2,057 research outputs found

    Cancer Courts Immune Response to Aid Growth

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    Student Engagement and Satisfaction with Online Labs

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    Hospitality and tourism is a ‘people business.’ So what happened when the need for social isolation as a result of COVID-19 forced hospitality educators to rethink their pedagogical strategies and move previously face-to-face courses online? In one of the first studies of its kind, Marissa Orlowski, Cynthia Mejia, Robin Back and Jason Fridrich from UCF Rosen College of Hospitality Management researched student engagement and satisfaction in online culinary and beverage labs

    What does a match mean? A Framework for Understanding Forensic Comparisons

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    On 11 March 2004, terrorists in Madrid, Spain detonated bombs on several commuter trains. In total, 191 people were killed and 1,400 were injured. After the bombing, examiners from the Federal Bureau of Investigation (FBI) identified a latent fingerprint found on a bag containing detonators and explosives as coming from an Oregon lawyer named Brandon Mayfield. Mayfield was arrested and held as a material witness for two weeks, until the Spanish National Police determined that the print did not, in fact, come from Mayfield, but from another man living in Spain

    Assessing the resources and requirements of statistics education in forensic science

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    Posted with permission of CSAFE.</p

    Estudio de la arquitectura sostenible para frenar la expansión urbana en Lomas Alta - Jicamarca

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    El presente proyecto de investigación tuvo como objetivo evaluar la estratificación de expansión urbana en el sector Lomas Alto, mediante una intervención arquitectónica implementando métodos sostenibles; la investigación tuvo la metodología de tipo cualitativa y diseño fenomenológico. Se basó en fundamentos teóricos por cada categoría como, Estrada (2021) plantea la arquitectura sostenible como medida para que la expansión urbana se desarrolle de manera ordenada y sin afectar a la imagen urbana; así mismo Huarancca, Alanya y Castellares (2020) mencionan que la expansión se genera por las migraciones a la ciudad, estableciéndose en áreas perimétricas de la ciudad. Se utilizó como participantes a 10 equipamientos y 3 especialistas en el tema a tratar; el tamaño de muestra fue por muestreo no probabilístico y fue tomado a criterio de los investigadores. La validez del instrumento se obtuvo mediante 3 expertos; la recolección de datos se obtuvo mediante la guía de entrevista y ficha de observación entre 10 y 18 ítems en ambas categorías. Teniendo como resultados la coincidencia de los especialistas y llegando a concluir en implementar la arquitectura sostenible en las periferias como alternativa para estratificar la expansión urbana y brindar mejor calidad de vida a los pobladores de Lomas Alto

    Unsettled Subjects/Unsettling Landscapes: Confronting Questions of Architecture in C.L.R. James's The Black Jacobins

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    We begin by acknowledging all those who live in present danger to their lives, their livelihoods and their loved ones: surviving and resisting the exploitation, subordination and marginalisation exacted by that system of racialised practices, structures and knowledges that we know of as colonialism. We acknowledge them in solidarity and recognise their struggle, offering as they do not just resistance but histories and practices of life. We will continue to seek counter-hegemonic socialist, feminist and decolonial knowledges, practices and affects in our work with one another as grounded beings in and of this only Earth

    Poplar phyllosphere harbors disparate isoprene-degrading bacteria

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    The climate-active gas isoprene (2-methyl-1,3-butadiene) is released to the atmosphere in huge quantities, almost equaling that of methane, yet we know little about the biological cycling of isoprene in the environment. Although bacteria capable of growth on isoprene as the sole source of carbon and energy have previously been isolated from soils and sediments, no microbiological studies have targeted the major source of isoprene and examined the phyllosphere of isoprene-emitting trees for the presence of degraders of this abundant carbon source. Here, we identified isoprene-degrading bacteria in poplar tree-derived microcosms by DNA stable isotope probing. The genomes of isoprene-degrading taxa were reconstructed, putative isoprene metabolic genes were identified, and isoprene-related gene transcription was analyzed by shotgun metagenomics and metatranscriptomics. Gram-positive bacteria of the genus Rhodococcus proved to be the dominant isoprene degraders, as previously found in soil. However, a wider diversity of isoprene utilizers was also revealed, notably Variovorax, a genus not previously associated with this trait. This finding was confirmed by expression of the isoprene monooxygenase from Variovorax in a heterologous host. A Variovorax strain that could grow on isoprene as the sole carbon and energy source was isolated. Analysis of its genome confirmed that it contained isoprene metabolic genes with an identical layout and high similarity to those identified by DNA-stable isotope probing and metagenomics. This study provides evidence of a wide diversity of isoprene-degrading bacteria in the isoprene-emitting tree phyllosphere and greatly enhances our understanding of the biodegradation of this important metabolite and climate-active gas

    Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: a systematic review

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    Introduction: Artificial intelligence (AI) and neuroimaging offer new opportunities for diagnosis and prognosis of dementia. Methods: We systematically reviewed studies reporting AI for neuroimaging in diagnosis and/or prognosis of cognitive neurodegenerative diseases. Results: A total of 255 studies were identified. Most studies relied on the Alzheimer's Disease Neuroimaging Initiative dataset. Algorithmic classifiers were the most commonly used AI method (48%) and discriminative models performed best for differentiating Alzheimer's disease from controls. The accuracy of algorithms varied with the patient cohort, imaging modalities, and stratifiers used. Few studies performed validation in an independent cohort. Discussion: The literature has several methodological limitations including lack of sufficient algorithm development descriptions and standard definitions. We make recommendations to improve model validation including addressing key clinical questions, providing sufficient description of AI methods and validating findings in independent datasets. Collaborative approaches between experts in AI and medicine will help achieve the promising potential of AI tools in practice. Highlights: There has been a rapid expansion in the use of machine learning for diagnosis and prognosis in neurodegenerative disease Most studies (71%) relied on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset with no other individual dataset used more than five times There has been a recent rise in the use of more complex discriminative models (e.g., neural networks) that performed better than other classifiers for classification of AD vs healthy controls We make recommendations to address methodological considerations, addressing key clinical questions, and validation We also make recommendations for the field more broadly to standardize outcome measures, address gaps in the literature, and monitor sources of bias

    Platelet Inhibition, Endothelial Function, and Clinical Outcome in Patients Presenting With ST-Segment-Elevation Myocardial Infarction Randomized to Ticagrelor Versus Prasugrel Maintenance Therapy: Long-Term Follow-Up of the REDUCE-MVI Trial

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    Background Off-target properties of ticagrelor might reduce microvascular injury and improve clinical outcome in patients with ST-segment-elevation myocardial infarction. The REDUCE-MVI (Evaluation of Microvascular Injury in Revascularized Patients with ST-Segment-Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel) trial reported no benefit of ticagrelor regarding microvascular function at 1 month. We now present the follow-up data up to 1.5 years. Methods and Results We randomized 110 patients with ST-segment-elevation myocardial infarction to either ticagrelor 90 mg twice daily or prasugrel 10 mg once a day. Platelet inhibition and peripheral endothelial function measurements includi
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