954 research outputs found
Clockwork / Linear Dilaton: Structure and Phenomenology
The linear dilaton geometry in five dimensions, rediscovered recently in the
continuum limit of the clockwork model, may offer a solution to the hierarchy
problem which is qualitatively different from other extra-dimensional scenarios
and leads to distinctive signatures at the LHC. We discuss the structure of the
theory, in particular aspects of naturalness and UV completion, and then
explore its phenomenology, suggesting novel strategies for experimental
searches. In particular, we propose to analyze the diphoton and dilepton
invariant mass spectra in Fourier space in order to identify an approximately
periodic structure of resonant peaks. Among other signals, we highlight
displaced decays from resonantly-produced long-lived states and
high-multiplicity final states from cascade decays of excited gravitons.Comment: 39 pages + appendices, 27 figures; v2: minor improvements; published
versio
ON RANDOM ITERATED FUNCTION SYSTEMS WITH GREYSCALE MAPS
In the theory of Iterated Function Systems (IFSs) it is known that one can find an IFS with greyscale maps (IFSM) to approximate any target signal or image with arbitrary precision, and a systematic approach for doing so was described. In this paper, we extend these ideas to the framework of random IFSM operators. We consider the situation where one has many noisy observations of a particular target signal and show that the greyscale map parameters for each individual observation inherit the noise distribution of the observation. We provide illustrative examples
What is the gamma gamma resonance at 750 GeV?
Run 2 LHC data show hints of a new resonance in the diphoton distribution at
an invariant mass of 750 GeV. We analyse the data in terms of a new boson,
extracting information on its properties and exploring theoretical
interpretations. Scenarios covered include a narrow resonance and, as
preliminary indications suggest, a wider resonance. If the width indications
persist, the new particle is likely to belong to a strongly-interacting sector.
We also show how compatibility between Run 1 and Run 2 data is improved by
postulating the existence of an additional heavy particle, whose decays are
possibly related to dark matter.Comment: v2: 45 pages, 12 figures, final. Factor of 2 changed in table 1, 4th
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Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity.
CD38 genetic variation has been associated with autism spectrum disorders and social anxiety disorder, which may result from CD38's regulation of oxytocin secretion. Converging evidence has found that the rs3796863 A-allele contributes to increased social sensitivity compared to the CC genotype. The current study examined the moderating role of CD38 genetic variants (rs3796863 and rs6449182) that have been associated with enhanced (or reduced) social sensitivity on neural activation related to neuroticism, which is commonly elevated in individuals with social anxiety and depression. Adults (n = 72) with varying levels of social anxiety and depression provided biological samples for DNA extraction, completed a measure of neuroticism, and participated in a standardized emotion processing task (affect matching) while undergoing fMRI. A significant interaction effect was found for rs3796863 x neuroticism that predicted right amygdala-subgenual anterior cingulate cortex (sgACC) functional connectivity. Simple slopes analyses showed a positive association between neuroticism and right amygdala-sgACC connectivity among rs3796863 A-allele carriers. Findings suggest that the more socially sensitive rs3796863 A-allele may partially explain the relationship between a known risk factor (i.e. neuroticism) and promising biomarker (i.e. amygdala-sgACC connectivity) in the development and maintenance of social anxiety and depression
Navigating the noise-depth tradeoff in adiabatic quantum circuits
Adiabatic quantum algorithms solve computational problems by slowly evolving
a trivial state to the desired solution. On an ideal quantum computer, the
solution quality improves monotonically with increasing circuit depth. By
contrast, increasing the depth in current noisy computers introduces more noise
and eventually deteriorates any computational advantage. What is the optimal
circuit depth that provides the best solution? Here, we address this question
by investigating an adiabatic circuit that interpolates between the
paramagnetic and ferromagnetic ground states of the one-dimensional quantum
Ising model. We characterize the quality of the final output by the density of
defects , as a function of the circuit depth and noise strength
. We find that is well-described by the simple form
, where the ideal case is controlled by the Kibble-Zurek mechanism, and the noise
contribution scales as . It follows that the
optimal number of steps minimizing the number of defects goes as
. We implement this algorithm on a noisy superconducting
quantum processor and find that the dependence of the density of defects on the
circuit depth follows the predicted non-monotonous behavior and agrees well
with noisy simulations. Our work allows one to efficiently benchmark quantum
devices and extract their effective noise strength
Functional and morphological evolution in gymnosperms : a portrait of implicated gene families
Gymnosperms diverged from their sister plant clade of flowering plants 300 Mya. Morphological and functional divergence between the two major seed plant clades involved significant changes in their reproductive biology, water‐conducting systems, secondary metabolism, stress defense mechanisms, and small RNA‐mediated epigenetic silencing. The relatively recent sequencing of several gymnosperm genomes and the development of new genomic resources have enabled whole‐genome comparisons within gymnosperms, and between angiosperms and gymnosperms. In this paper, we aim to understand how genes and gene families have contributed to the major functional and morphological differences in gymnosperms, and how this information can be used for applied breeding and biotechnology. In addition, we have analyzed the angiosperm versus gymnosperm evolution of the pleiotropic drug resistance (PDR) gene family with a wide range of functionalities in plants' interaction with their environment including defense mechanisms. Some of the genes reviewed here are newly studied members of gene families that hold potential for biotechnological applications related to commercial and pharmacological value. Some members of conifer gene families can also be exploited for their potential in phytoremediation applications
Unboundedness and downward closures of higher-order pushdown automata
We show the diagonal problem for higher-order pushdown automata (HOPDA), and
hence the simultaneous unboundedness problem, is decidable. From recent work by
Zetzsche this means that we can construct the downward closure of the set of
words accepted by a given HOPDA. This also means we can construct the downward
closure of the Parikh image of a HOPDA. Both of these consequences play an
important role in verifying concurrent higher-order programs expressed as HOPDA
or safe higher-order recursion schemes
Christian-Muslim Relations in a State Church Situation: Politics of Religion and Interfaith Dialogue
No abstract availabl
Primary vs. Secondary Antibody Deficiency: Clinical Features and Infection Outcomes of Immunoglobulin Replacement
<div><p>Secondary antibody deficiency can occur as a result of haematological malignancies or certain medications, but not much is known about the clinical and immunological features of this group of patients as a whole. Here we describe a cohort of 167 patients with primary or secondary antibody deficiencies on immunoglobulin (Ig)-replacement treatment. The demographics, causes of immunodeficiency, diagnostic delay, clinical and laboratory features, and infection frequency were analysed retrospectively. Chemotherapy for B cell lymphoma and the use of Rituximab, corticosteroids or immunosuppressive medications were the most common causes of secondary antibody deficiency in this cohort. There was no difference in diagnostic delay or bronchiectasis between primary and secondary antibody deficiency patients, and both groups experienced disorders associated with immune dysregulation. Secondary antibody deficiency patients had similar baseline levels of serum IgG, but higher IgM and IgA, and a higher frequency of switched memory B cells than primary antibody deficiency patients. Serious and non-serious infections before and after Ig-replacement were also compared in both groups. Although secondary antibody deficiency patients had more serious infections before initiation of Ig-replacement, treatment resulted in a significant reduction of serious and non-serious infections in both primary and secondary antibody deficiency patients. Patients with secondary antibody deficiency experience similar delays in diagnosis as primary antibody deficiency patients and can also benefit from immunoglobulin-replacement treatment.</p></div
Depressive symptoms during early adulthood and the development of physical multimorbidity in the UK: an observational cohort study
Background
An understanding of whether early-life depression is associated with physical multimorbidity could be instrumental for the development of preventive measures and the integrated management of depression. We therefore aimed to map out the cumulative incidence of physical multimorbidity over adulthood, and to determine the association between the presence of depressive symptoms during early adulthood and the development of physical multimorbidity in middle age.
Methods
In this observational cohort study, we used pooled data from the 1958 National Child Development Study (NCDS) and the 1970 British Cohort Study (BCS). Cohort waves were pooled in each decade of adult life available (when cohort members were aged 26 years in the BCS and 23 years in the NCDS [baseline]; 34 years in the BCS and 33 years in the NCDS [age 34 BCS/33 NCDS]; 42 years in the BCS and NCDS [age 42 BCS/NCDS]; and 46 years in the BCS and 50 years in the NCDS [age 46 BCS/50 NCDS]). We included participants who had completed the nine-item Malaise Inventory at baseline, and did not have a history of physical multimorbidity, any physical multimorbidity at baseline, or the presence of depressive symptoms before the development of physical multimorbidity. The presence of depressive symptoms was determined using the nine-item Malaise Inventory (cutoff score ≥4). Physical multimorbidity was defined as having at least two measures of any of the following ten self-reported groups of long-term conditions: asthma or bronchitis; backache; bladder or kidney conditions; cancer; cardiovascular conditions; convulsions or epilepsy; diabetes; hearing conditions; migraine; and stomach, bowel, or gall conditions. Cumulative incidence (with 95% CI) of physical multimorbidity was calculated for each decade considered after baseline, with physical multimorbidity being assessed as both a dichotomous and categorical variable. The association between depressive symptoms and the development of physical multimorbidity was assessed using adjusted relative risk ratios (with 95% CIs).
Findings
Analyses included 15 845 participants, of whom 4001 (25·25%; 95% CI 24·57–25·93) had depressive symptoms at baseline and 11 844 (74·75%; 74·07–75·42) did not. The cumulative incidence of physical multimorbidity (dichotomous) ranged over the study period from 2263 (18·44%; 95% CI 17·75–18·14) of 12 273 participants at age 34 BCS/33 NCDS, to 4496 (42·90%; 41·95–43·85) of 10 481 participants at age 46 BCS/50 NCDS, and was consistently higher in participants with depressive symptoms at baseline. The adjusted relative risk of physical multimorbidity was higher in participants with depressive symptoms than in those without and remained stable over the study period (adjusted relative rate ratio 1·67, 95% CI 1·50–1·87, at age 34 BCS/33 NCDS; 1·63, 1·48–1·79, at age 42 BCS/NCDS; and 1·58, 1·43–1·73, at age 46 BCS/50 NCDS).
Interpretation
The presence of depressive symptoms during early adulthood is associated with an increased risk of the development of physical multimorbidity in middle age. Although further research about the drivers of this relationship is needed, these results could help to enhance the integrated management of individuals with depressive symptoms and the development of preventive strategies to reduce the effect and burden of physical multimorbidity
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