Conus barbieri Raybaudi Massilia, 1995

Catálogo do Museo de Historia Natural USC. n. inventario 10009

Conus korni G. Raybaudi Massilia, 1993

Catálogo do Museo de Historia Natural USC. n. inventario 10012

Equilibrio trabajo familia y apoyo social en mujeres emprendedoras de la región del Maule.

57 p.La presente investigación tiene como objetivo identificar la relación de equilibrio trabajo- familia y apoyo social en las mujeres emprendedoras de la región del Maule. Por ello nuestro problema de investigación consiste en investigar cómo se encuentran las mujeres emprendedoras de la región del Maule, respecto a las variables equilibrio trabajo familia y apoyo social. A 100 mujeres con actividad emprendedora, pertenecientes a diversos programas, se les administraron los siguientes cuestionarios: Cuestionario de Interacción Trabajo-Familia, SWING (Moreno, Sanz, Rodríguez & Geurts, 2009), Escala Multidimensional de Percepción de Apoyo Social (The Multidimensional Scale of Perceived Social Support, MSPSS) y Cuestionario de Emprendimiento y Familia. La selección se realizó de forma no probabilística, no al azar, de manera intencionada, dado que se seleccionaron mujeres que forman parte de los programas Jefas de Hogar de la Ciudad de Linares, Jefas de Hogar de la ciudad de Talca, Capital Semilla Emprende y Capital Abeja Emprende de la ciudad de Talca. Se observa que los resultados del análisis de correlación entre la Interacción Trabajo- Familia y Apoyo Social señalaron que a mayor Interacción Trabajo - Familia, menor Apoyo Social y viceversa. Como conclusión, podemos concretar que la hipótesis general no se mantuvo, debido a que las variables son inversamente proporcionales. Se sugiere incorporar en futuras investigaciones variables como el apoyo familiar, funcionamiento familiar y autoeficacia parental. Respecto a las políticas públicas que existen en Chile, existe un valor elevado en cuanto a los costos y barreras para iniciar empresas que provengan del emprendimiento, así como las regulaciones y procesos burocráticos que dificultan elevadamente el incentivo a la creación de actividades emprendedoras y la potenciación de nuevas empresas. Palabras clave: Equilibrio Trabajo-Familia, Apoyo Social y Emprendimient

Omenn syndrome: the drama of a family, congenital ichthyosis is not always mundane!

Background: The case we are reporting is about one of the rare manifestations of severe combined immunodeficiency, Omenn syndrome (OS). Case presentation: A 43-days-old female presented with thick diffuse erythrodermic scaly ichthyosiform lesions on the scalp, face, and trunk since birth. lymphadenopathy, splenomegaly, and growth retardation as well as eosinophilia and increased serum IgE levels. A pregnancy was planned for an allograft of bone marrow, but the procedure was not carried out due to a persistent post-covid pneumopathy with bilateral parenchymal condensation that resulted in death. Conclusion: This case report intends to incite clinicians to be alert to this possible diagnosis and not to underrate an immune deficiency in the case of neonatal erythroderma

Eugenol and carvacrol migration from PHBV films and antibacterial action in different food matrices

[EN] The antibacterial effect of PHBV films with oregano or clove essential oil, or their main compounds, carvacrol (CA) and eugenol (EU), respectively, was analysed in food matrices (cheese, chicken breast and pumpkin and melon) and in vitro test for Escherichia coli and Listeria innocua. The migration of CA and EU in the different food matrices was determined to analyse the food matrix effect on the film¿s antimicrobial effectiveness. The antimicrobial activity in foods was less remarkable than in in vitro test. Despite the antilisterial effect in the in vitro test, this was not noticed in any food matrix. The most significant antibacterial effects against E. coli were observed in cheese and pumpkin, whereas the highest migration of both CA and UE took place in melon. This lack of correlation reflected that many compositional factors affect the active compound¿s availability to exert its antibacterial action in a specific food.The authors thank the Ministerio de Economía y Competitividad (Spain) for the financial support provided through Project AGL2016-76699-R. Author Raquel Requena thanks the Ministry of Education, Culture and Sport (Spain) for the FPU (FPU13/03444) Grant.Requena-Peris, R.; Vargas, M.; Chiralt A. (2019). Eugenol and carvacrol migration from PHBV films and antibacterial action in different food matrices. Food Chemistry. 277:38-45. https://doi.org/10.1016/j.foodchem.2018.10.093S384527

Cupricyclins, Novel Redox-Active Metallopeptides Based on Conotoxins Scaffold

Highly stable natural scaffolds which tolerate multiple amino acid substitutions represent the ideal starting point for the application of rational redesign strategies to develop new catalysts of potential biomedical and biotechnological interest. The knottins family of disulphide-constrained peptides display the desired characteristics, being highly stable and characterized by hypervariability of the inter-cysteine loops. The potential of knottins as scaffolds for the design of novel copper-based biocatalysts has been tested by engineering a metal binding site on two different variants of an ω-conotoxin, a neurotoxic peptide belonging to the knottins family. The binding site has been designed by computational modelling and the redesigned peptides have been synthesized and characterized by optical, fluorescence, electron spin resonance and nuclear magnetic resonance spectroscopy. The novel peptides, named Cupricyclin-1 and -2, bind one Cu2+ ion per molecule with nanomolar affinity. Cupricyclins display redox activity and catalyze the dismutation of superoxide anions with an activity comparable to that of non-peptidic superoxide dismutase mimics. We thus propose knottins as a novel scaffold for the design of catalytically-active mini metalloproteins