On the capability of Hom-Lie algebras

A Hom-Lie algebra (L, αL) is said to be capable if there exists a Hom-Lie algebra (H, αH) such that L – H/Z(H). We obtain a characterisation of capable Hom-Lie algebras involving its epicentre and we use this theory to further study the six-term exact sequence in homology and to obtain a Hopf-type formulae of the second homology of perfect Hom-Lie algebras.Agencia Estatal de Investigación | Ref. PID2020-115155GB-I0

On some properties of Lie-centroids of Leibniz algebras

We study some properties of Lie-centroids related to central Lie-derivations, generalized Lie-derivations and almost inner Lie-derivations. We also determine the Lie-centroid of the tensor product of a commutative associative algebra and a Leibniz algebra.Agencia Estatal de Investigación | Ref. PID2020-115155GB-I00Research Foundation–Flander

A Time-Domain Model for the Study of High-Frequency Wheelset–Track Interaction

A mathematical model of dynamic wheelset–track interaction is proposed in this paper. The model is defined in the time domain in order to introduce and correctly evaluate non-linear and time-variant phenomena related to the contact model and boundary conditions which play a very important role in rail surface degradation phenomena. The complete model can be divided into three main components: the model of the wheelset,the model of the track and the model of wheel–rail contact forces. In the paper, the wheelset is described as a rotating flexible body, and the gyroscopic and inertial effects associated with wheelset rotation are introduced to this model using an ‘Eulerian’ finite element approach based on 3D quadratic solid elements. The discrete supported track is modelled using finite Timoshenko beam element, which takes into account both the vertical and the lateral rail vibration valid up to 1500 Hz. The wheelset and the track are coupled by means of a contact model based on the nonlinear Hertz and Kalker theories. The flexible components of the interaction model make it possible to describe the train–track dynamics in a relatively high-fre-quency range, which allows the investigation of specific aspects such as rail corrugation. Some numerical results are presented in terms of contact forces and rail–wheel vibration speed in the paper. The effect of wheelset and track flexibility in specific frequency range on train–track interaction dynamics is briefly discussed

Análisis, desarrollo e implementación de nuevas funcionalidades para la optimización del módulo de estaciones meteorológicas remotas de la plataforma "Sistema Web de Gestión de Carreteras" (SWGC) de ITERNOVA

En este trabajo fin de grado se realizan mejoras en el módulo de estaciones meteorológicas remotas de ITERNOVA para la optimización de la captura de datos haciendo uso de API

Analysis of Different Scenarios to Include PV Rooftop Systems with Battery Energy Storage Systems in Olive Mills

The industrial sector is not the one with the highest energy consumption but, together with, it represents the most, together with the transport sector, the most polluting ones. Photovoltaic Rooftop systems and battery energy storage systems are very strong candidates to include renewable energy, allowing greater grid autonomy and greenhouse gas mitigation. Therefore, this paper aims to outline it will be provided a methodology based on monitored data to analyze the potential of photovoltaic Rooftops with battery energy storage systems regarding self-consumption and self-sufficiency indices in the industrial sector. Direct self-consumption and self-sufficiency indices, either with or without storage, will be analyzed. In addition, the iso self-consumption and iso self-sufficiency curves are used, which allow us to evaluate the matching between the generation and consumption profiles considering either direct self-consumption or the use of batteries. In this sense, a large, medium, and small olive mill were selected in order to cover the entire spectrum of these industries. Olive mills are suitable candidates for the incorporation of photovoltaic systems since generation profiles match the consumption profiles. However, the size of these systems is highly dependent on the period of consumption to be faced. Regarding batteries, both during the harvest and off-harvest periods, the impact on self-sufficiency becomes significant, reaching increases of up to 10%, depending on the battery capacity used.This research was funded by the Agencia Estatal de Investigación (AEI). Projects oriented towards the ecological transition and the digital transition. (Grant No. TED2021-131137B-I00 “Aportación a la Transición Ecológica en el sector Industrial a través del Autoconsumo Fotovoltaico”). The authors also would like to thank the Project “Contribución al abastecimiento de energía eléctrica en pequeñas y medianas empresas de Andalucía. AcoGED_PYMES”. Ref: 1380927. Programa Operativo Proyectos de ID+i en el marco del Programa Operativo FEDER Andalucía 2014/2020. The authors also acknowledge the support provided by the Thematic Network 723RT0150 “Red para la integración a gran escala de energías renovables en sistemas electricos (RIBIERSE-CYTED)” financed by the call for Thematic Networks of the CYTED (Ibero-American Program of Science and Technology for Development) for 2022

Adaptation and Validation of the Diabetic Foot Ulcer Scale-Short Form in Spanish Subjects

Diabetic foot ulcer (DFU) is a chronic complication that negatively affects the quality of life (QoL) of diabetic patients. In Spain, there is no specifically designed and validated instrument to assess the QoL of patients with DFU. Our aim was to adapt the Diabetic Foot Ulcer Scale-Short Form (DFS-SF) questionnaire to a Spanish population and validate it. A prospective, observational design was used. The DFS-SF was administered by personal interview. The validated SF-36 and EQ-5D generic instruments were used as reference tools. The reliability, validity, and sensitivity to changes were assessed using standard statistical methods. A sample of 141 patients with DFU was recruited. The content validity was 3.46 on average (maximum score of 4). The internal consistency of the DFS-SF subscales showed a standardized Cronbach’s α range between 0.720 and 0.948. The DFS-SF domains showed excellent reproducibility measures (intraclass correlation coefficient from 0.77–0.92). The criterion validity was good with significant correlations between each DFS-SF subscale and its corresponding SF-36 and EQ-5D subscales (p < 0.001). However, the questionnaire structure was not validated (comparative fit index = 0.844, root mean square error of approximation = 0.095, and standardized root mean square residual = 0.093). The instrument showed high sensitivity to ulcer changes over time (p < 0.001). The adapted and validated Spanish version of the DFS-SF questionnaire has good psychometric properties and shows good sensitivity to ulcer changes, although the construct validity was not optimal. The adapted questionnaire will be a useful tool specifically to assess the QoL in subjects with diabetic foot ulcers in the clinical and research settings in Spain.CIBERDEM is an initiative from Instituto de Salud Carlos III (Plan Nacional de I + D + I and Fondo Europeo de Desarrollo Regional). M.G.-C. held a predoctoral fellowship from the Ministerio de Educación, Cultura y Deporte, FPU15/03005. This project was developed in the context of the Programme “Doctorat en Medicina de la Universitat Autònoma de Barcelona”, Autonomous University of Barcelona

ADGRL3 (LPHN3) variants predict substance use disorder

Factors genètics; Desordre d'ús de substànciesFactores genéticos; Desorden de uso de sustanciasGenetic factors; Substance use disorder; ADGRL3 (LPHN3)Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use disorder (SUD). Variants in the ADGRL3 (LPHN3) gene predispose to ADHD and predict ADHD severity, disruptive behaviors comorbidity, long-term outcome, and response to treatment. In this study, we investigated whether variants within ADGRL3 are associated with SUD, a disorder that is frequently co-morbid with ADHD. Using family-based, case-control, and longitudinal samples from disparate regions of the world (n = 2698), recruited either for clinical, genetic epidemiological or pharmacogenomic studies of ADHD, we assembled recursive-partitioning frameworks (classification tree analyses) with clinical, demographic, and ADGRL3 genetic information to predict SUD susceptibility. Our results indicate that SUD can be efficiently and robustly predicted in ADHD participants. The genetic models used remained highly efficient in predicting SUD in a large sample of individuals with severe SUD from a psychiatric institution that were not ascertained on the basis of ADHD diagnosis, thus identifying ADGRL3 as a risk gene for SUD. Recursive-partitioning analyses revealed that rs4860437 was the predominant predictive variant. This new methodological approach offers novel insights into higher order predictive interactions and offers a unique opportunity for translational application in the clinical assessment of patients at high risk for SUDR01 DA039881/DA/NIDA NIH HHS/United States. DA039881/U.S. Department of Health & Human Services NIH, National Institute on Drug Abuse (NIDA)

Inhibitory effect against polymerase and ribonuclease activities of HIV-reverse transcriptase of the aqueous leaf extract of Terminalia triflora

Dichloromethane, methanol and aqueous extracts from the leaves of Terminalia triflora were investigated for their inhibitory effect on polymerase and ribonuclease activities of HIV reverse transcriptase.The most potent activity was found in the aqueous extract, which inhibited both polymerase and ribonuclease activities of the enzyme with an IC50 of 1.6 micro g/mL and 1.8 micro g/mL respectively. The antiinfective activity of the extract was demonstrated in HLT4LacZ-IIIB cell culture with an IC50 of 1.0 micro g/mL. The extract was submitted to a purification process by extractive and chromatographic methods. The activity remained in the hydrophillic fraction. Tannins present in this active purified fraction, as determined by TLC and HPLC methods, could account for the anti HIV-RT activity found in the aqueous extract

Clinical response to pandemic H1N1 influenza virus from a fatal and mild case in ferrets

Methods: Viral strains isolated from a patient showing mild disease-M (A/CastillaLaMancha/RR5661/2009) or from a fatal case-F (A/CastillaLaMancha/RR5911/2009), both without known comorbid conditions, were inoculated in two groups of ferrets and clinical and pathological conditions were analysed. Results: Mild to severe clinical symptoms were observed in animals from both groups. A clinical score distribution was applied in which ferrets with mild clinical signs were distributed on a non-severe group (NS) and ferrets with severe clinical signs on a severe group (S), regardless of the virus used in the infection. Animals on S showed a significant decrease in body weight compared to animals on NS at 4 to 7 days post-infection (dpi). Clinical progress correlated with histopathological findings. Concentrations of haptoglobin (Hp) and serum amyloid A (SAA) increased on both groups after 2 dpi. Clinically severe infected ferrets showed a stronger antibody response and higher viral titres after infection (p = 0.001). Conclusions: The severity in the progress of infection was independent from the virus used for infection suggesting that the host immune response was determinant in the outcome of the infection. The diversity observed in ferrets mimicked the variability found in the human population.The authors kindly thank Dr. Juan Ortín for his scientific contribution. This work was partially supported by Instituto de Salud Carlos III (Programa especial de investigación sobre la gripe pándemica GR09/0023, GR09/0040, GR09/0039), AGL2013-48923-C2-02 and CIBER de Enfermedades Infecciosa

Evaluación de competencias transversales en asignaturas relacionadas con Ingeniería Mecánica y de Materiales: Análisis y Resolución de Problemas, Aplicación y Pensamiento Práctico

[EN] Although the competence based curricula approach has been used in the development of the new programmes for Master and Bachelor degrees within the European Higher Education Area in recent years, the assessment of generic competences is still a pending task. This work presents a methodological proposal for the assessment of the competences of capacity for problem-solving and capacity for applying knowledge in practice, in subjects related to mechanical and materials engineering. In particular, this paper proposes a scale in order to quantify the level of achievement of each competence, and shows some assessment tools developed for this purpose. These tools are based on Checklists to evaluate the learning outcomes of each competence, that can be observed as evidences obtained from the assessment activities proposed during the course. These assessment activities are refered to the resolution of problems, individually and in groups. The learning outcomes, levels of achievement and the Checklist of each competence are presented. Some preliminary results from a first attempt to use this methodology in two subjects of Bachelor and Master degrees, are also described here. Finally, conclusions about preliminary results and the difficulties found in the development of these tools and its aplication are also presented.[ES] A pesar de que las competencias que se trabajan en los nuevos títulos de Grado y Máster figuran explícitamente en sus planes de estudios a partir de los cambios introducidos por el Espacio Europeo de Educación Superior, su evaluación sigue siendo una tarea pendiente a día de hoy. Este trabajo presenta una propuesta metodológica para la evaluación de las competencias de Análisis y Resolución de Problemas y de Aplicación y Pensamiento Práctico, en asignaturas relacionadas con la Ingeniería Mecánica y de Materiales. En particular, este trabajo propone una escala de valoración para cuantificar el nivel de logro de cada competencia, y muestra herramientas de evaluación desarrolladas para este propósito. Dichas herramientas están basadas en Listas de Control que evalúan resultados de aprendizaje de cada competencia, observados mediante las evidencias derivadas de la actividad de evaluación propuesta durante el curso, consistente en la resolución de problemas de forma autónoma y en grupo. Se detallan las escalas de desarrollo de cada competencia, sus resultados de aprendizaje y los ítems de cada Lista de Control. Se analizan algunos resultados preliminares derivados de un primer intento de uso de la metodología propuesta, en dos asignaturas de Grado y Máster. Finalmente se presentan conclusiones sobre los resultados preliminares, junto con las dificultades encontradas tanto en la elaboración de las herramientas de evaluación como en su implementación.Los autores quieren agradecer la ayuda económica y el apoyo institucional recibidos de la Universitat Politècnica de València a través del proyecto PIME/2014/A/012/B.Martínez Casas, J.; Sahuquillo Navarro, O.; Sonseca Olalla, A.; Carballeira, J.; Denia Guzmán, FD.; Suñer Martinez, JL.; Vila Tortosa, MP. (2015). Evaluación de competencias transversales en asignaturas relacionadas con Ingeniería Mecánica y de Materiales: Análisis y Resolución de Problemas, Aplicación y Pensamiento Práctico. En In-Red 2015 - CONGRESO NACIONAL DE INNOVACIÓN EDUCATIVA Y DE DOCENCIA EN RED. Editorial Universitat Politècnica de València. https://doi.org/10.4995/INRED2015.2015.1630OC