Supporting the employability agenda in university libraries: A case study from the University of Sheffield

Purpose: This paper aims to outline work to support the employability agenda in the Library at the University of Sheffield, set in the context of debates about the nature of employability, employability skills and information literacy in the workplace. Design/methodology/approach: The paper starts with a brief review of literature on employability and student skills in the UK higher education sector, the place of information literacy as an employability attribute and information literacy in the workplace. It goes on to outline work done in the Library at the University of Sheffield to support the employability agenda. This includes the development of a commercial awareness workshop in collaboration with other services and the incorporation of student and alumni voices in an employability guide. Findings: The literature reviewed highlights the differences between information literacy in the workplace and academia. This could present challenges and opportunities in promoting information literacy as an employability attribute. The case study highlights the benefits of working in collaboration with students and services beyond the library in the employability arena. Originality/value: The approaches taken in Sheffield may be of interest to other institutions looking to develop support for the employability agenda

A eukaryote assemblage intercalated with Marinoan glacial deposits in South Australia

Video of digital X-ray tomographs (µCT) in longitudinal plane through cylinder of siltstone, maximum diameter seen (left to right when viewing movie) is 5.4m

Sensor optimization in smart insoles for post-stroke gait asymmetries using total variation and L1 distances

By deploying pressure sensors on insoles, the forces exerted by the different parts of the foot when performing tasks standing up can be captured. The number and location of sensors to use are important factors in order to enhance the accuracy of parameters used in assessment while minimizing the cost of the device by reducing the number of deployed sensors. Selecting the best locations and the required number of sensors depends on the application and the features that we want to assess. In this paper, we present a computational process to select the optimal set of sensors to characterize gait asymmetries and plantar pressure patterns for stroke survivors based upon the total variation and L1 distances. The proposed mechanism is ecologically validated in a real environment with 14 stroke survivors and 14 control users. The number of sensors is reduced to 4, minimizing the cost of the device both for commercial users and companies and enhancing the cost to benefit ratio for its uptake from a national healthcare system. The results show that the sensors that better represent the gait asymmetries for healthy controls are the sensors under the big toe and midfoot and the sensors in the forefoot and midfoot for stroke survivors. The results also show that all four regions of the foot (toes, forefoot, midfoot, and heel) play an important role for plantar pressure pattern reconstruction for stroke survivors, while the heel and forefoot region are more prominent for healthy controls

Rubella virus infection, the Congenital Rubella Syndrome, and the link to autism

Rubella is a systemic virus infection that is usually mild. It can, however, cause severe birth defects known as the congenital rubella syndrome (CRS) when infection occurs early in pregnancy. As many as 8%–13% of children with CRS developed autism during the rubella epidemic of the 1960s compared to the background rate of about 1 new case per 5000 children. Rubella infection and CRS are now rare in the U.S. and in Europe due to widespread vaccination. However, autism rates have risen dramatically in recent decades to about 3% of children today, with many cases appearing after a period of normal development (‘regressive autism’). Evidence is reviewed here suggesting that the signs and symptoms of rubella may be due to alterations in the hepatic metabolism of vitamin A (retinoids), precipitated by the acute phase of the infection. The infection causes mild liver dysfunction and the spillage of stored vitamin A compounds into the circulation, resulting in an endogenous form of hypervitaminosis A. Given that vitamin A is a known teratogen, it is suggested that rubella infection occurring in the early weeks of pregnancy causes CRS through maternal liver dysfunction and exposure of the developing fetus to excessive vitamin A. On this view, the multiple manifestations of CRS and associated autism represent endogenous forms of hypervitaminosis A. It is further proposed that regressive autism results primarily from post-natal influences of a liver-damaging nature and exposure to excess vitamin A, inducing CRS-like features as a function of vitamin A toxicity, but without the associated dysmorphogenesis. A number of environmental factors are discussed that may plausibly be candidates for this role, and suggestions are offered for testing the model. The model also suggests a number of measures that may be effective both in reducing the risk of fetal CRS in women who acquire rubella in their first trimester and in reversing or minimizing regressive autism among children in whom the diagnosis is suspected or confirmed

Identifying conservation units after large-scale land clearing: a spatio-temporal molecular survey of endangered white-tailed black cockatoos (Calyptorhynchus spp.)

Aim: We examined how the threatened and endemic white-tailed black cockatoos of Western Australia have responded genetically to recent and comprehensive habitat loss with the ultimate aim of identifying units for conservation. We assessed the population structure, connectivity and genetic diversity at spatial and temporal scales for Calyptorhynchus baudinii and C. latirostris, which have undergone dramatic population declines. Genetic comparisons of pre- and post-population decline were carried out by including historical samples dating back to 1920. We examined samples collected from across 700 km of their distribution and sampled approximately 1% of the current population census size to produce significant insights into the population genetics of white-tailed black cockatoos and generate genetic information crucial for conservation management. Location: Southwest corner of Western Australia. Methods: Six hundred and eighty-four cockatoo samples were collected from 1920 to 2010 and profiled with 19 microsatellites to identify spatial population structure and loss of genetic diversity.Results: The temporal and spatial microsatellite data illustrated that the geographically defined genetic structuring in white-tailed black cockatoos is likely to represent a recent phenomenon. We identified: (1) spatial population substructure east and west of extensively cleared habitat (>95,800 km2), but the historical samples clustered with the current western population, regardless of origin, (2) a regional loss of allelic diversity over 3–4 generations for the current eastern population, (3) a lack of a genetic signal of the recent population decline, but perhaps a mid-Holocene population collapse and lastly, (4) limited genetic differentiation between the two currently recognized white-tailed black-cockatoo species suggests a review of taxonomy and/or management units should be undertaken. Main conclusion: Based on extensive spatio-temporal sampling, we have demonstrated that recent anthropogenic habitat modifications have affected the genetic structure of a long-lived and highly mobile species. Our results have identified areas of high conservation value and the importance of maintaining native vegetation migration corridors

Capillary pressure may predict preclinical changes in the eye

This is the final version. Available on open access from Springer Verlag via the DOI in this recordAIMS/HYPOTHESIS: Microvascular dysfunction is associated with end-organ damage. Macular oedema is an important component of diabetic retinopathy. Macular thickness can be accurately quantified by optical coherence tomography (OCT), enabling accurate assessment of the macular prior to clinically apparent abnormalities. We investigated whether macular (fovea) thickness in non-diabetic individuals is related to the microvascular variables controlling fluid filtration across a blood vessel wall, in particular capillary pressure and the microvascular filtration capacity (Kf). METHODS: We recruited 50 non-diabetic individuals (25 men, 25 women; age range: 26-78 years; BMI range: 20-46 kg/m(2)). Fovea thickness was assessed by OCT. Microvascular assessments included: finger nailfold capillary pressure; Kf; microvascular structural assessments, i.e. skin vasodilatory capacity, minimum vascular resistance (MVR) and microvascular distensibility; and endothelial function. RESULTS: At 214.6 (19.9) microm (mean [SD]), fovea thickness was within normal range. Capillary pressure, adjusted for BMI, was associated with fovea thickness (standardised beta 0.573, p = 0.006, linear regression). Fovea thickness was not associated with Kf, microvascular structural assessments or endothelial function. Capillary pressure was still associated with fovea thickness when adjusted for microvascular variables (Kf, vasodilatory capacity, MVR, microvascular distensibility or endothelial function), or for risk factors for diabetes (systemic blood pressure, insulin sensitivity, inflammation, glycaemic status and lipids) and age. CONCLUSIONS/INTERPRETATION: Capillary pressure, a key determinant of movement of fluid across a blood vessel wall, is associated with fovea thickness in non-diabetic individuals. This suggests that with regard to potential preventative or therapeutic targets, attention should be directed at the mechanisms determining retinal microvascular pressure.Diabetes UKNational Institute for Health Research (NIHR

Surfactants for heterogeneous processes in liquid or supercritical CO.sub.2

Heterogeneous polymer mixtures comprising a polymer in liquid or supercritical CO.sub.2 are stabilized by employing a poly(propylene oxide) or poly(butylene oxide) based surfactant. These surfactants are especially well suited for stabilizing heterogeneous polymer mixtures formed by micronizing techniques as well as by precipitation of a compressed fluid antisolvent applications.Board of Regents, University of Texas Syste

Collaborating to support the use and development of open educational resources: a White Rose Libraries research project

Interest in open educational resources (OER) has grown recently due to many external factors, including the restrictive, unsustainable and expensive business models for teaching materials that are being used by some publishers. In February 2021, the libraries of the UK White Rose University Consortium (White Rose Libraries) initiated a research project to explore the potential of OER and to create guidance in the form of an OER toolkit that could be used across all three institutions, and more widely. The project also aimed to seek improvements in the discovery of OER in the Ex Libris Primo discovery service which is used by all three libraries. This article outlines the methodology used to ascertain the needs of the libraries’ user groups to inform the development of the toolkit. A survey of academic staff across all three institutions was conducted, followed by user experience interviews. The survey findings established that more than half of respondents knew little or nothing about OER, and over half also said that they would be likely or extremely likely to consider using or adapting OER, clearly demonstrating the need for more awareness raising and guidance. The survey interview findings were then used to develop and refine the toolkit

First Constraints on Compact Dark Matter from Fast Radio Burst Microstructure

Despite existing constraints, it remains possible that up to $35\%$ of all dark matter is comprised of compact objects, such as the black holes in the 10-100\,M$_\odot$ range whose existence has been confirmed by LIGO. The strong gravitational lensing of transients such as FRBs and GRBs has been suggested as a more sensitive probe for compact dark matter than intensity fluctuations observed in microlensing experiments. Recently ASKAP has reported burst substructure down to $15\mu$s timescales in FRBs in the redshift range $0.3-0.5$. We investigate here the implications of this for the detectability of compact dark matter by FRBs. We find that a sample size of $\sim130$ FRBs would be required to constrain compact dark matter to less than the existing 35$\%$ limit with 95$\%$ confidence, if it were distributed along $\gtrsim 1\,$Gpc-long FRB sightlines through the cosmic web. Conversely, existing constraints on the fraction of compact dark matter permit as many as 1 in $\approx 40$ of all $z \lesssim 0.4$ FRBs to exhibit micro-lensed burst structure. Approximately $170$ FRBs intercepting halos within $\sim 50\,$kpc would be required to exclude the fraction of compact dark matter in each intercepted halo to a similar level. Furthermore, we consider the cumulative effects of lensing of the FRB signal by a macroscopic dark matter distribution. We conclude that lensing from a uniform distribution of compact objects is likely not observable, but suggest that FRBs may set meaningful limits on power-law distributions of dark matter.Comment: 3 Figures, 1 tabl