PND61 Cost-Utility of Fingolimod Compared With Dimethyl Fumarate (Dmf) In Highly Active Relapsing Remitting Multiple Sclerosis (Rrms) In England: Comparison of A Markov and Discrete Event Simulation Model

Numeración errónea en el original

Od realnego socjalizmu do kapitalizmu. Mirosława Dzielskiego koncepcja zmiany politycznej

The author of the article analyses the idea of political change, focusing on the question whether this change in Poland after the year 1989 was carried out by way of revolution or reforms. he considerations characterise mainly the idea of Mirosław Dzielski and his community, as well as relations with their opponents. Several elements of the above-named theory are brought out in the text. Firstly, the necessity of making comprehensive social changes for the success of the planned change. Secondly, reality diagnosis is necessary. Thirdly, planning of the form of political change, and finally, creation of the project for 'the system of freedom'. The article shows the uniqueness of Dzielski's opinions as a liberal. The author puts special emphasis on the fact that according to him, the reforms program should be directed not at communists but communism. What's more, he perceived that in the Polish conditions there was a collision between freedom and democracy, whereas in his opinion the primacy should go the former

RPO - co to takiego i czy pomoże bibliotekom?

A few words and links about regional operational programs for libraries for the years 2014-2020.Kilka słów i linków dotyczących Regionalnych Programów Operacyjnych w nowym okresie programowania (2014-2020) w odniesieniu do bibliotek

Mem − współczesna plotka internetowa

Udostępnienie publikacji Wydawnictwa Uniwersytetu Łódzkiego finansowane w ramach projektu „Doskonałość naukowa kluczem do doskonałości kształcenia”. Projekt realizowany jest ze środków Europejskiego Funduszu Społecznego w ramach Programu Operacyjnego Wiedza Edukacja Rozwój; nr umowy: POWER.03.05.00-00-Z092/17-00

Identification of areas of corporate social responsibility based on the example of Polish and German seaports in the Baltic sea region

PURPOSE: The main purpose of this text is to identify active areas of Corporate Social Responsibility in Polish and German ports of the Baltic Sea Region and to subject them to a comparative analysis in order to point out differences and identify their causes.DESIGN/METHODOLOGY/APPROACH: The publication employs research methods characteristic for social sciences, including comparative analysis, analytical methods relating to different types of reports and source material, and a dogmatic method focusing on the analysis of legal text.FINDINGS: Polish and German seaports, despite their proximity and location within the same water basin, differ in their CSR policies.PRACTICAL IMPLICATIONS: The results of this study can be used as a starting point for further analysis in the area of Social Responsibility of seaports and as a basis for developing existing and implementing new CSR activities.ORIGINALITY/VALUE: The research focused on selected ports located in the Baltic Sea Region. It is important that each port, despite many apparent similarities, is considered separately. This gives a clear picture of the development of public awareness, as it indicates that geographically and economically similar ports are in fact very different from each other.peer-reviewe

The relationship between glucose and the liver-alpha cell axis – A systematic review

Until recently, glucagon was considered a mere antagonist to insulin, protecting the body from hypoglycemia. This notion changed with the discovery of the liver-alpha cell axis (LACA) as a feedback loop. The LACA describes how glucagon secretion and pancreatic alpha cell proliferation are stimulated by circulating amino acids. Glucagon in turn leads to an upregulation of amino acid metabolism and ureagenesis in the liver. Several increasingly common diseases (e.g., non-alcoholic fatty liver disease, type 2 diabetes, obesity) disrupt this feedback loop. It is important for clinicians and researchers alike to understand the liver-alpha cell axis and the metabolic sequelae of these diseases. While most of previous studies have focused on fasting concentrations of glucagon and amino acids, there is limited knowledge of their dynamics after glucose administration. The authors of this systematic review applied PRISMA guidelines and conducted PubMed searches to provide results of 8078 articles (screened and if relevant, studied in full). This systematic review aims to provide better insight into the LACA and its mediators (amino acids and glucagon), focusing on the relationship between glucose and the LACA in adult and pediatric subjects

Socioeconomic inequalities in overweight and obesity among 6‐ to 9‐year‐old children in 24 countries from the World Health Organization European region

Childhood overweight and obesity have significant short- and long-term negative impacts on children's health and well-being. These challenges are unequally distributed according to socioeconomic status (SES); however, previous studies have often lacked standardized and objectively measured data across national contexts to assess these differences. This study provides a cross-sectional picture of the association between SES and childhood overweight and obesity, based on data from 123,487 children aged 6–9 years in 24 countries in the World Health Organization (WHO) European region. Overall, associations were found between overweight/obesity and the three SES indicators used (parental education, parental employment status, and family-perceived wealth). Our results showed an inverse relationship between the prevalence of childhood overweight/obesity and parental education in high-income countries, whereas the opposite relationship was observed in most of the middle-income countries. The same applied to family-perceived wealth, although parental employment status appeared to be less associated with overweight and obesity or not associated at all. This paper highlights the need for close attention to context when designing interventions, as the association between SES and childhood overweight and obesity varies by country economic development. Population-based interventions have an important role to play, but policies that target specific SES groups are also needed to address inequalities.The authors gratefully acknowledge support through a grant from the Russian Government in the context of the WHO European Office for the Prevention and Control of NCDs. The Ministries of health of Austria, Croatia, Greece, Italy, Malta, Norway, and the Russian Federation provided financial support for the meetings at which the protocol, data collection procedures, and analyses were discussed. Data collection in the countries was made possible through funding from: Albania: World Health Organization (WHO) Country Office Albania and the WHO Regional Office for Europe. Bulgaria: WHO Regional Office for Europe. Croatia: Ministry of Health, Croatian Institute of Public Health and WHO Regional Office for Europe. Czechia: Ministry of Health of the Czech Republic, grant nr. 17-31670A and MZCR—RVO EU 00023761. Denmark: The Danish Ministry of Health. France: Santé publique France, the French Agency for Public Health. Georgia: WHO. Ireland: Health Service Executive. Italy: Italian Ministry of Health; Italian National Institute of Health (Istituto Superiore di Sanità). Kazakhstan: the Ministry of Health of the Republic of Kazakhstan within the scientific and technical program. Kyrgyzstan: World Health Organization. Latvia: Centre for Disease Prevention and Control, Ministry of Health, Latvia. Lithuania: Science Foundation of Lithuanian University of Health Sciences and Lithuanian Science Council and WHO. Malta: Ministry of Health; Montenegro: WHO and Institute of Public Health of Montenegro. Poland, National Health Program, Ministry of Health. Portugal: Ministry of Health Institutions, the National Institute of Health, Directorate General of Health, Regional Health Directorates and the kind technical support from the Center for Studies and Research on Social Dynamics and Health (CEIDSS). Romania: Ministry of Health; Russian Federation: WHO. San Marino: Health Ministry, Educational Ministry, Social Security Institute and Health Authority. Spain: the Spanish Agency for Food Safety & Nutrition. Tajikistan: WHO Country Office in Tajikistan and Ministry of Health and Social Protection. Turkmenistan: WHO Country Office in Turkmenistan and Ministry of Health. Turkey: Turkish Ministry of Health and World Bank.info:eu-repo/semantics/publishedVersio

European Loess Records

Considering their distribution, thickness, and complexity around the margins of the Quaternary ice-sheets in the Northern Hemisphere, loess sequences can be considered as one of the best records of global environmental changes on the continents. European loess sequences have been intensively studied for many decades, but increasingly higher stratigraphic resolution and the availability of a growing range of climate proxy indicators has resulted in some notable advances in recent years. Climatic variability has been analyzed at high resolution, based on different proxies

Diminishing benefits of urban living for children and adolescents’ growth and development

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified