Fermion mass and mixing pattern in a minimal T7 flavor 331 model

We present a model based on the $SU(3)_{C}\otimes SU(3)_{L}\otimes U(1)_{X}$ gauge symmetry having an extra $T_{7}\otimes Z_{2}\otimes Z_{3}\otimes Z_{14}$ flavor group, which successfully describes the observed SM fermion mass and mixing pattern. In this framework, the light active neutrino masses arise via double seesaw mechanism and the observed charged fermion mass and quark mixing hierarchy is a consequence of the $Z_{2}\otimes Z_{3}\otimes Z_{14}$ symmetry breaking at very high energy. In our minimal $T_{7}$ flavor 331 model, the spectrum of neutrinos includes very light active neutrinos as well as heavy and very heavy sterile neutrinos. The model has in total 16 effective free parameters, which are fitted to reproduce the experimental values of the 18 physical observables in the quark and lepton sectors. The obtained physical observables for both quark and lepton sectors are compatible with their experimental values. The model predicts the effective Majorana neutrino mass parameter of neutrinoless double beta decay to be $$ 3 and 40 meV for the normal and the inverted neutrino spectrum, respectively. Furthermore, our model features a vanishing leptonic Dirac CP violating phase.Comment: 18 pages. Final version. To be published in Journal of Physics G. arXiv admin note: substantial text overlap with arXiv:1309.656

A predictive 331331 model with A4A_{4} flavour symmetry

We propose a predictive model based on the $SU(3)_{C}\otimes SU(3)_{L}\otimes U(1)_{X}$ gauge group supplemented by the $A_{4}\otimes Z_{3}\otimes Z_{4}\otimes Z_{6}\otimes Z_{16}$ discrete group, which successfully describes the SM fermion mass and mixing pattern. The small active neutrino masses are generated via inverse seesaw mechanism with three very light Majorana neutrinos. The observed charged fermion mass hierarchy and quark mixing pattern are originated from the breaking of the $Z_{4}\otimes Z_{6}\otimes Z_{16}$ discrete group at very high scale. The obtained values for the physical observables for both quark and lepton sectors are in excellent agreement with the experimental data. The model predicts a vanishing leptonic Dirac CP violating phase as well as an effective Majorana neutrino mass parameter of neutrinoless double beta decay, with values $m_{\beta \beta }=$ 2 and 48 meV for the normal and the inverted neutrino mass hierarchies, respectively.Comment: 20 pages. Final version published in Nuclear Physics

Óptica de campo cercano : análisis teórico-experimental de imágenes

El mapeo de modos evanescentes con un microsco pio Optico de campo cercano es numÈricamente es- tudiado. La influencia de componentes que se pro- pagan provenientes del esparcimiento inel·stico (fue- ra del plano) de ondas evanescentes sobre las distribuciones de intensidad y, consecuentemente, sobre las im·genes Ûpticas de campo cercano, es discutida. El esparcimiento elástico (en el plano) de modos evanescentes es modelado, considerando un esparcidor puntual cuya respuesta al campo evanescente incidente est· fenomenolÛgicamente relacionada a su polarizabilidad efectiva. El estudio est· orientado, en una primera aproximaciÛn, hacia el desarrollo de un modelo completo que pueda ser exitosamente usado en el an·lisis de im·genes Opticas de campo cercano

Anti-Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure

Chagas disease is a neglected tropical affection caused by the protozoan parasite Trypanosoma cruzi. There is no current effective treatment since the only two available drugs have a limited efficacy and produce side effects. Thus, investigation efforts have been directed to the identification of new drug leads. In this context, Ca2+ regulating mechanisms have been postulated as targets for antiparasitic compounds, since they present paramount differences when compared to host cells. Amiodarone is an antiarrhythmic with demonstrated trypanocidal activity acting through the disruption of the parasite intracellular Ca2+ homeostasis. We now report the effect of a benzofuran derivative based on the structure of amiodarone on T. cruzi. This derivative was able to inhibit the growth of epimastigotes in culture and of amastigotes inside infected cells, the clinically relevant phase. We also show that this compound, similarly to amiodarone, disrupts Ca2+ homeostasis in T. cruzi epimastigotes, via two organelles involved in the intracellular Ca2+ regulation and the bioenergetics of the parasite. We demonstrate that the benzofuran derivative was able to totally collapse the membrane potential of the unique giant mitochondrion of the parasite and simultaneously produced the alkalinization of the acidocalcisomes. Both effects are evidenced by a large increase in the intracellular Ca2+ concentration of T. cruzi.Fil: Pinto Martinez, Andrea. instituto de Estudios Avanzados; VenezuelaFil: Hernández Rodríguez, Vanessa. instituto de Estudios Avanzados; VenezuelaFil: Rodríguez Durán, Jessica Jenireth. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. instituto de Estudios Avanzados; VenezuelaFil: Hejchman, Elżbieta. Medical University of Warsaw; PoloniaFil: Benaim, Gustavo. Universidad Central de Venezuela; Venezuel

Evaluation of deep neural network architectures in the identification of bone fissures

Automated medical image processing, particularly of radiological images, can reduce the number of diagnostic errors, increase patient care and reduce medical costs. This paper seeks to evaluate the performance of three recent convolutional neural networks in the autonomous identification of fissures over two-dimensional radiological images. These architectures have been proposed as deep neural network types specially designed for image classification, which allows their integration with traditional image processing strategies for automatic analysis of medical images. In particular, we use three convolutional networks: ResNet (residual neural network), DenseNet (dense convolutional network), and NASNet (neural architecture search network) to learn information from a set of 200 images labeled half as fissured bones and half as seamless bones. All three networks are trained and adjusted under the same conditions, and their performance was evaluated with the same metrics. The final results consider not only the model's ability to predict the characteristics of an unknown image but also its internal complexity. The three neural models were optimized to reduce classification errors without producing network over-adjustment. In all three cases, generalization of behavior was observed, and the ability of the models to identify the images with fissures, however the expected performance was only achieved with the NASNet model

Detection of Human Papilloma Virus (HPV) in oral mucosa of women with cervical lesions and their relation to oral sex practices

<p>Abstract</p> <p>Background</p> <p>Previous studies have either investigated the relationship of HPV with oral cancer or the prevalence of HPV on the oral cavity. The purpose of this investigation was to study the prevalence of HPV in oral cavity of women with oral sex practices and cervical lesions.</p> <p>Methods</p> <p>Forty six (46) non-smokers and non-alcoholic patients attended the "Clínica de Displasias" of "Ciudad Juarez" were sampled. This population had a CIN diagnosis sometime between the previous six months. On previous consent they filled out a questionnaire related to their oral sex practices. Afterwards one swab from cheeks and another from palate/gum were taken; PCR was used to determine generic HPV, HPV16 and HPV18.</p> <p>Results</p> <p>Seventy two percent (72%) of the patients stated to have oral sex practices regularly which all of them were positive to HPV either in oral mucus, palate/gum or both. The total of the given results showed that 35% had HPV16; among those distributed in 26% with regular oral sex practices and 9% stated as never practiced oral sex. An association was found between oral HPV16 positivity and progression to cervical CIN advanced lesions. On the other hand HPV18 was not detected. The frequency of HPV16 was higher in buccal mucosa (23%) versus palate/gum (16%).</p> <p>Conclusions</p> <p>This study suggests that buccal HPV16 infection is associated with CIN progression.</p

Normas Internacionales de Informacion Financiera (NIIF para Pymes) : Aplicación de normas de información financiera para pymes en la COOTEL,S.A. para el año finalizado 2015

Debido a la globalización y al avance de la tecnología es urgente para las empresas el análisis de la estandarización contable, así como el óptimo desenvolvimiento de sus actividades, por tanto el presente documento aborda los diferentes requerimientos y exigencias que las entidades deben realizar para poder expresar que sus estados financieros son preparados y presentados en base a normas internacionales de información financiera para pequeñas y medianas entidades, (NIIF para PYMES) Además se toma en cuenta la evolución que durante la historia ha venido teniendo la contabilidad y se describe las generalidades que todo usuario de la contabilidad debe conocer. Para poder demostrar cómo se deben presentar los estados financieros utilizando la NIIF para PYMES se realizó un caso práctico de una entidad que preparaba y presentaba sus estados financieros con base a los principios contables, la gerencia decide adoptar las normas realizando así un proceso de transición que duro un periodo completo, pero que valió la pena pues los resultados fueron muy satisfactorios. Se demostró la estructura que según las normas de información financiera deben tener los estados financieros de una entidad, cuales son los ajustes a realizar al momento de aplicar la seccion 35 de la NIIF para PYMES en el caso práctico. Llagamos a la conclusión que la adecuada aplicación de la NIIF para PYMES permite a las entidades pequeñas y medianas ser reconocidas a nivel internacional así como la posibilidad de crecimiento económico

Evaluación del Desempeño de las Instituciones Bancarias : Calidad y eficiencia de recursos humanos, como area principal del banco de América Central BAC para el año 2014

Los RRHH consiste en la planeación, organización, el desarrollo, la coordinación y el control de técnicas capaces de promover el desempeño eficiente del personal en la medida en que la organización representa el medio que permita a las personas que colaboran en ella alcanzar los objetivos individuales relacionados directa o indirectamente con el trabajo Busca construir y mantener un entorno de excelencia en la calidad para habilitar mejor a la fuerza de trabajo en la consecución de los objetivos de calidad y de desempeño de la empresa. El módulo de gestión de recursos humanos cubre otros aspectos de los RRHH, incluye menos particularidades legales y está más enfocado a una política de gestión, Los factores que influyen en el comportamiento humano pueden ser internos y externos, Los factores externos están generados por el ambiente social en que se desenvuelve la persona tales como la familia, amistades y entorno laboral, Asimismo factores como el auto concepto, que es el sentimiento que una persona tiene de sí misma, y la autoestima, que es la forma en que una persona se valora a sí misma. Los recursos humanos buscan construir y mantener un entorno de excelencia en la calidad para habilitar mejor a la fuerza de trabajo en la consecución de los objetivos de calidad y de desempeño operativo de la empresa. Es un término moderno de lo que tradicionalmente se ha conocido como administración de personal o gerencia de persona