Alien Registration- Mcfarlane, Rev. James W. (Bangor, Penobscot County)

https://digitalmaine.com/alien_docs/11831/thumbnail.jp

Pathologic analysis of liver transplantation for primary biliary cirrhosis

A retrospective histopathologic review of all pathologic specimens from 394 adult liver transplant patients was undertaken with clinical correlation to determine if primary biliary cirrhosis has affected the posttrans‐plant course compared to all other indications for liver transplantation and if recurrent primary biliary cirrhosis has occurred after liver transplantation. We also compared the histopathologic features seen in native livers with primary biliary cirrhosis to failed allografts with chronic rejection. One hundred six of the 394 adult patients transplanted during this time (1981 to July, 1986) fulfilled clinicopathologic criteria for a diagnosis of primary biliary cirrhosis. Neither the incidence nor any qualitative pathologic feature of histologically documented acute cellular rejection differentiated subjects transplanted for primary biliary cirrhosis vs. other diseases. No correlation between the titers of antimitochon‐drial antibody and the presence of posttransplant hepatic dysfunction based on liver enzyme profiles or the development of chronic rejection was seen in patients transplanted for primary biliary cirrhosis. Minor differences noted in the posttransplant course of primary biliary cirrhosis patients as compared to other conditions (higher incidence of chronic rejection as a cause of graft failure) was seen, but this did not significantly affect graft or patient survival. Recurrent primary biliary cirrhosis could not be diagnosed with certainty in any patient. A comparison of failed chronically rejected allografts vs. native hepatectomies obtained from patients with primary biliary cirrhosis revealed the presence of chronic obliterative vasculopathy, centrilobular cholestasis, and lack of granulomas, cirrhosis, cholan‐giolar proliferation, copper‐associated protein deposition and Mallory's hyalin in specimens with chronic rejection. In contrast, livers removed from patients with primary biliary cirrhosis demonstrated a mild vasculopathy, cirrhosis, granulomas, copper‐associated protein deposition, Mallory's hyalin and periportal cholestasis. Both conditions demonstrated a nonsuppurative destructive cholangitis with bile duct paucity. Copyright © 1988 American Association for the Study of Liver Disease

Understanding and addressing ‘modern slavery’ in DRC-UK cobalt supply chains

The UK’s – and the world’s – ‘green industrial revolution’ is intrinsically tied to the artisanal and small-scale mining (ASM) of cobalt in the Democratic Republic of Congo (DRC). This largely informal sector produces approximately 12–21% of the world’s cobalt each year – a vital component in the manufacture of electric vehicle batteries powering the global transition to a low carbon economy and employing as many as 200,000 cobalt miners in DRC as well as supporting hundreds of thousands more people in related livelihood activities. Yet many artisanal cobalt miners suffer dangerous working conditions, human rights abuses, and abuses relating to child labour. Addressing these issues of modern slavery in ASM is therefore vital to the achievement of all 17 of the United Nation’s Sustainable Development Goals (SDGs), including SDG1 No Poverty, SDG13 Climate Action, and crucially, SDG8 Decent Work Economic Growth which includes Target 8.7 to ‘end modern slavery’ – the first international framework specifically using the term modern slavery.However, with ASM largely absent from modern slavery policy formation, there are significant gaps in how the concept is applied and addressed in ASM and overlaps with existing responsible mineral sourcing legislation and initiatives. The aim of this chapter, therefore, is to enhance understanding of how the term modern slavery is applied to ASM activities, examine the accompanying modern slavery legislation regarding ASM, including the 2015 UK Modern Slavery Act, and explore how communities and companies perceive, report, and address such issues in their mineral supply chains. Based on an in-depth review of the literature and drawing on the findings of practical research and training workshops held in the UK and DRC (January–March 2020), four recommendations are made to better address modern slavery in DRC-UK cobalt supply chains. To maximise the development potential of DRC’s ASM cobalt industry, the chapter argues that aside from the moral responsibility, there is a need to clearly demonstrate the market-driven ‘business imperatives’ for companies to engage directly in ASM formalisation initiatives that unlock shared value and move beyond compliance with modern slavery and responsible mineral sourcing and reporting requirements

The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1)

Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting viral genomes to cooperatively promote viral genome silencing. Central to the execution of this particular antiviral response is the small ubiquitin-like modifier (SUMO) signalling pathway. However, the participating SUMOylation enzymes are not fully characterized. We identify the SUMO ligase Protein Inhibitor of Activated STAT1 (PIAS1) as a constituent PML-NB protein. We show that PIAS1 localizes at PML-NBs in a SUMO interaction motif (SIM)-dependent manner that requires SUMOylated or SUMOylation competent PML. Following infection with herpes simplex virus 1 (HSV-1), PIAS1 is recruited to nuclear sites associated with viral genome entry in a SIM-dependent manner, consistent with the SIM-dependent recruitment mechanisms of other well characterized PML-NB proteins. In contrast to Daxx and Sp100, however, the recruitment of PIAS1 is enhanced by PML. PIAS1 promotes the stable accumulation of SUMO1 at nuclear sites associated with HSV-1 genome entry, whereas the accumulation of other evaluated PML-NB proteins occurs independently of PIAS1. We show that PIAS1 cooperatively contributes to HSV-1 restriction through mechanisms that are additive to those of PML and cooperative with those of PIAS4. The antiviral mechanisms of PIAS1 are counteracted by ICP0, the HSV-1 SUMO-targeted ubiquitin ligase, which disrupts the recruitment of PIAS1 to nuclear domains that contain infecting HSV-1 genomes through mechanisms that do not directly result in PIAS1 degradation

Growth and replication : exploring facade subdivision based on natural processes

Generative methods for subdivision of building façades are presented in this thesis through a series of case studies exploring methods of stochastic generation, tiling and tessellation and branching structures.  In each of these studies, a method of generative design based on natural phenomena of growth and replication is described algorithmically

Transnational comparison : A retrospective study on e-health in sparsely populated areas of the northern periphery

Peer reviewedPublisher PD

The Effect of an Aqueous Extract of Turmeric and a Combination of Chinese Herbs on Glucose Homeostasis

Type 2 Diabetes is currently in epidemic proportions throughout the world and the prevalence is increasing rapidly worldwide, costing several billion dollars to the world economy every year. If new treatments are found that would be economically viable for third world countries to produce there may be a way of controlling this epidemic. Although the effects of current hypoglycaemic drugs appear to be sufficient and blood glucose levels are normalised initially, they still tend not to stop the micro-vascular effects of the disease and their effectiveness appears to diminish overtime. There has been a recent trend for people to turn to alternative therapies for treatment of their diabetes and also there is a search for new and more effective treatments. Many herbs have been used by various cultures, however, little if any; scientific research has been carried out to show their efficacy and effectiveness. Therefore the aim of this study was to determine which of several culinary herbs, Australian plants and a combination of Traditional Chinese Medicines (Glucostat) might be beneficial in the treatment of Type 2 diabetes

Perspectives on Depression: A synthesis of biological and behavioural findings

Introduction: Depression is a complex and widespread phenomenon, with few effective treatments that may be universally applied. Although a great deal of research has been reported on various aspects of depression from the perspectives of the different disciplines of general psychiatry, genetics, neuroscience, endocrinology, immunology, pharmacology, psychology, behaviour analysis and evolutionary theory, there is no extant synthesis of those data that is recent or comprehensive in its coverage. This thesis therefore reviewed the literatures from these nine areas, focussing principally from a neurobiological perspective, and drew the findings from that review into a comprehensive model of the way in which depression develops and why it occurs. Method: Working from a selection of authoritative texts, plus cross-referencing and weekly checks of over 20 major journals that reported data on depression during the period 2000 to 2010, plus online electronic searches via four search engines, more than 100 review chapters and over 3,500 journal articles on depression were found across the disciplines mentioned above. From these, a subset of 768 sources was identified as holding information directly pertinent to the focus of this thesis. These sources were then reviewed and summarised in discrete sections of this thesis. From these summaries, a new model of depression was developed which encompassed the wider literature. Results & Conclusion: Commencing with genetic bases for depression (gender, predisposition to melancholic depression) and two major indicators of the organism's exaggerated responsivity to environmental threat (the 5-HTTLPR polymorphism, methylation of several key genes involved in the HPA axis function) which cause increases in the activity of the Hypothalamus-Pituitary-Adrenal (HPA) axis, the model developed in this thesis considers the effects of that HPA axis hyperactivation and resultant elevated circulating cortisol