Réalisation de transistors bipolaires à double hétérojonction (DHBT) GaAlAs/GaAs pour circuits intégrés I2L

Dans cet article, nous montrons l'intérêt du transistor bipolaire à double hétérojonction (DHBT) pour la filière logique rapide I2L (logique à injection). En effet l'interchangeabilité entre l'émetteur et le collecteur et la liberté de conception résultant de l'utilisation de deux hétérojonctions donnent aux DHBT un grand intérêt dans le domaine des circuits intégrés rapides à grande intégration tels que la logique à injection I2L. L'accent est mis sur le comportement en régime statique de dispositifs d'étude, réalisés par les techniques d'épitaxie par jets moléculaires et d'implantation ionique de magnésium. Les résultats les plus intéressants sont l'obtention de dispositifs symétriques présentant un gain en courant en régime de fonctionnement inverse de 40 pour un gain de 280 en régime normal et de tensions de saturation très faibles de l'ordre de 3 mV

Nuclear matter incompressibility coefficient in relativistic and nonrelativistic microscopic models

We systematically analyze the recent claim that nonrelativistic and relativistic mean field (RMF) based random phase approximation (RPA) calculations for the centroid energy E_0 of the isoscalar giant monopole resonance yield for the nuclear matter incompressibility coefficient, K_{nm}, values which differ by about 20%. For an appropriate comparison with the RMF based RPA calculations, we obtain the parameters for the Skyrme force used in the nonrelativistic model by adopting the same procedure as employed in the determination of the NL3 parameter set of an effective Lagrangian used in the RMF model. Our investigation suggest that the discrepancy between the values of K_{nm} predicted by the relativistic and nonrelativistic models is significantly less than 20%.Comment: Revtex file (13 pages), appearing in PRC-Rapid Com

Carbon nanotubes adhesion and nanomechanical behavior from peeling force spectroscopy

Applications based on Single Walled Carbon Nanotube (SWNT) are good example of the great need to continuously develop metrology methods in the field of nanotechnology. Contact and interface properties are key parameters that determine the efficiency of SWNT functionalized nanomaterials and nanodevices. In this work we have taken advantage of a good control of the SWNT growth processes at an atomic force microscope (AFM) tip apex and the use of a low noise (1E-13 m/rtHz) AFM to investigate the mechanical behavior of a SWNT touching a surface. By simultaneously recording static and dynamic properties of SWNT, we show that the contact corresponds to a peeling geometry, and extract quantities such as adhesion energy per unit length, curvature and bending rigidity of the nanotube. A complete picture of the local shape of the SWNT and its mechanical behavior is provided

The <i>Castalia</i> mission to Main Belt Comet 133P/Elst-Pizarro

We describe Castalia, a proposed mission to rendezvous with a Main Belt Comet (MBC), 133P/Elst-Pizarro. MBCs are a recently discovered population of apparently icy bodies within the main asteroid belt between Mars and Jupiter, which may represent the remnants of the population which supplied the early Earth with water. Castalia will perform the first exploration of this population by characterising 133P in detail, solving the puzzle of the MBC’s activity, and making the first in situ measurements of water in the asteroid belt. In many ways a successor to ESA’s highly successful Rosetta mission, Castalia will allow direct comparison between very different classes of comet, including measuring critical isotope ratios, plasma and dust properties. It will also feature the first radar system to visit a minor body, mapping the ice in the interior. Castalia was proposed, in slightly different versions, to the ESA M4 and M5 calls within the Cosmic Vision programme. We describe the science motivation for the mission, the measurements required to achieve the scientific goals, and the proposed instrument payload and spacecraft to achieve these

Liposomes in Biology and Medicine

Drug delivery systems (DDS) have become important tools for the specific delivery of a large number of drug molecules. Since their discovery in the 1960s liposomes were recognized as models to study biological membranes and as versatile DDS of both hydrophilic and lipophilic molecules. Liposomes--nanosized unilamellar phospholipid bilayer vesicles--undoubtedly represent the most extensively studied and advanced drug delivery vehicles. After a long period of research and development efforts, liposome-formulated drugs have now entered the clinics to treat cancer and systemic or local fungal infections, mainly because they are biologically inert and biocompatible and practically do not cause unwanted toxic or antigenic reactions. A novel, up-coming and promising therapy approach for the treatment of solid tumors is the depletion of macrophages, particularly tumor associated macrophages with bisphosphonate-containing liposomes. In the advent of the use of genetic material as therapeutic molecules the development of delivery systems to target such novel drug molecules to cells or to target organs becomes increasingly important. Liposomes, in particular lipid-DNA complexes termed lipoplexes, compete successfully with viral gene transfection systems in this field of application. Future DDS will mostly be based on protein, peptide and DNA therapeutics and their next generation analogs and derivatives. Due to their versatility and vast body of known properties liposome-based formulations will continue to occupy a leading role among the large selection of emerging DDS

On the origin and evolution of the material in 67P/Churyumov-Gerasimenko

International audiencePrimitive objects like comets hold important information on the material that formed our solar system. Several comets have been visited by spacecraft and many more have been observed through Earth- and space-based telescopes. Still our understanding remains limited. Molecular abundances in comets have been shown to be similar to interstellar ices and thus indicate that common processes and conditions were involved in their formation. The samples returned by the Stardust mission to comet Wild 2 showed that the bulk refractory material was processed by high temperatures in the vicinity of the early sun. The recent Rosetta mission acquired a wealth of new data on the composition of comet 67P/Churyumov-Gerasimenko (hereafter 67P/C-G) and complemented earlier observations of other comets. The isotopic, elemental, and molecular abundances of the volatile, semi-volatile, and refractory phases brought many new insights into the origin and processing of the incorporated material. The emerging picture after Rosetta is that at least part of the volatile material was formed before the solar system and that cometary nuclei agglomerated over a wide range of heliocentric distances, different from where they are found today. Deviations from bulk solar system abundances indicate that the material was not fully homogenized at the location of comet formation, despite the radial mixing implied by the Stardust results. Post-formation evolution of the material might play an important role, which further complicates the picture. This paper discusses these major findings of the Rosetta mission with respect to the origin of the material and puts them in the context of what we know from other comets and solar system objects

Evaluation of sesamum gum as an excipient in matrix tablets

In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated

MODELING AND PERFORMANCE OF DOUBLE HETEROJUNCTION GaAlAs/GaAs INTEGRATED INJECTION LOGIC. FABRICATION AND DC CHARACTERIZATION OF THE BASIC CELL

This paper first presents a quantitative estimate of the potentialities of the GaAlAs/GaAs H.I2L which relies on an accurate modeling related to physical device parameters. The interdependence of the forward and reverse current gains of the DHBTs processed by MBE and Mg-ion implantation which is subsequently analysed provides a verification of the charge-control models used for this evaluation

Modèle analytique compact d'une hétérojonction isotype GaAlAs/GaAs

A charge-control type model, based on the macroscopic theory of the diffusion, and using the energy band diagram proposed by Anderson, is presented. This model accounts for the more or less gradual change of the gap at the junction and allows to present the current variation law with the applied voltage under a compact analytical form. The typical parameters of this model are given as a function of the technological and geometrical characteristics of the junction.Dans le cadre de la théorie macroscopique de la diffusion et à partir du diagramme des bandes d'énergie proposé par Anderson, un modèle « à contrôle de la charge » est établi. Celui-ci prend en compte le caractère plus ou moins graduel du changement de largeur de bande interdite à la jonction et permet de préciser la loi de variation du courant avec la tension appliquée par des relations analytiques compactes. Les paramètres de ce modèle sont exprimés en fonction des caractéristiques technologiques et géométriques de la jonction