Analisis Senyawa Minyak Atsiri Daun Salam (Syzygium Polyanthum Wight.) dari Bekasi dan Lembang dengan Gc-Ms serta Aktivitas Antbakteri terhadap MRSA

Latar belakang: Daun salam dari tempat tumbuh yang berbeda dilaporkanmengandung senyawa minyak atsiri yang berbeda. Minyak atsiri dengan senyawa mayor golongan aldehid, fenol, atau terpenoid dilaporkan memberikan aktivitas antibakteri. Daun salam secara tradisional telah digunakan sebagai antibakteri.Tujuan penelitian ini untuk mengetahui senyawa mayor dalam minyak atsiri daun salam dari Bekasi dan Lembang, serta aktivitasnya terhadap MRSA. Metodologi: Minyak atsiri daun salam kedua daerah diperoleh dengan metode destilasi uap dan air. Setiap minyak atsiri diidentifikasi senyawanya dengan GCMS dan diuji aktivitasnya terhadap bakteri MRSA dengan metode difusi cakram pada rentang konsentrasi 12-200µL/mL. Hasil penelitian: Rendemen minyak atsiri daun salam dari Bekasi dan Lembang secara berurutan adalah 0,03% dan 0,06%. Prediksi senyawa, dengan SI ≥ 90%, minyak atsiri daun salam dari kedua daerah memiliki persentase area puncak terbesar, yaitu senyawa aldehid, diikuti senyawa terpenoid. Rentang diameter zona hambat minyak atsiri daun salam dari Bekasi adalah 9,2-15,8 mm, sedangkan dari Lembang adalah 0 mm. Kesimpulan: Minyak atsiri daun salam dari Lembang memiliki 5 senyawa mayor dan 3 diantaranya sama dengan dari Bekasi, yaitu n-oktanal, cis-4-desenal, dan n-dekanal, namun dengan persentase area puncak yang berbeda. Minyak atsiri daun salam dari Bekasi dapat memberikan daya hambat terhadap MRSA, sedangkan yang dari Lembang tidak memberikan daya hambat

A service mapping exercise of four health and social care staff mental health and wellbeing services, Resilience Hubs, to describe health service provision and interventions

Background: NHS England funded 40 Mental Health and Wellbeing Hubs to support health and social care staff affected by the COVID-19 pandemic. We aimed to document variations in how national guidance was adapted to the local contexts of four Hubs in the North of England.Methods: We used a modified version of Price’s (2019) service mapping methodology. Service level data were used to inform the analysis. A mapping template was adapted from a range of tools, including the European Service Mapping Schedule, and reviewed by Hub leads. Key data included service model; staffing; and interventions. Data were collected between March 2021 – March 2022 by site research assistants. Findings were accuracy-checked by Hub leads, and a logic model developed to theorise how the Hubs may effect change.Results: Hub goals and service models closely reflected guidance; offering: proactive outreach; team-based support; clinical assessment; onward referral, and rapid access to mental health support (in-house and external). Implementation reflected a service context of a client group with high mental health need, and high waiting times at external mental health services. Hubs were predominantly staffed by experienced clinicians, to manage these mental health presentations and organisational working. Formulation-based psychological assessment and the provision of direct therapy were not core functions of the NHS England model, however all Hubs incorporated these adaptations into their service models in response to local contexts, such as extensive waiting lists within external services, and/or client presentations falling between gaps in existing service provision. Finally, a standalone clinical records system was seen as important to reassure Hub users of confidentiality. Other more nuanced variation depended on localised contexts.Conclusion: This study provides a map for setting up services, emphasising early understandings of how new services will integrate within existing systems. Local and regional contexts led to variation in service configuration. Whilst additional Hub functions are supported by available literature, further research is needed to determine whether these functions should comprise essential components of staff wellbeing services moving forward. Future research should also determine the comparative effectiveness of service components, and the limits of permissible variation.Study registration: researchregistry6303.</p

A service mapping exercise of four health and social care staff mental health and wellbeing services, Resilience Hubs, to describe health service provision and interventions

Background: NHS England funded 40 Mental Health and Wellbeing Hubs to support health and social care staff affected by the COVID-19 pandemic. We aimed to document variations in how national guidance was adapted to the local contexts of four Hubs in the North of England. Methods: We used a modified version of Price’s (2019) service mapping methodology. Service level data were used to inform the analysis. A mapping template was adapted from a range of tools, including the European Service Mapping Schedule, and reviewed by Hub leads. Key data included service model; staffing; and interventions. Data were collected between March 2021 – March 2022 by site research assistants. Findings were accuracy-checked by Hub leads, and a logic model developed to theorise how the Hubs may effect change. Results: Hub goals and service models closely reflected guidance; offering: proactive outreach; team-based support; clinical assessment; onward referral, and rapid access to mental health support (in-house and external). Implementation reflected a service context of a client group with high mental health need, and high waiting times at external mental health services. Hubs were predominantly staffed by experienced clinicians, to manage these mental health presentations and organisational working. Formulation-based psychological assessment and the provision of direct therapy were not core functions of the NHS England model, however all Hubs incorporated these adaptations into their service models in response to local contexts, such as extensive waiting lists within external services, and/or client presentations falling between gaps in existing service provision. Finally, a standalone clinical records system was seen as important to reassure Hub users of confidentiality. Other more nuanced variation depended on localised contexts. Conclusion: This study provides a map for setting up services, emphasising early understandings of how new services will integrate within existing systems. Local and regional contexts led to variation in service configuration. Whilst additional Hub functions are supported by available literature, further research is needed to determine whether these functions should comprise essential components of staff wellbeing services moving forward. Future research should also determine the comparative effectiveness of service components, and the limits of permissible variation. Study registration: researchregistry6303

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Authorship and private correspondance (the letters of Mme de Graffigny, Mlle de Lespinasse, and Mme Roland)

L'étude des interactions des deux pactes, le pacte affectif et le pacte d'écriture, qui guident les écrivains de lettres permet de jeter un regard nouveau sur le rôle de l'auteur. Si l'on fait reposer la définition d'auteur sur la question des intentions de publication, la présence d'un auteur dans la lettre privée se révèle des plus ambigües. Si la définition d'auteur implique une aptitude à produire des textes à réelle teneur littéraire - textes qui intéressent en partie un vaste public de lecteurs - alors l'écrivain se révèle être un auteur, ou plutôt ce que nous appelerions un auteur à éclipse. Si l'on définit enfin l'auteur comme un sujet engagé dans un travail et un questionnement poètique continu, alors le travail que ces trois femmes ont accomplis en jouant avec les tensions qui exisentent entre les deux pactes épistolaires leur confère le titre d' auteur à part entière.The study of the two pacts, the emotional pact and the writers' pact, leads in the direction of a novel answer to the question of authorship in private letters. In terms of the definition of an author whose goal is publication, there is at best ambiguous indication of authorship in the letters. If the notion of authorship is defined as revolving around the ability to create texts of literarity - meaning, at least in part, texts that engage the general reader (whether or not they were intended for the general reader)- then the answer is yes, but this is a variable author. Under the definition of authorship that suggests that an author is someone who is engaged in a continuing work with poetic material, the work of the three women with the pacts fairly confers on them the title of "author."PARIS3-BU (751052102) / SudocSudocFranceUnited StatesFRU

A service mapping exercise of four health and social care staff mental health and wellbeing services, Resilience Hubs, to describe health service provision and interventions

Background: NHS England funded 40 Mental Health and Wellbeing Hubs to support health and social care staff affected by the COVID-19 pandemic. We aimed to document variations in how national guidance was adapted to the local contexts of four Hubs in the North of England.Methods: We used a modified version of Price’s (2019) service mapping methodology. Service level data were used to inform the analysis. A mapping template was adapted from a range of tools, including the European Service Mapping Schedule, and reviewed by Hub leads. Key data included service model; staffing; and interventions. Data were collected between March 2021 – March 2022 by site research assistants. Findings were accuracy-checked by Hub leads, and a logic model developed to theorise how the Hubs may effect change.Results: Hub goals and service models closely reflected guidance; offering: proactive outreach; team-based support; clinical assessment; onward referral, and rapid access to mental health support (in-house and external). Implementation reflected a service context of a client group with high mental health need, and high waiting times at external mental health services. Hubs were predominantly staffed by experienced clinicians, to manage these mental health presentations and organisational working. Formulation-based psychological assessment and the provision of direct therapy were not core functions of the NHS England model, however all Hubs incorporated these adaptations into their service models in response to local contexts, such as extensive waiting lists within external services, and/or client presentations falling between gaps in existing service provision. Finally, a standalone clinical records system was seen as important to reassure Hub users of confidentiality. Other more nuanced variation depended on localised contexts.Conclusion: This study provides a map for setting up services, emphasising early understandings of how new services will integrate within existing systems. Local and regional contexts led to variation in service configuration. Whilst additional Hub functions are supported by available literature, further research is needed to determine whether these functions should comprise essential components of staff wellbeing services moving forward. Future research should also determine the comparative effectiveness of service components, and the limits of permissible variation.<br/