676 research outputs found

    Approved but non-funded vaccines: Accessing individual protection

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    AbstractFunded immunization programs are best able to achieve high participation rates, optimal protection of the target population, and indirect protection of others. However, in many countries public funding of approved vaccines can be substantially delayed, limited to a portion of the at-risk population or denied altogether. In these situations, unfunded vaccines are often inaccessible to individuals at risk, allowing potentially avoidable morbidity and mortality to continue to occur. We contend that private access to approved but unfunded vaccines should be reconsidered and encouraged, with recognition that individuals have a prerogative to take advantage of a vaccine of potential benefit to them whether it is publicly funded or not. Moreover, numbers of “approved but unfunded” vaccines are likely to grow because governments will not be able to fund all future vaccines of potential benefit to some citizens. New strategies are needed to better use unfunded vaccines even though the net benefits will fall short of those of funded programs.Canada, after recent delays funding several new vaccine programs, has developed means to encourage private vaccine use. Physicians are required to inform relevant patients about risks and benefits of all recommended vaccines, publicly funded or not. Likewise, some provincial public health departments now recommend and promote both funded and unfunded vaccines. Pharmacists are key players in making unfunded vaccines locally available. Professional organizations are contributing to public and provider education about unfunded vaccines (e.g. herpes zoster, not funded in any province). Vaccine companies are gaining expertise with direct-to-consumer advertising. However, major challenges remain, such as making unfunded vaccines more available to low-income families and overcoming public expectations that all vaccines will be provided cost-free, when many other recommended personal preventive measures are user-pay. The greatest need is to change the widespread perception that approved vaccines should be publicly funded or ignored

    Geographic Variation in Sexual Attraction of Spodoptera frugiperda Corn- and Rice-Strain Males to Pheromone Lures

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    The corn- and rice-strains of Spodoptera frugiperda exhibit several genetic and behavioral differences and appear to be undergoing ecological speciation in sympatry. Previous studies reported conflicting results when investigating male attraction to pheromone lures in different regions, but this could have been due to inter-strain and/or geographic differences. Therefore, we investigated whether corn- and rice-strain males differed in their response to different synthetic pheromone blends in different regions in North America, the Caribbean and South America. All trapped males were strain typed by two strain-specific mitochondrial DNA markers. In the first experiment, we found a nearly similar response of corn and rice-strain males to two different 4-component blends, resembling the corn- and rice-strain female blend we previously described from females in Florida. This response showed some geographic variation in fields in Canada, North Carolina, Florida, Puerto Rico, and South America (Peru, Argentina). In dose-response experiments with the critical secondary sex pheromone component (Z)-7-dodecenyl acetate (Z7-12:OAc), we found some strain-specific differences in male attraction. While the response to Z7-12:OAc varied geographically in the corn-strain, rice-strain males showed almost no variation. We also found that the minor compound (Z)-11-hexadecenyl acetate (Z11-16:OAc) did not increase attraction of both strains in Florida and of corn-strain males in Peru. In a fourth experiment, where we added the stereo-isomer of the critical sex pheromone component, (E)-7-dodecenyl acetate, to the major pheromone component (Z)-9-tetradecenyl acetate (Z9-14:OAc), we found that this compound was attractive to males in North Carolina, but not to males in Peru. Overall, our results suggest that both strains show rather geographic than strain-specific differences in their response to pheromone lures, and that regional sexual communication differences might cause geographic differentiation between populations.Fil: Unbehend, Melanie. Instituto Max Planck Institut Fur Chemische Okologie; AlemaniaFil: Hänniger, Sabine. Instituto Max Planck Institut Fur Chemische Okologie; AlemaniaFil: Vasquez, Gissella M.. University Of North Carolina; Estados UnidosFil: Juárez, María Laura. Gobierno de Tucumán. Ministerio de Desarrollo Productivo. Estación Experimental Agroindustrial Obispo Colombres; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán; ArgentinaFil: Reisig, Dominic. University Of North Carolina; Estados UnidosFil: Mcneil, Jeremy N.. University of Western Ontario. Department of Biology; CanadáFil: Meagher, Robert L.. United States Department Of Agriculture; Estados UnidosFil: Jenkins, David A.. United States Department of Agriculture; ArgentinaFil: Heckel, David G.. Instituto Max Planck Institut Fur Chemische Okologie; AlemaniaFil: Groot, Astrid T.. University Of Amsterdam; Países Bajos. Instituto Max Planck Institut Fur Chemische Okologie; Alemani

    Chandra ACIS Survey of M33 (ChASeM33): A First Look

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    We present an overview of the Chandra ACIS Survey of M33 (ChASeM33): A Deep Survey of the Nearest Face-on Spiral Galaxy. The 1.4 Ms survey covers the galaxy out to R \approx 18\arcmin (\approx 4 kpc). These data provide the most intensive, high spatial resolution assessment of the X-ray source populations available for the confused inner regions of M33. Mosaic images of the ChASeM33 observations show several hundred individual X-ray sources as well as soft diffuse emission from the hot interstellar medium. Bright, extended emission surrounds the nucleus and is also seen from the giant \hii regions NGC 604 and IC 131. Fainter extended emission and numerous individual sources appear to trace the inner spiral structure. The initial source catalog, arising from \sim~2/3 of the expected survey data, includes 394 sources significant at the 3σ3\sigma confidence level or greater, down to a limiting luminosity (absorbed) of \sim1.6\ergs{35} (0.35 -- 8.0 keV). The hardness ratios of the sources separate those with soft, thermal spectra such as supernova remnants from those with hard, non-thermal spectra such as X-ray binaries and background active galactic nuclei. Emission extended beyond the Chandra point spread function is evident in 23 of the 394 sources. Cross-correlation of the ChASeM33 sources against previous catalogs of X-ray sources in M33 results in matches for the vast majority of the brighter sources and shows 28 ChASeM33 sources within 10\arcsec of supernova remnants identified by prior optical and radio searches. This brings the total number of such associations to 31 out of 100 known supernova remnants in M33.Comment: accepted for publication ApJS, full resolution images and complete tables available at http://hea-www.harvard.edu/vlp_m33_public

    FEL research and development at STFC Daresbury laboratory

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    In this paper we present an overview of current and proposed FEL developments at STFC Daresbury Laboratory in the UK. We discuss progress on the ALICE IR-FEL since first lasing in October 2010, covering the optimisation of the FEL performance, progress on the demonstration of a single shot cross correlation experiment and the results obtained so far with a Scanning Near-Field Optical Microscopy beamline. We discuss a proposal for a 250 MeV single pass FEL test facility named CLARA to be built at Daresbury and dedicated to research for future light source applications. Finally we present a brief overview of other recent research highlights

    The Microbial Rosetta Stone Database: A compilation of global and emerging infectious microorganisms and bioterrorist threat agents

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    BACKGROUND: Thousands of different microorganisms affect the health, safety, and economic stability of populations. Many different medical and governmental organizations have created lists of the pathogenic microorganisms relevant to their missions; however, the nomenclature for biological agents on these lists and pathogens described in the literature is inexact. This ambiguity can be a significant block to effective communication among the diverse communities that must deal with epidemics or bioterrorist attacks. RESULTS: We have developed a database known as the Microbial Rosetta Stone. The database relates microorganism names, taxonomic classifications, diseases, specific detection and treatment protocols, and relevant literature. The database structure facilitates linkage to public genomic databases. This paper focuses on the information in the database for pathogens that impact global public health, emerging infectious organisms, and bioterrorist threat agents. CONCLUSION: The Microbial Rosetta Stone is available at . The database provides public access to up-to-date taxonomic classifications of organisms that cause human diseases, improves the consistency of nomenclature in disease reporting, and provides useful links between different public genomic and public health databases

    An evaluation and comparison of conservation guidelines for an at-risk migratory songbird

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    For at-risk wildlife species, it is important to consider conservation within the process of adaptive management. Golden-winged Warblers (Vermivora chrysoptera) are Neotropical migratory songbirds that are experiencing long-term population declines due in part to the loss of early-successional nesting habitat. Recently-developed Golden-winged Warbler habitat management guidelines are being implemented by USDA: Natural Resource Conservation Service (2014) and its partners through the Working Lands For Wildlife (WLFW) program. During 2012–2014, we studied the nesting ecology of Golden-winged Warblers in managed habitats of the eastern US that conformed to WLFW conservation practices. We evaluated five NRCS “management scenarios” with respect to nesting success and attainment of recommended nest site vegetation conditions outlined in the Golden-winged Warbler breeding habitat guidelines. Using estimates of territory density, pairing rate, nest survival, and clutch size, we also estimated fledglingproductivity (number of fledglings/ha) for each management scenario. In general, Golden-winged Warbler nest survival declined as each breeding season advanced, but nest survival was similar across management scenarios. Within each management scenario, vegetation variables had little influence on nest survival. Still, percent Rubus cover and density of \u3e2 m tall shrubs were relevant in some management scenarios. All five management scenarios rarely attained recommended levels of nest site vegetation conditions for Golden-winged, yet nest survival was high. Fledgling productivity estimates for each management scenario ranged from 2.1 to 8.6 fledglings/10 hectares. Our results indicate that targeted habitat management for Golden-winged Warblers using a variety of management techniques on private lands has the capability to yield high nest survival and fledgling productivity, and thus have the potential to contribute to the species recovery

    High Cadence Time-Series Photometry of V1647 Orionis

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    We present high cadence (1-10 hr^-1) time-series photometry of the eruptive young variable star V1647 Orionis during its 2003-2004 and 2008-2009 outbursts. The 2003 light curve was obtained mid-outburst at the phase of steepest luminosity increase of the system, during which time the accretion rate of the system was presumably continuing to increase toward its maximum rate. The 2009 light curve was obtained after the system luminosity had plateaued, presumably when the rate of accretion had also plateaued. We detect a 'flicker noise' signature in the power spectrum of the lightcurves, which may suggest that the stellar magnetosphere continued to interact with the accretion disk during each outburst event. Only the 2003 power spectrum, however, evinces a significant signal with a period of 0.13 d. While the 0.13 d period cannot be attributed to the stellar rotation period, we show that it may plausibly be due to short-lived radial oscillations of the star, possibly caused by the surge in the accretion rate.Comment: 19 pages, 6 figures, accepted for publication in The Astronomical Journa

    Role of heavy-meson exchange in pion production near threshold

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    Recent calculations of ss-wave pion production have severely underestimated the accurately known ppppπ0pp\rightarrow pp\pi^0\ total cross section near threshold. In these calculations, only the single-nucleon axial-charge operator is considered. We have calculated, in addition to the one-body term, the two-body contributions to this reaction that arise from the exchange of mesons. We find that the inclusion of the scalar σ\sigma-meson exchange current (and lesser contributions from other mesons) increases the cross section by about a factor of five, and leads to excellent agreement with the data. The results are neither very sensitive to changes in the distorting potential that generates the NNNN wave function, nor to different choices for the meson-nucleon form factors. We argue that ppppπ0pp\rightarrow pp\pi^0\ data provide direct experimental evidence for meson-exchange contributions to the axial current.Comment: 28 Pages, IU-NTC #93-0
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