Long-term evolution of compact binaries with irradiation feedback

We resume the discussion about irradiation-driven mass transfer cycles in semi- detached compact binary systems. The analytical model that describes the onset of these cycles, which occur on a thermal timescale of the donor star, is reexamined. We take into account a contribution of the thermal relaxation which is not related to the irradiation of the donor star and which was neglected in previous studies. Cataclysmic variables (CVs) containing extended giant donors are more stable than previously thought. CVs close to the upper edge of the period gap can undergo cycles for low angular momentum loss rates, as they have been suggested by recent magnetic braking prescriptions, while they are stable for high braking rates. A model for the irradiation geometry that takes into account surface elements near the terminator of the donor star indicates that possibly also low-mass X-ray binaries (LMXBs) can undergo mass transfer cycles. Regarding the braking rate, which is necessary to drive cycles, basically the same restrictions apply for short period LMXBs as they do for short period CVs. We confirm that LMXBs containing giants can undergo cyles. In terms of an irradiation efficiency parameter \alpha CVs are susceptible to the irradiation instability for \alpha >= 0.1 while LMXBs are susceptible for \alpha <= 0.1. The predictions of the analytical model are checked by the first long-term evolutionary computations of systems undergoing mass transfer cycles with full 1D stellar models. For unevolved main sequence (MS) and giant donors the analytic model provides reasonable values for the boundaries of the stable and unstable regions while CVs containing highly evolved MS donors are more stable at high braking rates than expected.Taking into account irradiation the minimum period of CVs is increased by up to 1-2 minutes, depending on \alpha.Comment: 19 pages, 24 figures, accepted by A&

FamiIial vascuIar malformations Report of 25 members of one family

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65932/1/j.1399-0004.1984.tb04371.x.pd

The space density of cataclysmic variables: constraints from the ROSAT North Ecliptic Pole Survey

We use the ROSAT North Ecliptic Pole (NEP) survey to construct a small, but purely X-ray flux-limited sample of cataclysmic variable stars (CVs). The sample includes only 4 systems, 2 of which (RX J1715.6+6856 and RX J1831.7+6511) are new discoveries. We present time-resolved spectroscopy of the new CVs and measure orbital periods of 1.64 \pm 0.02 h and 4.01\pm 0.03 h for RX 1715.6+6856 and RX J1831.7+6511, respectively. We also estimate distances for all the CVs in our sample, based mainly on their apparent brightness in the infrared. The space density of the CV population represented by our small sample is (1.1 +2.3/-0.7) 10^-5 pc^-3. We can also place upper limits on the space density of any sub-population of CVs too faint to be included in the NEP survey. In particular, we show that if the overall space density of CVs is as high as 2 10^-4 pc^-3 (as has been predicted theoretically), the vast majority of CVs must be fainter than L_X \simeq 2 10^29 erg/s.Comment: 11 pages, 7 figure, accepted for publication in MNRA

Effectiveness of interventions to promote healthy diet in primary care: systematic review and meta-analysis of randomised controlled trials

Background A diet rich in fruit, vegetables and dietary fibre and low in fat is associated with reduced risk of chronic disease. This review aimed to estimate the effectiveness of interventions to promote healthy diet for primary prevention among participants attending primary care.&lt;p&gt;&lt;/p&gt; Methods A systematic review of trials using individual or cluster randomisation of interventions delivered in primary care to promote dietary change over 12 months in healthy participants free from chronic disease or defined high risk states. Outcomes were change in fruit and vegetable intake, consumption of total fat and fibre and changes in serum cholesterol concentration.&lt;p&gt;&lt;/p&gt; Results Ten studies were included with 12,414 participants. The design and delivery of interventions were diverse with respect to grounding in behavioural theory and intervention intensity. A meta-analysis of three studies showed an increase in fruit consumption of 0.25 (0.01 to 0.49) servings per day, with an increase in vegetable consumption of 0.25 (0.06 to 0.44) serving per day. A further three studies that reported on fruit and vegetable consumption together showed a pooled increment of 0.50 (0.13 to 0.87) servings per day. The pooled effect on consumption of dietary fibre, from four studies, was estimated to be 1.97 (0.43 to 3.52) gm fibre per day. Data from five studies showed a mean decrease in total fat intake of 5.2% of total energy (1.5 to 8.8%). Data from three studies showed a mean decrease in serum cholesterol of 0.10 (-0.19 to 0.00) mmol/L.&lt;p&gt;&lt;/p&gt; Conclusion Presently-reported interventions to promote healthy diet for primary prevention in primary care, which illustrate a diverse range of intervention methods, may yield small beneficial changes in consumption of fruit, vegetables, fibre and fat over 12 months. The present results do not exclude the possibility that more effective intervention strategies might be developed.&lt;p&gt;&lt;/p&gt

The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein

The hepatitis C virus (HCV) p7 ion channel and non-structural protein 2 (NS2) are both required for efficient assembly and release of nascent virions, yet precisely how these proteins are able to influence this process is unclear. Here, we provide both biochemical and cell biological evidence for a functional interaction between p7 and NS2. We demonstrate that in the context of a genotype 1b subgenomic replicon the localization of NS2 is affected by the presence of an upstream p7 with its cognate signal peptide derived from the C terminus of E2 (SPp7). Immunofluorescence analysis revealed that the presence of SPp7 resulted in the targeting of NS2 to sites closely associated with viral replication complexes. In addition, biochemical analysis demonstrated that, in the presence of SPp7, a significant proportion of NS2 was found in a detergent (Triton X-100)-insoluble fraction, which also contained a marker of detergent resistant rafts. In contrast, in replicons lacking p7, NS2 was entirely detergent soluble and the altered localization was lost. Furthermore, we found that serine 168 within NS2 was required for its localization adjacent to replication complexes, but not for its accumulation in the detergent-insoluble fraction. NS2 physically interacted with NS5A and this interaction was dependent on both p7 and serine 168 within NS2. Mutational and pharmacological analyses demonstrated that these effects were not a consequence of p7 ion channel function, suggesting that p7 possesses an alternative function that may influence the coordination of virus genome replication and particle assembly

Development of a modified floristic quality index as a rapid habitat assessment method in the northern Everglades

Floristic quality assessments (FQA) using floristic quality indices (FQIs) are useful tools for assessing and comparing vegetation communities and related habitat condition. However, intensive vegetation surveys requiring significant time and technical expertise are necessary, which limits the use of FQIs in environmental monitoring programs. This study modified standard FQI methods to develop a rapid assessment method for characterizing and modeling change in wetland habitat condition in the northern Everglades. Method modifications include limiting vegetation surveys to a subset of taxa selected as indicators of impact and eliminating richness and/or abundance factors from the equation. These modifications reduce the amount of time required to complete surveys and minimizes misidentification of species, which can skew results. The habitat characterization and assessment tool (HCAT) developed here is a FQA that uses a modified FQI to detect and model changes in habitat condition based on vegetation communities, characterize levels of impact as high, moderate, or low, provide predictive capabilities for assessing natural resource management or water management operation alternatives, and uniquely links a FQI with readily accessible environmental data. For application in the northern Everglades, surface water phosphorus concentrations, specific conductivity, distance from canal, and days since dry (5-year average) explained 67% of the variability in the dataset with \u3e 99.9% confidence. The HCAT approach can be used to monitor, assess, and evaluate habitats with the objective of informing management decisions (e.g., as a screening tool) to maximize conservation and restoration of protected areas and is transferable to other wetlands with additional modification

Pelagic phytoplankton community change‐points across nutrient gradients and in response to invasive mussels

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/136002/1/fwb12873_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/136002/2/fwb12873.pd