Experience of CT Guided Procedures in the Diagnosis of 55 patients with Intrathoracic Lesions from May 2009 to Feb 2011 at Ribat University Hospital(Sudan)

Objective: To present the experience of our center in the use of computed tomography (CT)guided Fine Needle Aspiration (FNA) and core tissue biopsy procedures as an effective way for obtaining adequate material from intra-thoracic lesions, with the aim of assessing their diagnostic yield and complications.Methods: the study included 55 patients who underwent CT-guided procedures between May 2009 and February 2011. All fine needle aspirations were performed with 20-gauge needles while coretissue biopsies were performed with 14 –gauge needles under CT guidance. The diagnostic yield of these procedures, complications, and patient’s feedback were studied.Results: Diagnosis was malignant lesions in 18(32.1%), benign in 35(62.5%), and in 2(0.036%) patients the sample was inadequate. So the diagnostic yield of CT guided procedures was 96.36%. 16 (89%) of the malignant sample were non-small cell lung cancer and 2(11%) were small cell lung cancer. The results of both procedures (fine needle aspirations and core tissue biopsies) done on the same lesion were similar in (93.7%) of the results. Patients who underwent other procedures before this (e.g. bronchoscopy) had similar results in 25% of the samples. Complications reported were hemoptysis in 5 (9.1%), pneumothorax in 2 (3.6%) and surgical emphysema in 1 (1.8%) patient. 5 (9.2%) of the patients described the pain of the procedure as intolerable.Conclusions: CT guided procedure has high diagnostic yield and is recommended for obtaining tissues for histological assessment. Tissue biopsy offers no substantial advantage over FNA in the evaluation of malignant lung lesions

Web-Based Specialist Support for Spinal Cord Injury Person's Care: Lessons Learned

Persons with disability from spinal cord injury (SCI) are subject to high risk of pathological events and need a regular followup even after discharge from the rehabilitation hospital. To help in followup, we developed a web portal for providing online specialist as well as GP support to SCI persons. After a feasibility study with 13 subjects, the portal has been introduced in the regional healthcare network in order to make it compliant with current legal regulations on data protection, including smartcard authentication. Although a number of training courses have been made to introduce SCI persons to portal use (up to 50 users), the number of accesses remained very low. Reasons for that have been investigated by means of a questionnaire submitted to the initial feasibility study subjects and included the still easier use of telephone versus our web-based smartcard-authenticated portal, in particular, because online communications are still perceived as an unusual way of interacting with the doctor. To summarize, the overall project has been appreciated by the users, but when it is time to ask for help to, the specialist, it is still much easier to make a phone call

Nematode diversity patterns at different spatial scales in bathyal sediments of the Mediterranean Sea

Understanding biodiversity patterns and how they are driven at different spatial scales is a crucial issue in eco- logical studies. This is particularly evident for the deep sea, the largest biome of the biosphere, where information on the scales of spatial variation is very scant. Here, we investigated deep-sea nematodes species richness, turnover and func- tional diversity, and life strategies at different spatial scales (from local to macro-regional) to identify the factors that shape regional (γ) and macro-regional (ε) deep-sea diver- sity. This study was conducted in several deep-sea habitats (canyons, open slopes, deep-water corals, and bathyal plains) over > 2000 km across the whole Mediterranean Basin, at a bathymetric range comprised between ca. 600 and 1300 m. Our results indicate that the patterns of local (α) diversity across the deep Mediterranean follow the gradients of the trophic conditions, which decrease from the western to the eastern basins. For all of the sites and habitats, the α diversity is generally low. Conversely, the turnover diversity changes significantly among habitats (β diversity) and between re- gions (δ diversity), showing values of dissimilarity (based on species presence/absence matrixes) between 59 and 90 % for β diversity and between 81 and 89 % for δ diversity. This suggests that patterns and values of γ and ε diversities in the deep Mediterranean Sea are related to turnover diversity among habitats and between regions (β and δ diversities), rather than to the local biodiversity (α diversity). These re- sults indicate also that the differences in β and δ diversi- ties are even more important than those in α diversity for the comprehension of the drivers of biodiversity in the deep Mediterranean Sea. We conclude that the presence of differ- ent habitats and gradients in environmental conditions, by promoting a high turnover diversity across the Mediterranean Sea, may play a crucial role in the levels of γ diversity of deep-sea nematodes

Preliminary results from a crowdsourcing experiment in immunohistochemistry

Background: Crowdsourcing, i.e., the outsourcing of tasks typically performed by a few experts to a large crowd as an open call, has been shown to be reasonably effective in many cases, like Wikipedia, the Chess match of Kasparov against the world in 1999, and several others. The aim of the present paper is to describe the setup of an experimentation of crowdsourcing techniques applied to the quantification of immunohistochemistry. Methods: Fourteen Images from MIB1-stained breast specimens were first manually counted by a pathologist, then submitted to a crowdsourcing platform through a specifically developed application. 10 positivity evaluations for each image have been collected and summarized using their median. The positivity values have been then compared to the gold standard provided by the pathologist by means of Spearman correlation. Results: Contributors were in total 28, and evaluated 4.64 images each on average. Spearman correlation between gold and crowdsourced positivity percentages is 0.946 (p < 0.001). Conclusions: Aim of the experiment was to understand how to use crowdsourcing for an image analysis task that is currently time-consuming when done by human experts. Crowdsourced work can be used in various ways, in particular statistically agregating data to reduce identification errors. However, in this preliminary experimentation we just considered the most basic indicator, that is the median positivity percentage, which provided overall good results. This method might be more aimed to research than routine: when a large number of images are in need of ad-hoc evaluation, crowdsourcing may represent a quick answer to the need. \ua9 Della Mea et al

Analisis Pengaruh Pajak Daerah terhadap Peningkatan Pendapatan Asli Daerah di Kabupaten Minahasa

This study aims to analyze the effect of Local Tax on Local Revenue in Minahasa District Year 2011-2015. This research was conducted from January to March 2017 in Minahasa District, North Minahasa District and Tomohon City with the object of Local Taxes research from 2011 to 2015. This study uses secondary data obtained from Minahasa District Revenue Office, Regional Finance Board and Asset Manager of Minahasa District, North Minahasa District and Tomohon City and Statistics Agency of Minahasa District. Data analysis used Contribution and Growth Matrix Analysis and Time Series Analysis. This study found that the contribution of local taxes to the original income of the period of 2011-2015 is still below 50 percetn and the local revenue is at the 5 percent level of Central Government Fund Transfer Income to the regions. This has resulted in poor welfare and prosperity of the population reflected in the per capita income level that is still lacking and the level of regional independence is still low. Analysis of regional tax trends for the year 2016-2020 has increased but still below 5 (five) billion rupiah each year so it still needs to be improved

An unusual interplay among disorder, Kondo-effect and spin-glass behavior in the Kondo lattices, Ce2_2Au1−x_{1-x}Cox_xSi3_3

We report the results of magnetic measurements for the solid solution Ce$_2$Au$_{1-x}$Co$_x$Si$_3$. The results reveal that this solid solution is characterized by a magnetic phase diagram (plot of magnetic transition temperature versus $x$) unusual for Kondo lattices. In particular, the spin-glass freezing induced by disorder is observed only for the compositions at the weak coupling limit; as one approaches the quantum critical point by a gradual replacement of Au by Co, this disorder effect is surprisingly suppressed in favor of long range antiferro-magnetic ordering in contrast to expectations. This unusual interplay between disorder, spin-glass freezing and the Kondo-effect calls for further refinement of theories on competition between magnetism and the Kondo effect.Comment: 4 pages, 3 figure

Southwest Pacific subtropics responded to last deglacial warming with changes in shallow water sources

Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Paleoceanography 29 (2014): 595–611, doi:10.1002/2013PA002584.This study examined sources of mixed layer and shallow subsurface waters in the subtropical Bay of Plenty, New Zealand, across the last deglaciation (~30–5 ka). δ18O and δ13C from planktonic foraminifera Globgerinoides bulloides and Globorotalia inflata in four sediment cores were used to reconstruct surface mixed layer thickness, δ18O of seawater (δ18OSW) and differentiate between high- and low-latitude water provenance. During the last glaciation, depleted planktonic δ18OSW and enriched δ13C (−0.4–0.1‰) indicate surface waters had Southern Ocean sources. A rapid δ13C depletion of ~1‰ in G. bulloides between 20 and 19 ka indicates an early, permanent shift in source to a more distal tropical component, likely with an equatorial Pacific contribution that persisted into the Holocene. At 18 ka, a smaller but similar shift in G. inflata δ13C depletion of ~0.3‰ suggests that deeper subsurface waters had a delayed reaction to changing conditions during the deglaciation. This contrasts with the isotopic records from nearby Hawke Bay, to the east of the North Island of New Zealand, which exhibited several changes in thermocline depth indicating switches between distal subtropical and proximal subantarctic influences during the early deglaciation ending only after the Antarctic Cold Reversal. Our results identify the midlatitude subtropics, such as the area around the North Island of New Zealand, as a key region to decipher high- versus low-latitude influences in Southern Hemisphere shallow water masses.Funding for this project came from NSF OCE-0823487 and 0823549-03.2014-12-1

Embedding the concept of ecosystems services:The utilisation of ecological knowledge in different policy venues

The concept of ecosystem services is increasingly being promoted by academics and policy makers as a means to protect ecological systems through more informed decision making. A basic premise of this approach is that strengthening the ecological knowledge base will significantly enhance ecosystem health through more sensitive decision making. However, the existing literature on knowledge utilisation, and many previous attempts to improve decision making through better knowledge integration, suggest that producing ‘more knowledge’ is only ever a necessary but insufficient condition for greater policy success. We begin this paper by reviewing what is already known about the relationship between ecological knowledge development and utilisation, before introducing a set of theme issue papers that examine—for the very first time—how this politically and scientifically salient relationship plays out across a number of vital policy venues such as land-use planning, policy-level impact assessment, and cost–benefit analysis. Following a detailed synthesis of the key findings of all the papers, this paper identifies and explores new research and policy challenges in this important and dynamic area of environmental governance

Effet antihypertensif d\'un extrait aqueux d\'écorce de tronc de Parkia biglobosa (mimosaceae) sur la pression artérielle de lapin.

Un extrait aqueux des écorces de tronc de Parkia biglobosa (EAPB), à des concentrations comprises entre 1,18 et 18, 93 mg/kg de poids corporel, induit une hypotension dose dépendante sur la pression artérielle de lapin. L'interaction Adrénaline - EAPB a révélé une réduction significative (

Preface

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