Galaxy Counts, Sizes, Colours and Redshifts in the Hubble Deep Field

We compare the galaxy evolution models of Bruzual & Charlot (1993) with the faint galaxy count, size and colour data from the Hubble and Herschel Deep Fields (Metcalfe et al 1996). For qo=0.05, we find that models where the SFR increases exponentially out to z>2 are consistent with all of the observational data. For qo=0.5, such models require an extra population of galaxies which are only seen at high redshift and then rapidly fade or disappear. We find that, whatever the cosmology, the redshift of the faint blue galaxies and hence the epoch of galaxy formation is likely to lie at z>2. We find no implied peak in the SFR at z=1 and we suggest that the reasons for this contradiction with the results of Madau et al (1996) include differences in faint galaxy photometry, in the treatment of spiral dust and in the local galaxy count normalisation.Comment: 8 pages, 5 eps figures, needs paspconf.st

Beyond Diagnosis: Evolving Prostate Biopsy in the Era of Focal Therapy

Despite decades of use as the “gold standard” in the detection of prostate cancer, the optimal biopsy regimen is still not universally agreed upon. While important aspects such as the need for laterally placed biopsies and the importance of apical cancer are known, repeated studies have shown significant patients with cancer on subsequent biopsy when the original biopsy was negative and an ongoing suspicion of cancer remained. Attempts to maximise the effectiveness of repeat biopsies have given rise to the alternate approaches of saturation biopsy and the transperineal approach. Recent interest in focal treatment of prostate cancer has further highlighted the need for accurate detection of prostate cancer, and in response, the introduction of transperineal template-guided biopsy. While the saturation biopsy approach and the transperineal template approach increase the detection rate of cancer in men with a previous negative biopsy and appear to have acceptable morbidity, there is a lack of clinical trials evaluating the different biopsy strategies. This paper reviews the evolution of prostatic biopsy and current controversies

The VIRMOS deep imaging survey: III. ESO/WFI deep U-band imaging of the 0226-04 deep field

In this paper we describe the U-band imaging of the F02 deep field, one of the fields in the VIRMOS Deep Imaging Survey. The observations were done at the ESO/MPG 2.2m telescope at La Silla (Chile) using the 8k x 8k Wide-Field Imager (WFI). The field is centered at alpha(J2000)=02h 26m 00s and delta(J2000)=-04deg 30' 00", the total covered area is 0.9 deg**2 and the limiting magnitude (50% completeness) is U(AB) ~ 25.4 mag. Reduction steps, including astrometry, photometry and catalogue extraction, are first discussed. The achieved astrometric accuracy (RMS) is ~ 0.2" with reference to the I-band catalog and ~ 0.07" internally (estimated from overlapping sources in different exposures). The photometric accuracy including uncertainties from photometric calibration, is < 0.1 mag. Various tests are then performed as a quality assessment of the data. They include: (i) the color distribution of stars and galaxies in the field, done together with the BVRI data available from the VIMOS survey; (ii) the comparison with previous published results of U-band magnitude-number counts of galaxies.Comment: 10 pages, 13 figures, accepted for publication on Astronomy and Astrophysic

Effects of Isomer Ratio on Pmdi Resin Reactivity and Oriented Strandboard Properties

The effect of varying 2,4'-MDI to 4,4'-MDI isomer ratio in diphenylmethane diisocyanate (pMDI) adhesives was investigated. In addition to probing resin cure kinetics, oriented strandboard panels were produced to investigate the effect of isomer ratio on panel properties. With one exception, differential scanning calorimetry results showed a trend of increasing activation energy with increasing 4,4'-MDI content—the opposite of what was predicted. Results of internal bond testing indicate that increasing 4,4'-MDI content gave higher internal bond strength, but no correlation was evident between resin and panel density, MOR, MOE, or 24-h thickness swell. It is important to note that isomer ratio was not the only variable within the resin series; oligomer content and hence viscosity increased as 4,4'-MDI content increased, which complicated the analysis

Effects of Selected Wood Species and Moisture Content on PMDI Resin Application and Panel Properties

This study investigated the effect of selected species and moisture conditions on resin distribution and composite panel properties. Flakeboard composites were made from aspen, pine, or poplar flakes that were equilibrated to 4, 8, or 12% moisture content (MC). Resin droplet size (resin "footprint") was measured, as was the percentage of the flake surface that was covered by resin. Aspen flakes showed higher resin coverage and also larger resin droplet sizes. Conversely, pine and poplar flakes had smaller resin droplets and lower resin coverage per flake surface, suggesting greater pMDI penetration. Internal bond (IB) testing revealed optimal performance for aspen flakes at 12% precure MC, and poplar and pine flakes at 8% precure MC. Modulus of rupture and modulus of elasticity results correlated with IB results. Aspen panels bonded at 8 and 12% MC had minimal thickness swell

Time-variability in the Interstellar Boundary Conditions of the Heliosphere: Effect of the Solar Journey on the Galactic Cosmic Ray Flux at Earth

During the solar journey through galactic space, variations in the physical properties of the surrounding interstellar medium (ISM) modify the heliosphere and modulate the flux of galactic cosmic rays (GCR) at the surface of the Earth, with consequences for the terrestrial record of cosmogenic radionuclides. One phenomenon that needs studying is the effect on cosmogenic isotope production of changing anomalous cosmic ray fluxes at Earth due to variable interstellar ionizations. The possible range of interstellar ram pressures and ionization levels in the low density solar environment generate dramatically different possible heliosphere configurations, with a wide range of particle fluxes of interstellar neutrals, their secondary products, and GCRs arriving at Earth. Simple models of the distribution and densities of ISM in the downwind direction give cloud transition timescales that can be directly compared with cosmogenic radionuclide geologic records. Both the interstellar data and cosmogenic radionuclide data are consistent with cloud transitions during the Holocene, with large and assumption-dependent uncertainties. The geomagnetic timeline derived from cosmic ray fluxes at Earth may require adjustment to account for the disappearance of anomalous cosmic rays when the Sun is immersed in ionized gas.Comment: Submitted to Space Sciences Review

Large Structures and Galaxy Evolution in COSMOS at z < 1.1

We present the first identification of large-scale structures (LSS) at z $< 1.1$ in the Cosmic Evolution Survey (COSMOS). The structures are identified from adaptive smoothing of galaxy counts in the pseudo-3d space ($\alpha,\delta$,z) using the COSMOS photometric redshift catalog. The technique is tested on a simulation including galaxies distributed in model clusters and a field galaxy population -- recovering structures on all scales from 1 to 20\arcmin without {\it a priori} assumptions for the structure size or density profile. Our procedure makes {\bf no} {\it a priori} selection on galaxy spectral energy distribution (SED, for example the Red Sequence), enabling an unbiased investigation of environmental effects on galaxy evolution. The COSMOS photometric redshift catalog yields a sample of $1.5\times10^5$ galaxies with redshift accuracy, $\Delta z_{FWHM}/(1+z) \leq 0.1$ at z $< 1.1$ down to I$_{AB} \leq 25$ mag. Using this sample of galaxies, we identify 42 large-scale structures and clusters. abstract truncated for astroph 25 line limit -- see preprintComment: 72 pages with 29 pages of figures, for cosmos apj suppl special issu

Polypharmacy, potentially serious clinically relevant drug-drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life

The aim of the study is to investigate the patterns of polypharmacy, clinical-relevant drug-drug interactions (DDIs), and potentially inappropriate medicines (PIMs), and whether polypharmacy, potential serious clinically-relevant DDIs, or PIMs can be associated with low quality of life (QoL) index scores of older adults with type 2 diabetes (T2D). A cross-sectional study was conducted using data of 670 elderly T2D sub-cohort from a nationwide pharmacy-based intensive monitoring study of inception cohort of T2D in Portugal. 72.09% were found on polypharmacy (≥5 medicines). Participants on polypharmacy were mostly females (P = .0115); more obese (P = .0131); have more comorbid conditions (P < .0001); more diabetes complications (P < .0001); and use more of glucose lowering drugs (P = .0326); insulin (P < .0001); chronic medicines (P < .0001); and have higher diabetes duration (P = .0088) than those without polypharmacy. 10.59% of the participants were found to have potential serious clinically relevant DDIs. The most frequent drug-combinations were angiotensin-converting enzyme (ACE) inhibitors with angiotensin-receptor blockers (ARBs), aspirin with Selective serotonin reuptake inhibitors (SSRIs), and clopidogrel with calcium channel blockers. PIMs are found in 36.11% of the participants. The most common PIMs were benzodiazepines, long-acting sulfonylureas, and iron overdose. The adjusted multivariate models show that Polypharmacy, PIMs, and potential serious clinically relevant DDIs were associated with lower QoL index scores (OR 1.80 95% CI 1.15-2.82), (OR 1.57 95% CI 1.07-2.28), and (OR 1.34 95% CI 0.73-2.48) respectively. The study shows that polypharmacy, potential serious clinical-relevant DDIs, and PIMs may correlate with risk of reduced health related QoL outcome of older adults with T2D.publishersversionpublishe