School Principals and the Child Welfare System: An Exploratory Study of Interviews Conducted on School Grounds

Investigators at child welfare agencies investigate allegations of abuse and neglect by interviewing the identified child victim. Schools are a customary location where an investigator may conduct the interview. Each state in America has independently determined the guidelines that determine how interviews are conducted. A literature review produced 17 articles that analyzed past legal proceedings where the constitutionality of whether a child could be interviewed at school without a warrant, court order, exigent circumstances, or parental consent was challenged. A national review of statutes and policies identified the varying approaches that states have authorized to regulate school-based interviews. Public school principals in Tennessee completed two surveys regarding school-based interviews. The first survey questioned what perceptions and understandings principals have of policies that regulate child welfare interview procedures. The second survey asked what steps that school principals have put in place to facilitate interview requests. Each survey was completed by 109 school principals. Revealed in the statutes and policies review was that policies issued by the Tennessee Department of Children’s Services (DCS) did not contain clear details to inform principals how to respond to all types of interview requests. The results of a binary logistic analysis suggested that the Title I status of the school that principals responded on behalf of was a statistically significant predictor of what knowledge principals had of DCS policies. Differences were found to exist between high school and non-high school principals in the results of Fisher’s exact test for how principals reported to facilitate interview requests. A research study with a larger sample size representing the responses from more principals in Tennessee is needed before recommending best practice standards for school-based interviews

School Social Workers and Extracurricular Activities: The Unanswered Questions About Potential Role Conflict

Abstract School social workers respond to students’ mental health needs from an education training perspective that defines set professional role boundaries in service provision that may differ from the multiple roles teachers have with students. One of those perspectives is a recognition of what may happen if a boundary crossing was to occur in a dual relationship with a client. Teachers are encouraged to take on a secondary role with students by coaching athletics or advising a club. Taking on dual roles with students has led to both increased job satisfaction and concerns regarding burnout for teachers. There is an absence of information that exists on what the experience has been of school social workers taking on secondary roles with students. Not having guidance for school social workers who elect to oversee extracurricular activities led the authors to explore what is the intended mission for the practice of school social work, how the existing literature on dual relationships may apply to school settings, and the findings from research conducted with teachers who take on dual roles with students. The recommendations provided are a need for data to establish what experience school social workers have with managing secondary roles and to not preclude school social workers from extracurricular activities when their presence can be of benefit to students and the school if dual relationships are properly managed

A genomic approach to the identification and characterization of HOXA13 functional binding elements

HOX proteins are important transcriptional regulators in mammalian embryonic development and are dysregulated in human cancers. However, there are few known direct HOX target genes and their mechanisms of regulation are incompletely understood. To isolate and characterize gene segments through which HOX proteins regulate transcription we used cesium chloride centrifugation-based chromatin purification and immunoprecipitation (ChIP). From NIH 3T3-derived HOXA13-FLAG expressing cells, 33% of randomly selected, ChIP clones were reproducibly enriched. Hox-enriched fragments (HEFs) were more AT-rich compared with cloned fragments that failed reproducible ChIP. All HEFs augmented transcription of a heterologous promoter upon coexpression with HOXA13. One HEF was from intron 2 of Enpp2, a gene highly upregulated in these cells and has been implicated in cell motility. Using Enpp2 as a candidate direct target, we identified three additional HEFs upstream of the transcription start site. HOXA13 upregulated transcription from an Enpp2 promoter construct containing these sites, and each site was necessary for full HOXA13-induced expression. Lastly, given that HOX proteins have been demonstrated to interact with histone deacetylases and/or CBP, we explored whether histone acetylation changed at Enpp2 upon HOXA13-induced activation. No change in the general histone acetylation state was observed. Our results support models in which occupation of multiple HOX binding sites is associated with highly activated genes

The Development Length and Anchorage Behavior of Headed Reinforcing Bars

Research has been conducted by several investigators on a new, innovative type of reinforcement, referred to as the headed bar. The development of the headed bar resulted out of the need to reduce the development length of the bar and anchor the reinforcement in a shorter length. Construction in earthquake prone regions and designing for blast or impact conditions requires dense reinforcement configurations.. In these areas, designs call for connection details of major structural members that become congested with reinforcement. So much congestion occurs that standard 90° or 180° hooks, as prescribed by codes such as AC~ become unmanageable and are not feasible in complex reinforcement configurations. As the main focus of this present study, the anchorage behavior of a headed bar embedded in concrete in terms of development length and bond strength is investigated. In addition, further research will be proposed to evaluate the use of headed bars in lap splice applications. This research includes a testing program consisting of concrete beam-end tests used to investigate the anchorage behavior of the headed bar. In order to form a basis for comparison, other beam-end specimens are tested using straight reinforcing bar, and still others using standard 180° hooked bars in addition to tests of the headed bar. Variables evaluated include the clear cover, bonded length, and transverse reinforcement. The results of this program show the headed bar to provide almost immediate development of the bar provided that an adequate amount of confinement in terms of cover or transverse reinforcement is used. The results show the headed bar to be an adequate, if not an improved substitute, for the standard hooked bar as set forth by ACI. Based on these results and comparisons to previously developed expressions from past research, a design equation is proposed to describe the development length of headed reinforcement. From this equation, a set of design guidelines also is developed and presented to ACI for inclusion in a future version of the ACI Building Code. Currently, there are no ACI code provisions that cover the use of the headed bar in structural design. Through this research, as well as studies being done at other institutions, a sufficient and accurate basis can be provided for the adoption of such standards into future editions of the ACI Building Code

The Pelvis and Beyond: Musculoskeletal Tender Points in Women With Chronic Pelvic Pain

To determine the feasibility of a detailed pain sensitivity assessment using body wide musculoskeletal tender points (TPs) in women with different types of chronic pelvic pain (CPP) and compare phenotypic differences

Biomarkers of brain injury following an American football game:A pilot study

The goals of this study were to determine if the biomarkers of head injury, NSE and S100B, increased in serum following an American football game. Serum creatine kinase (CK) and cortisol levels were also measured to determine muscle damage and stress caused by the football game. NSE, S100B, CK, and cortisol were measured in the serum of 17 football players before and after a collegiate junior varsity football game. No head injuries were reported by the players, athletic training staff, or coaches yet both NSE (Pre-game: 7.0 μg•L–1 ± 2.2 versus Post-game: 13.1 μg•L–1 ± 7.0, P &lt;0.001) and S100B (Pre-game: 0.013 μg•L–1 ± 0.012 versus Post-game: 0.069 μg•L–1 ± 0.036, P &lt;0.001) increased significantly. Neither CK (Pre-game: 90.5 U•L–1 ± 41.9 versus Post-game: 120.2 U•L–1 ± 62.7, P = 0.116) nor cortisol (Pre-game: 369.2 nmoles•L-1 ± 159.8 versus Post-game: 353.0 nmoles•L–1 ± 170.5, P = 0.349) increased significantly following the football game. There was little correlation found between S100B and body mass (R2 = 0.029) or CK (R2 = 0.352) levels. Although serum NSE and S100B increase as a result of playing in an American football game, the values are similar to or lower than levels found following competition in other contact and non-contact sports. Furthermore, the lack of correlation between S100B and body mass or CK indicates that S100B increases independent of body mass or muscle injury. </jats:p

IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System

PURPOSE: To improve persistence of adoptively transferred T-cell receptor (TCR)-engineered T cells and durable clinical responses, we designed a clinical trial to transplant genetically-modified hematopoietic stem cells (HSCs) together with adoptive cell transfer of T cells both engineered to express an NY-ESO-1 TCR. Here, we report the preclinical studies performed to enable an investigational new drug (IND) application. EXPERIMENTAL DESIGN: HSCs transduced with a lentiviral vector expressing NY-ESO-1 TCR and the PET reporter/suicide gene HSV1-sr39TK and T cells transduced with a retroviral vector expressing NY-ESO-1 TCR were coadministered to myelodepleted HLA-A2/Kb mice within a formal Good Laboratory Practice (GLP)-compliant study to demonstrate safety, persistence, and HSC differentiation into all blood lineages. Non-GLP experiments included assessment of transgene immunogenicity and in vitro viral insertion safety studies. Furthermore, Good Manufacturing Practice (GMP)-compliant cell production qualification runs were performed to establish the manufacturing protocols for clinical use. RESULTS: TCR genetically modified and ex vivo-cultured HSCs differentiated into all blood subsets in vivo after HSC transplantation, and coadministration of TCR-transduced T cells did not result in increased toxicity. The expression of NY-ESO-1 TCR and sr39TK transgenes did not have a detrimental effect on gene-modified HSC's differentiation to all blood cell lineages. There was no evidence of genotoxicity induced by the lentiviral vector. GMP batches of clinical-grade transgenic cells produced during qualification runs had adequate stability and functionality. CONCLUSIONS: Coadministration of HSCs and T cells expressing an NY-ESO-1 TCR is safe in preclinical models. The results presented in this article led to the FDA approval of IND 17471

Unimodality Problems in Ehrhart Theory

Ehrhart theory is the study of sequences recording the number of integer points in non-negative integral dilates of rational polytopes. For a given lattice polytope, this sequence is encoded in a finite vector called the Ehrhart $h^*$-vector. Ehrhart $h^*$-vectors have connections to many areas of mathematics, including commutative algebra and enumerative combinatorics. In this survey we discuss what is known about unimodality for Ehrhart $h^*$-vectors and highlight open questions and problems.Comment: Published in Recent Trends in Combinatorics, Beveridge, A., et al. (eds), Springer, 2016, pp 687-711, doi 10.1007/978-3-319-24298-9_27. This version updated October 2017 to correct an error in the original versio

Circumbinary Gas Accretion onto a Central Binary: Infrared Molecular Hydrogen Emission from GG Tau A

We present high spatial resolution maps of ro-vibrational molecular hydrogen emission from the environment of the GG Tau A binary component in the GG Tau quadruple system. The H2 v= 1-0 S(1) emission is spatially resolved and encompasses the inner binary, with emission detected at locations that should be dynamically cleared on several hundred-year timescales. Extensions of H2 gas emission are seen to ~100 AU distances from the central stars. The v = 2-1 S(1) emission at 2.24 microns is also detected at ~30 AU from the central stars, with a line ratio of 0.05 +/- 0.01 with respect to the v = 1-0 S(1) emission. Assuming gas in LTE, this ratio corresponds to an emission environment at ~1700 K. We estimate that this temperature is too high for quiescent gas heated by X-ray or UV emission from the central stars. Surprisingly, we find that the brightest region of H2 emission arises from a spatial location that is exactly coincident with a recently revealed dust "streamer" which seems to be transferring material from the outer circumbinary ring around GG Tau A into the inner region. As a result, we identify a new excitation mechanism for ro-vibrational H2 stimulation in the environment of young stars. The H2 in the GG Tau A system appears to be stimulated by mass accretion infall as material in the circumbinary ring accretes onto the system to replenish the inner circumstellar disks. We postulate that H2 stimulated by accretion infall could be present in other systems, particularly binaries and "transition disk" systems which have dust cleared gaps in their circumstellar environments.Comment: 18 pages, including 4 figures. Accepted for publication in Ap

Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment

Pituitary tumor transforming gene (PTTG)-binding factor (PBF or PTTG1IP) is a little characterized protooncogene that has been implicated in the etiology of breast and thyroid tumors. In this study, we created a murine transgenic model to target PBF expression to the thyroid gland (PBF-Tg mice) and found that these mice exhibited normal thyroid function, but a striking enlargement of the thyroid gland associated with hyperplastic and macrofollicular lesions. Expression of the sodium iodide symporter (NIS), a gene essential to the radioiodine ablation of thyroid hyperplasia, neoplasia, and metastasis, was also potently inhibited in PBF-Tg mice. Critically, iodide uptake was repressed in primary thyroid cultures from PBF-Tg mice, which could be rescued by PBF depletion. PBF-Tg thyroids exhibited upregulation of Akt and the TSH receptor (TSHR), each known regulators of thyrocyte proliferation, along with upregulation of the downstream proliferative marker cyclin D1. We extended and confirmed findings from the mouse model by examining PBF expression in human multinodular goiters (MNG), a hyperproliferative thyroid disorder, where PBF and TSHR was strongly upregulated relative to normal thyroid tissue. Furthermore, we showed that depleting PBF in human primary thyrocytes was sufficient to increase radioiodine uptake. Together, our findings indicate that overexpression of PBF causes thyroid cell proliferation, macrofollicular lesions, and hyperplasia, as well as repression of the critical therapeutic route for radioiodide uptake