Three-dimensional super Yang-Mills with unquenched flavor

We construct analytically the gravity duals of three-dimensional, super Yang-Mills-type theories with $\mathcal N=1$ supersymmetry coupled to $N_f$ quark flavors. The backreaction of the quarks on the color degrees of freedom is included, and corresponds on the gravity side to the backreaction of $N_f$ D6-branes on the background of $N$ D2-branes. The D6-branes are smeared over the compact part of the geometry, which must be a six-dimensional nearly K\"ahler manifold in order to preserve supersymmetry. For massless quarks, the solutions flow in the IR to an $AdS_4$ fixed point dual to a Chern-Simons-matter theory. For light quarks the theories exhibit quasi-conformal dynamics (walking) at energy scales $m_q \ll E \ll \lambda N_f / N$, with $\lambda = g_{\text{YM}}^2 N$ the 't Hooft coupling.Comment: 21 pages, 1 figure. v2 Minor editing, refs. added. Tallies with published versio

(Super)Yang-Mills at Finite Heavy-Quark Density

We study the gravitational duals of $d$-dimensional Yang-Mills theories with $d\leq 6$ in the presence of an ${\cal O} (N^2)$ density of heavy quarks, with $N$ the number of colors. For concreteness we focus on maximally supersymmetric Yang-Mills, but our results apply to a larger class of theories with or without supersymmetry. The gravitational solutions describe renormalization group flows towards infrared scaling geometries characterized by fixed dynamical and hyperscaling-violating exponents. The special case $d=5$ yields an $AdS_3 \times \mathbb{R}^4 \times S^4$ geometry upon uplifting to M-theory. We discuss the multitude of physical scales that separate different dynamical regimes along the flows, as well as the validity of the supergravity description. We also present exact black brane solutions that encode the low-temperature thermodynamics.Comment: 40 pages, 8 figures, 2 table

Multiple Mass Hierarchies from Complex Fixed Point Collisions

A pair of complex-conjugate fixed points that lie close to the real axis generates a large mass hierarchy in the real renormalization group flow that passes in between them. We show that pairs of complex fixed points that are close to the real axis and to one another generate multiple hierarchies, some of which can be parametrically enhanced. We illustrate this effect at weak coupling with field-theory examples, and at strong coupling using holography. We also construct complex flows between complex fixed points, including flows that violate the $c$-theorem.Comment: 24 pages + appendices, 12 figure

Anti-trbc1 antibody-based flow cytometric detection of t-cell clonality: Standardization of sample preparation and diagnostic implementation

© 2021 by the authors.A single antibody (anti-TRBC1; JOVI-1 antibody clone) against one of the two mutually exclusive T-cell receptor β-chain constant domains was identified as a potentially useful flow-cytometry (FCM) marker to assess Tαβ-cell clonality. We optimized the TRBC1-FCM approach for detecting clonal Tαβ-cells and validated the method in 211 normal, reactive and pathological samples. TRBC1 labeling significantly improved in the presence of CD3. Purified TRBC1+ and TRBC1− monoclonal and polyclonal Tαβ-cells rearranged TRBJ1 in 44/47 (94%) and TRBJ1+TRBJ2 in 48 of 48 (100%) populations, respectively, which confirmed the high specificity of this assay. Additionally, TRBC1+/TRBC1− ratios within different Tαβ-cell subsets are provided as reference for polyclonal cells, among which a bimodal pattern of TRBC1-expression profile was found for all TCRVβ families, whereas highly-variable TRBC1+/TRBC1− ratios were observed in more mature vs. naïve Tαβ-cell subsets (vs. total T-cells). In 112/117 (96%) samples containing clonal Tαβ-cells in which the approach was validated, monotypic expression of TRBC1 was confirmed. Dilutional experiments showed a level of detection for detecting clonal Tαβ-cells of ≤10−4 in seven out of eight pathological samples. These results support implementation of the optimized TRBC1-FCM approach as a fast, specific and accurate method for assessing T-cell clonality in diagnostic-FCM panels, and for minimal (residual) disease detection in mature Tαβ+ leukemia/lymphoma patients.This work was supported by the CB16/12/00400 (CIBERONC) and PI20-01346 grants, from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (Madrid, Spain) and FONDOS FEDER, and by the EuroFlow Foundation (Leiden, The Netherlands). N. Muñoz-García is supported by a pre-doctoral grant (Ref. IBPredoc17/00012) from IBSAL (Salamanca, Spain). M. Lima, N. Villamor, A.W. Langerak, J.J.M. van Dongen, A. Orfao, and J. Almeida are members of the EuroFlow Consortiu

Quantifying and addressing the prevalence and bias of study designs in the environmental and social sciences

Abstract: Building trust in science and evidence-based decision-making depends heavily on the credibility of studies and their findings. Researchers employ many different study designs that vary in their risk of bias to evaluate the true effect of interventions or impacts. Here, we empirically quantify, on a large scale, the prevalence of different study designs and the magnitude of bias in their estimates. Randomised designs and controlled observational designs with pre-intervention sampling were used by just 23% of intervention studies in biodiversity conservation, and 36% of intervention studies in social science. We demonstrate, through pairwise within-study comparisons across 49 environmental datasets, that these types of designs usually give less biased estimates than simpler observational designs. We propose a model-based approach to combine study estimates that may suffer from different levels of study design bias, discuss the implications for evidence synthesis, and how to facilitate the use of more credible study designs