Ground State Structure and Low Temperature Behaviour of an Integrable Chain with Alternating Spins

In this paper we continue the investigation of an anisotropic integrable spin chain, consisting of spins $s=1$ and $s=\frac{1}{2}$, started in our paper \cite{meissner}. The thermodynamic Bethe ansatz is analysed especially for the case, when the signs of the two couplings $\bar{c}$ and $\tilde{c}$ differ. For the conformally invariant model ($\bar{c}=\tilde{c}$) we have calculated heat capacity and magnetic susceptibility at low temperature. In the isotropic limit our analysis is carried out further and susceptibilities are calculated near phase transition lines (at $T=0$).Comment: 22 pages, LaTeX, uses ioplppt.sty and PicTeX macro

Network effects in a human capital based economic growth model

We revisit a recently introduced agent model[ACS {\bf 11}, 99 (2008)], where economic growth is a consequence of education (human capital formation) and innovation, and investigate the influence of the agents' social network, both on an agent's decision to pursue education and on the output of new ideas. Regular and random networks are considered. The results are compared with the predictions of a mean field (representative agent) model.Comment: to appear in Physica

Developmental expression of DAX1 in the European sea bass, Dicentrarchus labrax: lack of evidence for sexual dimorphism during sex differentiation

DAX1 (NR0B1), a member of the nuclear receptors super family, has been shown to be involved in the genetic sex determination and in gonadal differentiation in several vertebrate species. In the aquaculture fish European sea bass, Dicentrarchus labrax, and in the generality of fish species, the mechanisms of sex determination and differentiation have not been elucidated. The present study aimed at characterizing the European DAX1 gene and its developmental expression at the mRNA level

Impacts of Atmospheric Nitrogen Deposition on Surface Waters of the Western North Atlantic Mitigated by Multiple Feedbacks

The impacts of atmospheric nitrogen deposition (AND) on the chlorophyll and nitrogen dynamics of surface waters in the western North Atlantic (25 degrees N-45 degrees N, 65 degrees W-80 degrees W) are examined with a biogeochemical ocean model forced with a regional atmospheric chemistry model (Community Multiscale Air Quality, CMAQ). CMAQ simulations with year-specific emissions reveal the existence of a hot spot of AND over the Gulf Stream. The impact of the hot spot on the oceanic biogeochemistry is mitigated in three ways by physical and biogeochemical processes. First, AND significantly contributes to surface oceanic nitrogen concentrations only during the summer period, when the stratification is maximal and the background nitrogen inventories are minimal. Second, the increase in summer surface nitrate concentrations is accompanied by a reduction in upward nitrate diffusion at the base of the surface layer. This negative feedback partly cancels the nitrogen enrichment from AND. Third, gains in biomass near the surface force a shoaling of the euphotic layer and a reduction of about 5% in deep primary production and biomass on the continental shelf. Despite these mitigating processes, the impacts of AND remain substantial. AND increases surface nitrate concentrations in the Gulf Stream region by 14% during the summer (2% on average over the year). New primary production increases by 22% in this region during summer (8% on average). Although these changes may be difficult to distinguish from natural variability in observations, the results support the view that AND significantly enhances local carbon export

Ground state and low excitations of an integrable chain with alternating spins

An anisotropic integrable spin chain, consisting of spins $s=1$ and $s=\frac{1}{2}$, is investigated \cite{devega}. It is characterized by two real parameters $\bar{c}$ and $\tilde{c}$, the coupling constants of the spin interactions. For the case $\bar{c}<0$ and $\tilde{c}<0$ the ground state configuration is obtained by means of thermodynamic Bethe ansatz. Furthermore the low excitations are calculated. It turns out, that apart from free magnon states being the holes in the ground state rapidity distribution, there exist bound states given by special string solutions of Bethe ansatz equations (BAE) in analogy to \cite{babelon}. The dispersion law of these excitations is calculated numerically.Comment: 16 pages, LaTeX, uses ioplppt.sty and PicTeX macro

3D Models of Radiatively Driven Colliding Winds In Massive O+O Star Binaries: I. Hydrodynamics

The dynamics of the wind-wind collision in massive stellar binaries is investigated using three-dimensional hydrodynamical models which incorporate gravity, the driving of the winds, the orbital motion of the stars, and radiative cooling of the shocked plasma. In this first paper we restrict our study to main-sequence O+O binaries. The nature of the wind-wind collision region is highly dependent on the degree of cooling of the shocked plasma, and the ratio of the flow timescale of the shocked plasma to the orbital timescale. The pre-shock wind speeds are lower in close systems as the winds collide prior to their acceleration to terminal speeds. Radiative inhibition may also reduce the pre-shock wind speeds. Together, these effects can lead to rapid cooling of the post-shock gas. Radiative inhibition is less important in wider systems, where the winds are accelerated to higher speeds before they collide, and the resulting collision region can be largely adiabatic. In systems with eccentric orbits, cold gas formed during periastron passage can persist even at apastron, before being ablated and mixed into its surroundings and/or accelerated out of the system.Comment: 21 pages, 15 figures, accepted for publication in MNRA

Management of SARS-CoV-2 Infection: Key Focus in Macrolides Efficacy for COVID-19

Macrolides (e.g., erythromycin, fidaxomicin, clarithromycin, and azithromycin) are a class of bacteriostatic antibiotics commonly employed in medicine against various gram-positive and atypical bacterial species mostly related to respiratory tract infections, besides they possess anti-inflammatory and immunomodulatory effects. Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2). It was first detected in Wuhan, Hubei, China, in December 2019 and resulted in a continuing pandemic. Macrolides have been extensively researched as broad adjunctive therapy for COVID-19 due to its immunostimulant abilities. Among such class of drugs, azithromycin is described as azalide and is well-known for its ability to decrease the production of pro-inflammatory cytokines, including matrix metalloproteinases, tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. In fact, a report recently published highlighted the effectiveness of combining azithromycin and hydroxychloroquine for COVID-19 treatment. Indeed, it has been underlined that azithromycin quickly prevents SARS-CoV-2 infection by raising the levels of both interferons and interferon-stimulated proteins at the same time which reduces the virus replication and release. In this sense, the current review aims to evaluate the applications of macrolides for the treatment of COVID-19.NC-M acknowledges the Portuguese Foundation for Science and Technology under the Horizon 2020 Program (PTDC/PSI-GER/28076/2017)

Dietary Composition Modulates Brain Mass and Solubilizable ABeta Levels in a Mouse Model of Aggressive Alzheimer\u27s Amyloid Pathology

Objective: Alzheimer\u27s disease (AD) is a progressive neurodegenerative disease of the central nervous system (CNS). Recently, an increased interest in the role diet plays in the pathology of AD has resulted in a focus on the detrimental effects of diets high in cholesterol and fat and the beneficial effects of caloric restriction. The current study examines how dietary composition modulates cerebral amyloidosis and neuronal integrity in the TgCRND8 mouse model of AD. Methods: From 4 wks until 18 wks of age, male and female TgCRND8 mice were maintained on one of four diets: (1) reference (regular) commercial chow; (2) high fat/low carbohydrate custom chow (60 kcal% fat/30 kcal% protein/10 kcal% carbohydrate); (3) high protein/low carbohydrate custom chow (60 kcal% protein/30 kcal% fat/10 kcal% carbohydrate); or (4) high carbohydrate/low fat custom chow (60 kcal% carbohydrate/30 kcal% protein/10 kcal% fat). At age 18 wks, mice were sacrificed, and brains studied for (a) wet weight; (b) solubilizable Aβ content by ELISA; (c) amyloid plaque burden; (d) stereologic analysis of selected hippocampal subregions. Results: Animals receiving a high fat diet showed increased brain levels of solubilizable Aβ, although we detected no effect on plaque burden. Unexpectedly, brains of mice fed a high protein/low carbohydrate diet were 5% lower in weight than brains from all other mice. In an effort to identify regions that might link loss of brain mass to cognitive function, we studied neuronal density and volume in hippocampal subregions. Neuronal density and volume in the hippocampal CA3 region of TgCRND8 mice tended to be lower in TgCRND8 mice receiving the high protein/low carbohydrate diet than in those receiving the regular chow. Neuronal density and volume were preserved in CA1 and in the dentate gyrus. Interpretation: Dissociation of Aβ changes from brain mass changes raises the possibility that diet plays a role not only in modulating amyloidosis but also in modulating neuronal vulnerability. However, in the absence of a study of the effects of a high protein/low carbohydrate diet on nontransgenic mice, one cannot be certain how much, if any, of the loss of brain mass exhibited by high protein/low carbohydrate diet-fed TgCRND8 mice was due to an interaction between cerebral amyloidosis and diet. Given the recent evidence that certain factors favor the maintenance of cognitive function in the face of substantial structural neuropathology, we propose that there might also exist factors that sensitize brain neurons to some forms of neurotoxicity, including, perhaps, amyloid neurotoxicity. Identification of these factors could help reconcile the poor clinicopathological correlation between cognitive status and structural neuropathology, including amyloid pathology