2,275 research outputs found
The conformal frame freedom in theories of gravitation
It has frequently been claimed in the literature that the classical physical
predictions of scalar tensor theories of gravity depend on the conformal frame
in which the theory is formulated. We argue that this claim is false, and that
all classical physical predictions are conformal-frame invariants. We also
respond to criticisms by Vollick [gr-qc/0312041], in which this issue arises,
of our recent analysis of the Palatini form of 1/R gravity.Comment: 9 pages, no figures, revtex; final published versio
What makes efficient circularly polarised luminescence in the condensed phase: aggregation-induced circular dichroism and light emission
In this contribution, we conceptually present a new avenue to construction of molecular functional materials with high performance of circularly polarised luminescence (CPL) in the condensed phase. A molecule (1) containing luminogenic silole and chiral sugar moieties was synthesized and thoroughly characterized. In a solution of 1, no circular dichroism (CD) and fluorescence emission are observed, but upon molecular aggregation, both the CD and fluorescence are simultaneously turned on, showing aggregation-induced CD (AICD) and emission (AIE) effects. The AICD effect is supported by the fact that the molecules readily assemble into right-handed helical nanoribbons and superhelical ropes when aggregated. The AIE effect boosts the fluorescence quantum efficiency (ΦF) by 136 fold (ΦF, ∼0.6% in the solution versus ∼81.3% in the solid state), which surmounts the serious limitations of aggregation-caused quenching effect encountered by conventional luminescent materials. Time-resolved fluorescence study and theoretical calculation from first principles conclude that restriction of the low-frequency intramolecular motions is responsible for the AIE effect. The helical assemblies of 1 prefer to emit right-handed circularly polarised light and display large CPL dissymmetry factors (gem), whose absolute values are in the range of 0.08–0.32 and are two orders of magnitude higher than those of commonly reported organic materials. We demonstrate for the first time the use of a Teflon-based microfluidic technique for fabrication of the fluorescent pattern. This shows the highest gem of −0.32 possibly due to the enhanced assembling order in the confined microchannel environment. The CPL performance was preserved after more than half year storage under ambient conditions, revealing the excellent spectral stability. Computational simulation was performed to interpret how the molecules in the aggregates interact with each other at the molecular level. Our designed molecule represents the desired molecular functional material for generating efficient CPL in the solid state, and the current study shows the best results among the reported organic conjugated molecular systems in terms of emission efficiency, dissymmetry factor, and spectral stability
Studies of a three-stage dark matter and neutrino observatory based on multi-ton combinations of liquid xenon and liquid argon detectors
We study a three stage dark matter and neutrino observatory based on
multi-ton two-phase liquid Xe and Ar detectors with sufficiently low
backgrounds to be sensitive to WIMP dark matter interaction cross sections down
to 10E-47 cm^2, and to provide both identification and two independent
measurements of the WIMP mass through the use of the two target elements in a
5:1 mass ratio, giving an expected similarity of event numbers. The same
detection systems will also allow measurement of the pp solar neutrino
spectrum, the neutrino flux and temperature from a Galactic supernova, and
neutrinoless double beta decay of 136Xe to the lifetime level of 10E27 - 10E28
y corresponding to the Majorana mass predicted from current neutrino
oscillation data. The proposed scheme would be operated in three stages G2, G3,
G4, beginning with fiducial masses 1-ton Xe + 5-ton Ar (G2), progressing to
10-ton Xe + 50-ton Ar (G3) then, dependent on results and performance of the
latter, expandable to 100-ton Xe + 500-ton Ar (G4). This method of scale-up
offers the advantage of utilizing the Ar vessel and ancillary systems of one
stage for the Xe detector of the succeeding stage, requiring only one new
detector vessel at each stage. Simulations show the feasibility of reducing or
rejecting all external and internal background levels to a level <1 events per
year for each succeeding mass level, by utilizing an increasing outer thickness
of target material as self-shielding. The system would, with increasing mass
scale, become increasingly sensitive to annual signal modulation, the agreement
of Xe and Ar results confirming the Galactic origin of the signal. Dark matter
sensitivities for spin-dependent and inelastic interactions are also included,
and we conclude with a discussion of possible further gains from the use of
Xe/Ar mixtures
Search for Lorentz and CPT Violation Effects in Muon Spin Precession
The spin precession frequency of muons stored in the storage ring has
been analyzed for evidence of Lorentz and CPT violation. Two Lorentz and CPT
violation signatures were searched for: a nonzero
(=); and a sidereal variation of
. No significant effect is found, and the following
limits on the standard-model extension parameters are obtained: GeV; GeV; and the 95% confidence level limits
GeV and
GeV.Comment: 5 pages, 3 figures, submitted to Physical Review Letters, Modified to
answer the referees suggestion
An Improved Limit on the Muon Electric Dipole Moment
Three independent searches for an electric dipole moment (EDM) of the
positive and negative muons have been performed, using spin precession data
from the muon g-2 storage ring at Brookhaven National Laboratory. Details on
the experimental apparatus and the three analyses are presented. Since the
individual results on the positive and negative muon, as well as the combined
result, d=-0.1(0.9)E-19 e-cm, are all consistent with zero, we set a new muon
EDM limit, |d| < 1.9E-19 e-cm (95% C.L.). This represents a factor of 5
improvement over the previous best limit on the muon EDM.Comment: 19 pages, 15 figures, 7 table
Search for Lorentz and CPT Violation Effects in Muon Spin Precession
The spin precession frequency of muons stored in the storage ring has
been analyzed for evidence of Lorentz and CPT violation. Two Lorentz and CPT
violation signatures were searched for: a nonzero
(=); and a sidereal variation of
. No significant effect is found, and the following
limits on the standard-model extension parameters are obtained: GeV; GeV; and the 95% confidence level limits
GeV and
GeV.Comment: 5 pages, 3 figures, submitted to Physical Review Letters, Modified to
answer the referees suggestion
Final Report of the Muon E821 Anomalous Magnetic Moment Measurement at BNL
We present the final report from a series of precision measurements of the
muon anomalous magnetic moment, a_mu = (g-2)/2. The details of the experimental
method, apparatus, data taking, and analysis are summarized. Data obtained at
Brookhaven National Laboratory, using nearly equal samples of positive and
negative muons, were used to deduce a_mu(Expt) = 11 659 208.0(5.4)(3.3) x
10^-10, where the statistical and systematic uncertainties are given,
respectively. The combined uncertainty of 0.54 ppm represents a 14-fold
improvement compared to previous measurements at CERN. The standard model value
for a_mu includes contributions from virtual QED, weak, and hadronic processes.
While the QED processes account for most of the anomaly, the largest
theoretical uncertainty, ~0.55 ppm, is associated with first-order hadronic
vacuum polarization. Present standard model evaluations, based on e+e- hadronic
cross sections, lie 2.2 - 2.7 standard deviations below the experimental
result.Comment: Summary paper of E821 Collaboration measurements of the muon
anomalous magnetic moment, each reported earlier in Letters or Brief Reports;
96 pages, 41 figures, 16 tables. Revised version submitted to PR
The Muon Anomalous Magnetic Moment and the Standard Model
The muon anomalous magnetic moment measurement, when compared with theory,
can be used to test many extensions to the standard model. The most recent
measurement made by the Brookhaven E821 Collaboration reduces the uncertainty
on the world average of a_mu to 0.7 ppm, comparable in precision to theory.
This paper describes the experiment and the current theoretical efforts to
establish a correct standard model reference value for the muon anomaly.Comment: Plenary Talk; PANIC'02 XVI Particles and Nuclear International
Conference, Osaka, Japan; Sept. 30 - Oct. 4, 2002; Report describes the
published 0.7 ppm result and updates the theory statu
News from the Muon (g-2) Experiment at BNL
The magnetic moment anomaly a_mu = (g_mu - 2) / 2 of the positive muon has
been measured at the Brookhaven Alternating Gradient Synchrotron with an
uncertainty of 0.7 ppm. The new result, based on data taken in 2000, agrees
well with previous measurements. Standard Model evaluations currently differ
from the experimental result by 1.6 to 3.0 standard deviations.Comment: Talk presented at RADCOR - Loops and Legs 2002, Kloster Banz,
Germany, September 8-13 2002, to be published in Nuclear Physics B (Proc.
Suppl.); 5 pages, 3 figure
Machine Learning Identifies Clinical and Genetic Factors Associated With Anthracycline Cardiotoxicity in Pediatric Cancer Survivors
BACKGROUND Despite known clinical risk factors, predicting anthracycline cardiotoxicity remains challenging. OBJECTIVES This study sought to develop a clinical and genetic risk prediction model for anthracycline cardiotoxicity in childhood cancer survivors. METHODS We performed exome sequencing in 289 childhood cancer survivors at least 3 years from anthracycline exposure. In a nested case-control design, 183 case patients with reduced left ventricular ejection fraction despite low-dose doxorubicin (\u3c= 250 mg/m(2)), and 106 control patients with preserved left ventricular ejection fraction despite doxorubicin \u3e250 mg/m(2) were selected as extreme phenotypes. Rare/low-frequency variants were collapsed to identify genes differentially enriched for variants between case patients and control patients. The expression levels of 5 top-ranked genes were evaluated in human induced pluripotent stem cell-derived cardiomyocytes, and variant enrichment was confirmed in a replication cohort. Using random forest, a risk prediction model that included genetic and clinical predictors was developed. RESULTS Thirty-one genes were differentially enriched for variants between case patients and control patients (p \u3c 0.001). Only 42.6% case patients harbored a variant in these genes compared to 89.6% control patients (odds ratio: 0.09; 95% confidence interval: 0.04 to 0.17; p = 3.98 x 10(-15)). A risk prediction model for cardiotoxicity that included clinical and genetic factors had a higher prediction accuracy and lower misclassification rate compared to the clinical-only model. In vitro inhibition of gene-associated pathways (PI3KR2, ZNF827) provided protection from cardiotoxicity in cardiomyocytes. CONCLUSIONS Our study identified variants in cardiac injury pathway genes that protect against cardiotoxicity and informed the development of a prediction model for delayed anthracycline cardiotoxicity, and it also provided new targets in autophagy genes for the development of cardio-protective drugs
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