Craniofacial diversification in the domestic pigeon and the evolution of the avian skull.

A central question in evolutionary developmental biology is how highly conserved developmental systems can generate the remarkable phenotypic diversity observed among distantly related species. In part, this paradox reflects our limited knowledge about the potential for species to both respond to selection and generate novel variation. Consequently, the developmental links between small-scale microevolutionary variations within populations to larger macroevolutionary patterns among species remain unbridged. Domesticated species, such as the pigeon, are unique resources for addressing this question, because a history of strong artificial selection has significantly increased morphological diversity, offering a direct comparison of the developmental potential of a single species to broader evolutionary patterns. Here, we demonstrate that patterns of variation and covariation within and between the face and braincase in domesticated breeds of the pigeon are predictive of avian cranial evolution. These results indicate that selection on variation generated by a conserved developmental system is sufficient to explain the evolution of crania as different in shape as the albatross or eagle, parakeet or hummingbird. These 'rules' of cranio-facial variation are a common pattern in the evolution of a broad diversity of vertebrate species and may ultimately reflect structural limitations of a shared embryonic bauplan on functional variation

Reversible Motion In a Contact Line

When a body of liquid sits on a surface, an irregular border between the wet and dry regions of the surface exists, called the contact line. Driving this contact line back and forth repeatedly can change its shape.We use a syringe pump to cyclically infuse and withdraw a predetermined volume of water, and take photos of the contact line after each cycle. Comparing these images to each other determines if the contact line is returning to the same shape. We find that below a critical value of infused volume, after many cycles the contact line reaches a steady state in which it always returns to the same shape. Above that value the shape fluctuates in the steady state. This suggests a transition similar to that seen in other systems like particle suspensions and solids

An analysis of early insulin glargine added to metformin with or without sulfonylurea: impact on glycaemic control and hypoglycaemia

Aim: To evaluate the benefits of initiating insulin at an earlier versus later treatment stage, and regimens with/without sulfonylurea (SU)

An evaluation of a public partnership project between academic institutions and young people with Black African, Asian and Caribbean heritage

BackgroundThis project (named Reinvent) aimed to promote Public Involvement (PI) in health research. Academics worked with a community group, the Eloquent Praise & Empowerment Dance Company, to develop a community partnership with young people from Black African, Asian and Caribbean heritage communities. The goal of this paper is to evaluate the Reinvent project for key learnings on how to engage and build partnerships with young people from Black African, Asian and Caribbean heritage communities.MethodsReinvent developed a steering group which consisted of five young people, one academic, a Race Equality Ambassador and the Director of Eloquent. The steering group co-produced an agenda for two workshops and the evaluation tools used. The content of the workshops included drama exercises, discussions on physical and mental health, nutrition and school-life, short introductions to the concepts of research and PI, and group work to critique and improve a video currently used to promote PI in health research to young people. The evaluation tools included using the ‘Cube’ evaluation framework, video-blogging and collecting anonymous feedback.FindingsThe responses to the ‘Cube’ evaluation framework were positive across all four domains (agenda, voice, contribute change) in both workshops. A few of the young people described having a better understanding of the meaning and practice of PI in a video-blog. The anonymous feedback suggested that the workshops had increased young people’s confidence in sharing their thoughts and opinions about health and PI.ConclusionReinvent has shown that academic institutions and young people from an under-served community can partner to co-design workshops and apply evaluation tools. Working with young people in an environment in which they were comfortable, and by researchers joining in with the activities that the young people enjoyed (such as dance), enabled more informal and open conversations to develop. More work is needed to build upon this project so that young people can feel confident and supported to get involved in PI activities relating to research

How to Be Unfaithful to Eurocentrism: A Spanglish Decolonial Critique to Knowledge Gentrification, Captivity and Storycide in Qualitative Research

From a position of academic activism, we critique the longstanding dominance del production of knowledge that solely implicates fidelity to Eurocentric methodological technologies en qualitative research. Influenced by an Andean decolonial perspective, en Spanglish we problematize métodos of analysis as the dominant research practice, whereby las stories o relatos result en su appropriation, captivity and gentrification, first by researchers’ authorship and later by the publishing industry copyrights. We highlight the racializing and capitalist colonial/modern Eurocentric agenda del current market of knowledge production that displaces to la periphery all knowledge o relatos that do not subscribe to Euro-US American methodological parameters of what counts as knowledge. Therefore, we intend to heighten the readers’ audibility of another possibility of knowing that does not come from Eurocentric methodologically produced stories. At the forefront of our critique, and as an introduction to a decolonial option, we include our written, uttered, and painted stories, with the political intent of social transformation of coloniality. These seek to denounce power structures that have had incarnated effects on our lives y comunidades. We intend to invite researchers to serve as witnesses of our experiences rather than as critics of methodological rigor. We include final commentaries on a decolonial project to rethink the unquestionable fidelity and dependency toward the current research order of things of el center and la periphery. This is so as to render European technologies of knowledge as only one alternative among many other possible means of legitimate knowledge making in qualitative research. We discuss our hope for epistemological coexistence by which fair and reciprocal intercultural translations of knowledge making could take place, not in the name of equality, but difference

A supramodal representation of the body surface

The ability to accurately localize both tactile and painful sensations on the body is one of the most important functions of the somatosensory system. Most accounts of localization refer to the systematic spatial relation between skin receptors and cortical neurons. The topographic organization of somatosensory neurons in the brain provides a map of the sensory surface. However, systematic distortions in perceptual localization tasks suggest that localizing a somatosensory stimulus involves more than simply identifying specific active neural populations within a somatotopic map. Thus, perceptual localization may depend on both afferent inputs and other unknown factors. In four experiments, we investigated whether localization biases vary according to the specific skin regions and subset of afferent fibers stimulated. We represented localization errors as a ‘perceptual map’ of skin locations. We compared the perceptual maps of stimuli that activate Aβ (innocuous touch), Aδ (pinprick pain), and C fibers (non-painful heat) on both the hairy and glabrous skin of the left hand. Perceptual maps exhibited systematic distortions that strongly depended on the skin region stimulated. We found systematic distal and radial (i.e., towards the thumb) biases in localization of touch, pain, and heat on the hand dorsum. A less consistent proximal bias was found on the palm. These distortions were independent of the population of afferent fibers stimulated, and also independent of the response modality used to report localization. We argue that these biases are likely to have a central origin, and result from a supramodal representation of the body surface

Development of convection in high temperature coil annealing furnaces using rotating cylinder technique

The present study investigates the usage of rotating cylinders to generate gas circulation inside high-temperature coil annealing furnaces during the annealing treatment of grain-oriented electrical steel. This technique has been investigated to reduce temperature differentials (hotspots) within the furnace space, a phenomenon that occurs due to extremely high temperatures, the static nature of the gas inside of the furnace and long operation conditions. Finite volume numerical simulation using ANSYS Fluent was performed to test the validity of the proposed technique. The numerical results showed fluctuations in velocity magnitude of the fluid in comparison with a case when the technique was not employed. This is because of the vortex generation under the effect of the cylinder rotation. The generation of turbulence enhances gas-mixing quality, and thus it would save a great amount of energy required for the process, producing a product with desired magnetic properties at lower cost