Preschool and maternal labour market outcomes: evidence from a regression discontinuity design

Expanding preschool education has the dual goals of improving child outcomes and work incentives for mothers. This paper provides evidence on the second, identifying the impact of preschool attendance on maternal labor market outcomes in Argentina. A major challenge in identifying the causal effect of preschool attendance on parental outcomes is non-random selection into early education. We address this by relying on plausibly exogenous variation in preschool attendance that is induced when children are born on either side of Argentina's enrollment cutoff date of July 1. Because of enrollment cutoff dates, 4 year-olds born just before July 1 are 0.3 more likely to attend preschool. Our regression-discontinuity estimates compare maternal employment outcomes of 4 year-old children on either side of this cutoff, identifying effects among the subset of complying households (who are perhaps more likely to face constraints on their level 2 preschool attendance). Our findings suggest that, on average, 13 mothers start to work for every 100 youngest children in the household that start preschool (though, in our preferred specification, this estimate is not statistically significant at conventional levels). Furthermore, mothers are 19.1 percentage points more likely to work for more than 20 hours a week (i.e., more time than their children spend in school) and they work, on average, 7.8 more hours per week as consequence of their youngest offspring attending preschool. We find no effect on maternal labor outcomes when a child that is not the youngest in the household attends preschool. Finally, we find that at the point of transition from kindergarten to primary school some employment effects persist. Our preferred estimates condition on mother's schooling and other exogenous covariates, given evidence that mothers' schooling is unbalanced in the vicinity of the July 1 cutoff in the sample of 4 year-olds. Using a large set of natality records, we found no evidence that this is due to precise birth date manipulation by parents. Other explanations, like sample selection, are also not fully consistent with the data, and we must remain agnostic on this point. Despite this shortcoming, the credibility of the estimates is partly enhanced by the consistency of point estimates with Argentine research using a different EPH sample and sources of variation in preschool attendance (Berlinski and Galiani 2007). A growing body of research suggests that pre-primary school can improve educational outcomes for children in the short and long run (Blau and Currie 2006; Schady 2006). This paper provides further evidence that, ceteris paribus, an expansion in preschool education may enhance the employment prospects of mothers of children in preschool age

Up-scaling orange-fleshed sweetpotato (Ipomoea batatas (L) Lam) technologies in western Kenya.

Vitamin A deficiency is a major nutritional problem in Kenya, leading to night blindness and high mortality rate in infants. Consumption of orange-fleshed sweetpotato (OFSP) that is high in -carotene (pro-vitamin A), can reduce the risk of the deficiency. The utilization of the OFSP in Kenya despite its nutritional advantage is limited. Efforts by the Government extension service to promote the crop has had limited impact. The Kenya Agricultural Research Institute in collaboration with the International Potato Centre and farmers developed a number of OFSP technologies that can enhance its utilization. The ASARECA/AfDB-supported project “Dissemination of New Agricultural Technologies in Africa” (DONATA) for Orange-fleshed sweetpotato (OFSP) was initiated in Bungoma and Busia counties of Western Kenya in 2008. The project used the Innovation Platforms for Technology Adoption (IPTAs) approach in up-scale the proven OFSP technologies. IPTA acts as the institutional mechanism bringing together different stakeholders for scaling out and scaling-up of OFSP technologies along the value chain. Within three years 29 technologies on seed systems, agronomic practises, postharvest processing and marketing were promoted to 7500 beneficiaries. This was achieved through training of 215 extension agents and 1250 farmers on different aspects of OFSP. Thirteen information products were made available to the users through 15 different uptake pathways. Area under OFSP root production increased by over 600% while productivity per unit area increased from 8 to 16 tons/ha in the project countie

Efficacy of pimobendan in the prevention of congestive heart failure or sudden death in doberman pinschers with preclinical dilated cardiomyopathy (the PROTECT study)

<p>Background: The benefit of pimobendan in delaying the progression of preclinical dilated cardiomyopathy (DCM) in Dobermans is not reported.</p> <p>Hypothesis: That chronic oral administration of pimobendan to Dobermans with preclinical DCM will delay the onset of CHF or sudden death and improve survival.</p> <p>Animals: Seventy-six client-owned Dobermans recruited at 10 centers in the UK and North America.</p> <p>Methods: The trial was a randomized, blinded, placebo-controlled, parallel group multicenter study. Dogs were allocated in a 1:1 ratio to receive pimobendan (Vetmedin capsules) or visually identical placebo.</p> <p>The composite primary endpoint was prospectively defined as either onset of CHF or sudden death. Time to death from all causes was a secondary endpoint.</p> <p>Results: The proportion of dogs reaching the primary endpoint was not significantly different between groups (P = .1). The median time to the primary endpoint (onset of CHF or sudden death) was significantly longer in the pimobendan (718 days, IQR 441–1152 days) versus the placebo group (441 days, IQR 151–641 days) (log-rank P = 0.0088). The median survival time was significantly longer in the pimobendan (623 days, IQR 491–1531 days) versus the placebo group (466 days, IQR 236–710 days) (log-rank P = .034).</p> <p>Conclusion and Clinical Importance: The administration of pimobendan to Dobermans with preclinical DCM prolongs the time to the onset of clinical signs and extends survival. Treatment of dogs in the preclinical phase of this common cardiovascular disorder with pimobendan can lead to improved outcome.</p&gt

Computer modeling of diabetes and Its transparency: a report on the Eighth Mount Hood Challenge

Objectives The Eighth Mount Hood Challenge (held in St. Gallen, Switzerland, in September 2016) evaluated the transparency of model input documentation from two published health economics studies and developed guidelines for improving transparency in the reporting of input data underlying model-based economic analyses in diabetes. Methods Participating modeling groups were asked to reproduce the results of two published studies using the input data described in those articles. Gaps in input data were filled with assumptions reported by the modeling groups. Goodness of fit between the results reported in the target studies and the groups’ replicated outputs was evaluated using the slope of linear regression line and the coefficient of determination (R2). After a general discussion of the results, a diabetes-specific checklist for the transparency of model input was developed. Results Seven groups participated in the transparency challenge. The reporting of key model input parameters in the two studies, including the baseline characteristics of simulated patients, treatment effect and treatment intensification threshold assumptions, treatment effect evolution, prediction of complications and costs data, was inadequately transparent (and often missing altogether). Not surprisingly, goodness of fit was better for the study that reported its input data with more transparency. To improve the transparency in diabetes modeling, the Diabetes Modeling Input Checklist listing the minimal input data required for reproducibility in most diabetes modeling applications was developed. Conclusions Transparency of diabetes model inputs is important to the reproducibility and credibility of simulation results. In the Eighth Mount Hood Challenge, the Diabetes Modeling Input Checklist was developed with the goal of improving the transparency of input data reporting and reproducibility of diabetes simulation model results

La estrategia Educativa 2020 o las limitaciones del Banco Mundial para promover el "aprendizaje para todos"

La nueva Estrategia Educativa 2020 del Banco Mundial establece las prioridades de reforma educativa en paises en vias de desarrollo para la decada siguiente. El titulo explicito de la estrategia, Aprendizaje para Todos, es un claro reconocimiento de que, mas alla de politicas centradas en el acceso, se debe hacer algo mas para asegurar que la educacion derive en experiencias positivas de aprendizaje. Sin embargo, como este articulo sostiene, las opciones de politicas explicitas y latentes en la Estrategia 2020 no son las mas adecuadas para lograr el Aprendizaje para Todos. El articulo desarrolla tres tipos de argumentos al respecto. El primero se refiere al fuerte apego del Banco a un conocimiento disciplinario y un enfoque metodológico que es insufi ciente para entender lo que aprenden los niños en la escuela y por que. El segundo argumento se refiere al sesgo pro-mercado de la Estrategia por lo que respecta a la reforma del sector publico y a nuevas formas de oferta educativa. En tercer lugar, el articulo senala las principales ausencias de la Estrategia, con especial atencion a las omisiones relacionadas con la compleja relación entre educación y pobreza.The World Bank's 2020 Education Strategy establishes the new education priorities in developing countries for the next decade. Its title, Learning for All, clearly recognizes that, beyond policies focusing on access, something else must be done to ensure that schooling involves positive learning experiences. However, as this paper argues, the 2020 Strategy explicit and latent policy options might not be adequate to achieve Learning for All. This paper develops three arguments on that matter. The fi rst one refers to the Bank's strong attachment to a disciplinary knowledge and a methodological approach that do not suffi ce to understand what children learn at school and why. The second one addresses its pro-market bias when it approaches the public sector reforms and the new forms of providing education. The last argument points out the main omissions of this Strategy, especially in what regards the complex relation between education and poverty

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. Interpretation ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials

Preschool and maternal labour market outcomes: evidence from a regression discontinuity design

Expanding preschool education has the dual goals of improving child outcomes and work incentives for mothers. This paper provides evidence on the second, identifying the impact of preschool attendance on maternal labor market outcomes in Argentina. A major challenge in identifying the causal effect of preschool attendance on parental outcomes is non-random selection into early education. We address this by relying on plausibly exogenous variation in preschool attendance that is induced when children are born on either side of Argentina's enrollment cutoff date of July 1. Because of enrollment cutoff dates, 4 year-olds born just before July 1 are 0.3 more likely to attend preschool. Our regression-discontinuity estimates compare maternal employment outcomes of 4 year-old children on either side of this cutoff, identifying effects among the subset of complying households (who are perhaps more likely to face constraints on their level 2 preschool attendance). Our findings suggest that, on average, 13 mothers start to work for every 100 youngest children in the household that start preschool (though, in our preferred specification, this estimate is not statistically significant at conventional levels). Furthermore, mothers are 19.1 percentage points more likely to work for more than 20 hours a week (i.e., more time than their children spend in school) and they work, on average, 7.8 more hours per week as consequence of their youngest offspring attending preschool. We find no effect on maternal labor outcomes when a child that is not the youngest in the household attends preschool. Finally, we find that at the point of transition from kindergarten to primary school some employment effects persist. Our preferred estimates condition on mother's schooling and other exogenous covariates, given evidence that mothers' schooling is unbalanced in the vicinity of the July 1 cutoff in the sample of 4 year-olds. Using a large set of natality records, we found no evidence that this is due to precise birth date manipulation by parents. Other explanations, like sample selection, are also not fully consistent with the data, and we must remain agnostic on this point. Despite this shortcoming, the credibility of the estimates is partly enhanced by the consistency of point estimates with Argentine research using a different EPH sample and sources of variation in preschool attendance (Berlinski and Galiani 2007). A growing body of research suggests that pre-primary school can improve educational outcomes for children in the short and long run (Blau and Currie 2006; Schady 2006). This paper provides further evidence that, ceteris paribus, an expansion in preschool education may enhance the employment prospects of mothers of children in preschool age

The role of auxiliary oxidants in the maintenance of a balanced redox poise for photosynthesis in bacteria

Carotenoid absorbance changes were used to monitor the development of membrane potential in intact cell suspensions of Rhodopseudomonas capsulata strain N22. Low concentrations of phenazine methosulphate almost completely inhibited the generation of membrane potential in the light by anaerobic cells. The light-dependent reactions were restored by addition of either trimethylamine N-oxide, dimethylsulphoxide, nitrous oxide, or oxygen. In Rhodopseudomonas capsulata strain N22 DNAR addition of nitrate was also effective. The inhibition by phenazine methosulphate and restoration by auxiliary oxidant were observed in the presence of sufficient rotenone to block NADH dehydrogenase or with low concentrations of uncoupling agent to dissipate the membrane potential under dark, anaerobic conditions. It is suggested that in intact cells of these organisms there are mechanisms which operate to maintain the electron-transport chain at an optimal redox poise for efficient photosynthesis. Phenazine methosulphate perturbs the optimal redox poise by hastening equilibrium of the photosynthetic electron-transport chain with low-potential couples in the cell. The addition of auxiliary oxidants restores the optimal redox poise. This suggests a role in photosynthesis for the pathways of respiratory electron flow to nitrate, nitrous oxide, trimethylamine N-oxide/dimethylsulphoxide and oxygen