23 research outputs found
Journeying Toward Liberation: Creating Civic Utopias through Restorative Literacies
In this article, we forward three narratives from educators whose lived experiences moving from underrepresented youth to queer educators support the necessity of furthering representation for historically marginalized youth across classroom spaces. We begin with situating our argument in response to current policies that would seek to silence historically marginalized voices, histories, literacies, and thereby inhibit a more just social and civic future. Our narratives provide three varied perspectives of lived experiences as youth moving toward our current status as queer educators. Finally, we seek to call in other educators to engage advocacy and resources to support this work in challenging times
The Vehicle, Fall 2007
Table of Contents
Is This Thing On?Nichole D\u27Antoniopage 1
Death Came KnockingJacob Dawsonpage 5
Awaiting DecemberRebecca Griffithpage 9
ginamarieElizabeth Hoodpage 11
She LongsJennifer O\u27Neilpage 12
ForgottenStephanie Drozdpage 13
Art House WomanGreg Harrellpage 14
Young Woman OlderAmanda Vealepage 15
FirstRebecca Griffithpage 17
FlowJacob Dawsonpage 19
Am Animal AwareDanielle Meyerpage 20
Geneva 04\u27Stephanie Guyerpage 21
Poland, 1942.Jennifer O\u27Neilpage 22
Witness to the Atrophy of ForestsDanielle Meyerpage 23
Helvellyn IJacob Fosterpage 24
Three Out of Five Ain\u27t BadThomas McElweepage 25
FarceAmanda Vealepage 31
Strength of EmotionJennifer O\u27Neilpage 32
About the Authors
Art Submissions
Prerequisite for a RequiemJenna Smithcover
Girl 3Jenna Smithpage 14
ManJenna Smithpage 16
Give Peace a ChanceMegan Mathypage 16
GraceJennifer O\u27Neilpage 20
Oh, the Places You\u27ll Go!Megan Mathypage 23https://thekeep.eiu.edu/vehicle/1086/thumbnail.jp
The Vehicle, Fall 2007
Table of Contents
Is This Thing On?Nichole D\u27Antoniopage 1
Death Came KnockingJacob Dawsonpage 5
Awaiting DecemberRebecca Griffithpage 9
ginamarieElizabeth Hoodpage 11
She LongsJennifer O\u27Neilpage 12
ForgottenStephanie Drozdpage 13
Art House WomanGreg Harrellpage 14
Young Woman OlderAmanda Vealepage 15
FirstRebecca Griffithpage 17
FlowJacob Dawsonpage 19
Am Animal AwareDanielle Meyerpage 20
Geneva 04\u27Stephanie Guyerpage 21
Poland, 1942.Jennifer O\u27Neilpage 22
Witness to the Atrophy of ForestsDanielle Meyerpage 23
Helvellyn IJacob Fosterpage 24
Three Out of Five Ain\u27t BadThomas McElweepage 25
FarceAmanda Vealepage 31
Strength of EmotionJennifer O\u27Neilpage 32
About the Authors
Art Submissions
Prerequisite for a RequiemJenna Smithcover
Girl 3Jenna Smithpage 14
ManJenna Smithpage 16
Give Peace a ChanceMegan Mathypage 16
GraceJennifer O\u27Neilpage 20
Oh, the Places You\u27ll Go!Megan Mathypage 23https://thekeep.eiu.edu/vehicle/1086/thumbnail.jp
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations.
Germline loss-of-function mutations in the transcription factor signal transducer and activator of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function mutations in STAT3 are associated with large granular lymphocytic leukemic, myelodysplastic syndrome, and aplastic anemia. Recently, germline mutations in STAT3 have also been associated with autoimmune disease. Here, we report on 13 individuals from 10 families with lymphoproliferation and early-onset solid-organ autoimmunity associated with 9 different germline heterozygous mutations in STAT3. Patients exhibited a variety of clinical features, with most having lymphadenopathy, autoimmune cytopenias, multiorgan autoimmunity (lung, gastrointestinal, hepatic, and/or endocrine dysfunction), infections, and short stature. Functional analyses demonstrate that these mutations confer a gain-of-function in STAT3 leading to secondary defects in STAT5 and STAT1 phosphorylation and the regulatory T-cell compartment. Treatment targeting a cytokine pathway that signals through STAT3 led to clinical improvement in 1 patient, suggesting a potential therapeutic option for such patients. These results suggest that there is a broad range of autoimmunity caused by germline STAT3 gain-of-function mutations, and that hematologic autoimmunity is a major component of this newly described disorder. Some patients for this study were enrolled in a trial registered at www.clinicaltrials.gov as #NCT00001350
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
Germline loss-of-function mutations in the transcription factor signal transducer and activator of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function mutations in STAT3 are associated with large granular lymphocytic leukemic, myelodysplastic syndrome, and aplastic anemia. Recently, germline mutations in STAT3 have also been associated with autoimmune disease. Here, we report on 13 individuals from 10 families with lymphoproliferation and early-onset solid-organ autoimmunity associated with 9 different germline heterozygous mutations in STAT3. Patients exhibited a variety of clinical features, with most having lymphadenopathy, autoimmune cytopenias, multiorgan autoimmunity (lung, gastrointestinal, hepatic, and/or endocrine dysfunction), infections, and short stature. Functional analyses demonstrate that these mutations confer a gain-of-function in STAT3 leading to secondary defects in STAT5 and STAT1 phosphorylation and the regulatory T-cell compartment. Treatment targeting a cytokine pathway that signals through STAT3 led to clinical improvement in 1 patient, suggesting a potential therapeutic option for such patients. These results suggest that there is a broad range of autoimmunity caused by germline STAT3 gain-of-function mutations, and that hematologic autoimmunity is a major component of this newly described disorder. Some patients for this study were enrolled in a trial registered at www.clinicaltrials.gov as #NCT00001350