Assessing Burnout and Well-Being in Higher Education Health Science Faculty

This study aimed to examine and compare the extent of burnout among health science faculty at a higher education institution and their self-reported perception of well-being during the COVID-19 pandemic. The design of the study was cross-sectional, descriptive survey research. An electronic questionnaire was developed to measure the constructs of burnout and well-being. Validated instruments used in the survey included the Oldenburg Burnout Inventory (OLBI) and the World Health Organization-5 Well-being Index. The Qualtrics ® platform was used to distribute the survey to all full-time faculty within the College of Health Sciences. 45 respondents from nursing, community and environmental health, kinesiology, social work, respiratory care, allied health sciences, and radiologic sciences completed the survey. Significant differences were observed in the extent of burnout and perception of well-being between faculty members who had clinical teaching responsibilities within their faculty role compared to those who did not, p = 0.005, Partial Eta Squared = 0.318. Faculty with a 9-month contract appointment had significantly lower OLBI-Disengagement scores (p = 0.024) and OLBI-Full Burnout scores (p = 0.047) compared with those with another contract length. There was a significantly negative relationship between the extent of burnout and perception of well-being. In this sample of health science faculty, burnout, as characterized by increased exhaustion and disengagement, was moderately prevalent and associated with poorer well-being

DNA Polymerase III Holoenzyme From Thermus Thermophilus Identification Expression Purification of Components and use to Reconstitute a Processive Replicase

DNA replication in bacteria is performed by a specialized multicomponent replicase, the DNA polymerase III holoenzyme, that consist of three essential components: a polymerase, the β sliding clamp processivity factor, and the DnaX complex clamp-loader. We report here the assembly of the minimal functional holoenzyme from Thermus thermophilus (Tth), an extreme thermophile. The minimal holoenzyme consists of α (pol III catalytic subunit), β (sliding clamp processivity factor), and the essential DnaX (τ/γ), δ and δ′ components of the DnaX complex. We show with purified recombinant proteins that these five components are required for rapid and processive DNA synthesis on long single-stranded DNA templates. Subunit interactions known to occur in DNA polymerase III holoenzyme from mesophilic bacteria including δ-δ′ interaction, δδ′-τ/γ complex formation, and α-τ interaction, also occur within the Tth enzyme. As in mesophilic holoenzymes, in the presence of a primed DNA template, these subunits assemble into a stable initiation complex in an ATP-dependent manner. However, in contrast to replicative polymerases from mesophilic bacteria, Tth holoenzyme is efficient only at temperatures above 50 °C, both with regard to initiation complex formation and processive DNA synthesis. The minimalTth DNA polymerase III holoenzyme displays an elongation rate of 350 bp/s at 72 °C and a processivity of greater than 8.6 kilobases, the length of the template that is fully replicated after a single association event

Pengaruh Koordinasi Mata-Tangan, Daya Ledak Otot Lengan, dan Kemampuan Motorik terhadap Kemampuan Passing Bawah dalam Permainan Bolavoli pada Murid SD Inpres Sepee Kabupaten Barru

ABSTRAK Penelitian ini bertujuan untuk mengetahui: (1) Untuk mengetahui pengaruh koordinasi mata-tangan terhadap kemampuan motorik pada Murid SD Inpres Sepee Kabupaten Barru, (2) Untuk mengetahui pengaruh daya ledak otot lengan terhadap kemampuan motorik pada Murid SD Inpres Sepee Kabupaten Barru, (3) Untuk mengetahui pengaruh koordinasi mata tangan terhadap kemampuan passing bawah dalam permainan bolavoli pada Murid SD Inpres Sepee Kabupaten Barru, (4) Untuk mengetahui pengaruh daya ledak otot lengan terhadap kemampuan passing bawah dalam permainan bolavoli pada Murid SD Inpres Sepee Kabupaten Barru, (5) Untuk mengetahui pengaruh kemampuan motorik terhadap kemampuan passing bawah dalam permainan bolavoli pada Murid SD Inpres Sepee Kabupaten Barru, (6) Untuk mengetahui pengaruh koordinasi mata tanga terhadap kemampuan passing bawah dalam permainan bolavoli melalui kemampuan motorik pada Murid SD Inpres Sepee Kabupaten Barru, (7) Untuk mengetahui pengaruh daya ledak otot lengan terhadap kemampuan passing bawah dalam permainan bolavoli melalui kemampuan motorik pada Murid SD Inpres Sepee Kabupaten Barru. Jenis penelitian ini adalah penelitian deskriptif dan inferensial. Populasinya adalah Murid SD Inpres Sepee Kabupaten Barru. Teknik penentuan sampelnya adalah Berdasarkan penggunaan rumus Slovin diperoleh jumlah sampel ditetapkan sebanyak 30 responden. Teknik analisis data yang digunakan adalah analisis statistik deskritif dan inferensial dengan bantuan program komputer SPSS versi 18 Pada taraf kepercayaan 95% atau α=0,05. Berdasarkan hasil penelitian dapat disimpulkan: (1) Ada pengaruh koordinasi mata-tangan terhadap kemampuan motorik pada Murid SD Inpres Sepee Kabupaten Barru, (2) Ada pengaruh daya ledak otot lengan terhadap kemampuan motorik pada Murid SD Inpres Sepee Kabupaten Barru, (3) Ada pengaruh koordinasi mata tangan terhadap kemampuan passing bawah dalam permainan bolavoli pada Murid SD Inpres Sepee Kabupaten Barru, (4) Ada pengaruh daya ledak otot lengan terhadap kemampuan passing bawah dalam permainan bolavoli pada Murid SD Inpres Sepee Kabupaten Barru, (5) Ada pengaruh kemampuan motorik terhadap kemampuan passing bawah dalam permainan bolavoli pada Murid SD Inpres Sepee Kabupaten Barru, (6) Ada pengaruh koordinasi mata tanga terhadap kemampuan passing bawah dalam permainan bolavoli melalui kemampuan motorik pada Murid SD Inpres Sepee Kabupaten Barru, (7) Ada pengaruh daya ledak otot lengan terhadap kemampuan passing bawah dalam permainan bolavoli melalui kemampuan motorik pada Murid SD Inpres Sepee Kabupaten Barru. ABSTRACT Hadijah. 2016. "Effects of Hand-Eye Coordination, Burst Power Arm Muscles and Motor Ability to Ability Passing Down the volleyball game on Elementary Students Instruction Sepee Barru". (Supervised by

Bostonia

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Leveraging Economies of Scale via Collaborative Interdisciplinary Global Health Tracks (CIGHTs): Lessons From Three Programs

As interest in global health education continues to increase, residency programs seeking to accommodate learners’ expectations for global health learning opportunities often face challenges providing high-quality global health training. To address these challenges, some residency programs collaborate across medical specialties to create interdepartmental global health residency tracks or collaborative interdepartmental global health tracks (CIGHTs). In this Perspective, the authors highlight the unique aspects of interdepartmental tracks that may benefit residency programs by describing three established U.S.-based programs as models: those at Indiana University, Mount Sinai Hospital, and the University of Virginia. Through collaboration and economies of scale, CIGHTs are able to address some of the primary challenges inherent to traditional global health tracks: lack of institutional faculty support and resources, the need to develop a global health curriculum, a paucity of safe and mentored international rotations, and inconsistent resident interest. Additionally, most published global health learning objectives and competencies (e.g., ethics of global health work, pre-departure training) are not discipline-specific and can therefore be addressed across departments—which, in turn, adds to the feasibility of CIGHTs. Beyond simply sharing the administrative burden, however, the interdepartmental learning central to CIGHTs provides opportunities for trainees to gain new perspectives in approaching global health not typically afforded in traditional global health track models. Residency program leaders looking to implement or modify their global health education offerings, particularly those with limited institutional support, might consider developing a CIGHT as an approach that leverages economies of scale and provides new opportunities for collaboration

Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility

Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes

Abiotic Proxies of Benthic Megafaunal Assemblages in the Coastal Gulf of Maine: A Template for Ocean Planning?

Planning how to accommodate growing coastal populations is the impetus for ocean planning (OP), which has become a goal for many countries including the United States. One big challenge for OP will be describing vast marine ecosystems using limited resources. We sought to develop abiotic proxies that characterize megafaunal communities and tested this approach over nearly 300km of coast in the Gulf of Maine (GOM) using stratified-random remotely operated vehicle surveys. Together, depth, substrate and oceanographic processes explained a significant portion of variance in models for the species structure, biomass and diversity of benthic assemblages (these variables explained 36.2%-54.7%). According to canonical correlation analysis, depth and substrate were the strongest determinants of community structure. While cumulative biomass and biodiversity related to the oceanographic gradient of the GOM coastal current system, according to generalized additive modeling. Our results suggest abiotic factors can be strong forcing functions for the assembly of marine communities. Locally, substrate heterogeneity interacts with traits of benthic species to create fme-scale differences in species structure. At a coastal scale, depth regulates available primary and secondary production. Lastly, at a regional scale, thermography creates biogeographic patterns in benthic assemblages, which may be most vulnerable to climate change. Our approach allows localized studies to be scaled up for large marine ecosystems and could become a template for considering the multi-scale spatial extent of assemblages in the context of ocean activities. Using abiotic proxies as templates for marine assemblages could allow managers and policy-makers to conduct OP without depending on costly and time-consuming surveys of entire large marine ecosystems

McHenry_etal_2016_Survey_Data

The data comes from a remotely operated vehicle (ROV) survey conducted during the summer months of 2010-2013 along the coastal Gulf of Maine shelf. The survey aimed 1) to characterize the distribution and abundance of benthic megafauna with respect to near-shore abiotic conditions, 2) to develop spatially-explicit maps of ecological attributes of near-shore benthic assemblages, and 3) use such maps to inform the application of ecological principles when engaging in marine spatial planning. This file contains a data matrix of species abundances for the most dominantly observed species (i.e., greater than 5 observations), assemblage biomass, economic value, and shannon-weiner species diversity by site, along with values of associated summertime abiotic conditions (i.e.,mean transect depth, substrate type, water-mass position, bottom temperature, bottom current speed/direction, and bottom salinity). Depth and substrate type values were recorded from the ROV surveys, while the water-mass values were acquired from HYCOM GLBu0.08 4D model output via the Marine Geo-spatial Ecology Toolbox in ArcGIS 10.3. See McHenry et al. 2016 for a full description the survey design, data processing methods, and analytical approaches used by this study

Sovereign states in the Caribbean have lower social-ecological vulnerability to coral bleaching than overseas territories

Xunta de Galicia Consellería de EducaciónEuropean Research Council 100010663 | Ref. GA. 679812Waitt Foundation 10000785