INCLUDING INDIGENOUS AND LOCAL KNOWLEDGE IN THE WORK OF THE INTERGOVERNMENTAL SCIENCE-POLICY PLATFORM ON BIODIVERSITY AND ECOSYSTEM SERVICES (IPBES) GLOBAL ASSESSMENT : Outcomes and lessons for the future

This chapter makes a strong case for greater inclusion of Indigenous and Local Knowledge (ILK) in global environmental policy fora and in science-policy interfaces. The chapter specifically looks at the IPBES Global Assessment which has developed one of the first global-scale mechanisms for operationalizing ILK in sustainability decision-making. The types of knowledges that have been successfully integrated into this assessment include ways in which ILK can help (1) to assess ecosystem change and associated human vulnerability; (2) to inform the achievement of global goals like the Sustainable Development Goals and Aichi Targets; and (3) to inform policy-relevant options for decision-makers. It is argued that other global initiatives seeking to engage ILK in their endeavours can learn from the ILK approach of the IPBES Global Assessment.Peer reviewe

REDD+ on the rocks? Conflict over forest and politics of justice in Vietnam

In Vietnam, villagers involved in a REDD+ (reduced emissions from deforestation and forest degradation) pilot protect areas with rocks which have barely a tree on them. The apparent paradox indicates how actual practices differ from general ideas about REDD+ due to ongoing conflict over forest, and how contestations over the meaning of justice are a core element in negotiations over REDD+. We explore these politics of justice by examining how the actors involved in the REDD+ pilot negotiate the particular subjects, dimensions, and authority of justice considered relevant, and show how politics of justice are implicit to practical decisions in project implementation. Contestations over the meaning of justice are an important element in the practices and processes constituting REDD+ at global, national and local levels, challenging uniform definitions of forest justice and how forests ought to be managed

Evolutionary conservation of regulated longevity assurance mechanisms

Short abstract: A multi-level cross-species comparative analysis of gene-expression changes accompanying increased longevity in mutant nematodes, fruit flies and mice with reduced insulin/IGF-1 signaling revealed candidate conserved mechanisms

The Vehicle, Fall 2007

Table of Contents Is This Thing On?Nichole D\u27Antoniopage 1 Death Came KnockingJacob Dawsonpage 5 Awaiting DecemberRebecca Griffithpage 9 ginamarieElizabeth Hoodpage 11 She LongsJennifer O\u27Neilpage 12 ForgottenStephanie Drozdpage 13 Art House WomanGreg Harrellpage 14 Young Woman OlderAmanda Vealepage 15 FirstRebecca Griffithpage 17 FlowJacob Dawsonpage 19 Am Animal AwareDanielle Meyerpage 20 Geneva 04\u27Stephanie Guyerpage 21 Poland, 1942.Jennifer O\u27Neilpage 22 Witness to the Atrophy of ForestsDanielle Meyerpage 23 Helvellyn IJacob Fosterpage 24 Three Out of Five Ain\u27t BadThomas McElweepage 25 FarceAmanda Vealepage 31 Strength of EmotionJennifer O\u27Neilpage 32 About the Authors Art Submissions Prerequisite for a RequiemJenna Smithcover Girl 3Jenna Smithpage 14 ManJenna Smithpage 16 Give Peace a ChanceMegan Mathypage 16 GraceJennifer O\u27Neilpage 20 Oh, the Places You\u27ll Go!Megan Mathypage 23https://thekeep.eiu.edu/vehicle/1086/thumbnail.jp

The Vehicle, Fall 2007

Table of Contents Is This Thing On?Nichole D\u27Antoniopage 1 Death Came KnockingJacob Dawsonpage 5 Awaiting DecemberRebecca Griffithpage 9 ginamarieElizabeth Hoodpage 11 She LongsJennifer O\u27Neilpage 12 ForgottenStephanie Drozdpage 13 Art House WomanGreg Harrellpage 14 Young Woman OlderAmanda Vealepage 15 FirstRebecca Griffithpage 17 FlowJacob Dawsonpage 19 Am Animal AwareDanielle Meyerpage 20 Geneva 04\u27Stephanie Guyerpage 21 Poland, 1942.Jennifer O\u27Neilpage 22 Witness to the Atrophy of ForestsDanielle Meyerpage 23 Helvellyn IJacob Fosterpage 24 Three Out of Five Ain\u27t BadThomas McElweepage 25 FarceAmanda Vealepage 31 Strength of EmotionJennifer O\u27Neilpage 32 About the Authors Art Submissions Prerequisite for a RequiemJenna Smithcover Girl 3Jenna Smithpage 14 ManJenna Smithpage 16 Give Peace a ChanceMegan Mathypage 16 GraceJennifer O\u27Neilpage 20 Oh, the Places You\u27ll Go!Megan Mathypage 23https://thekeep.eiu.edu/vehicle/1086/thumbnail.jp

RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina

SummaryA fundamental principle governing organ size and function is the fine balance between cell proliferation and cell differentiation. Here, we identify RONIN (THAP11) as a key transcriptional regulator of retinal progenitor cell (RPC) proliferation. RPC-specific loss of Ronin results in a phenotype strikingly similar to that resulting from the G1- to S-phase arrest and photoreceptor degeneration observed in the Cyclin D1 null mutants. However, we determined that, rather than regulating canonical cell-cycle genes, RONIN regulates a cohort of mitochondrial genes including components of the electron transport chain (ETC), which have been recently implicated as direct regulators of the cell cycle. Coincidentally, with premature cell-cycle exit, Ronin mutants exhibited deficient ETC activity, reduced ATP levels, and increased oxidative stress that we ascribe to specific loss of subunits within complexes I, III, and IV. These data implicate RONIN as a positive regulator of mitochondrial gene expression that coordinates mitochondrial activity and cell-cycle progression

Response to "Practice what you preach : Ensuring scientific spheres integrate Indigenous Peoples' and Local Communities' rights and agency too" by Lopez-Maldonado

Non peer reviewe

p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans

The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2–DAF-16 insulin signaling pathway control Caenorhabditis elegans intestinal innate immunity. pmk-1 loss-of-function mutants have enhanced sensitivity to pathogens, while daf-2 loss-of-function mutants have enhanced resistance to pathogens that requires upregulation of the DAF-16 transcription factor. We used genetic analysis to show that the pathogen resistance of daf-2 mutants also requires PMK-1. However, genome-wide microarray analysis indicated that there was essentially no overlap between genes positively regulated by PMK-1 and DAF-16, suggesting that they form parallel pathways to promote immunity. We found that PMK-1 controls expression of candidate secreted antimicrobials, including C-type lectins, ShK toxins, and CUB-like genes. Microarray analysis demonstrated that 25% of PMK-1 positively regulated genes are induced by Pseudomonas aeruginosa infection. Using quantitative PCR, we showed that PMK-1 regulates both basal and infection-induced expression of pathogen response genes, while DAF-16 does not. Finally, we used genetic analysis to show that PMK-1 contributes to the enhanced longevity of daf-2 mutants. We propose that the PMK-1 pathway is a specific, indispensable immunity pathway that mediates expression of secreted immune response genes, while the DAF-2–DAF-16 pathway appears to regulate immunity as part of a more general stress response. The contribution of the PMK-1 pathway to the enhanced lifespan of daf-2 mutants suggests that innate immunity is an important determinant of longevity

Willpower Satisficing

Satisficing Consequentialism is often rejected as hopeless. Perhaps its greatest problem is that it risks condoning the gratuitous prevention of goodness above the baseline of what qualifies as “good enough”. I propose a radical new willpower-based version of the view that avoids this problem, and that better fits with the motivation of avoiding an excessively demanding conception of morality. I further demonstrate how, by drawing on the resources of an independent theory of blameworthiness, we may obtain a principled specification of what counts as “good enough”

Property rights regimes and natural resources: A conceptual analysis revisited

More than two decades ago, Schlager and Ostrom (1992) developed ‘a conceptual schema for arraying property-rights regimes that distinguishes among diverse bundles of rights’. The conceptual framework has profoundly influenced research on natural resource governance, common property, and community resource management. However, currently natural resource governance has changed dramatically, challenging the applicability of the conceptual schema. There are now many more social actors involved in resource management than the local communities at the focus of original analysis. Additionally, resource management increasingly provides access to various kinds of benefits from outside the immediate context, including indirect benefits such as payments for environmental services and results-based payments for REDD+. These changes demand addition of new property rights to the original framework. Those changes of governance process demand addition of property right to original framework. This paper updates the conceptual schema in reaction to changes in natural resource governance, proposing three specific modifications on the focus of use rights, control rights and authoritative rights to come up with a framework that distinguishes eight types of property rights. We apply the framework to three purposefully selected governance interventions in China and Laos that include the provision of indirect benefits in addition to the direct benefits derived by local people from natural resources. The empirical application shows how contemporary governance changes may not lead to local people’s outright dispossession, since they continue to possess direct use rights to natural resources. However, local people may be excluded from control and authoritative rights, which are exercised exclusively by state agencies and international actors. The latter make available indirect benefits to local people, which may or may not translate into use rights in the sense of policy-based entitlements. The empirical insights suggest the possibility of a wider trend of ‘compensated exclusions’ in natural resource governance