Growth of German dairy farms under the EU milk quota

We estimate determinants of growth among German dairy farms between 1997 und 2005 under the EU milk quota system. Higher milk yield per cow, more family labour, and higher milk prices increase the growth rate of growing farms, ceteris paribus. Older growing farmers tend to grow at lower rates. In line with Weiss’ findings (1999) for Austrian farms, Gibrat’s Law of relative firm growth being independent of initial firm size does not hold for our subsample of farms growing in milk production, either: the growth rate is quite high for small farms and has a minimum for farms around 325,000 kg of initial quota. For the 16% of growing farms that have more initial quota the growth rate increases up to some out-of-sample maximum. We corrected for selection bias by means of a multinomial logit model which explains the choice among different growth regimes in more detail than the well-known Heckman procedure. In our case, e.g. age impacts the choice between growth and stagnation but not between growth and exiting from milk production; crop subsidies only influence the decision between growth and exiting from milk production but not the decision between growth and decline or stagnation.Keywords: farm growth, Gibrat’s Law, milk quota, multinomial logit, selection bias, Agricultural and Food Policy, Farm Management, Land Economics/Use,

Une mélancolie romantique.Concept de création et création de concept dans Les Chimères de Nerval.

Résumé Dans cet article, je tente de montrer comment concept et œuvre poétique sont à même de s'éclairer l'un l'autre, et ce à partir de l'idée de mélancolie dans Les Chimères de Gérard de Nerval. La mélancolie apparaît comme un thème récurrent du recueil, lui donnant une cohérence et dévoilant la profondeur d'un questionnement existentiel qui hante toute l’écriture nervalienne. Réciproquement, le régime poétique du langage donne forme au concept, l'incarne dans les images et le rythme qui lui sont propres, et par là en développe la portée comme la signification. L'étude de la mélancolie chez Nerval révèle ultimement un mode de création proprement romantique, en quête d'un sens qui ne se donne qu'à travers un travail de l'imagination mobilisant les formes fantomatiques d'un passé en permanente recomposition.Abstract In this article, I will try to show how concepts and poetical works can shed light on each other, by studying the idea of melancholy in Gérard de Nerval’s Les Chimères. Melancholy appears as a recurring theme in the volume of poetry, making the book coherent and revealing the depth of an existential question haunting the Nervalian writing. Conversely, the poetical regime of language gives substance to the concept. Indeed, it embodies representations and rhythm of its own, thus contributing to developing its meaning. The study of melancholy in Nerval’s work ultimately reveals a mode of creation that is characteristically romantic, in search of a meaning which is only unveiled through a work of imagination mobilizing the ghostly forms of a past in perpetual rearrangement

A tool for sustainability impact assessment (ToSIA)of forest-wood chains linked with a database of sustainability indicators collected within the EFORWOOD project

Within the EFORWOOD project new approaches to assess the sustainability impacts of forest-wood chains (FWC) using indicators of environmental, social and economic sustainability were developed

Translation and Cognition: Cases of Asymmetry. An Editorial

This editorial outlines the theoretical and methodological underpinnings of the current special issue, signalling some of the practical implications of the problems investigated. As the title of the collection highlights the convergence of “translation” and “cognition”, emphasis is here first placed on what “cognitive” can be taken to stand for in translationcentred research. I then discuss the other identifying idea of the issue - that of asymmetry - i.e. the observation that conceptual-semantic content is variably partitioned as it gets coded in different languages. Special attention is paid to cross-linguistic conventionalisation misalignment which requires sensitisation to translation scenarios where the symmetry of the source and target structures is only illusory

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α

Many functional aspects of the protein kinase p38α have been illustrated by more than three hundred structures determined in the presence of reducing agents. These structures correspond to free forms and complexes with activators, substrates, and inhibitors. Here we report the conformation of an oxidized state with an intramolecular disulfide bond between Cys119 and Cys162 that is conserved in vertebrates. The structure of the oxidized state does not affect the conformation of the catalytic site, but alters the docking groove by partially unwinding and displacing the short αD helix due to the movement of Cys119 towards Cys162. The transition between oxidized and reduced conformations provides a mechanism for fine-tuning p38α activity as a function of redox conditions, beyond its activation loop phosphorylation. Moreover, the conformational equilibrium between these redox forms reveals an unexplored cleft for p38α inhibitor design that we describe in detail.© 2023. The Author(s)

SERPINB5 and AKAP12 -- Expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma

<p>Abstract</p> <p>Background</p> <p>Early metastasis and infiltration are survival limiting characteristics of pancreatic ductal adenocarcinoma (PDAC). Thus, PDAC is likely to harbor alterations in metastasis suppressor genes that may provide novel diagnostic and therapeutic opportunities. This study investigates a panel of metastasis suppressor genes in correlation to PDAC phenotype and examines promoter methylation for regulatory influence on metastasis suppressor gene expression and for its potential as a diagnostic tool.</p> <p>Methods</p> <p>Metastatic and invasive potential of 16 PDAC cell lines were quantified in an orthotopic mouse model and mRNA expression of 11 metastasis suppressor genes determined by quantitative RT-PCR. Analysis for promoter methylation was performed using methylation specific PCR and bisulfite sequencing PCR. Protein expression was determined by Western blot.</p> <p>Results</p> <p>In general, higher metastasis suppressor gene mRNA expression was not consistent with less aggressive phenotypes of PDAC. Instead, mRNA overexpression of several metastasis suppressor genes was found in PDAC cell lines vs. normal pancreatic RNA. Of the investigated metastasis suppressor genes, only higher <it>AKAP12 </it>mRNA expression was correlated with decreased metastasis (P < 0.05) and invasion scores (P < 0.01) while higher <it>SERPINB5 </it>mRNA expression was correlated with increased metastasis scores (P < 0.05). Both genes' promoters showed methylation, but only increased <it>SERPINB5 </it>methylation was associated with loss of mRNA and protein expression (P < 0.05). <it>SERPINB5 </it>methylation was also directly correlated to decreased metastasis scores (P < 0.05).</p> <p>Conclusions</p> <p><it>AKAP12 </it>mRNA expression was correlated to attenuated invasive and metastatic potential and may be associated with less aggressive phenotypes of PDAC while no such evidence was obtained for the remaining metastasis suppressor genes. Increased <it>SERPINB5 </it>mRNA expression was correlated to increased metastasis and mRNA expression was regulated by methylation. Thus, <it>SERPINB5 </it>methylation was directly correlated to metastasis scores and may provide a diagnostic tool for PDAC.</p

Global Ocean Science Report: The Current Status of Ocean Science around the World

The IOC-UNESCO Global Ocean Science Report (GOSR) aims to provide a status report on ocean science. It identifies and quantifies the elements that drive the productivity and performance of ocean science, including workforce, infrastructure, resources, networks and outputs. The report is intended to facilitate international ocean science cooperation and collaboration. It helps to identify gaps in science organization and capacity and develop options to optimize the use of scientific resources and advance ocean science and technology by sharing expertise and facilities, promoting capacity-building and transferring marine technology. As the first consolidated assessment of global ocean science, the GOSR assists the science-policy interface and supports managers, policy-makers, governments and donors, as well as scientists beyond the ocean community. The GOSR offers decision-makers an unprecedented tool to identify gaps and opportunities to advance international collaboration in ocean science and technology and harness its potential to meet societal needs, address global challenges and drive sustainable development for all

Navigating the Future V: Marine Science for a Sustainable Future

Navigating the Future is a publication series produced by the European Marine Board providing future perspectives on marine science and technology in Europe. Navigating the Future V (NFV) highlights new knowledge obtained since Navigating the Future IV1 (2013). It is set within the framework of the 2015 Paris Agreement2 and builds on the scientific basis and recommendations of the IPCC reports3. NFV gives recommendations on the science required during the next decade to deliver the ocean we need to support a sustainable future. This will be important for the United Nations Decade of Ocean Science for Sustainable Development4 (2021 – 2030), the implementation of the UN Sustainable Development Goals5 and the European Commission’s next framework programme, Horizon Europe6 (2021 - 2027). There is a growing need to strengthen the links between marine science, society and policy since we cannot properly manage what we do not know. In recent years, the ocean and seas have received new prominence in international agendas. To secure a safe planet a priority is the management of the ocean as a “common good for humanity”, which requires smarter observations to assess of the state of the ocean and predictions about how it may change in the future. The ocean is a three-dimensional space that needs to be managed over time (thus four-dimensional), and there is a need for management and conservation practices that integrate the structure and function of marine ecosystems into these four dimensions (Chapter 2). This includes understanding the dynamic spatial and temporal interplay between ocean physics, chemistry and biology. Multiple stressors including climate change, pollution and over-fishing affect the ocean and we need to better understand and predict their interactions and identify tipping points to decide on management priorities (Chapter 3). This should integrate our understanding of land-ocean-atmosphere processes and approaches to reducing impacts. An improved science base is also needed to help predict and minimize the impact of extreme events such as storm surges, heat waves, dynamic sea-floor processes and tsunamis (Chapter 4). New technologies, data handling and modelling approaches will help us to observe, understand and manage our use of the fourdimensional ocean and the effect of multiple stressors (Chapter 5). Addressing these issues requires a strategic, collective and holistic approach and we need to build a community of sustainability scientists that are able to provide evidence-based support to policy makers within the context of major societal challenges (Chapter 6). We outline new frontiers, knowledge gaps and recommendations needed to manage the ocean as a common good and to develop solutions for a sustainable future (Chapter 7). The governance of sustainability should be at the core of the marine research agenda through co-production and collaboration with stakeholders to identify priorities. There is need for a fully integrated scientific assessment of resilience strategies, associated trade-offs and underlying ethical concepts for the ocean, which should be incorporated into decision support frameworks that involve stakeholders from the outset. To allow the collection, processing and access to all data, a key priority is the development of a business model that ensures the long-term economic sustainability of ocean observations