Nuevas localidades con fauna ictiológica para el Neógeno menorquín

New places having ichthyological fauna are described in the Neogene of the island of Menorca (Balearic, Spain) and the Myliobatis sp. is shown to exist for the first time in the island All the referentes are summarized in the chart which is given

Nuevas localidades con fauna ictiológica para el Neógeno menorquín

Se citan nuevas localidades con fauna ictiológica en el Neógeno de la Isla de Menorca y se da a conocer el hallazgo de Myliobatis sp. por primera vez en la Isla. Al propio tiempo se sintetizan en un cuadro todas las referencias conocidas.New places having ichthyological fauna are described in the Neogene of the island of Menorca (Balearic, Spain) and the Myliobatis sp. is shown to exist for the first time in the island All the referentes are summarized in the chart which is given

Sobre la presencia de flysch en los sedimentos paleozoicos de la Isla de Menorca

En esta nota se señala por vez primera la presencia de turbiditas en la isla de Menorca. Son de edad paleozoica sin, en la actualidad, poderla aún precisar con exactitud. El trabajo debe considerarse como preliminar. Las turbiditas de los afloramientos de cala Tirant, de la carretera de Mahón a Fornells km 5,7 y km 20, del pueblo de Fornells y de la carretera de Mahón a Ciudadela km 19 y 23,7 son de facies de cuenca, y las turbiditas de cala Mesquida y de Els Freus son de facies de pendiente o marginales.In this paper it is shown, for the first time, the presence of turbidites in the Menorca Island (Baleares). They are of a Paleozoic age though its precise datation can not yet be known and this paper must be considered as a preliminary one. The turbidite outcrops of cala Tirant, those of the Mahón-Fornells road (km 5,7 and km 20), those of Fornells village and those encountered on the Mahón-Ciudadela road (km 19 and km 23,7) have a basin facies and the turbidites of cala Mesquida and of Els Freus have a marginal or slope one

Nueva aportación al conocimiento del Cuaternario menorquín

En esta nota, por una parte, se estudian unos materiales sedimentados bajo la acción del viento, que han suministrado abundante fauna, cuyo estudio permite conocer la posición estratigráfica de los mismos y, por la otra, se intenta establecer una síntesis general de los depósitos cuaternarios eólicos de la isla.Quaternary sediments from Menorca (Balearic Island) deposited by wind action contain a rich fauna o£ gasteropods

Confirmación de la presencia de Ornithogalum umbellatum (Hyacinthaceae) en la Península Ibérica

The study of plant material from three populations in northeastern Spain and southern France revealed the presence of O. umbellatum as a new record for the Iberian flora. Although this species had been cited in the Iberian Peninsula by various authors within the last two centuries, its presence in this territory could not been confirmed in recent years. A complete description is presented for O. umbellatum and an identification key is included to cover all species of Ornithogalum s. str. (O. subgen. Ornithogalum) of the Iberian Peninsula, as an amendment for their taxonomic treatment in Flora iberica.Se da a conocer la existencia de O. umbellatum en la Península Ibérica a partir de la localización y el estudio de tres poblaciones en el noreste de España y el sureste de Francia. Durante los dos últimos siglos esta especie ya había sido citada de la Península Ibérica por varios autores, pero no se había podido confirmar su presencia en dicho territorio hasta ahora. Así mismo, se presenta una descripción completa de O. umbellatum y se proporciona una clave dicotómica para la identificación de todos los táxones de Ornithogalum s. str. (O. subgen. Ornithogalum) de la Península Ibérica, como adición al tratamiento taxonónimo de Flora iberica

O- vs. N-protonation of 1-dimethylaminonaphthalene-8-ketones: formation of a peri N–C bond or a hydrogen bond to the pi-electron density of a carbonyl group

X-ray crystallography and solid-state NMR measurements show that protonation of a series of 1-dimethylaminonaphthalene-8-ketones leads either to O protonation with formation of a long N–C bond (1.637–1.669 Å) between peri groups, or to N protonation and formation of a hydrogen bond to the π surface of the carbonyl group, the latter occurring for the larger ketone groups (C(O)R, R = t-butyl and phenyl). Solid state 15N MAS NMR studies clearly differentiate the two series, with the former yielding significantly more deshielded resonances. This is accurately corroborated by DFT calculation of the relevant chemical shift parameters. In the parent ketones X-ray crystallography shows that the nitrogen lone pair is directed towards the carbonyl group in all cases

Efficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up.

Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memantine in the treatment of pain and other clinical variables (global function, clinical impression, depression, anxiety, quality of life) in FM patients. A double-blind, parallel randomised controlled trial was developed. A total of 63 patients diagnosed with FM were recruited from primary health care centres in Zaragoza, Spain. Memantine was administered at doses of 20mg/d after 1 month of titration. Assessments were carried out at baseline, posttreatment, and 3- and 6-month follow-up. Compared with a placebo group, memantine significantly decreased ratings on a pain visual analogue scale (Cohen's d=1.43 at 6 months) and pain measured with a sphygmomanometer (d=1.05). All other secondary outcomes except anxiety also improved, with moderate-to-large effect sizes at 6 months. Compared with placebo, the absolute risk reduction obtained with memantine was 16.13% (95% confidence interval=2.0% to 32.6%), and the number needed to treat was 6.2 (95% confidence interval=3 to 47). Tolerance was good, with dizziness (8 patients) and headache (4 patients) being the most frequent side effects of memantine. Although additional studies with larger sample sizes and longer follow-up times are needed, this study provides preliminary evidence of the utility of memantine for the treatment of FM

Abundance and Characteristics of Microplastics in Commercially sold fishes from Cebu Island, Philippines

This study documents microplastics (MPs) in the top three commercially sold fishes viz. Auxis rochei, Rastrelliger kanagurta and Chanos chanos in major public markets of Cebu Island, Philippines. MPs were found in the gastrointestinal tracts (FGIT) and quantified and characterized according to size, type, and color. In general, nine (97.3%) of 81 FGIT samples contained 635 total pieces of MPs with size ranging 0.01 to 0.50 and 1.00 to 2.00 mm. Transparent microfibers (91%) were the most predominant MPs, with blue (48%) as the most common MP color observed, followed by red (39%), black (8%) and white (5%). Chanos chanos proved to be the most susceptible fish to MP ingestion with a mean average of 11.6 pieces per individual fish, followed by A. rochei with 6.6 pieces, and R. kanagurta with 5.3 pieces. The results indicated that MPs were ubiquitous and high in commercially sold fishes in major public wet markets of Cebu Island, Philippines. The ingestion of fishes is of primary concern as a route of human exposure to MPs because they filter a large volume of seawater and are typically eaten whole without gut removal. Further study is needed on the potential consequences of MPs to aquatic populations to assess comprehensive exposure integrating multiple sources and routes.

Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA

The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. In this study, we present a novel DNA-based next-generation sequencing (NGS) methodology for KD ABL1 mutation detection and monitoring with a 1.0E−4 sensitivity. This approach was validated with a well-stablished RNA-based nested NGS method. The correlation of both techniques for the quantification of ABL1 mutations was high (Pearson r = 0.858, p < 0.001), offering DNA-DeepNGS a sensitivity of 92% and specificity of 82%. The clinical impact was studied in a cohort of 129 patients (n = 67 for CML and n = 62 for B-ALL patients). A total of 162 samples (n = 86 CML and n = 76 B-ALL) were studied. Of them, 27 out of 86 harbored mutations (6 in warning and 21 in failure) for CML, and 13 out of 76 (2 diagnostic and 11 relapse samples) did in B-ALL patients. In addition, in four cases were detected mutation despite BCR::ABL1 < 1%. In conclusion, we were able to detect KD ABL1 mutations with a 1.0E−4 sensitivity by NGS using DNA as starting material even in patients with low levels of disease.Tis project was funded in part by CRIS CANCER FOUNDATION