Focusing on the extended X-ray emission in 3C 459 with a Chandra follow-up observation

6 pages, 4 figures. Reproduced with permission from Astronomy & Astrophysics. © 2019 ESO.Aims. We investigated the X-ray emission properties of the powerful radio galaxy 3C 459 revealed by a recent Chandra follow-up observation carried out in October 2014 with a 62 ks exposure. Methods. We performed an X-ray spectral analysis from a few selected regions on an image obtained from this observation and also compared the X-ray image with a 4.9 GHz VLA radio map available in the literature. Results. The dominant contribution comes from the radio core but significant X-ray emission is detected at larger angular separations from it, surrounding both radio jets and lobes. According to a scenario in which the extended X-ray emission is due to a plasma collisionally heated by jet-driven shocks and not magnetically dominated, we estimated its temperature to be ∼0.8 keV. This hot gas cocoon could be responsible for the radio depolarization observed in 3C 459, as recently proposed also for 3C 171 and 3C 305. On the other hand, our spectral analysis and the presence of an oxygen K edge, blueshifted at 1.23 keV, cannot exclude the possibility that the X-ray radiation originating from the inner regions of the radio galaxy could be intercepted by some outflow of absorbing material intervening along the line of sight, as already found in some BAL quasars.Peer reviewe

Effect of Mn substitution by Ga on the optical properties of a metallic manganite

In a metallic manganite like La(2/3)Sr(1/3)MnO(3), the substitution of Mn(+3) by Ga(+3) dilutes the ferromagnetic order and locally cancels the Jahn-Teller distortion, without heavily affecting the crystal structure. One can thus follow the changes in the charge dynamics induced by Ga, until the ferro-metallic manganite is turned into an insulator. Here this phenomenon is studied in detail through the infrared reflectivity of five samples of La(2/3)Sr(1/3)Mn(1-x)Ga(x)O(3), with x increasing from 0 to 0.30 and for 50 < T < 320 K. A simple model which links the measured optical parameters to the magnetization M(x, T) well describes the behavior of the plasma frequency, the scattering rate, and the mid-infrared absorption along the metal-to-insulator transition.Comment: 8 pages including 7 figure

Observation of charge-density-wave excitations in manganites

In the optical conductivity of four different manganites with commensurate charge order (CO), strong peaks appear in the meV range below the ordering temperature T_{CO}. They are similar to those reported for one-dimensional charge density waves (CDW) and are assigned to pinned phasons. The peaks and their overtones allow one to obtain, for La{1-n/8}Ca{n/8}$MnO{3} with n = 5, 6, the electron-phonon coupling, the effective mass of the CO system, and its contribution to the dielectric constant. These results support a description of the CO in La-Ca manganites in terms of moderately weak-coupling and of the CDW theory.Comment: To be published on Phys. Rev. Let

How neutral is the intergalactic medium surrounding the redshift z=7.085 quasar ULAS J1120+0641?

The quasar ULAS J1120+0641 at redshift z=7.085 has a highly ionised near zone which is smaller than those around quasars of similar luminosity at z~6. The spectrum also exhibits evidence for a damping wing extending redward of the systemic Lya redshift. We use radiative transfer simulations in a cosmological context to investigate the implications for the ionisation state of the inhomogeneous IGM surrounding this quasar. Our simulations show that the transmission profile is consistent with an IGM in the vicinity of the quasar with a volume averaged HI fraction of f_HI>0.1 and that ULAS J1120+0641 has been bright for 10^6--10^7 yr. The observed spectrum is also consistent with smaller IGM neutral fractions, f_HI ~ 10^-3--10-4, if a damped Lya system in an otherwise highly ionised IGM lies within 5 proper Mpc of the quasar. This is, however, predicted to occur in only ~5 per cent of our simulated sight-lines for a bright phase of 10^6--10^7 yr. Unless ULAS J1120+0641 grows during a previous optically obscured phase, the low age inferred for the quasar adds to the theoretical challenge of forming a 2x10^9 M_sol black hole at this high redshift.Comment: 5 pages, 4 figures, accepted to MNRAS letter

Near-zone sizes and the rest frame extreme ultra-violet spectral index of the highest redshift quasars

The discovery of quasars with redshifts higher than six has prompted a great deal of discussion in the literature regarding the role of quasars, both as sources of reionization, and as probes of the ionization state of the IGM. However the extreme ultra-violet (EUV) spectral index cannot be measured directly for high redshift quasars owing to absorption at frequencies above the Lyman limit, and as a result, studies of the impact of quasars on the intergalactic medium during reionization must assume a spectral energy distribution in the extreme ultra-violet based on observations at low redshift, z<1. In this paper we use regions of high Ly-alpha transmission (near-zones) around the highest redshift quasars to measure the quasar EUV spectral index at z~6. We jointly fit the available observations for variation of near-zone size with both redshift and luminosity, and propose that the observed relation provides evidence for an EUV spectral index that varies with absolute magnitude in the high redshift quasar sample, becoming softer at higher luminosity. Using a large suite of detailed numerical simulations we find that the typical value of spectral index for a luminous quasar at z~6 is constrained to be alpha=1.3+/-0.4 for a specific luminosity of the form L\propto\nu^{-alpha}. We find the scatter in spectral index among individual quasars to be in the range ~0.75-1.25. These values are in agreement with direct observations at low redshift, and indicate that there has been no significant evolution in the EUV spectral index of quasars over 90% of cosmic time.Comment: 12 pages, 8 figures. Submitted to MNRA

Mutations in MUSK causing congenital myasthenic syndrome impair MuSK–Dok-7 interaction

We describe a severe congenital myasthenic syndrome (CMS) caused by two missense mutations in the gene encoding the muscle specific receptor tyrosine kinase (MUSK). The identified MUSK mutations M605I and A727V are both located in the kinase domain of MuSK. Intracellular microelectrode recordings and microscopy studies of the neuromuscular junction conducted in an anconeus muscle biopsy revealed decreased miniature endplate potential amplitudes, reduced endplate size and simplification of secondary synaptic folds, which were consistent with postsynaptic deficit. The study also showed a striking reduction of the endplate potential quantal content, consistent with additional presynaptic failure. Expression studies in MuSK deficient myotubes revealed that A727V, which is located within the catalytic loop of the enzyme, caused severe impairment of agrin-dependent MuSK phosphorylation, aggregation of acetylcholine receptors (AChRs) and interaction of MuSK with Dok-7, an essential intracellular binding protein of MuSK. In contrast, M605I, resulted in only moderate impairment of agrin-dependent MuSK phosphorylation, aggregation of AChRs and interaction of MuSK with Dok-7. There was no impairment of interaction of mutants with either the low-density lipoprotein receptor-related protein, Lrp4 (a co-receptor of agrin) or with the mammalian homolog of the Drosophila tumorous imaginal discs (Tid1). Our findings demonstrate that missense mutations in MUSK can result in a severe form of CMS and indicate that the inability of MuSK mutants to interact with Dok-7, but not with Lrp4 or Tid1, is a major determinant of the pathogenesis of the CMS caused by MUSK mutations

Prospects for detecting the 21cm forest from the diffuse intergalactic medium with LOFAR

We discuss the feasibility of the detection of the 21cm forest in the diffuse IGM with the radio telescope LOFAR. The optical depth to the 21cm line has been derived using simulations of reionization which include detailed radiative transfer of ionizing photons. We find that the spectra from reionization models with similar total comoving hydrogen ionizing emissivity but different frequency distribution look remarkably similar. Thus, unless the reionization histories are very different from each other (e.g. a predominance of UV vs. x-ray heating) we do not expect to distinguish them by means of observations of the 21cm forest. Because the presence of a strong x-ray background would make the detection of 21cm line absorption impossible, the lack of absorption could be used as a probe of the presence/intensity of the x-ray background and the thermal history of the universe. Along a random line of sight LOFAR could detect a global suppression of the spectrum from z>12, when the IGM is still mostly neutral and cold, in contrast with the more well-defined, albeit broad, absorption features visible at lower redshift. Sharp, strong absorption features associated with rare, high density pockets of gas could be detected also at z~7 along preferential lines of sight.Comment: 12 pages, 13 figures. MNRAS, in pres

Admission Hyperglycemia in Setting of Acute Heart Failure is Associated with Increased In-hospital Mortality Among Patients without Diabetes

Background: Heart Failure (HF) in the setting of comorbid diabetes mellitus (DM) has been extensively examined and is associated with increased mortality. More recently, hyperglycemia independent of DM status during critical illness admissions has become recognized as an indicator of poor outcomes. Despite evolving understanding of DM in the setting of acute HF, hyperglycemia at time of admission for acute HF has not been examined with regard to in-hospital treatment and patient outcomes. Objective: The goal of this study is to examine differences in in-hospital treatment and outcomes of patients hospitalized for acute HF according to glycemic status. Methods: The sample consisted of 9,748 residents of the Worcester (MA) metropolitan area hospitalized at all 11 greater Worcester medical centers for acute decompensated HF during the years 1995 - 2004 with data available on diabetic status and admission glucose measurements. Patients were stratified into three groups based on history of DM and admission hyperglycemia defined by glucose ≥200 mg/dL: 1) nondiabetic, normoglycemic (NDNG); 2) non-diabetic, hyperglycemic (NDHG); and 3) diabetic (DM). Results: Non-diabetic, normoglycemic patients were similar to NDHG patients with respect to age and medical history and were significantly older and less likely to have a history of various comorbid conditions such as hypertension, stroke and renal disease when compared to diabetics (p-values Conclusions: The results of our population-based investigation suggest that non-diabetic patients hospitalized for acute HF who are hyperglycemic at the time of admission represent a vulnerable group of patients at risk for increased mortality during hospitalization. Hyperglycemia ≥200 mg/dL during acute HF hospitalization should be taken into account when providing in-hospital management for HF with additional consideration given to ascertainment of diabetic status and glycemic control

Mutations in LAMB2 causing a severe form of synaptic congenital myasthenic syndrome

BackgroundWe describe a severe form of congenital myasthenic syndrome (CMS) associated with congenital nephrosis and ocular malformations caused by two truncating mutations in the gene encoding the laminin beta2 subunit (LAMB2).Methods and resultsMutational analysis in the affected patient, who has a history of a serious untoward reaction to treatment with acetylcholinesterase inhibition, revealed two frame-shifting heteroallelic mutations, a maternally inherited 1478delG and a paternally inherited 4804delC. An anconeus muscle biopsy demonstrated a profound distortion of the architecture and function of the neuromuscular junction, which was strikingly similar to that seen in mice lacking laminin beta2 subunit. The findings included: pronounced reduction of the axon terminal size with encasement of the nerve endings by Schwann cells, severe widening of the primary synaptic cleft and invasion of the synaptic space by the processes of Schwann cells, and moderate simplification of postsynaptic folds and intact expression of the endplate acetylcholinesterase. The endplate potential quantal content was notably reduced, while the frequencies and amplitudes of miniature endplate potentials were only moderately diminished and the decay phases of miniature endplate potentials were normal. Western blot analysis of muscle and kidney tissue and immunohistochemistry of kidney tissue showed no laminin beta2 expression.ConclusionThis case, which represents a new type of synaptic CMS, exemplifies the wide variability of phenotypes associated with LAMB2 mutations and underscores the fundamental role that laminin beta2 plays in the development of the human neuromuscular junction

Ionization near-zones associated with quasars at z ~ 6

We analyze the size evolution of HII regions around 27 quasars between z=5.7 to 6.4 ('quasar near-zones' or NZ). We include more sources than previous studies, and we use more accurate redshifts for the host galaxies, with 8 CO molecular line redshifts and 9 MgII redshifts. We confirm the trend for an increase in NZ size with decreasing redshift, with the luminosity normalized proper size evolving as: R_{NZ,corrected} = (7.4 \pm 0.3) - (8.0 \pm 1.1) \times (z-6) Mpc. While derivation of the absolute neutral fraction remains difficult with this technique, the evolution of the NZ sizes suggests a decrease in the neutral fraction of intergalactic hydrogen by a factor ~ 9.4 from z=6.4 to 5.7, in its simplest interpretation. Alternatively, recent numerical simulations suggest that this rapid increase in near-zone size from z=6.4 to 5.7 is due to the rapid increase in the background photo-ionization rate at the end of the percolation or overlap phase, when the average mean free path of ionizing photons increases dramatically. In either case, the results are consistent with the idea that z ~ 6 to 7 corresponds to the tail end of cosmic reionization. The scatter in the normalized NZ sizes is larger than expected simply from measurement errors, and likely reflects intrinsic differences in the quasars or their environments. We find that the near-zone sizes increase with quasar UV luminosity, as expected for photo-ionization dominated by quasar radiation.Comment: 16 pages, aas format, 4 figures, to appear in the ApJ letter