ESTIMATE OF TRUNK INCLINATION DURING FAST MOVEMENTS BY INERTIAL SENSING

The purpose of this study was to identify a reliable algorithm to estimate the inclination of a trunk-mounted inertial measurement unit (IMU) during fast movements and to test its subject- and task-specificity. Ten amateur football players performed three times the approach phase of the drive block technique and a fast sit-to-stand-to-sit task. IMU data were processed using an ad hoc adaptive Kaman filter, and pitch angular displacements were obtained and compared to stereophotogrammetric reference estimates. Tuning of the algorithm parameters was performed and relevant accuracy was tested in terms of root mean squared difference (RMSD) and correlation coefficient. Strong correlation (>0.978) were observed for both motor tasks, together with RMSD smaller than 4.4±1.7 deg. The tuned algorithm proved to be neither subject- nor task-specific (p>0.05)

Static and thermal FE analysis of a Flexible Electronic BOard (FEBO) prototype and the characterization of its innovative materials

An FE model of an experimental flexible electronic board was built to determine its performance in terms of mechanical and thermal distortions, heat and transient thermal flow, thereby detecting critical issues and identifying opportunities for improvement. Commercial sensors were connected to the flexible board (100x40x2mm), which was based on a commercial thermoplastic polyurethane (TPU), with a PEDOT-based conductive resin trapped in a PEGDA network, a biocompatible polymer. Three thermal loads (ΔT=175°C, ΔT=100°C, ΔT=50°C) were applied which revealed critical stresses for high ΔTs but at ΔT=50°C only the connectors had a critical σvm, while for ΔT=50°C + 1mm displacement a critical strain value occurred in one area of the substrate. Heat transient analysis and overheating simulations were performed to determine the heat flow behavior for the photodiode and accelerometer. FE analyses allow more studies to be undertaken to improve material properties and suggest redesign activities for similar concept demonstrators. The funds of the European Union and the Piedmont Region, and agreements with the most important players in SBE (Simulation Based Engineering) software sales and services, allowed the authors (ITACAe srl, Proplast, and Politecnico di Torino) to conduct industrial research and experimental development together with manufacturers and users of innovative technologies to identify, study and optimize the design parameters of the board while simultaneously contributing to its technological development

Variegated silencing through epigenetic modifications of a large Xq region in a case of balanced X;2 translocation with Incontinentia Pigmenti-like phenotype

Molecular mechanisms underlying aberrant phenotypes in balanced X;autosome translocations are scarcely understood. We report the case of a de novo reciprocal balanced translocation X;2(q23;q33) presenting phenotypic alterations highly suggestive of Incontinentia Pigmenti (IP) syndrome, a genodermatosis with abnormal skin pigmentation and neurological failure, segregating as X-linked dominant disorder. Through molecular studies, we demonstrated that the altered phenotype could not be ascribed to chromosome microdeletions or to XIST-mediated inactivation of Xq24-qter. Interestingly, we found that the Xq24-qter region, which translocated downstream of the heterochromatic band 2q34, undergoes epigenetic silencing mediated by DNA methylation and histone alterations. Among the downregulated genes, we found the inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma (IKBKG/NEMO), the causative gene of IP. We hypothesize that a mosaic functional nullisomy of the translocated genes, through a Position Effect Variegation-like heterochromatization, might be responsible for the proband's phenotypic anomalies. Partial silencing of IKBKG may be responsible for the skin anomalies observed, thereby mimicking the IP pathological condition. In addition to its clinical relevance, this paper addresses fundamental issues related to the chromatin status and nuclear localization of a human euchromatic region translocated proximally to heterochromatin. In conclusion, the study provides new insight into long-range gene silencing mechanisms and their direct impact in human disease

Lung anatomy, energy load, and ventilator-induced lung injury

High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective. We aimed to find the volumetric VILI threshold and see whether PEEP is protective per se or indirectly

Baseline genetic distinctiveness supports structured populations of thornback ray in the Mediterranean Sea

The thornback ray (Raja clavata) is the most important chondrichthyan in terms of landings in the Mediterranean Sea. Intense harvesting may induce negative genetic effects reducing the resilience of overfished species. For this reason, genetic diversity information should be considered in fisheries management and conservation policies. Microsatellite markers were used to unravel the genetic features (variability, connectivity, sex-biased dispersal) of R. clavata populations, both at the small (around the coast of Sardinia, western Mediterranean Sea) and larger spatial scales (at the pan-Mediterranean level, and between the Atlantic Ocean and the Mediterranean Sea). Individual clustering, multivariate and variance analyses rejected the hypothesis of genetic homogeneity, with significant genetic differences between Mediterranean and Atlantic rays, as well as within the Mediterranean Sea between its western and eastern basins. The data indicated that both the Strait of Gibraltar and the Sicilian Channel seem to be effective in limiting the dispersal of thornback ray individuals, but a further structuring was identified, with the significant genetic differentiation of the populations located in the Algero-Provençal and Tyrrhenian basins. Such a fine-scale arrangement suggests the occurrence of additional barriers to species dispersal. A lack of significant genetic differentiation, stable over the years, was measured at a local scale among R. clavata Sardinian samples. Several possible mechanisms, both biological and abiotic (e.g. migratory behaviour, waterfronts and oceanographic discontinuities), are discussed. Overall, the genetic data presented, both at the local and regional level, could represent the baseline information for the temporal monitoring of populations and assessing the effects of present or future fisheries-related management actions. The data obtained are information of paramount importance for minimizing the gaps in our current knowledge of the genetic diversity of thornback rays and maximizing the information needed for the correct protection of R. clavata populations

Strongly structured populations and reproductive habitat fragmentation increase the vulnerability of the Mediterranean starry ray Raja asterias (Elasmobranchii, Rajidae)

1. The Mediterranean starry ray (Raja asterias) populations within the Mediterranean Sea are susceptible to high rates of bycatch in the multispecies trawl fisheries. Understanding its population structure and identifying critical habitats are crucial for assessing species vulnerability and setting the groundwork for specific management measures to prevent population decline. 2. To assess the population structure of R. asterias in the Mediterranean, the genetic variation in nine population samples at one mitochondrial marker and eight nuclear microsatellite loci was analysed. Moreover, 172 egg cases collected in the Strait of Sicily were identified at species level using integrated molecular and morphological approaches. 3. Genetic analyses revealed that the Mediterranean starry ray comprises three distinct units inhabiting the western, the central-western, and the central-eastern areas of the Mediterranean. An admixture zone occurs in the Strait of Sicily and the Ionian Sea, where individuals of the central-western and central-eastern population units intermingle. 4. The joint morphometric–genetic analyses of rajid egg cases confirmed the presence of more than one species in the admixture area, with a predominance of egg cases laid by R. asterias. DNA barcoding revealed that egg cases and embryos of R. asterias shared several haplotypes with adult individuals from the centralwestern and central-eastern Mediterranean Sea, revealing that females of both populations laid numerous eggs in this area. 5. According to these findings, detailed taxonomic determination of egg cases, when combined with seasonal migration studies, could improve the capability to identify important spawning or nursery areas for the Mediterranean starry ray, particularly in those admixture zones relevant to maintaining genetic diversity. 6. Finally, these new insights should be considered to update the Action Plan for the Conservation of Cartilaginous Fishes in the Mediterranean Sea with effective measures to reduce the impact of skate bycatch in trawling and safeguard egg cases in nursery areas

Spectro-polarimetric observations of the CIZA J2242.8+5301 northern radio relic: no evidence of high-frequency steepening

Observations of radio relics at very high frequency (>10 GHz) can help to understand how particles age and are (re-)accelerated in galaxy cluster outskirts and how magnetic fields are amplified in these environments. In this work, we present new single-dish 18.6 GHz Sardinia Radio Telescope and 14.25 GHz Effelsberg observations of the well known northern radio relic of CIZA J2242.8+5301. We detected the relic which shows a length of $\sim$1.8 Mpc and a flux density equal to $\rm S_{14.25\,GHz}=(9.5\pm3.9)\,mJy$ and $\rm S_{18.6\,GHz}=(7.67\pm0.90)\,mJy$ at 14.25 GHz and 18.6 GHz respectively. The resulting best-fit model of the relic spectrum from 145 MHz to 18.6 GHz is a power-law spectrum with spectral index $\alpha=1.12\pm0.03$: no evidence of steepening has been found in the new data presented in this work. For the first time, polarisation properties have been derived at 18.6 GHz, revealing an averaged polarisation fraction of $\sim40\%$ and a magnetic field aligned with the 'filaments' or 'sheets' of the relic.Comment: 10 pages, 8 figure

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“An unnecessary cut?” multilevel health systems analysis of drivers of caesarean sections rates in Italy: A systematic review

From Springer Nature via Jisc Publications RouterBackground: Improvements in medical technologies have seen over-medicalization of childbirth. Caesarean section (CS) is a lifesaving procedure proven effective in reducing maternal and perinatal mortality across the globe. However, as with any medical procedure, the CS intrinsically carries some risk to its beneficiaries. In recent years, CS rates have risen alarmingly in high-income countries. Many exceeding the World Health Organisation (WHO) recommendation of a 10 to 15% annual CS rate. While this situation poses an increased risk to women and their children, it also represents an excess human and financial burden on health systems. Therefore, from a health system perspective this study systematically summarizes existing evidence relevant to the factors driving the phenomenon of increasing CS rates using Italy as a case study. Methods: Employing the WHO Health System Framework (WHOHSF), this systematic review used the PRISMA guidelines to report findings. PubMed, SCOPUS, MEDLINE, Cochrane Library and Google Scholar databases were searched up until April 1, 2020. Findings were organised through the six dimensions of the WHOHSF framework: service delivery, health workforce, health system information; medical products vaccine and technologies, financing; and leadership and governance. Results: CS rates in Italy are affected by complex interactions among several stakeholder groups and contextual factors such as the hyper-medicalisation of delivery, differences in policy and practice across units and the national context, issues pertaining to the legal and social environment, and women’s attitudes towards pregnancy and childbirth. Conclusion: Mitigating the high rates of CS will require a synergistic multi-stakeholder intervention. Specifically, with processes able to attract the official endorsement of policy makers, encourage concensus between regional authorities and local governments and guide the systematic compliance of delivery units with its clinical guidelines.20pubpu