Padre de Camilo José Cela

Camilo Cela, padre de Camilo José Cela, en la plaza de Cataluña de Barcelona en 1959, rodeado de palomasCopia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 201

Tracking the invasion of Hemiramphus far and Saurida undosquamis along the southern Mediterranean coasts: A Local Ecological Knowledge study

Local Ecological Knowledge of 92 professional fishers from Tunisia and Libya was used to investigate on the occurrence and establishment of the exotic Hemiramphus far and Saurida undosquamis along the southern Mediterranean coasts. According to fisherman’s knowledge, H. far and S. undosquamis appeared in Libya, in 1980 and 1989 respectively. In Tunisia these species were observed afterwards, in 2004 and 2007. Currently both H. far and S. undosquamis result to be well distributed and established, along the entire surveyed area, from Tubrouk (eastern Libya) to Tabarka (western Tunisia). A statistical analysis of the qualitative trends in abundance perceived by the respondents show that both species have significantly increased in abundance in Tunisia. In Libya an increase of the abundance of H. far was also apparent during the first decade of the 21st century but the current abundance of S. undosquamis resulted to be stable at the level of occasional captures. Given the lack of regular environmental monitoring programmes in the area, these findings provide information that could not have been obtained otherwise. Besides improving our understanding on the status and chronology of these invasions, this approach highlights the value of fisherman’s knowledge to reconstruct ecological process in the course of rapid historical modifications

Sequence information gain based motif analysis

Background: The detection of regulatory regions in candidate sequences is essential for the understanding of the regulation of a particular gene and the mechanisms involved. This paper proposes a novel methodology based on information theoretic metrics for finding regulatory sequences in promoter regions. Results: This methodology (SIGMA) has been tested on genomic sequence data for Homo sapiens and Mus musculus. SIGMA has been compared with different publicly available alternatives for motif detection, such as MEME/MAST, Biostrings (Bioconductor package), MotifRegressor, and previous work such Qresiduals projections or information theoretic based detectors. Comparative results, in the form of Receiver Operating Characteristic curves, show how, in 70 % of the studied Transcription Factor Binding Sites, the SIGMA detector has a better performance and behaves more robustly than the methods compared, while having a similar computational time. The performance of SIGMA can be explained by its parametric simplicity in the modelling of the non-linear co-variability in the binding motif positions. Conclusions: Sequence Information Gain based Motif Analysis is a generalisation of a non-linear model of the cis-regulatory sequences detection based on Information Theory. This generalisation allows us to detect transcription factor binding sites with maximum performance disregarding the covariability observed in the positions of the training set of sequences. SIGMA is freely available to the public at http://​b2slab.​upc.​edu

A comparison between the clinical frailty scale and the hospital frailty risk score to risk stratify older people with emergency care needs

Background Older adults living with frailty who require treatment in hospitals are increasingly seen in the Emergency Departments (EDs). One quick and simple frailty assessment tool—the Clinical Frailty Scale (CFS)—has been embedded in many EDs in the United Kingdom (UK). However, it carries time/training and cost burden and has significant missing data. The Hospital Frailty Risk Score (HFRS) can be automated and has the potential to reduce costs and increase data availability, but has not been tested for predictive accuracy in the ED. The aim of this study is to assess the correlation between and the ability of the CFS at the ED and HFRS to predict hospital-related outcomes. Methods This is a retrospective cohort study using data from Leicester Royal Infirmary hospital during the period from 01/10/2017 to 30/09/2019. We included individuals aged + 75 years as the HFRS has been only validated for this population. We assessed the correlation between the CFS and HFRS using Pearson’s correlation coefficient for the continuous scores and weighted kappa scores for the categorised scores. We developed logistic regression models (unadjusted and adjusted) to estimate Odds Ratios (ORs) and Confidence Intervals (CIs), so we can assess the ability of the CFS and HFRS to predict 30-day mortality, Length of Stay (LOS) > 10 days, and 30-day readmission. Results Twelve thousand two hundred thirty seven individuals met the inclusion criteria. The mean age was 84.6 years (SD 5.9) and 7,074 (57.8%) were females. Between the CFS and HFRS, the Pearson correlation coefficient was 0.36 and weighted kappa score was 0.15. When comparing the highest frailty categories to the lowest frailty category within each frailty score, the ORs for 30-day mortality, LOS > 10 days, and 30-day readmission using the CFS were 2.26, 1.36, and 1.64 and for the HFRS 2.16, 7.68, and 1.19. Conclusion The CFS collected at the ED and the HFRS had low/slight agreement. Both frailty scores were shown to be predictors of adverse outcomes. More research is needed to assess the use of historic HFRS in the ED

STECF Multiannual management plans SWW and NWW (STECF-15-08)

The STECF was tasked with an analysis of the likely effects of proposed management plans for the Southwestern (Bay of Biscay and Iberia) and Northwestern (Celtic sea) waters. Quantitative analyses were carried out to compare the likely effect of those management plans and of the direct application of the CFP on both stocks and fleets involved in these fisheries. Based on the results of simulations of the provisions of the proposed management plans, STECF concluded that, setting fishing opportunities in line with single-species FMSY ranges will provide managers with additional flexibility compared to the basic provisions of the 2013 CFP. Such flexibility is likely to help alleviate the problem of mismatches in quota availability in mixed-species fisheries thereby reducing the risk of early closure of some fisheries due to choke species. Adopting FMSY ranges will therefore increase the likelihood that desired exploitation rates will be achieved and will reduce the risk that some fishing fleets will go out of business. STECF considers that it is crucial that managers take note that persistent fishing at the upper limits of the FMSY ranges across all or most stocks simultaneously negates the flexibility introduced by the FMSY ranges and greatly increases the risk of overfishing. Such an approach will also increase the risk that the objectives of the CFP will not be achieved. STECF concludes that single species biomass safeguards for all stocks should be maintained to provide a basic level of protection. STECF notes that for the fleets affected by the SWW MAP, those providing the highest employment are generally not dependent to a great extent on the species that will be regulated through the MAP proposals. STECF notes that in the NWW there are some fleets which provide significant levels of employment and seem to be very dependent on the species that will be regulated through the MAP proposals. Nevertheless, there are a number of fleets in the NWW area that are not included in the employment analysis because of an absence of appropriate data. .Regarding the number and scope of MAPs as currently defined, STECF considers that a MAP covering a wider geographic area has advantages in terms of reducing management overheads and avoiding multiple regulations affecting the sector. A larger MAP area however, may have disadvantages associated with reducing the emphasis on local management measures and this may discourage the involvement of stakeholders, although this effect will depend on how the process of regionalization operates within the MAP. To evaluate the question of whether management of the species that drive the fisheries adequately allows for the management of by-catch species, the EWG carried out an analysis of correlations between catches of driver species identified in the plan and a variety of by-catch species. The analysis suggested only limited correlation. In view of this, the STECF notes that it is unlikely that relying on the TAC of the driver species to manage other species will be effective, in accordance with CFP requirements. STECF however notes that when analysis was performed at the fleet level, there were more obvious correlations, suggesting some scope to use fleet related management measures for the driver species as a way of managing some of the bycatch species. STECF therefore concludes that management of exploitation rates of non-driver (or bycatch) species is unlikely to occur as an automatic consequence of the management of the main (driver) stocks by TAC considered in the MAP.DG MAR

Identifying Persistent Hot Spot Areas of Undersized Fish and Crustaceans in Southern European Waters: Implication for Fishery Management Under the Discard Ban Regulation

The recent establishment of the “landing obligation” under the reformed EU Common Fishery Policy has the twofold objective of reducing the excessive practice of discarding unwanted catch at sea and encouraging more selective and sustainable fisheries. Within this context, the awareness of the spatial distribution of potential unwanted catches is important for devising management measures aimed to decrease discards. This study analyzed the distribution of Hot Spot density areas of demersal fish and crustaceans below the Minimum Conservation Reference Size (MCRS) in four different southern European seas: continental Portuguese coast, Catalan Sea, South of Sicily, Liguria and northern Tyrrhenian Seas using both bottom trawl survey data and information on the spatial distribution of commercial fisheries. Critical areas for discarding were identified as zones where the highest densities of individuals below MCRS were consistently recorded throughout a series of years. Results clearly showed a patchy distribution of undersized individuals in each investigated area, highlighting the overlap between high density patches of both discards and fishing effort. The present findings provide a relevant knowledge for supporting the application of spatial-based management actions, such as the designation of Fisheries Restricted Areas (FRAs), in order to minimize the by-catch of undersized specimens and improve the sustainability of demersal fisheries

Plasma coenzyme Q10 status is impaired in selected genetic conditions.

Identifying diseases displaying chronic low plasma Coenzyme Q10 (CoQ) values may be important to prevent possible cardiovascular dysfunction. The aim of this study was to retrospectively evaluate plasma CoQ concentrations in a large cohort of pediatric and young adult patients. We evaluated plasma CoQ values in 597 individuals (age range 1 month to 43 years, average 11 years), studied during the period 2005-2016. Patients were classified into 6 different groups: control group of healthy participants, phenylketonuric patients (PKU), patients with mucopolysaccharidoses (MPS), patients with other inborn errors of metabolism (IEM), patients with neurogenetic diseases, and individuals with neurological diseases with no genetic diagnosis. Plasma total CoQ was measured by reverse-phase high-performance liquid chromatography with electrochemical detection and ultraviolet detection at 275 nm. ANOVA with Bonferroni correction showed that plasma CoQ values were significantly lower in the PKU and MPS groups than in controls and neurological patients. The IEM group showed intermediate values that were not significantly different from those of the controls. In PKU patients, the Chi-Square test showed a significant association between having low plasma CoQ values and being classic PKU patients. The percentage of neurogenetic and other neurological patients with low CoQ values was low (below 8%). In conclusión, plasma CoQ monitoring in selected groups of patients with different IEM (especially in PKU and MPS patients, but also in IEM under protein-restricted diets) seems advisable to prevent the possibility of a chronic blood CoQ suboptimal status in such groups of patients

IST-2000-30148 I-METRA: D3.1 Design, analysis and selection of suitable algorithms

This deliverable contains a description of the space-time coding algorithms to be simulated within the I-METRA project. Different families of algorithms have been selected and described in this document with the objective of evaluating their performance. One of the main objectives of the I-METRA project is to impact into the current standardisation efforts related to the introduction of Multiple Input Multiple Output (MIMO) configurations into the High Speed Downlink and Uplink Packet Access concepts of UMTS (HSDPA and HSUPA). This required a review of the current specifications for these systems and the analysis of the impact of the potential incorporation of the selected MIMO schemes.Preprin

IST-2000-30148 I-METRA: D3.2 Implementation of relevant algorithms

This deliverable provides a high level description of the software developed within the I-METRA project following the selection reported in D3.1 "Design, Analysis and Selection of Suitable Algorithms".Preprin