Radial Structure in the TW Hya Circumstellar Disk

We present new near-infrared interferometric data from the CHARA array and the Keck Interferometer on the circumstellar disk of the young star, TW Hya, a proposed "transition disk." We use these data, as well as previously published, spatially resolved data at 10 μm and 7 mm, to constrain disk models based on a standard flared disk structure. We find that we can match the interferometry data sets and the overall spectral energy distribution with a three-component model, which combines elements at spatial scales proposed by previous studies: optically thin, emission nearest the star, an inner optically thick ring of emission at roughly 0.5 AU followed by an opacity gap and, finally, an outer optically thick disk starting at ~4 AU. The model demonstrates that the constraints imposed by the spatially resolved data can be met with a physically plausible disk but this requires a disk containing not only an inner gap in the optically thick disk as previously suggested, but also a gap between the inner and outer optically thick disks. Our model is consistent with the suggestion by Calvet et al. of a planet with an orbital radius of a few AU. We discuss the implications of an opacity gap within the optically thick disk

Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain.

Angelman syndrome (AS) is a neurological genetic disorder caused by loss of expression of the maternal copy of UBE3A in the brain. Due to brain-specific genetic imprinting at this locus, the paternal UBE3A is silenced by a long antisense transcript. Inhibition of the antisense transcript could lead to unsilencing of paternal UBE3A, thus providing a therapeutic approach for AS. However, widespread delivery of gene regulators to the brain remains challenging. Here, we report an engineered zinc finger-based artificial transcription factor (ATF) that, when injected i.p. or s.c., crossed the blood-brain barrier and increased Ube3a expression in the brain of an adult mouse model of AS. The factor displayed widespread distribution throughout the brain. Immunohistochemistry of both the hippocampus and cerebellum revealed an increase in Ube3a upon treatment. An ATF containing an alternative DNA-binding domain did not activate Ube3a. We believe this to be the first report of an injectable engineered zinc finger protein that can cause widespread activation of an endogenous gene in the brain. These observations have important implications for the study and treatment of AS and other neurological disorders

CHARA/MIRC observations of two M supergiants in Perseus OB1: temperature, Bayesian modeling, and compressed sensing imaging

Two red supergiants of the Per OB1 association, RS Per and T Per, have been observed in H band using the MIRC instrument at the CHARA array. The data show clear evidence of departure from circular symmetry. We present here new techniques specially developed to analyze such cases, based on state-of-the-art statistical frameworks. The stellar surfaces are first modeled as limb-darkened discs based on SATLAS models that fit both MIRC interferometric data and publicly available spectrophotometric data. Bayesian model selection is then used to determine the most probable number of spots. The effective surface temperatures are also determined and give further support to the recently derived hotter temperature scales of red su- pergiants. The stellar surfaces are reconstructed by our model-independent imaging code SQUEEZE, making use of its novel regularizer based on Compressed Sensing theory. We find excellent agreement between the model-selection results and the reconstructions. Our results provide evidence for the presence of near-infrared spots representing about 3-5% of the stellar flux

First visual orbit for the prototypical colliding-wind binary WR 140

Wolf-Rayet stars represent one of the final stages of massive stellar evolution. Relatively little is known about this short-lived phase and we currently lack reliable mass, distance, and binarity determinations for a representative sample. Here we report the first visual orbit for WR 140(=HD193793), a WC7+O5 binary system known for its periodic dust production episodes triggered by intense colliding winds near periastron passage. The IOTA and CHARA interferometers resolved the pair of stars in each year from 2003--2009, covering most of the highly-eccentric, 7.9 year orbit. Combining our results with the recent improved double-line spectroscopic orbit of Fahed et al. (2011), we find the WR 140 system is located at a distance of 1.67 +/- 0.03 kpc, composed of a WR star with M_WR = 14.9 +/- 0.5 Msun and an O star with M_O = 35.9 +/- 1.3 Msun. Our precision orbit yields key parameters with uncertainties times 6 smaller than previous work and paves the way for detailed modeling of the system. Our newly measured flux ratios at the near-infrared H and Ks bands allow an SED decomposition and analysis of the component evolutionary states.Comment: Complete OIFITS dataset included via Data Conservancy Projec

Multiplicity of Galactic Cepheids from long-baseline interferometry I. CHARA/MIRC detection of the companion of V1334 Cygni

We aim at determining the masses of Cepheids in binary systems, as well as their geometric distances and the flux contribution of the companions. The combination of interferometry with spectroscopy will offer a unique and independent estimate of the Cepheid masses. Using long-baseline interferometry at visible and infrared wavelengths, it is possible to spatially resolve binary systems containing a Cepheid down to milliarcsecond separations. Based on the resulting visual orbit and radial velocities, we can then derive the fundamental parameters of these systems, particularly the masses of the components and the geometric distance. We therefore performed interferometric observations of the first-overtone mode Cepheid V1334 Cyg with the CHARA/MIRC combiner. We report the first detection of a Cepheid companion using long-baseline interferometry. We detect the signature of a companion orbiting V1334 Cyg at two epochs. We measure a flux ratio between the companion and the Cepheid f = 3.10+/-0.08%, giving an apparent magnitude mH = 8.47+/-0.15mag. The combination of interferometric and spectroscopic data have enabled the unique determination of the orbital elements: P = 1938.6+/-1.2 days, Tp = 2 443 616.1+/-7.3, a = 8.54+/-0.51mas, i = 124.7+/-1.8{\deg}, e = 0.190+/-0.013, {\omega} = 228.7+/-1.6{\deg}, and {\Omega} = 206.3+/-9.4{\deg}. We derive a minimal distance d ~ 691 pc, a minimum mass for both stars of 3.6 Msol, with a spectral type earlier than B5.5V for the companion star. Our measured flux ratio suggests that radial velocity detection of the companion using spectroscopy is within reach, and would provide an orbital parallax and model-free masses.Comment: Published in A&

Imaging the Algol Triple System in H Band with the CHARA Interferometer

Algol (Beta Per) is an extensively studied hierarchical triple system whose inner pair is a prototype semi-detached binary with mass transfer occurring from the sub-giant secondary to the main-sequence primary. We present here the results of our Algol observations made between 2006 and 2010 at the CHARA interferometer with the Michigan Infrared Combiner in the H band. The use of four telescopes with long baselines allows us to achieve better than 0.5 mas resolution and to unambiguously resolve the three stars. The inner and outer orbital elements, as well as the angular sizes and mass ratios for the three components are determined independently from previous studies. We report a significantly improved orbit for the inner stellar pair with the consequence of a 15% change in the primary mass compared to previous studies. We also determine the mutual inclination of the orbits to be much closer to perpendicularity than previously established. State-of-the-art image reconstruction algorithms are used to image the full triple system. In particular an image sequence of 55 distinct phases of the inner pair orbit is reconstructed, clearly showing the Roche-lobe-filling secondary revolving around the primary, with several epochs corresponding to the primary and secondary eclipses

First Results from the CHARA Array. II. A Description of the Instrument

The CHARA Array is a six 1-m telescope optical/IR interferometric array located on Mount Wilson California, designed and built by the Center for High Angular Resolution Astronomy of Georgia State University. In this paper we describe the main elements of the Array hardware and software control systems as well as the data reduction methods currently being used. Our plans for upgrades in the near future are also described

On Alternative Supermatrix Reduction

We consider a nonstandard odd reduction of supermatrices (as compared with the standard even one) which arises in connection with possible extension of manifold structure group reductions. The study was initiated by consideration of the generalized noninvertible superconformal-like transformations. The features of even- and odd-reduced supermatrices are investigated on a par. They can be unified into some kind of "sandwich" semigroups. Also we define a special module over even- and odd-reduced supermatrix sets, and the generalized Cayley-Hamilton theorem is proved for them. It is shown that the odd-reduced supermatrices represent semigroup bands and Rees matrix semigroups over a unit group.Comment: 22 pages, Standard LaTeX with AmS font

Resolving Vega and the inclination controversy with CHARA/MIRC

Optical and infrared interferometers definitively established that the photometric standard Vega (alpha Lyrae) is a rapidly rotating star viewed nearly pole-on. Recent independent spectroscopic analyses could not reconcile the inferred inclination angle with the observed line profiles, preferring a larger inclination. In order to resolve this controversy, we observed Vega using the six-beam Michigan Infrared Combiner on the Center for High Angular Resolution Astronomy Array. With our greater angular resolution and dense (u,v)-coverage, we find Vega is rotating less rapidly and with a smaller gravity darkening coefficient than previous interferometric results. Our models are compatible with low photospheric macroturbulence and also consistent with the possible rotational period of ~0.71 days recently reported based on magnetic field observations. Our updated evolutionary analysis explicitly incorporates rapid rotation, finding Vega to have a mass of 2.15+0.10_-0.15 Msun and an age 700-75+150 Myrs, substantially older than previous estimates with errors dominated by lingering metallicity uncertainties (Z=0.006+0.003-0.002).Comment: Accepted for publication in ApJ Letter