1,914 research outputs found
Transmission line design for a power distribution system at 20 kHz for aircraft
A low inductance, low characteristic impedance transmission line was designed for a 20 kHz power distribution system. Several different conductor configurations were considered: strip lines, interdigitated metal ribbons, and standard insulated wires in multiwire configurations (circular and rectangular cylindrical arrangements). The final design was a rectangular arrangement of multiple wires of the same gauge with alternating polarities from wire to wire. This offered the lowest inductance per unit length (on the order of several nanohenries/meter) and the lowest characteristic impedance (on the order of one Ohm). Standard multipin connectors with gold-plated elements were recommended with this transmission line, the junction boxes to be internally connected with flat metal ribbons for low inductance, and the line to be constructed in sections of suitable length. Computer programs for the calculation of inductance of multiwire lines and of capacitances of strip lines were developed
ARXPS-studies ofcˆ-axis textured YBa2Cu3Ox-films
YBa2Cu3Ox sputter deposited cold on MgO grows in O2 annealing epitaxially to a transparent, superconducting film with Tc 80K. The unscraped surfaces of these films are smooth showing XPS lines changing with photoelectron take-off angle. This enhanced data base allows to separate the different chemical compounds (hydroxide, peroxide, carbonate, carboxyle, cuprate, graphite ...) and to obtain their spatial distribution. This yields the compounds, their amount and distribution making up the cinder growing with O2-anneal at internal and external surfaces. The cinder stoichiometry gives insights in the chemistry going on in O2 annealing. Below the cinder the signature ofcˆ-axis oriented YBa2Cu3Ox is identified, showing that a Ba-oxide layer forms the stable surface. This coats insulating CuO2 and Y-oxide layers yielding so an intrinsic dead layer
Search for hidden-photon dark matter with the FUNK experiment
Many extensions of the Standard Model of particle physics predict a parallel
sector of a new U(1) symmetry, giving rise to hidden photons. These hidden
photons are candidate particles for cold dark matter. They are expected to
kinetically mix with regular photons, which leads to a tiny oscillating
electric-field component accompanying dark matter particles. A conducting
surface can convert such dark matter particles into photons which are emitted
almost perpendicularly to the surface. The corresponding photon frequency
follows from the mass of the hidden photons. In this contribution we present a
preliminary result on a hidden photon search in the visible and near-UV
wavelength range that was done with a large, 14 m2 spherical metallic mirror
and discuss future dark matter searches in the eV and sub-eV range by
application of different detectors for electromagnetic radiation.Comment: Contribution to the 35th International Cosmic Ray Conference
ICRC2017, 10 to 20 July, 2017, Bexco, Busan, Korea. arXiv admin note: text
overlap with arXiv:1711.0296
Position des Grundschullehramts im Bildungssystem und Konsequenzen für die Ausbildung von Grundschullehrkräften
Die Verfasserinnen fokussieren die Grundschule als Institution im deutschen Bildungssystem. Daraus leiten sie Stellenwert und Bedeutungszuschreibungen ab und verweisen auf sowohl breit angelegte als auch ambivalente Anforderungen an Grundschullehrkräfte. Eine Analyse von Ausbildungsstrukturen, Besoldung, Stundendeputaten und Quer-oder Seiteneinstiegsmöglichkeiten soll Aufschluss über den Stellenwert des Grundschullehramts geben. Dabei zeigt sich ein heterogenes Bild der einzelnen Bundesländer. (DIPF/Orig.
The influence of contour fragmentation on recognition memory: An event-related potential study
Multifunctional PLGA nanoparticles combining transferrin-targetability and pH-stimuli sensitivity enhanced doxorubicin intracellular delivery and in vitro antineoplastic activity in MDR tumor cells
Targeted delivery aims to enhance cellular uptake and improve therapeutic outcome with higher disease specificity. The expression of transferrin receptor (TfR) is upregulated on tumor cells, which make the protein Tf and its receptor vastly relevant when applied to targeting strategies. Here, we proposed Tf-decorated pH-sensitive PLGA nanoparticles containing the chemosensitizer poloxamer as a carrier for doxorubicin delivery to tumor cells (Tf-DOX-PLGA-NPs), aiming at alleviating multidrug resistance (MDR). We performed a range of in vitro studies to assess whether targeted NPs have the ability to improve DOX antitumor potential on resistant NCI/ADR-RES cells. All evaluations of the Tf-decorated NPs were performed comparatively to the nontargeted counterparts, aiming to evidence the real role of NP surface functionalization, along with the benefits of pH-sensitivity and poloxamer, in the improvement of antiproliferative activity and reversal of MDR. Tf-DOX-PLGA-NPs induced higher number of apoptotic events and ROS generation, along with cell cycle arrest. Moreover, they were efficiently internalized by NCI/ADR-RES cells, increasing DOX intracellular accumulation, which supports the greater cell killing ability of these targeted NPs with respect to MDR cells. Altogether, these findings supported the effectiveness of the Tf-surface modification of DOX-PLGA-NPs for an improved antiproliferative activity. Therefore, our pH-responsive Tf-inspired NPs are a promising smart drug delivery system to overcome MDR effect at some extent, enhancing the efficacy of DOX antitumor therapy
Joint Elastic Side-Scattering Lidar and Raman Lidar Measurements of Aerosol Optical Properties in South East Colorado
We describe an experiment, located in south-east Colorado, USA, that measured
aerosol optical depth profiles using two Lidar techniques. Two independent
detectors measured scattered light from a vertical UV laser beam. One detector,
located at the laser site, measured light via the inelastic Raman
backscattering process. This is a common method used in atmospheric science for
measuring aerosol optical depth profiles. The other detector, located
approximately 40km distant, viewed the laser beam from the side. This detector
featured a 3.5m2 mirror and measured elastically scattered light in a bistatic
Lidar configuration following the method used at the Pierre Auger cosmic ray
observatory. The goal of this experiment was to assess and improve methods to
measure atmospheric clarity, specifically aerosol optical depth profiles, for
cosmic ray UV fluorescence detectors that use the atmosphere as a giant
calorimeter. The experiment collected data from September 2010 to July 2011
under varying conditions of aerosol loading. We describe the instruments and
techniques and compare the aerosol optical depth profiles measured by the Raman
and bistatic Lidar detectors.Comment: 34 pages, 16 figure
An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo
The glucagon-like peptide-1 receptor (GLP1R) is expressed in peripheral tissues and the brain, where it exerts pleiotropic actions on metabolic and inflammatory processes. Detection and visualization of GLP1R remains challenging, partly due to a lack of validated reagents. Previously, we generated LUXendins, antagonistic red and far-red fluorescent probes for specific labeling of GLP1R in live and fixed cells/tissue. We now extend this concept to the green and near-infrared color ranges by synthesizing and testing LUXendin492, LUXendin551, LUXendin615 and LUXendin762. All four probes brightly and specifically label GLP1R in cells and pancreatic islets. Further, LUXendin551 acts as chemical beta cell reporter in preclinical rodent models, while LUXendin762 allows non-invasive imaging, highlighting differentially-accessible GLP1R populations. We thus expand the color palette of LUXendins to seven different spectra, opening up a range of experiments using widefield microscopy available in most labs through super-resolution imaging and whole animal imaging. With this, we expect that LUXendins will continue to generate novel and specific insight into GLP1R biology
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