Testing for symmetry and conditional symmetry using asymmetric kernels

The final publication is available at Springer via http://dx.doi.org/10.1007/s10463-014-0469-6.e financial support from the ESRC under the grant RES-062-23-0311 (Fernandes), from the ARC grant DP0988579 (Mendes), and from the SNSF through the NCCR Finrisk (Scaillet).ESRC under the grant RES-062-23-0311 (Fernandes), from the ARC grant DP0988579 (Mendes), and from the SNSF through the NCCR Finrisk (Scaillet)

Smooth interface effects on the Raman scattering in zinc-blende AlN/GaN superlattices

Raman spectra of (AlN)(8-delta)/(AlxGa1-xN)(delta)/(GaN)(8-delta)/(AlxGa1-xN)(delta) superlattices with interface thickness varying between delta = 0 and delta = 3 are calculated. The influence of the nonabrupt interface related broadening is described in the complete range of scattering, with special attention to the modes giving stronger contribution to the Raman intensity. It is shown that the dispersion of folded acoustic phonons does not change appreciably with the interface smoothing. For delta = 0 the Raman spectra display new peaks due to the enhancement of some confined optic modes.6119130601306

Model inference for spreadsheets

Many errors in spreadsheet formulas can be avoided if spreadsheets are built automati- cally from higher-level models that can encode and enforce consistency constraints in the generated spreadsheets. Employing this strategy for legacy spreadsheets is dificult, because the model has to be reverse engineered from an existing spreadsheet and existing data must be transferred into the new model-generated spreadsheet. We have developed and implemented a technique that automatically infers relational schemas from spreadsheets. This technique uses particularities from the spreadsheet realm to create better schemas. We have evaluated this technique in two ways: First, we have demonstrated its appli- cability by using it on a set of real-world spreadsheets. Second, we have run an empirical study with users. The study has shown that the results produced by our technique are comparable to the ones developed by experts starting from the same (legacy) spreadsheet data. Although relational schemas are very useful to model data, they do not t well spreadsheets as they do not allow to express layout. Thus, we have also introduced a mapping between relational schemas and ClassSheets. A ClassSheet controls further changes to the spreadsheet and safeguards it against a large class of formula errors. The developed tool is a contribution to spreadsheet (reverse) engineering, because it lls an important gap and allows a promising design method (ClassSheets) to be applied to a huge collection of legacy spreadsheets with minimal effort.We would like to thank Orlando Belo for his help on running and analyzing the empirical study. We would also like to thank Paulo Azevedo for his help in conducting the statistical analysis of our empirical study. We would also like to thank the anonymous reviewers for their suggestions which helped us to improve the paper. This work is funded by ERDF - European Regional Development Fund through the COMPETE Programme (operational programme for competitiveness) and by National Funds through the FCT - Fundacao para a Ciencia e a Tecnologia (Portuguese Foundation for Science and Technology) within project FCOMP-01-0124-FEDER-010048. The first author was also supported by FCT grant SFRH/BPD/73358/2010

The phylogenetically-related pattern recognition receptors EFR and XA21 recruit similar immune signaling components in monocots and dicots

During plant immunity, surface-localized pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs). The transfer of PRRs between plant species is a promising strategy for engineering broad-spectrum disease resistance. Thus, there is a great interest in understanding the mechanisms of PRR-mediated resistance across different plant species. Two well-characterized plant PRRs are the leucine-rich repeat receptor kinases (LRR-RKs) EFR and XA21 from Arabidopsis thaliana (Arabidopsis) and rice, respectively. Interestingly, despite being evolutionary distant, EFR and XA21 are phylogenetically closely related and are both members of the sub-family XII of LRR-RKs that contains numerous potential PRRs. Here, we compared the ability of these related PRRs to engage immune signaling across the monocots-dicots taxonomic divide. Using chimera between Arabidopsis EFR and rice XA21, we show that the kinase domain of the rice XA21 is functional in triggering elf18-induced signaling and quantitative immunity to the bacteria Pseudomonas syringae pv. tomato (Pto) DC3000 and Agrobacterium tumefaciens in Arabidopsis. Furthermore, the EFR:XA21 chimera associates dynamically in a ligand-dependent manner with known components of the EFR complex. Conversely, EFR associates with Arabidopsis orthologues of rice XA21-interacting proteins, which appear to be involved in EFR-mediated signaling and immunity in Arabidopsis. Our work indicates the overall functional conservation of immune components acting downstream of distinct LRR-RK-type PRRs between monocots and dicots

Health services performance for TB treatment in Brazil: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Researches to evaluate Primary Health Care performance in TB control in Brazil show that different cities aggregate local specificities in the dynamics of coping with the disease. This study aims to evaluate health services' performance in TB treatment in cities across different Brazilian regions.</p> <p>Methods</p> <p>This cross-sectional study was conducted in five cities that are considered priorities for TB control in Brazil: Itaboraí (ITA), Ribeirão Preto (RP) and São José do Rio Preto (SJRP) in the Southeast; Campina Grande (CG) and Feira de Santana (FS) in the Northeast. Data were collected through interviews with 514 TB patients under treatment in 2007, using the <it>Primary Care Assessment Tool </it>adapted for TB care in Brazil. Indicators were constructed based on the mean response scores (Likert scale) and compared among the study sites.</p> <p>Results</p> <p>"Access to treatment" was evaluated as satisfactory in the Southeast and regular in the Northeast, which displayed poor results on 'home visits' and 'distance between treatment site and patient's house'. "Bond" was assessed as satisfactory in all cities, with a slightly better performance in RP and SJRP. "Range of services" was rated as regular, with better performance of southeastern cities. 'Health education', 'DOT' and 'food vouchers' were less offered in the Northeast. "Coordination" was evaluated as satisfactory in all cities. "Family focus" was evaluated as satisfactory in RP and SJRP, and regular in the others. 'Professional asking patient's family about other health problems' was evaluated as unsatisfactory, except in RP.</p> <p>Conclusions</p> <p>Two types of obstacles are faced for health service performance in TB treatment in the cities under analysis, mainly in the Northeast. The first is structural and derives from difficulties to access health services and actions. The second is organizational and derives from the way health technologies and services are distributed and integrated. Incentives to improve care organization and management practices, aimed at the integration of primary, secondary and tertiary services, can contribute towards a better performance of health services in TB treatment.</p

Reliable identification of protein-protein interactions by crosslinking mass spectrometry

Protein-protein interactions govern most cellular pathways and processes, and multiple technologies have emerged to systematically map them. Assessing the error of interaction networks has been a challenge. Crosslinking mass spectrometry is currently widening its scope from structural analyses of purified multi-protein complexes towards systems-wide analyses of protein-protein interactions (PPIs). Using a carefully controlled large-scale analysis of Escherichia coli cell lysate, we demonstrate that false-discovery rates (FDR) for PPIs identified by crosslinking mass spectrometry can be reliably estimated. We present an interaction network comprising 590 PPIs at 1% decoy-based PPI-FDR. The structural information included in this network localises the binding site of the hitherto uncharacterised protein YacL to near the DNA exit tunnel on the RNA polymerase.TU Berlin, Open-Access-Mittel – 2021DFG, 390540038, EXC 2008: Unifying Systems in Catalysis "UniSysCat"DFG, 392923329, GRK 2473: Bioaktive Peptide - Innovative Aspekte zur Synthese und BiosyntheseDFG, 426290502, Erfassung der strukturellen Organisation des Mycoplasma pneumoniae Proteoms mittels in-Zell Crosslinking-Massenspektrometri