721 research outputs found
Track train dynamics analysis and test program: Methodology development for the derailment safety analysis of six-axle locomotives
The operational safety of six axle locomotives is analyzed. A locomotive model with corresponding data on suspension characteristics, a method of track defect characterization, and a method of characterizing operational safety are used. A user oriented software package was developed as part of the methodology and was used to study the effect (on operational safety) of various locomotive parameters and operational conditions such as speed, tractive effort, and track curvature. The operational safety of three different locomotive designs was investigated
Treatment of travellers' diarrhoea with fleroxacin: a case study
A double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy and safety of fleroxacin for one or two days as treatment for patients with travellers' diarrhoea. A total of 195 patients who were suffering with acute diarrhoea of less than six days' duration were enrolled. One hundred and fifty-one patients, of whom 49 received placebo, 54 received fleroxacin 400 mg for one day and 48 received fleroxacin 400 mg for two days, were included in the analysis of efficacy. The results showed that fleroxacin was significantly superior to placebo, but that there was no significant difference in terms of efficacy between the one- and two-day regimens. Adverse events, particularly minor neuropsychiatric disturbances such as headache and insomnia, were significantly more common amongst patients receiving active treatment. In conclusion, a single dose of fleroxacin 400 mg could be recommended as self-treatment for visitors to high-risk countries who develop travellers' diarrhoe
Probing the Magnetized Interstellar Medium Surrounding the Planetary Nebula Sh 2-216
We present 1420 MHz polarization images of a 2.5 X 2.5 degree region around
the planetary nebula (PN) Sh 2-216. The images are taken from the Canadian
Galactic Plane Survey (CGPS). An arc of low polarized intensity appears
prominently in the north-east portion of the visible disk of Sh 2-216,
coincident with the optically identified interaction region between the PN and
the interstellar medium (ISM). The arc contains structural variations down to
the ~1 arcminute resolution limit in both polarized intensity and polarization
angle. Several polarization-angle "knots" appear along the arc. By comparison
of the polarization angles at the centers of the knots and the mean
polarization angle outside Sh 2-216, we estimate the rotation measure (RM)
through the knots to be -43 +/- 10 rad/m^2. Using this estimate for the RM and
an estimate of the electron density in the shell of Sh 2-216, we derive a
line-of-sight magnetic field in the interaction region of 5.0 +/- 2.0 microG.
We believe it more likely the observed magnetic field is interstellar than
stellar, though we cannot completely dismiss the latter possibility. We
interpret our observations via a simple model which describes the ISM magnetic
field around Sh 2-216, and comment on the potential use of old PNe as probes of
the magnetized ISM.Comment: 25 pages, 4 figures. Accepted for publication in the Astrophysical
Journa
Glucose-nonfermenting Gram-negative bacilli associated with clinical veterinary specimens.
Glucose-nonfermenting gram-negative bacilli (NFB) have been recognized recently as opportunistic pathogens of humans. With few exceptions, strains of NFB have not been considered important enough to be identified when isolated from animals. In this study, all NFB isolated during a 1-year period in a clinical veterinary microbiology laboratory were identified to determine their prevalence. Of the 347 strains of NFB obtained, the most common species were Pseudomonas aeruginosa, Acinetobacter calcoaceticus, Bordetella bronchiseptica, and Pseudomonas pseudoalcaligenes. Of all clinical veterinary specimens submitted for cultures, 10% contained nonfermenters
Metal Abundances in the Magellanic Stream
We report on the first metallicity determination for gas in the Magellanic
Stream, using archival HST GHRS data for the background targets Fairall 9, III
Zw 2, and NGC 7469. For Fairall 9, using two subsequent HST revisits and new
Parkes Multibeam Narrowband observations, we have unequivocally detected the
MSI HI component of the Stream (near its head) in SII1250,1253 yielding a
metallicity of [SII/H]=-0.55+/-0.06(r)+/-0.2(s), consistent with either an SMC
or LMC origin and with the earlier upper limit set by Lu et al. (1994). We also
detect the saturated SiII1260 line, but set only a lower limit of
[SiII/H]>-1.5. We present serendipitous detections of the Stream, seen in
MgII2796,2803 absorption with column densities of (0.5-1)x10^13 cm^-2 toward
the Seyfert galaxies III Zw 2 and NGC 7469. These latter sightlines probe gas
near the tip of the Stream (80 deg down-Stream of Fairall 9). For III Zw 2, the
lack of an accurate HI column density and the uncertain MgIII ionization
correction limits the degree to which we can constrain [Mg/H]; a lower limit of
[MgII/HI]>-1.3 was found. For NGC 7469, an accurate HI column density
determination exists, but the extant FOS spectrum limits the quality of the
MgII column density determination, and we conclude that [MgII/HI]>-1.5.
Ionization corrections associated with MgIII and HII suggest that the
corresponding [Mg/H] may range lower by 0.3-1.0 dex. However, an upward
revision of 0.5-1.0 dex would be expected under the assumption that the Stream
exhibits a dust depletion pattern similar to that seen in the Magellanic
Clouds. Remaining uncertainties do not allow us to differentiate between an LMC
versus SMC origin to the Stream gas.Comment: 30 pages, 8 figures, LaTeX (aaspp4), also available at
http://casa.colorado.edu/~bgibson/publications.html, accepted for publication
in The Astronomical Journa
Polarization of Broad Absorption Line QSOs I. A Spectropolarimetric Atlas
We present a spectropolarimetric survey of 36 broad absorption line
quasi-stellar objects (BAL QSOs). The continuum, absorption trough, and
emission line polarization of BAL QSOs yield clues about their structure. We
confirm that BAL QSOs are in general more highly polarized than non-BAL QSOs,
consistent with a more equatorial viewing direction for the former than the
latter. We have identified two new highly-polarized QSOs in our sample
(1232+1325 and 1333+2840). The polarization rises weakly to the blue in most
objects, perhaps due to scattering and absorption by dust particles. We find
that a polarization increase in the BAL troughs is a general property of
polarized BAL QSOs, indicating an excess of scattered light relative to direct
light, and consistent with the unification of BAL QSOs and non-BAL QSOs. We
have also discovered evidence of resonantly scattered photons in the red wing
of the C IV broad emission lines of a few objects. In most cases, the broad
emission lines have lower polarization and a different position angle than the
continuum. The polarization characteristics of low-ionization BAL QSOs are
similar to those of high-ionization BAL QSOs, suggesting a similar BAL wind
geometry.Comment: 39 pages, 6 figures (20 .gif files), accepted for publication in The
Astrophysical Journal Supplement
Why royalties ? Evidence from French distribution networks

Working paper GATE 2011-02This empirical note deals with the contractual design of relationships in distribution networks. In the framework of agency theory, I study the royalty rate as an incentive device for the upstream firm in maintaining brand-name value, using recent French data to estimate probit models. The results are consistent with the analytical framework
Alpha-band rhythms in visual task performance: phase-locking by rhythmic sensory stimulation
Oscillations are an important aspect of neuronal activity. Interestingly, oscillatory patterns are also observed in behaviour, such as in visual performance measures after the presentation of a brief sensory event in the visual or another modality. These oscillations in visual performance cycle at the typical frequencies of brain rhythms, suggesting that perception may be closely linked to brain oscillations. We here investigated this link for a prominent rhythm of the visual system (the alpha-rhythm, 8-12 Hz) by applying rhythmic visual stimulation at alpha-frequency (10.6 Hz), known to lead to a resonance response in visual areas, and testing its effects on subsequent visual target discrimination. Our data show that rhythmic visual stimulation at 10.6 Hz: 1) has specific behavioral consequences, relative to stimulation at control frequencies (3.9 Hz, 7.1 Hz, 14.2 Hz), and 2) leads to alpha-band oscillations in visual performance measures, that 3) correlate in precise frequency across individuals with resting alpha-rhythms recorded over parieto-occipital areas. The most parsimonious explanation for these three findings is entrainment (phase-locking) of ongoing perceptually relevant alpha-band brain oscillations by rhythmic sensory events. These findings are in line with occipital alpha-oscillations underlying periodicity in visual performance, and suggest that rhythmic stimulation at frequencies of intrinsic brain-rhythms can be used to reveal influences of these rhythms on task performance to study their functional roles
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Setting targets for HIV/AIDS-What lessons can be learned from other disease control programmes?
Our analysis of experience from programmes targeting malaria, leprosy and TB shows the importance of drawing broadly on research and implementation expertise, and civil society more broadly, when setting targets for HIV control. The engagement of stakeholders from the highest burden settings, including affected populations, is crucial, to ensure that disease control efforts uphold human rights and tackle HIV-related stigma and discrimination.
An appropriate balance is needed between ambitious, galvanising global targets that drive funding and political/public engagement, and targets that reflect the complexities and local epidemiological variations in disease profile. Ethical issues and unintended consequences need to be considered when setting targets—particularly around local effects and opportunity costs of having foregone other areas of disease control and public health. Intermediate and adaptable targets are needed that allow for course corrections to programmes.
Overly burdensome reporting requirements for individual local programmes and countries should be avoided, as well as potential for overlapping and sometimes conflicting targets both within and across vertical disease programmes. Process targets should be distinguished from outcome targets, which should be measurable and based on high-quality data.
Retention of expert healthcare worker skills and specialist services is vital, while moving towards integrated health systems if effective disease control programmes are to be maintained. Target development should seek areas of programme delivery where an opportunity to codevelop targets and integrate services exists. Global efforts to move to universal health coverage (UHC), for example, could be factored in when developing targets.
Sustaining investment and continuing political interest in the end phase of any elimination or eradication strategy, once incidence and prevalence are low, are critical to achieve success. Equity- and access-based service delivery targets become increasingly important as the elimination strategy nears its end and should be factored into planning.
Achieving disease elimination and/or eradication is only possible with sufficient investment in research to develop new prevention tools such as vaccines, point-of-care diagnostics, and treatments to counteract the effects of increasing drug resistance and the challenging latency period of diseases; public health infrastructure upgrades that address wider determinants of health; and health and surveillance systems that allow for equitable delivery and access to services
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