Gregory McMahon Associate Professor of History, COLA, travels to Turkey

Every summer since 1993, Professor McMahon has travelled to central Turkey to conduct a research project at the Çadır Höyük Excavation site. He takes UNH students with him to integrate teaching and research

Zasuk proti vzhodu: Çadır Höyük, Transkavkazija in kompleksna povezljivost v pozni bakreni dobi

The investigation of ‘complex connectivities’ as defined by Tomlinson (1999) as a critical element in the understanding of how modern globalization works has been repurposed by archaeologists as a model to explain the mechanisms at work in the archaeological past. This study applies Tomlinson’s model to interpret evidence that such connectivities linked the vast Uruk system in Mesopotamia, the contemporary Kura-Araxes culture in Transcaucasia, and the north central Anatolian plateau in the second half of the fourth millennium BCE, known as the Late Chalcolithic period. We focus on the site of Çadır Höyük, on the north central Anatolian plateau. The occupants of this rural settlement experienced some dramatic changes in the later fourth millennium, including substantial reorganization of their village plan, expansions and contractions in socioeconomic activity and long-distance trade, more elaborate burials, and possibly the evolution of new sociopolitical and religious ideologies. Here we explore the increasing evidence that socioeconomic ‘complex connectivity,’ with both Mesopotamia and especially Transcaucasia, played some role in the substantial modifications and internal dynamics at Late Chalcolithic Çadır Höyük.Preučevanje ‘kompleksne povezljivosti’, kot jo je definiral Tomlinson (1999), je ključno za razumevanje načina, kako so arheologi spremenili model moderne globalizacije za to, da bi lahko razlagali mehanizme, ki so delovali v arheološki preteklosti. V članku uporabljamo Tomlinsonovo mrežo kompleksnih povezljivosti pri razlagi dokazov o sočasnosti kulture Kura-Araxes v Transkavkaziji ter v severnem centralnem delu Anatolije v drugi polovici četrtega tisočletja pr. n. št. oz. v času pozne bakrene dobe, in sicer v okviru širšega globalnega konteksta sistema mesta Uruk v Mezopotamiji. Osredotočamo se na najdišče Çadır Höyük v severni centralni Anatoliji. Prebivalci te ruralne naselbine so bili konec četrtega tisočletja priča dramatičnim spremembam, ki so vključevale veliko reorganizacijo načrta vasi, širitve in krčenja družbenoekonomskih aktivnosti in menjave na dolge razdalje, bolj izpopolnjene načine pokopa in morda evolucijo novih družbenopolitičnih in verskih ideologij. Raziskujemo tudi dokaze o tem, da je imela družbenoekonomska ‘kompleksna povezljivost’ s Transkavkazijo in Mezopotamijo pomembno vlogo pri bistvenih spremembah in notranji dinamiki na pozno bakrenodobnem najdišču Çadır Höyük

Automated optical identification of a large complete northern hemisphere sample of flat spectrum radio sources with S_6cm > 200 mJy

This paper describes the automated optical APM identification of radio sources from the Jodrell Bank - VLA Astrometric Survey (JVAS), as used for the search for distant radio-loud quasars. The sample has been used to investigate possible relations between optical and radio properties of flat spectrum radio sources. From the 915 sources in the sample, 756 have an optical APM identification at a red (e) and/or blue (o) plate,resulting in an identification fraction of 83% with a completeness and reliability of 98% and 99% respectively. About 20% are optically identified with extended APM objects on the red plates, e.g. galaxies. However the distinction between galaxies and quasars can not be done properly near the magnitude limit of the POSS-I plates. The identification fraction appears to decrease from >90% for sources with a 5 GHz flux density of >1 Jy, to <80% for sources at 0.2 Jy. The identification fraction, in particular that for unresolved quasars, is found to be lower for sources with steeper radio spectra. In agreement with previous studies, we find that the quasars at low radio flux density levels also tend to have fainter optical magnitudes, although there is a large spread. In addition, objects with a steep radio-to-optical spectral index are found to be mainly highly polarised quasars, supporting the idea that in these objects the polarised synchrotron component is more prominent. It is shown that the large spread in radio-to-optical spectral index is possibly caused by source to source variations in the Doppler boosting of the synchrotron component [Abridged].Comment: LaTex, 17 pages, 5 gif figures, 4 tables. Accepted for publication in MNRAS. High resolution figures can be found at http://www.roe.ac.uk/~ignas

Referral Patterns, Procedures, and Outcomes of a Large Community- Based Urology Group: a Retrospective Chart Review

In 2012 The United States Preventive Services Task Force (USPSTF) recommended against prostate cancer (Pca) screening. The purpose of our study is to assess the effects of the USPSTF grade D recommendation for PSA based screening on new PCa diagnoses within a large-community based private practice setting. We completed a retrospective chart review of men with an elevated PSA seen in our clinic between May 2009–May 2015 who had undergone a prostate biopsy and were diagnosed with PCa. We observed that following the 2012 USPSTF recommendations, there was a significant increase in patients with clinically significant prostate cancer GG ≥ 2, with the majority being 55-65 years of age. In addition we observed a decrease in the diagnosis of very low and low risk PCa with an increased incidence of intermediate and high risk PCa

Desferrioxamine biosynthesis : diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC

Hydroxamate groups play key roles in the biological function of diverse natural products. Important examples include trichostatin A, which inhibits histone deacetylases via coordination of the active site zinc(II) ion with a hydroxamate group, and the desferrioxamines, which use three hydroxamate groups to chelate ferric iron. Desferrioxamine biosynthesis in Streptomyces species involves the DesD-catalysed condensation of various N-acylated derivatives of N-hydroxycadaverine with two molecules of N-succinyl-N-hydroxycadaverine to form a range of linear and macrocyclic tris-hydroxamates. However, the mechanism for assembly of the various N-acyl-N-hydroxycadaverine substrates of DesD from N-hydroxycadaverine has until now been unclear. Here we show that the desC gene of Streptomyces coelicolor encodes the acyl transferase responsible for this process. DesC catalyses the N-acylation of N-hydroxycadaverine with acetyl, succinyl and myristoyl-CoA, accounting for the diverse array of desferrioxamines produced by S. coelicolor. The X-ray crystal structure of DesE, the ferrioxamine lipoprotein receptor, in complex with ferrioxamine B (which is derived from two units of N-succinyl-N-hydroxycadaverine and one of N-acetyl-N-hydroxycadaverine) was also determined. This shows that the acetyl group of ferrioxamine B is solvent exposed, suggesting that the corresponding acyl group in longer chain congeners can protrude from the binding pocket, providing insights into their likely functio

Effects of spaceflight on musculoskeletal health: A systematic review and meta-analysis, considerations for interplanetary travel

Background: If interplanetary travel is to be successful over the coming decades, it is essential that countermeasures to minimize deterioration of the musculoskeletal system are as effective as possible, given the increased duration of spaceflight associated with such missions. The aim of this review, therefore, is to determine the magnitude of deconditioning of the musculoskeletal system during prolonged spaceflight and recommend possible methods to enhance the existing countermeasures. Methods: A literature search was conducted using PubMed, Ovid and Scopus databases. 5541 studies were identified prior to the removal of duplicates and the application of the following inclusion criteria: (1) group means and standard deviations for pre- and post-spaceflight for measures of strength, muscle mass or bone density were reported (or provided by the corresponding author when requested via e-mail), (2) exercise-based countermeasures were included, (3) the population of the studies were human, (4) muscle function was assessed and (5) spaceflight rather than simulated spaceflight was used. The methodological quality of the included studies was evaluated using a modified Physiotherapy Evidence Database (PEDro) scale for quality, with publication bias assessed using a failsafe N (Rosenthal method), and consistency of studies analysed using I2 as a test of heterogeneity. Secondary analysis of studies included Hedges’ g effect sizes, and between-study differences were estimated using a random-effects model. Results: A total of 11 studies were included in the meta-analyses. Heterogeneity of the completed meta-analyses was conducted revealing homogeneity for bone mineral density (BMD) and spinal muscle size (Tau2 \u3c 0.001; I2 = 0.00%, p \u3e 0.05), although a high level of heterogeneity was noted for lower body force production (Tau2 = 1.546; I2 = 76.03%, p \u3c 0.001) and lower body muscle mass (Tau2 = 1.386; I2 = 74.38%, p \u3c 0.001). The estimated variance ( ≤ -0.306) for each of the meta-analyses was significant (p ≤ 0.033), for BMD (− 0.48 to − 0.53, p \u3c 0.001), lower body force production (− 1.75, p \u3c 0.001) and lower body muscle size (− 1.98, p \u3c 0.001). Spaceflight results in small reductions in BMD of the femur (Hedges g = − 0.49 [− 0.69 to – 0.28]), trochanter (Hedges g = − 0.53 [− 0.77 to – 0.29]), and lumbo-pelvic region (Hedges g = − 0.48 [− 0.73 to – 0.23]), but large decreases in lower limb force production (Hedges g = − 1.75 [− 2.50 to – 0.99]) and lower limb muscle size (Hedges g = − 1.98 [− 2.72 to – 1.23]). Conclusions: Current exercise countermeasures result in small reductions in BMD during long-duration spaceflight. In contrast, such exercise protocols do not alleviate the reductions in muscle function or muscle size, which may be attributable to the low to moderate loads reported by crewmembers and the interference effect associated with concurrent training. It is recommended that higher-load resistance exercise and the use of high-intensity interval training should be investigated, to determine if such modifications to the reported training practices result in more effective countermeasures to the deleterious effect of long-duration spaceflight on the muscular system

Discovery of a Radio-Selected z ~ 6 Quasar

We present the discovery of only the second radio-selected, z ~ 6 quasar. We identified SDSS J222843.54+011032.2 (z=5.95) by matching the optical detections of the deep Sloan Digital Sky Survey (SDSS) Stripe 82 with their radio counterparts in the Stripe82 VLA Survey. We also matched the Canadian-France-Hawaiian Telescope Legacy Survey Wide (CFHTLS Wide) with the Faint Images of the Radio Sky at Twenty-cm (FIRST) survey but have yet to find any z ~ 6 quasars in this survey area. The discovered quasar is optically-faint, z = 22.3 and M_{1450} ~ -24.5, but radio-bright, with a flux density of f$_{1.4GHz, peak}$ = 0.31mJy and a radio-loudness of R ~ 1100 (where R = f_{5GHz}/f_{2500}). The i-z color of the discovered quasar places it outside the color selection criteria for existing optical surveys. We conclude by discussing the need for deeper wide-area radio surveys in the context of high-redshift quasars.Comment: 20 pages, 6 figures, and ApJ accepte

(6R)-2-tert-Butyl-6-[(4R,5S)-3-isopropyl-4-methyl-5-phenyl­oxazolidin-2-yl]phenol

In the title compound, C23H31NO2, the lone pair on the nitro­gen atom is oriented to facilitate intra­molecular hydrogen bonding with the hydr­oxy group residing on the phenyl substituent. The five-membered ring adopts an envelope confornmation with the O atom at the flap. The absolute stereochemistry was verified by measurement of optical activity using a digital polarimeter