough understanding of its diverse and complex uses. Sites with exceptional preservation of organic materials provide a unique opportunity for further research. The burial site of Cueva de los Murciélagos in southern Iberia, uncovered during 19th-century mining activities, contained the best-preserved hunter-gatherer basketry in southern Europe, together with other unique organic artifacts associated with the first farming communities, such as sandals and a wooden hammer. We present 14 14C dates for the perishable artifacts (N = 76), situating the assemblage between the Early and Middle Holocene (c. 7500 to 4200 cal BCE). Our integrated analysis includes raw material determination and technological and chrono-cultural contextualization of this unique and important set of materials.Comunidad de Madrid CM/JIN/2021-009MCIN Ramon y Cajal fellowship RYC2019-028346, RYC2019-026697-IAGAUR. R.P.H. 2021-SGR 00190Junior Distinguished Researcher BG20/0007

Cueva del sol, a solar marker in the sierra de la plata (Tarifa, Cádiz)

En el ámbito geográfico que nos ocupa, entornos de la Laguna de la Janda y Campo de Gibraltar, existen unos trescientos abrigos con arte rupestre escasamente estudiados. En veintidós de ellos está representada la figura soliforme en sus paredes rocosas. La denominada Cueva del Sol es uno de los abrigos que forman parte de este conjunto. Sus especiales características, tanto geográficas como iconográficas, y los reveladores resultados de observaciones astronómicas apuntan a la existencia de un marcador solar del solsticio de invierno, y convierten a esta cavidad en una de las más excepcionales del conjunto y, tal vez, de la península ibérica. Los datos obtenidos hacen que este abrigo pueda llevarnos a determinar algunos aspectos concretos sobre los cultos aso - ciados al comportamiento solar y su función como regulador de las actividades productivas y, por ende, acercarnos a la cosmovisión de los hacedores de estas pinturas. Para ello es condición sine qua non un análisis individual y profundo, realizado a partir de un enfoque teórico-metodológico basado sobre todo en la Arqueoastronomía, la Arqueología del Paisaje, la Semiótica o la Etnografía, entre otras disciplinas.In the geographical area under study, surround - ings of the Laguna de la Janda and the Campo de Gibraltar , there are over three hundred rock-shelters with cave paint - ings, which have barely been studied. The sun-shaped figure is depicted on the rocky walls of twenty-two of these rock- shelters. The Cueva del Sol is one of the rock-shelters that forms part of this set. Due to both its special geographical and iconographic characteristics as well as the revealing results of astronomic observation that confirmed the existence of a winter solstice marker (sun dagger), this rock-shelter is one of the most exceptional of the set and maybe of the ibe - rian peninsula. The characteristics of this rock-shelter enable us to determine some specific aspects on worship associated to the behaviour of the sun and its role in regulating produc - tion activities thus bringing us closer to the worldview of the creators of these paintings. For this purpose, a detailed and individual analysis from a theoretical and methodological ap - proach, mainly based on Archaeoastronomy, Landscape Archaeology, Semiotics and Ethnography, amongst other disci - plines, is a conditio sine qua non

Calidad e innovación de las páginas Web de enfermería en el periodo 2010-2012.

Objective: Assess the web pages of Spanish registered nurse associations and nursing scientific societies for quality and innovation.Methods: Descriptive observational study conducted in July–September periods of 2010 and 2012. We used the Bermúdez-Tamayo questionnaire to assess the quality and tools Google PageRank and Alexa TrafficRank for measuring visibility and popularity respectively. To assess the degree of adaptation to the Web 2.0, we analyzed the presence of: Blogs, forums, communities, search engines, RSS, multimedia contents, opinion comments, all tools that facilitate interaction with users.Results: The mean score ± standard deviation on the questionnaire quality in 2010 was 6.6 (SD 2.4) points and 8.2 (SD 2.9) in 2012. In general the visibility and popularity of the web analyzed is low, while it has increased the presence of 2.0 tools up to the 89.4% in the second periods of the study, being scientific societies which developed mainly use.Discussion: There is high variability in the quality of the websites studied, although with a growing interest in the same in most of the assessed organizations. The nursing web pages should improve the visibility and popularity to efficiently disseminate their content and services.The process of adaption to the web 2.0 is at an expansive stage, in fact, the 89,4% of web pages studied used some web 2.0 tool.Objetivo: Evaluar la calidad y la innovación de las páginas web de colegios oficiales y sociedades científicas de enfermería en España. Métodos: Estudio observacional descriptivo realizado en dos periodos: Julio-Septiembre de 2010 y Julio-Septiembre de 2012. Se ha utilizado el cuestionario de Bermúdez–Tamayo para evaluar la calidad y las herramientas PageRank de Google y Alexa TrafficRank para medir la visibilidad y popularidad respectivamente. Para valorar el grado de adaptación de las páginas web al entorno 2.0, se han analizado la presencia de: Blog, foros, comunidades, buscadores, RSS, contenidos multimedia, comentarios de opinión, herramientas todas ellas, que facilitan la interrelación con los usuarios. Resultados: La puntuación media + desviación estándar en el cuestionario de calidad en 2010 fue de 6,6 (DE 2,4) puntos y de 8,2 (DE 2,9) en 2012. En general, la visibilidad y popularidad de las web analizadas es escasa, mientras se ha incrementado la presencia de herramientas 2.0 hasta alcanzar el 89,4% en la segunda fase del estudio, siendo las sociedades científicas las que desarrollaron mayoritariamente su uso. Conclusiones: Existe una alta variabilidad en la calidad de los sitios web estudiados, aunque aunque con un creciente interés por la misma en gran parte de las organizaciones evaluadas. Las páginas web de enfermería deben mejorar la visibilidad y popularidad para difundir de manera eficiente sus contenidos y servicios. El proceso de adaptación a la web 2.0 está en fase expansiva, de hecho, el 89,4% de las web estudiadas utiliza alguna herramienta 2.0..

Virtualidad y pedagogía. Diseño de agentes pedagógicos virtuales en español

En este artículo se describe el proceso de diseño previsto para un agente pedagógico virtual de pregunta y respuesta para entrenar a jóvenes en la presentación de entrevistas de trabajo.La posibilidad de generar aplicaciones de bajo costo que permitan el trabajo con comunidades educativas marginales se enfrentan a diversas problemáticas, siendo particular la ausencia de soluciones disponibles en idioma español, así como la poca experiencia o cercanía de docentes al diseño y trabajo con humanos virtuales. Para ello se diseña una solución informática para el rápido desarrollo de personajes de pregunta y respuesta para el idioma español

Current trends in access to treatment for hepatitis B in immigrants vs non-immigrants

Universal vaccination for hepatitis B virus (HBV) and migratory movements have changed the demographic characteristics of this disease in Spain and in Europe. Therefore, we evaluated the characteristics of the disease and the possible differences according to origin (immigrants vs non-immigrants) and access to treatment. This is a multicenter cross-sectional study (June 2014 to May 2015) in which outpatients with a positive HBsAg were seen and followed in four Hepatology units. Demographic and clinical data and indication and access to treatment were collected in two different regions of Catalonia (Spain) where there are no barriers to treatment due to a comprehensive coverage under the National Health System. A total of 951 patients were evaluated (48.1% men). Of these, 46.6% were immigrants (58.7% of them were born in Africa) and were significantly younger compared to non-immigrants. The proportions of patients with alcohol consumption, being overweight, and other indicators of metabolic co-morbidities were significantly higher in non-immigrants. Among the 937 patients receiving HBeAg examination, 91.7% were HBeAg-negative. Chronic HBeAg-positive infection was significantly higher in immigrants (3.9% vs 0.6%, P = 0.001) and chronic HBeAg-negative hepatitis was higher non-immigrants (31.7% vs 21.4%, P < 0.001). Not only was the proportion of patients who met treatment criteria significantly higher among non-immigrants (38.4% vs 29.2%, P = 0.003), but also the proportion of those with indication of effectively receiving therapy at the time of data collection (83.2% vs 57.8 %, P < 0.001). The immigrant population with HBV is younger and has a lower prevalence of metabolic co-morbidities and a higher frequency of chronic HBeAg infection. Despite having access to care and an indication for treatment, some do not get adequately treated due to several factors including local adaptation that precludes access to treatment

Characterizing the phenotype and mode of inheritance of patients with inherited peripheral neuropathies carrying MME mutations

[EN] Background Mutations in the metalloendopeptidase (MME) gene were initially identified as a cause of autosomal recessive Charcot-Marie-Tooth disease type 2 (CMT2). Subsequently, variants in MME were linked to other late-onset autosomal dominant polyneuropathies. Thus, our goal was to define the phenotype and mode of inheritance of patients carrying changes in MME. Methods We screened 197 index cases with a hereditary neuropathy of the CMT type or distal hereditary motor neuropathy (dHMN) and 10 probands with familial amyotrophic lateral sclerosis (fALS) using a custom panel of 119 genes. In addition to the index case subjects, we also studied other clinically and/or genetically affected and unaffected family members. Results We found 17 variants in MME in a total of 20 index cases, with biallelic MME mutations detected in 13 cases from nine families (three in homozygosis and six in compound heterozygosis) and heterozygous variants found in 11 families. All patients with biallelic variants had a similar phenotype, consistent with late-onset axonal neuropathy. Conversely, the phenotype of patients carrying heterozygous mutations was highly variable [CMT type 1 (CMT1), CMT2, dHMN and fALS] and mutations did not segregate with the disease. Conclusion MME mutations that segregate in an autosomal recessive pattern are associated with a late-onset CMT2 phenotype, yet we could not demonstrate that MME variants in heterozygosis cause neuropathy. Our data highlight the importance of establishing an accurate genetic diagnosis in patients carrying MME mutations, especially with a view to genetic counselling.The authors thank the patients and healthy relatives for having participated in this project. We are grateful to the Eurobiobank CIBERER and the Biobank La Fe for their participation in the collection and processing of patient samples. We also thank the technicians at the Department of Genomics and Translational Genetics (CIPF) who participated in the quality control and processing of DNA samples (Virginia Rejas and Laura Ramírez), and the Bachelor¿s thesis student Andrea Ballester who helped with some clinical data collection. This project was funded by the Instituto de Salud Carlos III (ISCIII), FEDER (Grants no. PI12/00946 and PI16/00403 to TS, PI15/00187 to CE). MF holds a grant funded by the IIS La Fe (Grant no. 2015/0085). AS-M holds a grant funded by the Fundació Per Amor a l'Art (FPAA). JFV-C holds a ' Rio Hortega' contract funded by the ISCIII.Lupo, V.; Frasquet, M.; Sánchez-Monteagudo, A.; Pelayo-Negro, A.; García-Sobrino, T.; Sedano, MJ.; Pardo, J.... (2018). Characterizing the phenotype and mode of inheritance of patients with inherited peripheral neuropathies carrying MME mutations. Journal of Medical Genetics. 55(12):814-823. https://doi.org/10.1136/jmedgenet-2018-105650814823551

The Impact Of Rituximab Infusion Protocol On The Long-term Outcome In Anti-musk Myasthenia Gravis

Objective: To evaluate whether the clinical benefit and relapse rates in anti-muscle-specific kinase (MuSK) myasthenia gravis (MG) differ depending on the protocol of rituximab followed. Methods: This retrospective multicentre study in patients with MuSK MG compared three rituximab protocols in terms of clinical status, relapse, changes in treatment, and adverse side effects. The primary effectiveness endpoint was clinical relapse requiring a further infusion of rituximab. Survival curves were estimated using Kaplan-Meier methods and survival analyses were undertaken using Cox proportional-hazards models. Results: Twenty-five patients were included: 11 treated with protocol 4 + 2 (375 mg/m(2)/4 weeks, then monthly for 2 months), five treated with protocol 1 + 1 (two 1 g doses 2 weeks apart), and nine treated with protocol 4 (375 mg/m(2)/4 weeks). Mean follow-up was 5.0 years (SD 3.3). Relapse occurred in 18.2%, 80%, and 33.3%, and mean time to relapse was 3.5 (SD 1.5), 1.1 (SD 0.4), and 2.5 (SD 1.4) years, respectively. Based on Kaplan-Meier estimates, patients treated with protocol 4 + 2 had fewer and later relapses than patients treated with the other two protocols (log-rank test P = 0.0001). Patients treated with protocol 1 + 1 had a higher risk of relapse than patients treated with protocol 4 + 2 (HR 112.8, 95% CI, 5.7-2250.4, P = 0.002). Patients treated with protocol 4 showed a trend to a higher risk of relapse than those treated with protocol 4 + 2 (HR 9.2, 95% CI 0.9-91.8, P = 0.059). InterpretationThis study provides class IV evidence that the 4 + 2 rituximab protocol has a lower clinical relapse rate and produces a more durable response than the 1 + 1 and 4 protocols in patients with MuSK MG

Application of new technologies in archeology of the Civil War: The Yesares, Pinto (Madrid)

[EN] The surveys carried out in the municipality of Pinto (Madrid) have enabled us to locate various structural remains linked to the military operations that took place around the capital during the Spanish Civil War (1936-1939). In order to identify and record them, surveys were complemented with the use of GPS and air photographs from different time periods. Afterwards, and in collaboration with researchers from various universities, further methods aimed at generating a complete special representation of the area were applied directly to one of the sites which produced the best results, known as "los Yesares". These methods include topographic mapping that resulted in cartographic material at different scales, the photographic recording with flying Unmanned Aerial Vehicles, and the use of land scanners and GPS-corrected photogrammetrics with which to obtain 3D models.[ES] Los trabajos de prospección llevados a cabo en el término municipal de Pinto (Madrid) han permitido localizar diferentes enclaves con restos inmuebles relacionados con las operaciones militares realizadas en torno a la capital durante la Guerra Civil Española (1936-1939). Para su identificación y documentación se recurrió al uso de GPS durante las batidas de prospección así como a fotografías aéreas de diferentes períodos que ayudaron en el proceso. Posteriormente, en colaboración con investigadores de diversas universidades se aplicaron en una de las zonas de mayor relevancia, el yacimiento de "Los Yesares", diversas técnicas con el objetivo de conseguir una representación espacial lo más completa posible. Estas técnicas incluyeron levantamientos topográficos para realizar cartografías a diferentes escalas, la captación de imágenes mediante vuelos UAV (Unmanned Aerial Vehicle) y el uso de escáneres terrestres y técnicas de fotogrametría para la obtención de representaciones 3D.Díaz Moreno, MÁ.; Crespo Fraguas, Á.; Farjas Abadía, M.; Ruíz Serrano, C.; Martínez Pardo-Gil, G.; Alfonso Carbajosa, E.; Pereira Sieso, J.... (2015). Aplicación de nuevas tecnologías en la Arqueología de la Guerra Civil: Los Yesares, Pinto (Madrid). Virtual Archaeology Review. 6(12):122-136. doi:10.4995/var.2015.4167122136612AMADO, X. y BARREIRO, M. (2004): "La gestión del impacto y la prospección arqueológica", Arqueología Espacial, 24-25.CASTELLANO, R. (2004): Los restos del asedio. Fortificaciones de la Guerra Civil en el Frente de Madrid. Ejército Nacional, Madrid, AlmenaFARJAS, M. (2003): "Las Ciencias cartográficas en la arqueología: La búsqueda de la métrica en los modelos de divulgación cientrifica", DATUM XXI, 3, 4-12.FARJAS, M. (2012): La topografía y sus métodos: Principios de investigación, Bilbao, Astrolabio.FARJAS, M. y GARCÍA-LÁZARO, F.J. (2008): Modelización Tridimensional y Sistemas Laser Escaner aplicados al Patrimonio Histórico, Madrid, La Ergástula.FARJAS, M.; BELLIDO, D.; y GONZÁLEZ, L. (2014): Tecnología UAV en yacimientos arqueológicos. Análisis de precisión de los modelos digitales de superficie y de los productos fotogramétricos derivados, Saarbücken (Alemania), Publicia.GÓMEZ, L., QUIROGA, V., FERNANDEZ, J.A. (2009): "El patrimonio intangible. Infografía para preservar la memoria del pasado", Arqueoweb, 12.GONZÁLEZ RUIBAL, A. (2008): "Arqueología de la Guerra Civil Española", Complutum, 19, 11-20.LÓPEZ FRAILE, F.J. (2007): "La infografía 3D como sistema de documentación y divulgación", Primer Simposio de la Investigación y Difusión Arqueopaleontologica en elMarco de la Iniciativa Privada. AUDEMA, 429-444.MONTERO BARRADO, S. (2001): "Arqueología de la Guerra Civil en Madrid", Historia y Comunicación Social, 6.RASCÓN, S. y SÁNCHEZ, A.L. (2007): "Las nuevas tenologías alicadas a la didáctica del patrimonio", Ponencia en el curso: Claves para una interpretación educativa del patrimonio artístico de las ciudades, Alcalá de Henares, Centro Internacional de Estudios Históricos Cisneros.RODRIGUEZ, J.M. (2010): "De la reconstrucción tradicional a la virtual. Una visión desde la Arqueología", Virtual Archaeology Review, Volumen 1 Número 1.RUIZ ZAPATERO, G. (2004): "La prospección arqueológica de superficie en los inicios del siglo XXI", Arqueología Espacial, 24-25.Principios de Sevilla. Principios Internacionales de la Arqueología Virtual, (2012): Forum Internacional de Arqueología Virtual