Treatment of symptomatic calcaneal lipoma with osseoscopy using a synthetic allograft

Objective: This study evaluated the results of symptomatic calcaneal lipoma patients treated with a recently introduced minimally invasive arthroscopic method. Materials and methods: Seven patients treated with osseoscopy in our clinic for calcaneal lipoma between 2013 and 2018 were evaluated. The median age of the patients was 37.7 years and five were male. The common compliant of the patients was pain that partially disrupted daily life. Surgery was utilized for patients who did not respond to conservative methods (sports restriction, partial weight bearing, and heel support) had persistent pain longer than 3 months and had a risk of impending fracture (>30% loss in trabecular bones). Results: The mean follow-up period after surgery was 21 (12–33) months. In all patients, the location of the ICL was in Ward’s triangle and the mean size was 28.8 (20-43) mm. According to Milgram’s classification, three ICLs were stage I, two were stage II, and two were stage III. The radiological result was evaluated using the classification system of Glutting and Chang. There was no persistent cyst and no recurrence. The radiological success rate was 100%. The mean ankle-hindfoot scale score (max. 100 pts) increased from a preoperative 74.7 ± 5.3 points (range: 69–83) to a postoperative 96.7 ± 2.62 points (range: 93-100). Conclusions: In the treatment of calcaneal lipoma, treatment with osseoscopy is easy and fast, has low complication rates, and is a cosmetically desirable alternative. The use of synthetic allografts to fill the cavity is a safe, inexpensive, and easy alternative

Soft-Sediment Deformation Structures Interpreted as Seismites in the Kolankaya Formation, Denizli Basin (SW Turkey)

The NW-trending Denizli basin of the SW Turkey is one of the neotectonic grabens in the Aegean extensional province. It is bounded by normal faults on both southern and northern margins. The basin is filled by Neogene and Quaternary terrestrial deposits. Late Miocene- Late Pliocene aged Kolankaya formation crops out along the NW trending Karakova uplift in the Denizli basin. It is a typical fluviolacustrine succession that thickens and coarsens upward, comprising poorly consolidated sand, gravelly sand, siltstone and marl. Various soft-sediment deformation structures occur in the formation, especially in fine- to medium grained sands, silts and marls: load structures, flame structures, clastic dikes (sand and gravely-sand dike), disturbed layers, laminated convolute beds, slumps and synsedimentary faulting. The deformation mechanism and driving force for the soft-sediment deformation are related essentially to gravitational instability, dewatering, liquefaction-liquidization, and brittle deformation. Field data and the wide lateral extent of the structures as well as regional geological data show that most of the deformation is related to seismicity and the structures are interpreted as seismites. The existence of seismites in the Kolankaya Formation is evidence for continuing tectonic activity in the study area during the Neogene and is consistent with the occurrence of the paleoearthquakes of magnitude >5

Association Between Apolipoprotein E Polymorphism and Subclinic Atherosclerosis in Patients with Type 1 Diabetes Mellitus

Objective The most important cause of morbidity and mortality in type 1 diabetes mellitus (DM) is atherosclerosis. Apolipoprotein E (Apo E) polymorphism is accused of being the genetic risk factor for atherosclerosis. The aim of the present study was to determine which Apo E polymorphism was related to atherosclerosis in patients with type 1 DM

Bağdere Tufası’nın jeolojik, jeokimyasal ve jeokronolojik özellikleri (Elazığ, D Türkiye)

Çalışmaya konu olan tufa yüzleği, Türkiye’nin ikinci büyüklükteki neotektonik yapısı olan sol yanal doğrultu atımlı Doğu Anadolu Fay Sistemi’nin önemli zonlarından biri olan Elazığ Fay Zonu üstünde, Elazığ şehir merkezinin yaklaşık 20 km güneybatısında bulunur. Tufaların yanal-düşey ilişkili olduğu Kuvaterner yaşlı Palu Formasyonu, karasal kökenli kırıntılı çökellerle karakterize edilir. Tufa oluşumunda kaynak kaya rolü oynayan Devoniyen-Jura yaşlı Keban Metamorfitleri’nin Elazığ çevresindeki yüzlekleri, çoğunlukla mermerlerle karakterize edilir. Keban Metamorfitleri’nin litolojisi ve sol yanal doğrultu atımlı Elazığ Fay Zonu’nun meydana getirdiği kırıklı yapı, akışkan dolaşımında ve bundan dolayı tufanın oluşmasında önemli bir görev almıştır. Tufa örneklerinde belirlenen element miktarları, Ca: 384719-390151 ppm, Mg: 3498-4764 ppm, Sr: 112-338 ppm düzeyindedir. δ13C değerleri, 0.4 ila 2.6 (‰ PDP), δ18O değerleri ise -9.9 ila -11.4 (‰PDB) arasındadır. Çalışmadan elde edilen veriler birlikte değerlendirildiğinde, Bağdere tufasının, sığ göl ortamında oluştuğu düşünülmektedir. Örneklerden elde edilen U-Th yaş verileri, tufa çökeliminin günümüzden en azından 524,597 yıl önce başlamış olduğuna işaret etmektedir

Comparative study of the Pleistocene Cakmak quarry (Denizli Basin, Turkey) and modern Mammoth Hot Springs deposits (Yellowstone National Park, USA)

This study compares and contrasts the travertine depositional facies of two of the largest sites of travertine formation, located in very different geological contexts, i.e. the modern Mammoth Hot Spring (MHS) system in the active volcanic complex of Yellowstone National Park (USA) and the Pleistocene Cakmak quarry, a well-exposed example of the Ballık travertines in the extensional Denizli Basin (Turkey). New, 2D to 3D facies maps of both travertine systems, combined with microscopy, assist in proposing an integrated spring depositional model, based on the existing MHS facies model, understanding general controls on meter to kilometer scale travertine deposit architecture and its preservation, and provide quantitative estimates of facies spatial coverage and slope using GIS. The comparison resulted in the distinction of eight facies, grouped in five downstream facies zones from Vent to Distal Slope. Notwithstanding the different geological context of both travertine systems, observations show that several of the facies are strikingly comparable (draping Apron and Channel Facies, top-slope Pond Facies, crystalline Proximal Slope Facies and Distal Slope Facies), whereas other facies do not have a precise, exposed equivalent (Vent Facies, pavement Apron and Channel Facies, extended Pond facies and phyto Proximal Slope Facies). Combining observations of active springs at MHS with the Cakmak vertical travertine quarry exposures demonstrates that lateral and vertical facies transitions are a sensitive record of changes in the spring dynamics (flow intensity and paths) that become well-preserved in the geological record, and can be recognized as prograding, aggrading, retrograding trends or erosive surfaces, traceable over tens to hundreds of meters. Quantification of facies specific coverage at MHS shows that Proximal and Distal Slope Facies deposits cover as much as ∼90% of the total mapped surface area. In addition, only ∼7% of the surface is found to be marked by a waterfilm related to an active flowing spring. Slope statistics reveal that strong slope breaks can often be related to transgressive Apron and Channel Facies belts and that variable, but steep slopes (up to 40°) are dominated by Proximal Slope Facies, in agreement with the Cakmak exposures. Integrating travertine facies and architecture of deposits formed in distinct geological contexts can improve the prediction of general spring facies distributions and controls in other, modern and ancient, subsurface travertine systems

Comparative analysis of percutaneous excision and radiofrequency ablation for osteoid osteoma

BACKGROUND This retrospective study aims to compare the efficacy of computed tomography-guided percutaneous excision and radiofrequency ablation in the treatment of osteoid osteoma. MATERIAL AND METHODS We evaluated 40 patients with osteoid osteoma who underwent either percutaneous excision or radiofrequency ablation between 2012 and 2015. The cohort consisted of 10 female and 30 male patients, with a mean age of 15.1 years (range: 4-27 years) and a mean follow-up time of 19.02 months (range: 11-39 months). Percutaneous excision was performed in 20 patients, while radiofrequency ablation was performed in the remaining 20 patients. RESULTS The success rates of percutaneous excision and radiofrequency ablation were comparable, with unsuccessful outcomes observed in 10% and 5% of patients, respectively. The reasons for failure in the percutaneous excision group were attributed to a marking error and incomplete excision of the wide-based nidus. Complications were limited to pathological fracture (n=1) and deep infection (n=1) in the percutaneous excision group, while no complications were encountered in the radiofrequency ablation group. CONCLUSIONS Both percutaneous excision and radiofrequency ablation demonstrate high success rates in treating osteoid osteoma. However, radiofrequency ablation offers the advantage of a quicker return to daily activities without the need for activity restrictions or splints. While being a more cost-effective option, percutaneous excision should be considered cautiously to minimize potential complications

Atmospheric Pressure Mass Spectrometry of Single Viruses and Nanoparticles by Nanoelectromechanical Systems

Mass spectrometry of intact nanoparticles and viruses can serve as a potent characterization tool for material science and biophysics. Inaccessible by widespread commercial techniques, the mass of single nanoparticles and viruses (>10MDa) can be readily measured by NEMS (Nanoelectromechanical Systems) based Mass Spectrometry, where charged and isolated analyte particles are generated by Electrospray Ionization (ESI) in air and transported onto the NEMS resonator for capture and detection. However, the applicability of NEMS as a practical solution is hindered by their miniscule surface area, which results in poor limit-of-detection and low capture efficiency values. Another hindrance is the necessity to house the NEMS inside complex vacuum systems, which is required in part to focus analytes towards the miniscule detection surface of the NEMS. Here, we overcome both limitations by integrating an ion lens onto the NEMS chip. The ion lens is composed of a polymer layer, which charges up by receiving part of the ions incoming from the ESI tip and consequently starts to focus the analytes towards an open window aligned with the active area of the NEMS electrostatically. With this integrated system, we have detected the mass of gold and polystyrene nanoparticles under ambient conditions and with two orders-of-magnitude improvement in capture efficiency compared to the state-of-the-art. We then applied this technology to obtain the mass spectrum of SARS-CoV-2 and BoHV-1 virions. With the increase in analytical throughput, the simplicity of the overall setup and the operation capability under ambient conditions, the technique demonstrates that NEMS Mass Spectrometry can be deployed for mass detection of engineered nanoparticles and biological samples efficiently.Comment: 38 pages, 6 figure

Multiscale approach to (micro)porosity quantification in continental spring carbonate facies: Case study from the Cakmak quarry (Denizli, Turkey)

Carbonate spring deposits gained renewed interest as potential contributors to subsurface reservoirs and as continental archives of environmental changes. In contrast to their fabrics, petrophysical characteristics – and especially the importance of microporosity (< 1µm) – are less understood. This study presents the combination of advanced petrophysical and imaging techniques to investigate the pore network characteristics of three, common and widespread spring carbonate facies, as exposed in the Pleistocene Cakmak quarry (Denizli, Turkey): the extended Pond, the dipping crystalline Proximal Slope Facies and the draping Apron and Channel Facies deposits formed by encrustation of biological substrate. Integrating mercury injection capillary pressure, bulk and diffusion Nuclear Magnetic Resonance (NMR), NMR profiling and Brunauer–Emmett–Teller (BET) measurements with microscopy and micro-computer tomography (µ-CT), shows that NMR T2 distributions systematically display a single group of micro-sized pore bodies, making up between 6 and 33% of the pore space (average NMR T2 cut-off value: 62 ms). Micropore bodies are systematically located within cloudy crystal cores of granular and dendritic crystal textures in all facies. The investigated properties therefore do not reveal differences in micropore size or shape with respect to more or less biology-associated facies. The pore network of the travertine facies is distinctive in terms of (i) the percentage of microporosity, (ii) the connectivity of micropores with meso- to macropores, and (ii) the degree of heterogeneity at micro- and macroscale. Results show that an approach involving different NMR experiments provided the most complete view on the 3-D pore network especially when microporosity and connectivity are of interest

Multiscale approach to (micro)porosity quantification in continental spring carbonate facies: Case study from the Cakmak quarry (Denizli, Turkey)

Carbonate spring deposits gained renewed interest as potential contributors to subsurface reservoirs and as continental archives of environmental changes. In contrast to their fabrics, petrophysical characteristics – and especially the importance of microporosity (< 1µm) – are less understood. This study presents the combination of advanced petrophysical and imaging techniques to investigate the pore network characteristics of three, common and widespread spring carbonate facies, as exposed in the Pleistocene Cakmak quarry (Denizli, Turkey): the extended Pond, the dipping crystalline Proximal Slope Facies and the draping Apron and Channel Facies deposits formed by encrustation of biological substrate. Integrating mercury injection capillary pressure, bulk and diffusion Nuclear Magnetic Resonance (NMR), NMR profiling and Brunauer–Emmett–Teller (BET) measurements with microscopy and micro-computer tomography (µ-CT), shows that NMR T2 distributions systematically display a single group of micro-sized pore bodies, making up between 6 and 33% of the pore space (average NMR T2 cut-off value: 62 ms). Micropore bodies are systematically located within cloudy crystal cores of granular and dendritic crystal textures in all facies. The investigated properties therefore do not reveal differences in micropore size or shape with respect to more or less biology-associated facies. The pore network of the travertine facies is distinctive in terms of (i) the percentage of microporosity, (ii) the connectivity of micropores with meso- to macropores, and (ii) the degree of heterogeneity at micro- and macroscale. Results show that an approach involving different NMR experiments provided the most complete view on the 3-D pore network especially when microporosity and connectivity are of interest