Managing change in North Shore’s Residential 3 Built Heritage zone: An evaluation of resource consent outcomes

The goal of the study presented in this report has been to determine the extent to which resource consent outcomes in North Shore City’s Residential 3 Built Heritage zone comply with the District Plan. To this end, a sample of 250 properties was selected representing a sample size of 6.5%. The records for each of these properties was checked to identify those that have had a consent granted for additions and alterations to buildings, new and relocated buildings, and the demolition or removal of houses in the Residential 3 zone. This revealed that 100 properties in the sample (or 40%) have been granted a total of 126 resource consents for one or more of these activities. Each of the 100 properties was visited and the outcomes of the consents were compared against the District Plan assessment criteria

Plan effectiveness monitoring: Built heritage, Wellington City District Plan

The goal of this project has been to assess the effectiveness of the built heritage provisions in the Wellington City District Plan. To this end, sixty nine buildings were chosen from the Plan’s Heritage List: Buildings (a sample size of around 14%), which include: 55 buildings that have had at least one resource consent granted under the District Plan. A total of 80 consents were assessed for these buildings as part of this project; 14 buildings that have had no resource consents granted. Each building was visited and an evaluation was undertaken regarding the effects of consented activities on heritage values. The effects of permitted activities (i.e. repair and maintenance) were assessed for the buildings that have no consent history. The evaluation relates only to the effects that could be viewed from the street

Nuclear hormone receptor architecture - form and dynamics: The 2009 FASEB Summer Conference on Dynamic Structure of the Nuclear Hormone Receptors

Nuclear hormone receptors (NHRs) represent a large and diverse family of ligand-activated transcription factors involved in regulating development, metabolic homeostasis, salt balance and reproductive health. The ligands for these receptors are typically small hydrophobic molecules such as steroid hormones, thyroid hormone, vitamin D3 and fatty acid derivatives. The first NHR structural information appeared ~20 years ago with the solution and crystal structures of the DNA binding domains and was followed by the structure of the agonist and antagonist bound ligand binding domains of different NHR members. Interestingly, in addition to these defined structural features, it has become clear that NHRs also possess significant structural plasticity. Thus, the dynamic structure of the NHRs was the topic of a recent stimulating and informative FASEB Summer Research Conference held in Vermont

Nitroarylurea-terminated supramolecular polymers that exhibit facile thermal repair and aqueous swelling-induced sealing of defects

Bi- and tri-armed polyethylene glycol units endcapped with nitroaryl urea units have been synthesised. These endcapped polymers are able to self-assemble via complementary supramolecular interactions, specifically urea-urea and nitro-urea hydrogen bonding, to afford materials with dramatically increased mechanical and thermal properties when compared to those of the uncapped polyethylene glycol precursors. Thin films of the capped polymeric systems are able to self-repair following defect creation. Control over the mechanical and thermal characteristics (in terms of bulk viscosity) of the self-assembled networks was achieved by varying the proportion of tri-armed to bi-armed self-assembly units included in the polymer. These systems demonstrate water absorption and swelling capabilities that are also controllable by varying the ratio of the two types of unit. These physical properties have been optimised to realise a secondary pathway to puncture-repair as a result of swelling on water contact

Bromodomain protein BRD4 is a transcriptional repressor of autophagy and lysosomal function

Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic material in lysosomes. The process promotes cellular fidelity, and while the core machinery of autophagy is known, the mechanisms that promote and sustain autophagy are less well defined. Here we report that the epigenetic reader BRD4 and the methyltransferase G9a repress a TFEB/TFE3/MITF-independent transcriptional program that promotes autophagy and lysosome biogenesis. We show that BRD4 knockdown induces autophagy in vitro and in vivo in response to some, but not all, situations. In the case of starvation, a signaling cascade involving AMPK and histone deacetylase SIRT1 displaces chromatin-bound BRD4, instigating autophagy gene activation and cell survival. Importantly, this program is directed independently and also reciprocally to the growth-promoting properties of BRD4 and is potently repressed by BRD4-NUT, a driver of NUT midline carcinoma. These findings therefore identify a distinct and selective mechanism of autophagy regulation

Firing the climate canon: a literary critique of the genre of climate change

This article makes the case for more climate change, where climate change refers to the prevailing ideologies and frameworks that inform our understanding of environmental change in the first place. It reviews the mainstream literature in popular science writing, fiction and poetry from the point of view of a political frame analysis of climate change, to demonstrate how a certain understanding of climate change maps onto conventions of literary genre. This understanding, and associated literature, are critiqued on the basis of their continued attachment to dualistic and teleological narratives of human mastery and progress, such as to make the case for a literature which offers something radically other. The current political context, not least Donald Trump’s victory and Brexit, are cited as evidence of the contemporary importance of alternatives to the establishment approach to climate mitigation than either denial or scepticism – in both literature, and more broadly