Cancelled operations: a 7-day cohort study of planned adult inpatient surgery in 245 UK National Health Service hospitals.

BACKGROUND: Cancellation of planned surgery impacts substantially on patients and health systems. This study describes the incidence and reasons for cancellation of inpatient surgery in the UK NHS. METHODS: We conducted a prospective observational cohort study over 7 consecutive days in March 2017 in 245 NHS hospitals. Occurrences and reasons for previous surgical cancellations were recorded. Using multilevel logistic regression, we identified patient- and hospital-level factors associated with cancellation due to inadequate bed capacity. RESULTS: We analysed data from 14 936 patients undergoing planned surgery. A total of 1499 patients (10.0%) reported previous cancellation for the same procedure; contemporaneous hospital census data indicated that 13.9% patients attending inpatient operations were cancelled on the day of surgery. Non-clinical reasons, predominantly inadequate bed capacity, accounted for a large proportion of previous cancellations. Independent risk factors for cancellation due to inadequate bed capacity included requirement for postoperative critical care [odds ratio (OR)=2.92; 95% confidence interval (CI), 2.12-4.02; P CONCLUSIONS: A significant proportion of patients presenting for surgery have experienced a previous cancellation for the same procedure. Cancer surgery is relatively protected, but bed capacity, including postoperative critical care requirements, are significant risk factors for previous cancellations

Semaphorins and Their Roles in Breast Cancer: Implications for Therapy Resistance

Breast cancer is the most common cancer worldwide and a leading cause of cancer-related deaths in women. The clinical management of breast cancer is further complicated by the heterogeneous nature of the disease, which results in varying prognoses and treatment responses in patients. The semaphorins are a family of proteins with varied roles in development and homoeostasis. They are also expressed in a wide range of human cancers and are implicated as regulators of tumour growth, angiogenesis, metastasis and immune evasion. More recently, semaphorins have been implicated in drug resistance across a range of malignancies. In breast cancer, semaphorins are associated with resistance to endocrine therapy as well as breast cancer chemotherapeutic agents such as taxanes and anthracyclines. This review will focus on the semaphorins involved in breast cancer progression and their association with drug resistance

World-sheet scattering in AdS_5 x S^5 at two loops

We study the AdS_5 x S^5 sigma-model truncated to the near-flat-space limit to two-loops in perturbation theory. In addition to extending previously known one-loop results to the full SU(2|2)^2 S-matrix we calculate the two-loop correction to the dispersion relation and then compute the complete two-loop S-matrix. The result of the perturbative calculation can be compared with the appropriate limit of the conjectured S-matrix for the full theory and complete agreement is found.Comment: 26pages, 3 figure

Supporting patients experiencing poverty-related mental distress: development and evaluation of a training resource in general practices in eleven regions of England

This is the final version. Available from Elsevier via the DOI in this record. National Institute for Health Researc

Review of AdS/CFT Integrability: An Overview

This is the introductory chapter of a review collection on integrability in the context of the AdS/CFT correspondence. In the collection we present an overview of the achievements and the status of this subject as of the year 2010.Comment: 31 pages, v2: reference added, references to other chapters updated, v3: footnote 1 on location of references added, v4: minor changes, references added, accepted for publication in Lett. Math. Phys, v5: minor corrections, links to chapters updated, attached IntAdS.pdf with all chapters in one file, see http://arxiv.org/src/1012.3982/anc/IntAdS.pdf or http://www.phys.ethz.ch/~nbeisert/IntAdS.pd

Worldsheet Scattering in AdS_5 x S^5

We calculate the S-matrix in the gauge-fixed sigma-model on AdS_5 x S^5 to the leading order in perturbation theory, and analyze how supersymmetry is realized on the scattering states. A mild nonlocality of the supercharges implies that their action on multi-particle states does not follow the Leibniz rule, which is replaced by a nontrivial coproduct. The plane wave symmetry algebra is thus naturally enhanced to a Hopf algebra. The scattering matrix elements obey the classical Yang-Baxter equation modified by the existence of the coproduct. This structure mirrors that of the large 't Hooft coupling expansion of the S-matrix for the spin chain in the dual super-Yang-Mills theory.Comment: 51 pages, v2: references added, v3: sign in (2.12), (6.19) and (6.21) corrected; v4: discussion of classical YBE is considerably modifie

Animated Edge Textures in Node-Link Diagrams: a Design Space and Initial Evaluation

International audienceNetwork edge data attributes are usually encoded using color, opacity, stroke thickness and stroke pattern, or some combination thereof. In addition to these static variables, it is also possible to animate dynamic particles flowing along the edges. This opens a larger design space of animated edge textures, featuring additional visual encodings that have potential not only in terms of visual mapping capacity but also playfulness and aesthetics. Such animated edge textures have been used in several commercial and design-oriented visualizations, but to our knowledge almost always in a relatively ad hoc manner. We introduce a design space and Web-based framework for generating animated edge textures, and report on an initial evaluation of particle properties – particle speed, pattern and frequency – in terms of visual perception

Review of AdS/CFT Integrability, Chapter IV.3: N=6 Chern-Simons and Strings on AdS4xCP3

We review the duality and integrability of N=6 superconformal Chern-Simons theory in three dimensions and IIA superstring theory on the background AdS4xCP3. We introduce both of these models and describe how their degrees of freedom are mapped to excitations of a long-range integrable spin-chain. Finally, we discuss the properties of the Bethe equations, the S-matrix and the algebraic curve that are special to this correspondence and differ from the case of N=4 SYM theory and strings on AdS5xS5.Comment: 22 pages, see also overview article arXiv:1012.3982, v2: references to other chapters updated, v3: references added, v4: brief discussion of giant magnons added, further minor changes, published version, v5: union of v3 and v4 because changes made in v3 were accidentally lost in v