The Evolving Role and Responsibilities of IS Managers in Logistics

This article provides a description of the evolving role of IS managers, their competencies, job requirements, and training needs. Key findings for developing effective training options and their implications are discussed. The data comes from an original research project funded by the Council of Logistics Management

The Growing Importance Of Operating Employees And Keys To Developing Effective Training Options

This study provides a description of the changing role of transportation operating employees, their competencies, job requirements, and training needs.  Four key findings for developing effective training options are discussed.  The data come from 43 logistics organizations in 20 states using the Common Metric Questionnaire, formal and informal interviews, and a descriptive newsletter

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear transactive response DNA-binding protein 43 (TDP-43). Here we identify that TDP-43 regulates expression of the neuronal growth-associated factor stathmin-2. Lowered TDP-43 levels, which reduce its binding to sites within the first intron of stathmin-2 pre-messenger RNA, uncover a cryptic polyadenylation site whose utilization produces a truncated, non-functional mRNA. Reduced stathmin-2 expression is found in neurons trans-differentiated from patient fibroblasts expressing an ALS-causing TDP-43 mutation, in motor cortex and spinal motor neurons from patients with sporadic ALS and familial ALS with GGGGCC repeat expansion in the C9orf72 gene, and in induced pluripotent stem cell (iPSC)-derived motor neurons depleted of TDP-43. Remarkably, while reduction in TDP-43 is shown to inhibit axonal regeneration of iPSC-derived motor neurons, rescue of stathmin-2 expression restores axonal regenerative capacity. Thus, premature polyadenylation-mediated reduction in stathmin-2 is a hallmark of ALS-FTD that functionally links reduced nuclear TDP-43 function to enhanced neuronal vulnerability

Microbial Community Shifts in Response to Acid Mine Drainage Pollution Within a Natural Wetland Ecosystem

Natural wetlands are known to play an important role in pollutant remediation, such as remediating acid mine drainage (AMD) from abandoned mine sites. However, many aspects of the microbiological mechanisms underlying AMD remediation within wetlands are poorly understood, including the role and composition of associated microbial communities. We have utilized an AMD-polluted river-wetland system to perform rRNA sequence analysis of microbial communities that play a role in biogeochemical activities that are linked to water quality improvement. Next-generation sequencing of bacterial 16S rRNA gene amplicons from river and wetland sediment samples identified variation in bacterial community structure and diversity on the basis of dissolved and particulate metal concentrations, sediment metal concentrations and other water chemistry parameters (pH and conductivity), and wetland plant presence. Metabolic reconstruction analysis allowed prediction of relative abundance of microbial metabolic pathways and revealed differences between samples that cluster on the basis of the severity of AMD pollution. Global metabolic activity was predicted to be significantly higher in unpolluted and wetland sediments in contrast to polluted river sediments, indicating a metabolic stress response to AMD pollution. This is one of the first studies to explore microbial community structure dynamics within a natural wetland exposed to AMD and our findings indicate that wetland ecosystems play critical roles in maintaining diversity and metabolic structure of sediment microbial communities subject to high levels of acidity and metal pollution. Moreover, these microbial communities are predicted to be important for the remediation action of the wetland

The Grizzly, March 22, 2007

Speaker on Ethics in the Pharmaceutical Industry • New Plans for the Field House • Potential Carcinogen Found Abundant in Collegeville • WeCAN Button and T-Shirt Campaign Successful • Scientific Sexual Healing • Nutrition Tips: Atkins in the News • Brief History of St. Patrick\u27s Day • Spotlight on Professor Laurian Bowles • Opinions: Obama-mania! • Bears Hungry for CC Crown • Longball Key to Bears Victoryhttps://digitalcommons.ursinus.edu/grizzlynews/1734/thumbnail.jp

Bristol and Bath by Design; To understand the economic and cultural value of design in the Bristol and Bath region

The aim of the project was to collect data on designcompanies in the Bristol and Bath region, and to gain abetter understanding of the economic and cultural valueof the design-led sector. To do this, our primary researchwas to develop a range of qualitative and quantitativemethods that could gather and then analyse the data

The Grizzly, April 19, 2007

Airband a Success • Omega Chi Blood Drive • Hillel Holocaust Discussion • Letter to the Editor • What Dreams May Come • Ivory-billed Woodpecker Not Extinct! • Fiber Facts • Earth-Shattering Drumming • Opinions: No Child Left Behind? Really?; Gitmo on Strike • Bears Win 11th in a Row; Coach McGowan Earns 200th Victory • Women\u27s Lacrosse Hangs Tough with #4 Gettysburghttps://digitalcommons.ursinus.edu/grizzlynews/1738/thumbnail.jp

The Grizzly, February 15, 2007

Darfur Fast Week Kickoff • United Men of Color Reception • The Peter Pan Project • CoSA Kickoff a Success • Power of Purple • Preview of The Laramie Project • Nutrition Tips • Inside Look at New Member Education • Opinions: Black History Month; Our Long-Awaited Greek Column • Heartbreak at Hopkins • Guntli Leading Rebounder • Senior Day Basketball Double-Headerhttps://digitalcommons.ursinus.edu/grizzlynews/1731/thumbnail.jp

The Grizzly, April 26, 2007

Crimes on the Web • Capoeira Performance Brings Brazil to Ursinus • Relay for Life Raises $47,000 for American Cancer Society • Holocaust Survivor Speaks at Ursinus • The Fonts, They are a Changin\u27 • International Experience • Breakaway from a Nightmare • How to Have a Great Summer • Opinions: Goodbye, Ursinus • Men\u27s Tennishttps://digitalcommons.ursinus.edu/grizzlynews/1739/thumbnail.jp

Cancer-selective, single agent chemoradiosensitising gold nanoparticles

Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and PEG-amine resulted in selective uptake and toxicity towards cancer cells at unprecedentedly low nanomolar concentrations. Chemotoxicity was prevented by co-administration of N-acetyl cysteine antioxidant, or partially prevented by the caspase inhibitor Z-VAD-FMK. In addition to their intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers at low concentrations is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics