ENVIRONMENTALLY FRIENDLY TECHNOLOGY: THE BEHAVIOUR OF NATURAL AND SYNTHETIC BINDER SYSTEMS WITHIN PAPER COATINGS

Coating shrinkage upon drying is a phenomenon well known to the paper coating industry, where it often causes changes in the final structure of the coating layer leading to poor results in terms of gloss, light scattering, surface strength, coverage, uniformity and printability. Such shrinkage has in previous studies been wrongly associated with shrinkage of the polymeric binders used in the coating formulation, by making erroneous comparison with solvent-based paint systems. Natural binders, as starch or proteins, which come from renewable resources and are therefore environmentally friendly, suffer more from this shrinkage phenomenon than synthetic binders. The aim of this research project was to improve the understanding of the processes involved in the drying of a coating layer and to create a model able to describe them. Shrinkage while the coating layer dries has been successfully measured by observing the deflection of coated strips of a synthetic elastically-deformable substrate. Ground calcium carbonate was used as the coating pigment, together with latex binders of both low and high glass transition temperature, Tg, respectively, and also with starch which is a natural film-forming water soluble binder. The final dry coatings were studied with mercury porosimetry and by scanning electron microscopy in order to characterise their porous structure. The flow and rheological properties of the coating colour formulations were measured in order to probe the particle-particle interaction between the different species in the wet coating colour. The void space of the dry coating layers was modelled using Pore-Cor, a software which generates simulated porous networks. A new algorithm was developed to model, within the simulated void space, the effective particles or "skeletal elements" representative of the solid phase of the dried porous system. The water-filled porous structures at the beginning of the shrinkage process (first critical concentration, FCC) were subsequently modelled by creating Pore-Cor structures with the same solid skeletal elements distribution as at the second critical concentration (at which the particles lock their positions), but with higher given porosity to account for the water present The capillary forces acting on the surface of the simulated coating were calculated, and found to be several orders of magnitude larger than the measured shrinkage forces. The shrinkage process was thus described as resulting from the effect of capillary forces in the plane of the coating layer resisted by a stick-slip process, where the capillary forces yield shrinkage only if a resistance force within the drying coating layer holds the structure in place and allows the menisci to form. The stick-slip theory was strongly supported by quantitative comparisons between the experimental forces required to intrude mercury, and the capillary forces within the simulated void structure.Omya AG, Oftringen, Switzerlan

Occupational markers and pathology of the castrato singer Gaspare Pacchierotti (1740\u20131821)

Following the birth of modern opera in Italy in 1600, the demand for soprano voices grew up and the prepuberal castration was carried out to preserve the young male voice into adult life. Among the castrati, Gaspare Pacchierotti was probably one of the most famous. The remains of Pacchierotti were exhumed for the first time in 2013, for a research in the reconstruction of his biological profile, to understand the secrets behind his sublime voice and how the castration influenced the body. All the findings discovered, through anthropological and Computed Tomography analyses, are consistent both with the occupational markers of a singer and with the hormonal effects of castration. The erosion of cervical vertebrae, the insertion of respiratory muscles and muscles of the arms can be an effect of the bodily position and exercise during singing. The hormonal effect of castration were related to osteoporosis and to the disorders of spine

New Insights into the role of GSK-3 in the regulation of human cardiac electrophysiology

Cardiac arrhythmias still represent a serious health issue, leading to adverse outcomes, such as heart failure and sudden death. Several drugs used to treat noncardiac diseases, including antibiotics or antipsychotics, can also be responsible for arrhythmia development. Therefore, a major challenge is a deeper comprehension of the molecular mechanisms regulating cardiac electro- physiology, together with the development of predic- tive tools aimed at understanding how a specific condition or drug can favor arrhythmic events

In vitro Removal of Therapeutic Drugs with a Novel Adsorbent System

Background/Aim: Substances in the middle molecular weight range have been shown to play a significant pathogenetic role in as diverse disorders as end-stage renal disease and multiple organ failure. To overcome the limitations in the amount removed by hemofilters, new sorbents with a high biocompatibility are actively being developed. Furthermore, biocompatible sorbents by their nonspecific adsorptive behavior could have great impact on detoxification treatment in exogenous intoxications. We performed an in vitro evaluation of a newly developed highly biocompatible sorbent cartridge (Betasorb(R)), examining its adsorptive capacity concerning therapeutic drugs. Methods: Uremic blood spiked with a range of therapeutic drugs was recirculated for 2 h in an in vitro hemoperfusion circuit containing a Betasorb device for hemoperfusion. The drug concentrations before and after the passage of the cartridge were measured, and the total amount removed was calculated. Results: The sorbent showed effective removal of glycopeptide antibiotics, digoxin, theophylline, phenobarbital, phenytoin, carbamazepine, and valproic acid. Moderate removal could be demonstrated for tacrolimus and cyclosporine A; aminoglycosides were removed to a small extent only. Conclusions: Betasorb hemoperfusion shows a potent adsorptive capacity concerning therapeutic drugs (except aminoglycosides) and could be of major value in the treatment of intoxications. On the other hand, drug monitoring and possible adjustments are necessary during Betasorb hemoperfusion to maintain the therapeutic ranges of the drugs in blood. Copyright (C) 2002 S. Karger AG, Basel

Crop Management with the IoT: an Interdisciplinary Survey

In this study we analyze how crop management is going to benefit from the Internet of Things providing an overview of its architecture and components from an agronomic and a technological perspective. The present analysis highlights that IoT is a mature enabling technology, with articulated hardware and software components. Cheap networked devices may sense crop fields at a finer grain, to give timeliness warnings on stress conditions and the presence of disease to a wider range of farmers. Cloud computing allows to reliably store and access heterogeneous data, developing and deploy farm services. From this study emerges that IoT is also going to increase attention to sensor quality and placement protocol, while Machine Learning should be oriented to produce understandable knowledge, which is also useful to enhance Cropping System Simulation systems

Using FADN Data to Estimate CO2 Abatement Costs from Italian Arable Crops

The assessment of economic and environmental sustainability of agricultural systems represents a critical issue, which has been addressed in this work with a multi-objective programming model to explore the abatement costs (AC) of CO2 for a set of representative contexts of Italian arable land agriculture. The study was based on the FADN-compliant Italian database RICA and estimates the abatement costs of CO2 emissions in a short time horizon, using linear multi-objective programming and compromise programming. RICA data were used to quantify technical parameters of the model, adopting an innovative concept of a cropping scheme to simulate land-use adaptation. The study shows a quite diversified situation regarding income and emission levels per hectare across the Italian region and farm classes. A reduction of CO2 emissions higher than 5 kg/ha at an AC lower than 1 EUR/kg is affordable only in seven regions, among which Abruzzo, Lombardy, and Puglia show the highest potential. Comparing the estimated abatement costs for CO2 emissions with the corresponding European Trade System prices highlights a difference of 1 order of magnitude, proving that emission reductions for Italian arable crops still require research and innovation to lower adaptation costs

the letter of the madonna to the people of messina in chinese by the jesuit metello saccano an unknown seventeenth century manuscript

The depository of the Regional Museum of Messina preserves a small, frail canvas bearing two inscriptions. The first, particularly fragmented, is in Italian in four lines, while the second is in Chinese characters in fourteen columns. The museum documentation provides no information regarding the manuscript's significance, author, origin, and period. This article shows that the manuscript is a Chinese version of the legendary Letter of the Madonna, the letter of protection that Mary is said to have delivered to a delegation from Messina that accompanied Paul the Apostle to Jerusalem. Furthermore, the article identifies the manuscript's author and the date of composition: the Sicilian Jesuit Metello Saccano (1612–62), a missionary in China and Cochin China from 1644 until his death. Intent on spreading the cult of the Madonna of the Letter, in the early 1660s, he sent this elegant Chinese version of the letter to Placido Giunta (1593–1674), his spiritual director and the rector of the Jesuit novitiate of Messina

Feasibility investigation of a smart thermoacoustic configuration for general aviation aircrafts

One of the most disturbing noise for passengers is related to the engine fan. This noise is mainly tonal and in the low-frequency range. Reducing its impact for the comfort of passengers is an important and challenging issue in aeronautics. One suitable way to reduce cabin noise is to use efficient thermal acoustic insulation blankets between the interior trim panel and the exterior shell. General Aviation Aircrafts, are generally equipped with a cabin poorly efficient both in terms of thermal and acoustic insulation; this due mainly to the not availability of the most innovative solutions or materials like those used on Large Passenger Aircraft. In this context the authors have faced this crucial issue within SPAIN Project “Smart Panels for SAT Aircrafts Cabin Insulation” which makes part of the Systems Integrated Technology Demonstrator (ITD) Program in EU Clean Sky 2. This project aims scientific and technological breakthroughs in the development and validation of new insulation treatments used in aircraft developing a thermo-acoustic insulation system with materials and innovative solutions highly efficient at an affordable cost for this class of aircrafts. According to the available materials on the market with high thermal and acoustic individual performance, SPAIN goal is to design, develop and test an efficient insulation panel suitable for the General Aviation Aircraft compliant with the technical specification in terms of and weight to performance, and cost to performance aspects. Another item that has been strongly worked on, is the integration technology of this solution with the actual interiors configuration with specific focus to maintenance aspects. A set of sandwich configurations have been designed for each specific area of the fuselage to fulfil the overall noise level target; preliminary test have been performed at coupon level and sub-assembly level to confirm the expected outcomes

Extreme dry and wet spells face changes in their duration and timing

Dry spells are sequences of days without precipitation. They can have negative implications for societies, including water security and agriculture. For example, changes in their duration and within-year timing can pose a threat to food production and wildfire risk. Conversely, wet spells are sequences of days with precipitation above a certain threshold, and changes in their duration and within-year timing can impact agriculture, flooding or the prevalence of water-related vector-borne diseases. Here we assess changes in the duration and within-year timing of extreme dry and wet spells over 60 years (1958-2017) using a consistent global land surface precipitation dataset of 5093 rain gauge locations. The dataset allowed for detailed spatial analyses of the United States, Europe and Australia. While many locations exhibit statistically significant changes in the duration of extreme dry and wet spells, the changes in the within-year timing are less often significant. Our results show consistencies with observations and projections from state-of-the-art climate and water resources research. In addition, we provide new insights regarding trends in the timing of extreme dry and wet spells, an aspect being equally important for possible future implications of extremes in a changing climate, which has not yet received the same level of attention and is characterized by larger uncertainty