Dosimetric planning of radioiodine therapy on the basis of pharmacokinetic modeling

The program complex of pharmacokinetic modeling and dosimetric planning of radioiodine therapy on the basis of clinical diagnostic data is developed. For 16 patients with the diagnosis «diffuse toxic goiter» (Graves' disease) individual kinetic parameters of transport of the thyroid radiopharmaceutical taken orally are identified and calculations of the absorbed doses in the thyroid, the stomach, the blood tissue, and the periodic-depletion bladder are performed. Three approaches to purpose of activity of radiopharmaceutical and feature of individual dosimetric planning of radioiodine therapy are considered and analysed

Profinite automata

Many sequences of p-adic integers project modulo pα to p-automatic sequences for every α≥0. Examples include algebraic sequences of integers, which satisfy this property for every prime p, and some cocycle sequences, which we show satisfy this property for a fixed p. For such a sequence, we construct a profinite automaton that projects modulo pα to the automaton generating the projected sequence. In general, the profinite automaton has infinitely many states. Additionally, we consider the closure of the orbit, under the shift map, of the p-adic integer sequence, defining a shift dynamical system. We describe how this shift is a letter-to-letter coding of a shift generated by a constant-length substitution defined on an uncountable alphabet, and we establish some dynamical properties of these shifts

Origin and mobility of Iron Age Gaulish groups in present-day France revealed through archaeogenomics

The Iron Age period occupies an important place in French history, as the Gauls are regularly presented as the direct ancestors of the extant French population. We documented here the genomic diversity of Iron Age communities originating from six French regions. The 49 acquired genomes permitted us to highlight an absence of discontinuity between Bronze Age and Iron Age groups in France, lending support to a cultural transition linked to progressive local economic changes rather than to a massive influx of allochthone groups. Genomic analyses revealed strong genetic homogeneity among the regional groups associated with distinct archaeological cultures. This genomic homogenisation appears to be linked to individuals’ mobility between regions as well as gene flow with neighbouring groups from England and Spain. Thus, the results globally support a common genomic legacy for the Iron Age population of modern-day France that could be linked to recurrent gene flow between culturally differentiated communities

Amélioration de la productivité sur une ligne de conditionnement des formes injectables par la méthode SMED

TOURS-BU Sciences Pharmacie (372612104) / SudocSudocFranceF

Physique-Tout le cours en fiches

International audienc

Physique-Tout le cours en fiches

International audienc

Physique-Tout le cours en fiches

International audienc

What Should We Do or Not Do for the Preservation or Remedial Action in Prehistoric Painted Caves?

International audienc