Real-time in vivo dosimetry in high dose rate prostate brachytherapy

Background and purpose: Single fraction treatments of 15 Gy or 19 Gy are common in HDR prostate brachytherapy. In vivo dosimetry (IVD) is therefore important to ensure patient safety. This study assesses clinical IVD and investigates error detection thresholds for real-time treatment monitoring. Materials and methods: IVD was performed for 40 treatments planned using intra-operative trans-rectal ultrasound (TRUS) with a MOSFET inserted into an additional needle. Post-treatment TRUS images were acquired for 20 patients to assess needle movement. Monte Carlo simulations of treatment plans were performed for 10 patients to assess impact of heterogeneities. Per-needle and total plan uncertainties were estimated and retrospectively applied to the measured data as error detection thresholds. Results: The mean measured dose was −6.4% compared to prediction (range + 5.1% to −15.2%). Needle movement and heterogeneities accounted for −1.8% and −1.6% of this difference respectively (mean values for the patients analysed). Total plan uncertainty (k = 2) ranged from 11% to 17% and per needle uncertainty (k = 2) ranged from 18% to 110% (mean 31%). One out of 40 plans and 5% of needles were outside k = 2 error detection threshold. Conclusions: IVD showed good agreement with predicted dose within measurement uncertainties, providing reassurance in the accuracy of dose delivery. Thresholds for real-time error detection should be calculated on an individual plan/needle basis

Transistor Circuits

Contains research objectives and reports on two research projects

Observations and Simulations of Basin Effects in the Kathmandu Valley During the 2015 Gorkha, Nepal, Earthquake Sequence

The M7.8 Gorkha, Nepal main shock ruptured a segment of the Main Himalayan Thrust (MHT) directly below Kathmandu Valley, causing strong shaking levels across the valley. Strong-motion data reveal an initial 6 s source pulse that was amplified and reverberated within the basin. One of the striking features of the observed ground motions in the valley was the exceptionally low energy of periods less than 2 s, which likely limited the extent and severity of structural damage in Kathmandu compared with alternative rupture scenarios of the same magnitude in the region. Isolated cases of liquefaction and lateral spreading of unconsolidated sediments were also observed, but have not yet revealed a systematic damage pattern. Initial analysis of available data suggests that several different factors, including source and path as well as site effects, were responsible for the unusual ground motions characteristics. In this paper, we provide a short description of the Kathmandu Valley geology and analyze available strong-motion records from the main shock and three strong aftershocks, with the intent to shed light on earthquake reconnaissance observations from this earthquake

Circuit Theory

Contains research objectives and reports on two research projects.U.S. Air Force under Air Force Contract AF19(604)-5200Lincoln Laboratory, Purchase Order DDL-B22

First Results from the KMOS Lens-Amplified Spectroscopic Survey (KLASS): Kinematics of Lensed Galaxies at Cosmic Noon

We present the first results of the KMOS Lens-Amplified Spectroscopic Survey (KLASS), a new ESO Very Large Telescope (VLT) large program, doing multi-object integral field spectroscopy of galaxies gravitationally lensed behind seven galaxy clusters selected from the HST Grism Lens-Amplified Survey from Space (GLASS). Using the power of the cluster magnification we are able to reveal the kinematic structure of 25 galaxies at $0.7 \lesssim z \lesssim 2.3$, in four cluster fields, with stellar masses $8 \lesssim \log{(M_\star/M_\odot)} \lesssim 11$. This sample includes 5 sources at $z>1$ with lower stellar masses than in any previous kinematic IFU surveys. Our sample displays a diversity in kinematic structure over this mass and redshift range. The majority of our kinematically resolved sample is rotationally supported, but with a lower ratio of rotational velocity to velocity dispersion than in the local universe, indicating the fraction of dynamically hot disks changes with cosmic time. We find no galaxies with stellar mass $<3 \times 10^9 M_\odot$ in our sample display regular ordered rotation. Using the enhanced spatial resolution from lensing, we resolve a lower number of dispersion dominated systems compared to field surveys, competitive with findings from surveys using adaptive optics. We find that the KMOS IFUs recover emission line flux from HST grism-selected objects more faithfully than slit spectrographs. With artificial slits we estimate slit spectrographs miss on average 60% of the total flux of emission lines, which decreases rapidly if the emission line is spatially offset from the continuum.Comment: Accepted for publication in Ap

Inferences on the Timeline of Reionization at z~8 From the KMOS Lens-Amplified Spectroscopic Survey

Detections and non-detections of Lyman alpha (Ly$\alpha$) emission from $z>6$ galaxies ($<1$ Gyr after the Big Bang) can be used to measure the timeline of cosmic reionization. Of key interest to measuring reionization's mid-stages, but also increasing observational challenge, are observations at z > 7, where Ly$\alpha$ redshifts to near infra-red wavelengths. Here we present a search for z > 7.2 Ly$\alpha$ emission in 53 intrinsically faint Lyman Break Galaxy candidates, gravitationally lensed by massive galaxy clusters, in the KMOS Lens-Amplified Spectroscopic Survey (KLASS). With integration times of ~7-10 hours, we detect no Ly$\alpha$ emission with S/N>5 in our sample. We determine our observations to be 80% complete for 5$\sigma$ spatially and spectrally unresolved emission lines with integrated line flux $>5.7\times10^{-18}$ erg s$^{-1}$ cm$^{-2}$. We define a photometrically selected sub-sample of 29 targets at $z=7.9\pm0.6$, with a median 5$\sigma$ Ly$\alpha$ EW limit of 58A. We perform a Bayesian inference of the average intergalactic medium (IGM) neutral hydrogen fraction using their spectra. Our inference accounts for the wavelength sensitivity and incomplete redshift coverage of our observations, and the photometric redshift probability distribution of each target. These observations, combined with samples from the literature, enable us to place a lower limit on the average IGM neutral hydrogen fraction of $> 0.76 \; (68\%), \; > 0.46 \; (95\%)$ at z ~ 8, providing further evidence of rapid reionization at z~6-8. We show that this is consistent with reionization history models extending the galaxy luminosity function to $M_\textrm{UV} \lesssim -12$, with low ionizing photon escape fractions, $f_\textrm{esc} \lesssim 15\%$.Comment: Accepted for publication in MNRA

Through the looking GLASS: HST spectroscopy of faint galaxies lensed by the Frontier Fields cluster MACS0717.5+3745

The Grism Lens-Amplified Survey from Space (GLASS) is a Hubble Space Telescope (HST) Large Program, which will obtain 140 orbits of grism spectroscopy of the core and infall regions of 10 galaxy clusters, selected to be among the very best cosmic telescopes. Extensive HST imaging is available from many sources including the CLASH and Frontier Fields programs. We introduce the survey by analyzing spectra of faint multiply-imaged galaxies and $z\gtrsim6$ galaxy candidates obtained from the first seven orbits out of fourteen targeting the core of the Frontier Fields cluster MACS0717.5+3745. Using the G102 and G141 grisms to cover the wavelength range 0.8-1.7$\mu$m, we confirm 4 strongly lensed systems by detecting emission lines in each of the images. For the 9 $z\gtrsim6$ galaxy candidates clear from contamination, we do not detect any emission lines down to a seven-orbit 1$\sigma$ noise level of $\sim$5$\times$10$^{-18}$erg s$^{-1}$cm$^{-2}$. Taking lensing magnification into account, our flux sensitivity reaches $\sim$0.2-5$\times$10$^{-18}$erg s$^{-1}$cm$^{-2}$. These limits over an uninterrupted wavelength range rule out the possibility that the high-$z$ galaxy candidates are instead strong line emitters at lower redshift. These results show that by means of careful modeling of the background - and with the assistance of lensing magnification - interesting flux limits can be reached for large numbers of objects, avoiding pre-selection and the wavelength restrictions inherent to ground-based multi-slit spectroscopy. These observations confirm the power of slitless HST spectroscopy even in fields as crowded as a cluster core.Comment: Accepted by ApJ letters, 8 pages, 4 figures, GLASS website at http://glass.physics.ucsb.ed

The Grism Lens-Amplified Survey from Space (GLASS). I. Survey overview and first data release

We give an overview of the Grism Lens Amplified Survey from Space (GLASS), a large Hubble Space Telescope program aimed at obtaining grism spectroscopy of the fields of ten massive clusters of galaxies at redshift z=0.308-0.686, including the Hubble Frontier Fields (HFF). The Wide Field Camera 3 yields near infrared spectra of the cluster cores, covering the wavelength range 0.81-1.69mum through grisms G102 and G141, while the Advanced Camera for Surveys in parallel mode provides G800L spectra of the infall regions of the clusters. The WFC3 spectra are taken at two almost orthogonal position angles in order to minimize the effects of confusion. After summarizing the scientific drivers of GLASS, we describe the sample selection as well as the observing strategy and data processing pipeline. We then utilize MACSJ0717.5+3745, a HFF cluster and the first one observed by GLASS, to illustrate the data quality and the high-level data products. Each spectrum brighter than H_AB=23 is visually inspected by at least two co-authors and a redshift is measured when sufficient information is present in the spectra. Furthermore, we conducted a thorough search for emission lines through all the GLASS WFC3 spectra with the aim of measuring redshifts for sources with continuum fainter than H_AB=23. We provide a catalog of 139 emission-line based spectroscopic redshifts for extragalactic sources, including three new redshifts of multiple image systems (one probable, two tentative). In addition to the data itself we also release software tools that are helpful to navigate the data.Comment: ApJ in press. GLASS data available at https://archive.stsci.edu/prepds/glass/ . More info on GLASS available at http://glass.physics.ucsb.edu

Alewife planktivory controls the abundance of two invasive predatory cladocerans in Lake Michigan

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74873/1/j.1365-2427.2007.01728.x.pd

Detection of Lyman-Alpha Emission From a Triple Imaged z=6.85 Galaxy Behind MACS J2129.4-0741

We report the detection of Ly$\alpha$ emission at $\sim9538$\AA{} in the Keck/DEIMOS and \HST WFC3 G102 grism data from a triply-imaged galaxy at $z=6.846\pm0.001$ behind galaxy cluster MACS J2129.4$-$0741. Combining the emission line wavelength with broadband photometry, line ratio upper limits, and lens modeling, we rule out the scenario that this emission line is \oii at $z=1.57$. After accounting for magnification, we calculate the weighted average of the intrinsic Ly$\alpha$ luminosity to be $\sim1.3\times10^{42}~\mathrm{erg}~\mathrm{s}^{-1}$ and Ly$\alpha$ equivalent width to be $74\pm15$\AA{}. Its intrinsic UV absolute magnitude at 1600\AA{} is $-18.6\pm0.2$ mag and stellar mass $(1.5\pm0.3)\times10^{7}~M_{\odot}$, making it one of the faintest (intrinsic $L_{UV}\sim0.14~L_{UV}^*$) galaxies with Ly$\alpha$ detection at $z\sim7$ to date. Its stellar mass is in the typical range for the galaxies thought to dominate the reionization photon budget at $z\gtrsim7$; the inferred Ly$\alpha$ escape fraction is high ($\gtrsim 10$\%), which could be common for sub-$L^*$ $z\gtrsim7$ galaxies with Ly$\alpha$ emission. This galaxy offers a glimpse of the galaxy population that is thought to drive reionization, and it shows that gravitational lensing is an important avenue to probe the sub-$L^*$ galaxy population.Comment: Accepted by ApJ Letter