A study of the reactions of third grade pupils to the various types of children's literature that were available during three specific periods: 1900-1920; 1920-1940; 1940-1953

Thesis (Ed.M.)--Boston Universit

What is the most effective way to treat recurrent canker sores?

Amlexanox appears to be most effective overall. Amlexanox 5% paste reduces ulcer size, pain duration, and healing time (strength of recommendation [SOR]: A, multiple randomized controlled trials [RCTs]). Topical steroids may alleviate pain and decrease ulcer burden, defined as total number of ulcers over a measured time, usually 4 to 6 weeks (SOR: B, multiple small heterogenous RCTs). Chemical cautery agents also lessen pain (SOR: A, single RCTs on differing agents), and chlorhexidine mouthwashes may reduce overall ulcer burden (SOR: B, heterogeneous RCTs). The herbal preparation Eupatorium laevigatum alleviates pain and improves healing (SOR: B, single RCT). Oral vitamin B12 supplements and avoiding toothpastes containing sodium lauryl sulfate may prevent recurrent ulcers (SOR: B, small RCTs)

Extragalactic Constraints on the Initial Mass Function

The local stellar mass density is observed to be significantly lower than the value obtained from integrating the cosmic star formation history (SFH), assuming that all the stars formed with a Salpeter initial mass function (IMF). Even other favoured IMFs, more successful in reconciling the observed $z=0$ stellar mass density with that inferred from the SFH, have difficulties in reproducing the stellar mass density observed at higher redshift. In this study we investigate to what extent this discrepancy can be alleviated for any universal power-law IMF. We find that an IMF with a high-mass slope shallower (2.15) than the Salpeter slope (2.35) reconciles the observed stellar mass density with the cosmic star formation history, but only at low redshifts. At higher redshifts $z>0.5$ we find that observed stellar mass densities are systematically lower than predicted from the cosmic star formation history, for any universal power-law IMF.Comment: 6 pages, 5 figures, accepted to MNRA

Immunoglobulin G from bovine milk primes intestinal epithelial cells for increased colonization of bifidobacteria

peer-reviewedAbstract A bovine colostrum fraction (BCF) was recently shown to enhance the adherence of several commensal organisms to intestinal epithelial cells through modulating the epithelial cell surface. In this study, the main components of the BCF were examined to investigate the active component/s responsible for driving the changes in the intestinal cells. The adherence of various bifidobacteria to HT-29 cells was increased when the intestinal cells were pre-incubated with immunoglobulin G (IgG). Modulation of the intestinal cells by IgG was concentration dependent with 16 mg/mL IgG resulting in a 43-fold increase in the adhesion of Bifidobacterium longum NCIMB 8809 to HT-29 cells. Periodate treatment of colostral IgG prior to performing the colonization studies resulted in a reduction in the adhesion of the strain to the intestinal cells demonstrating that the glycans of IgG may be important in modulating the intestinal cells for enhanced commensal adhesion. IgG isolated from mature milk also resulted in significant increases in adhesion of the Bifidobacterium strains tested albeit at reduced levels (3.9-fold). The impact of IgG on the HT-29 cells was also visualised via scanning electron microscopy. This study builds a strong case for the inclusion of IgG ingredients sourced from cow’s milk in functional foods aimed at increasing numbers of health promoting bacteria in the human gut

Characterisation of nerve‐mediated ATP release from bladder detrusor muscle and its pathological implications

Background and Purpose. To characterise the molecular mechanisms that determine variability of atropine‐resistance of nerve‐mediated contractions in human and guinea‐pig detrusor smooth muscle Experimental Approach. Atropine‐resistance of nerve‐mediated contractions, and the role of P2X1 receptors, was measured in isolated preparations from guinea‐pigs and also humans with or without overactive bladder syndrome, from which the mucosa was removed. Nerve‐mediated ATP release was measured directly with amperometric ATP‐sensitive electrodes. Ecto‐ATPase activity of guinea‐pig and human detrusor samples was measured in vitro by measuring the concentration‐dependent rate of ATP breakdown. The transcription of ecto‐ATPase subtypes in human samples was measured by qPCR. Key Results Atropine resistance was greatest in guinea‐pig detrusor, absent in human tissue from normally‐functioning bladders and intermediate in human overactive bladder. Greater atropine resistance correlated with reduction of contractions by the ATP‐diphospho‐hydrolase apyrase, directly implicating ATP in their generation. E‐NTPDase‐1 was the most abundantly transcribed ecto‐ATPase of those tested and transcription was reduced in tissue from human overactive, compared to normal, bladders. E‐NTPDase‐1 enzymatic activity was inversely related to the magnitude of atropine resistance. Nerve‐mediated ATP release was continually measured and varied with stimulation frequency over the range 1‐16 Hz. Conclusion and Implications Atropine‐resistance in nerve‐mediated detrusor contractions is due to ATP release and its magnitude is inversely related to E‐NTPDase‐1 activity. ATP is released under different stimulation conditions compared to acetylcholine that implies different routes for their release</p

Photometric Catalogue of Quasars and Other Point Sources in the Sloan Digital Sky Survey

We present a catalogue of about 6 million unresolved photometric detections in the Sloan Digital Sky Survey Seventh Data Release classifying them into stars, galaxies and quasars. We use a machine learning classifier trained on a subset of spectroscopically confirmed objects from 14th to 22nd magnitude in the SDSS {\it i}-band. Our catalogue consists of 2,430,625 quasars, 3,544,036 stars and 63,586 unresolved galaxies from 14th to 24th magnitude in the SDSS {\it i}-band. Our algorithm recovers 99.96% of spectroscopically confirmed quasars and 99.51% of stars to i $\sim$21.3 in the colour window that we study. The level of contamination due to data artefacts for objects beyond $i=21.3$ is highly uncertain and all mention of completeness and contamination in the paper are valid only for objects brighter than this magnitude. However, a comparison of the predicted number of quasars with the theoretical number counts shows reasonable agreement.Comment: 16 pages, Ref. No. MN-10-2382-MJ.R2, accepted for publication in MNRAS Main Journal, April 201

The stellar evolution of Luminous Red Galaxies, and its dependence on colour, redshift, luminosity and modelling

We present a series of colour evolution models for Luminous Red Galaxies (LRGs) in the 7th spectroscopic data release of the Sloan Digital Sky Survey (SDSS), computed using the full-spectrum fitting code VESPA on high signal-to-noise stacked spectra. The colour-evolution models are computed as a function of colour, luminosity and redshift, and we do not a-priori assume that LRGs constitute a uniform population of galaxies in terms of stellar evolution. By computing star-formation histories from the fossil record, the measured stellar evolution of the galaxies is decoupled from the survey's selection function, which also evolves with redshift. We present these evolutionary models computed using three different sets of Stellar Population Synthesis (SPS) codes. We show that the traditional fiducial model of purely passive stellar evolution of LRGs is broadly correct, but it is not sufficient to explain the full spectral signature. We also find that higher-order corrections to this model are dependent on the SPS used, particularly when calculating the amount of recent star formation. The amount of young stars can be non-negligible in some cases, and has important implications for the interpretation of the number density of LRGs within the selection box as a function of redshift. Dust extinction, however, is more robust to the SPS modelling: extinction increases with decreasing luminosity, increasing redshift, and increasing r-i colour. We are making the colour evolution tracks publicly available at http://www.icg.port.ac.uk/~tojeiror/lrg_evolution/.Comment: 29 pages, 34 figures, re-submitted to MNRAS after addressing the referee's repor

Radio Emission and AGN Feedback in Post-starburst Galaxies

We investigate radio-mode AGN activity among post-starburst galaxies from the Sloan Digital Sky Survey to determine whether AGN feedback may be responsible for the cessation of star formation. Based on radio morphology and radio-loudness from the FIRST and NVSS data, we separate objects with radio activity due to an AGN from ongoing residual star formation. Of 513 SDSS galaxies with strong A-star spectra, 12 objects have 21-cm flux density above 1 mJy. These galaxies do not show optical AGN emission lines. Considering that the lifetime of radio emission is much shorter than the typical time-scale of the spectroscopic features of post-starburst galaxies, we conclude that the radio-emitting AGN activity in these objects was triggered after the end of the recent starburst, and thus cannot be an important feedback process to explain the post-starburst phase. The radio luminosities show a positive correlation with total galaxy stellar mass, but not with the mass of recently formed stars. Thus the mechanical power of AGN feedback derived from the radio luminosity is related to old stellar populations dominating the stellar mass, which in turn are related to the masses of central supermassive black holes.Comment: 11 pages, 6 figures, accepted for publication in MNRA

A public catalogue of stellar masses, star formation and metallicity histories and dust content from the Sloan Digital Sky Survey using VESPA

We applied the VESPA algorithm to the Sloan Digital Sky Survey final data release of the Main Galaxies and Luminous Red Galaxies samples. The result is a catalogue of stellar masses, detailed star formation and metallicity histories and dust content of nearly 800,000 galaxies. We make the catalogue public via a T-SQL database, which is described in detail in this paper. We present the results using a range of stellar population and dust models, and will continue to update the catalogue as new and improved models are made public. The data and documentation are currently online, and can be found at http://www-wfau.roe.ac.uk/vespa/. We also present a brief exploration of the catalogue, and show that the quantities derived are robust: luminous red galaxies can be described by one to three populations, whereas a main galaxy sample galaxy needs on average two to five; red galaxies are older and less dusty; the dust values we recover are well correlated with measured Balmer decrements and star formation rates are also in agreement with previous measurements.Comment: Accepted for publication in ApJS. New and extended sections, references added, some figures changed. Conclusions and catalogue unchange