Validity of a four-factor modelunderlying the physical fitness in adults with intellectual disabilities a confirmatory factor analysis

Purpose: To use confirmatory factor analysis to test whether a four factor might explain the clustering of the components of the physical fitness in adults with intellectual disabilities (FID). Relevance: Individuals with intellectual disabilities (ID) are significantly weaker than individuals without ID at all stages of life. These subjects might be particularly susceptible to loss of basic function because of poor physical fitness. Participants: We studied 267 adults with intellectual disability of the Spanish Special Olympics Games. Methods: The four-factor model included: the flexibility, the strength, the balance and the cardiorespiratory endurance with 9 variables of the fitness assessment. Analysis: The construct validity of the model was assessed through the factor loadings, interpreted as the correlation between the variables in the model and their underlying factor, which is the FID construct. Results: Factor loading were 0,55 for the passive knee extension, o,52 for Functional shoulder rotation, −0.71 for the timed-stand test, 0.58 for the grip test, 0.75 the single leg stance with eyes open, 0.69 single leg stance with eyes closed, 0.72 for the resting heart rate, 0.56 for the two-minute step test (2MST) 0,97 for 2 minutes after finish 2MST. The four-factor model also showed a good fit to the data, as indicated by a high comparative fit index (CFI=0,93) and a low standardized root mean square residual (SRMR=0,072) Conclusions: A four underlying factor has shown acceptable validity to represent FID Implications: The new model of FID can offer understanding better these construct in this special populationUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Bullying and gender violence at school: analysis of teacher perception

Nowadays gender violence and bullying continue to be considered a matter of great concern to society. This study analyses the teachers'' perceptions of these two social problems in the educational context. The interventions that are carried out from the school to prevent and respond to these behaviours are studied. From a methodological point of view, the study responds to the paradigm of qualitative research. We interviewed fifteen teachers of Early Childhood Education, Primary Education and Secondary Education of the Spanish educational system. The information collected indicates that teachers advocate a necessary reinforcement of emotional competencies and social skills from schools. In addition, they express their dissatisfaction due to the insufficient strategies applied from the school to respond to these violent behaviours. These results support any initiative that aims to train teachers to prevent possible cases of bullying or gender violence

Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T-cells and tumour cells

Extracellular vesicles (EVs) mediate the cross-talk between cancer cells and the cells of the surrounding Tumour Microenvironment (TME). Professional killer cells include Natural Killer (NK) cells and CD8+ Cytotoxic T-lymphocytes (CTLs), which represent some of the most effective immune defense mechanisms against cancer cells. Recent evidence supports the role of EVs released by NK cells and CTLs in killing cancer cells, paving the road to a possible therapeutic role for such EVs. This review article provides the state-of-the-art knowledge on the role of NK- and CTL-derived EVs as anticancer agents, focusing on the different functions of different sub-types of EVs. We also reviewed the current knowledge on the effects of cancer-derived EVs on NK cells and CTLs, identifying areas for future investigation in the emerging new field of EV-mediated immunotherapy of cancer

INTEGRAL-RXTE observations of Cygnus X-1

We present first results from contemporaneous observations of Cygnus X-1 with INTEGRAL and RXTE, made during INTEGRAL's performance verification phase in 2002 November and December. Consistent with earlier results, the 3-250 keV data are well described by Comptonization spectra from a Compton corona with a temperature of kT~50-90 keV and an optical depth of tau~1.0-1.3 plus reflection from a cold or mildly ionized slab with a covering factor of Omega/2pi~0.2-0.3. A soft excess below 10 keV, interpreted as emission from the accretion disk, is seen to decrease during the 1.5 months spanned by our observations. Our results indicate a remarkable consistency among the independently calibrated detectors, with the remaining issues being mainly related to the flux calibration of INTEGRAL.Comment: 6 pages, 3 figures. Figs. 2 and 3 are best viewed in color. Accepted for publication in the INTEGRAL special edition of A&A

p27Kip1 V109G as a biomarker for CDK4/6 inhibitors indication in hormone receptor–positive breast cancer

Biomarker; Hormone receptor-positive; Breast cancerBiomarcador; Cáncer de mama; Receptor hormonal positivoBiomarcador; Càncer de mama; Receptor hormonal positiuCDK4/6 inhibitors benefit a minority of patients who receive them in the breast cancer adjuvant setting. p27Kip1 is a protein that inhibits CDK/Cyclin complexes. We hypothesized that single-nucleotide polymorphisms that impaired p27Kip1 function could render patients refractory to endocrine therapy but responsive to CDK4/6 inhibitors, narrowing the patient subpopulation that requires CDK4/6 inhibitors. We found that the p27Kip1 V109G single-nucleotide polymorphism is homozygous in approximately 15% of hormone-positive breast cancer patients. Polymorphic patients experience rapid failure in response to endocrine monotherapy compared with wild-type or heterozygous patients in the first-line metastatic setting (progression-free survival: 92 vs 485 days, P < .001); when CDK4/6 inhibitors are added, the differences disappear (progression-free survival: 658 vs 761 days, P = .92). As opposed to wild-type p27Kip1, p27Kip1 V109G is unable to suppress the kinase activity of CDK4 in the presence of endocrine inhibitors; however, palbociclib blocks CDK4 kinase activity regardless of the p27Kip1 status. p27Kip1 genotyping could constitute a tool for treatment selection.MM is supported by the Spanish Ministry of Science and Innovation (RTI2018-095582-B-100; PLEC2021-007892 and RED2018-102723-T), AES (DTS21/00132) and Comunidad de Madrid (B2017/BMD-3884 and Y2020/BIO-6519). MQF is a recipient of the following grants: AES—PI 19/00454 funded by the ISCIII and co-funded by the European Regional Development Fund (ERDF), and B2017/BMD3733 (Immunothercan-CM) – Call for Coordinated Research Groups from the Madrid Region—Madrid Regional Government—ERDF funds. This study was also funded by a donation from CRIS Contra El Cancer Foundation

Measurement of the pp→ZZproduction cross section and constraints on anomalous triple gauge couplings in four-lepton final states at √s=8TeV

A measurement of the inclusive ZZproduction cross section and constraints on anomalous triple gauge couplings in proton–proton collisions at √s=8TeVare presented. The analysis is based on a data sample, corresponding to an integrated luminosity of 19.6fb−1, collected with the CMS experiment at the LHC. The measurements are performed in the leptonic decay modes ZZ →, where=e, μand =e, μ, τ. The measured total cross section σ(pp →ZZ) =7.7 ±0.5(stat)+0.5−0.4(syst)±0.4 (theo) ±0.2(lumi)pb, for both Zbosons produced in the mass range 6

Searches for light- and heavy-flavour three-jet resonances in pp collisions at √ s = 8 TeV

A search for three-jet hadronic resonance production in pp collisions at a centre-of-mass energy of 8 TeV has been conducted by the CMS Collaboration at the LHC with a data sample corresponding to an integrated luminosity of 19.4 fb−1. The search method is model independent, and events are selected that have high jet multiplicity and large values of jet transverse momenta. The signal models explored assume R-parity-violating supersymmetric gluino pair production and have final states with either only light-flavour jets or both light- and heavy-flavour jets. No significant deviation is found between the selected events and the expected standard model multijet and tt background. For a gluino decaying into light-flavour jets, a lower limit of 650 GeV on the gluino mass is set at a 95% confidence level, and for a gluino decaying into one heavy- and two light-flavour jets, gluino masses between 200 and 835 GeV are, for the first time, likewise excluded

Measurement of the production cross section for a Wboson and two bjets in ppcollisions at √s=7TeV

The production cross section for a Wboson and two b jets is measured using proton–proton collisions at √s=7TeVin a data sample collected with the CMS experiment at the LHC corresponding to an integrated luminosity of 5.0fb−1. The W +bbevents are selected in the W →μνdecay mode by requiring a muon with transverse momentum pT\u3e25GeVand pseudorapidity |η| \u3c2.1, and exactly two b-tagged jets with pT\u3e25GeVand |η| \u3c2.4. The measured W +bbproduction cross section in the fiducial region, calculated at the level of final-state particles, is σ(pp →W +bb) ×B(W →μν) =0.53 ±0.05 (stat.)±0.09 (syst.)±0.06 (theo.)±0.01 (lum.)pb, in agreement with the standard model prediction. In addition, kinematic distributions of the W +bbsystem are in agreement with the predictions of a simulation using MadGraph and pythia

Search for top-squark pairs decaying into Higgs or Z bosons in pp collisions at √s=8TeV

A search for supersymmetry through the direct pair production of top squarks, with Higgs (H) or Z bosons in the decay chain, is performed using a data sample of proton–proton collisions at √s=8TeVcollected in 2012 with the CMS detector at the LHC. The sample corresponds to an integrated luminosity of 19.5fb−1. The search is performed using a selection of events containing leptons and bottom-quark jets. No evidence for a significant excess of events over the standard model background prediction is observed. The results are interpreted in the context of simplified supersymmetric models with pair production of a heavier top-squark mass eigenstate ˜ t2decaying to a lighter top-squark mass eigenstate ˜t1via either ˜t2→H˜ t1or ˜t2→Z˜ t1, followed in both cases by ˜t1→t˜ χ01, where ˜ χ01is an undetected, stable, lightest supersymmetric particle. The interpretation is performed in the region where the mass difference between the ˜ t1and ˜ χ01states is approximately equal to the top-quark mass (m˜ t1−m˜ χ01mt), which is not probed by searches for direct ˜ t1squark pair production. The analysis excludes top squarks with masses m˜ t2\u3c575GeVand m˜ t1\u3c400GeVat a 95% confidence level