1,280 research outputs found
Differential Brain Activation to Angry Faces by Elite Warfighters: Neural Processing Evidence for Enhanced Threat Detection
10.1371/journal.pone.0010096PLoS ONE54
The Dynamics and Metallicity Distribution of the Distant Dwarf Galaxy VV124
VV124 (UGC 4879) is an isolated, dwarf irregular/dwarf spheroidal (dIrr/dSph) transition-type
galaxy at a distance of 1.36 Mpc. Previous low-resolution spectroscopy yielded inconsistent radial
velocities for different components of the galaxy, and photometry hinted at the presence of a stellar
disk. In order to quantify the stellar dynamics, we observed individual red giants in VV124 with the Keck/DEIMOS spectrograph. We validated members based on their positions in the color-magnitude
diagram, radial velocities, and spectral features. Our sample contains 67 members. The average
radial velocity is = −29.1 ± 1.3 km s^(−1), in agreement with the previous radio measurements
of H I gas. The velocity distribution is Gaussian, indicating that VV124 is supported primarily by
velocity dispersion inside a radius of 1.5 kpc. Outside that radius, our measurements provide only an
upper limit of 8.6 km s^(−1) on any rotation in the photometric disk-like feature. The velocity dispersion
is σ_v = 9.4± 1.0 km s^(−1), from which we inferred a mass of M_(1/2) = (2.1 ± 0.2)× 10^7 M_⊙ and a mass-to-
light ratio of (M/L_V)_(1/2) = 5.2 ± 1.1 M_⊙/L_⊙, both measured within the half-light radius. Thus,
VV124 contains dark matter. We also measured the metallicity distribution from neutral iron lines.
The average metallicity, = −1.14 ± 0.06, is consistent with the mass-metallicity relation
defined by dwarf spheroidal galaxies. The dynamics and metallicity distribution of VV124 appear
similar to dSphs of similar stellar mass
Trial Characteristics and Appropriateness of Statistical Methods Applied for Design and Analysis of Randomized School-Based Studies Addressing Weight-Related Issues: A Literature Review
Objective. To evaluate whether clustering effects, often quantified by the intracluster correlation coefficient (ICC), were appropriately accounted for in design and analysis of school-based trials. Methods. We searched PubMed and extracted variables concerning study characteristics, power analysis, ICC use for power analysis, applied statistical models, and the report of the ICC estimated from the observed data. Results. N = 263 papers were identified, and N = 121 papers were included for evaluation. Overall, only a minority (21.5%) of studies incorporated ICC values for power analysis, fewer studies (8.3%) reported the estimated ICC, and 68.6% of studies applied appropriate multilevel models. A greater proportion of studies applied the appropriate models during the past five years (2013-2017) compared to the prior years (74.1% versus 63.5%, p = 0.176). Significantly associated with application of appropriate models were a larger number of schools (p = 0.030), a larger sample size (p = 0.002), longer follow-up (p = 0.014), and randomization at a cluster level (p < 0.001) and so were studies that incorporated the ICC into power analysis (p = 0.016) and reported the estimated ICC (p = 0.030). Conclusion. Although application of appropriate models has increased over the years, consideration of clustering effects in power analysis has been inadequate, as has report of estimated ICC. To increase rigor, future school-based trials should address these issues at both the design and analysis stages
Opioid agonist treatment in transition: A cross-country comparison between Austria, Germany and Switzerland
Background and aims: OAT is a well developed and successful treatment strategy for opioid dependent patients in Europe. It has significantly contributed to the fight against the HIV and HCV pandemics, leading to an increased life expectancy in this population. Building on the OAT experiences in Austria, Germany, and Switzerland and their models of care, the objective of this study is to analyse experiences and changes in patient structures to identify necessary adaptations for the system of care.
Methods: We analysed national register-based data from patients receiving OAT during the period spanning from 2010 to 2020 in Austria, Germany (cases), and Switzerland. We examined and compared OAT policies and practice at national levels through a review of literature and publicly available policy documents.
Results: Across these three countries, the life expectancy of OAT patients increased substantially. The mean age increased from 33.0 in 2010 to 39.1 in 2020 in Austria, from 35.6 years to 41.5 years in Germany (cases), and from 39.6 to 47.1 in Switzerland, respectively. In all three countries, the percentage of patients/cases aged 60 years and older increased more than tenfold between 2010 and 2020.
Conclusions: Integrated support models, reliable care structures, internationally comparable high treatment coverage, flexible prescribing practices, and a wide range of available OAT medications are successful strategies. The experiences in these countries indicate that it is possible to address the complex and chronic nature of opioid dependence and its concurrent mental and physical health challenges, resulting in an increasing life expectancy of OAT patients
Effect of metabolosome encapsulation peptides on enzyme activity, co-aggregation, incorporation and bacterial microcompartment formation
Metabolosomes, catabolic bacterial microcompartments, are proteinaceous organelles that are associated with the breakdown of metabolites such as propanediol and ethanolamine. They are composed of an outer multi-component protein shell that encases a specific metabolic pathway. Protein cargo found within BMCs is directed by the presence of an encapsulation peptide that appears to trigger aggregation prior to the formation of the outer shell. We investigated the effect of three distinct encapsulation peptides on foreign cargo in a recombinant BMC system. Our data demonstrate that these peptides cause variation with respect to enzyme activity and protein aggregation. We observed that the level of protein aggregation generally correlates with the size of metabolosomes, while in the absence of cargo BMCs self-assemble into smaller compartments. The results agree with a flexible model for BMC formation based around the ability of the BMC shell to associate with an aggregate formed due to the interaction of encapsulation peptides
Multi-Element Abundance Measurements from Medium-Resolution Spectra. III. Metallicity Distributions of Milky Way Dwarf Satellite Galaxies
We present metallicity distribution functions (MDFs) for the central regions
of eight dwarf satellite galaxies of the Milky Way: Fornax, Leo I and II,
Sculptor, Sextans, Draco, Canes Venatici I, and Ursa Minor. We use the
published catalog of abundance measurements from the previous paper in this
series. The measurements are based on spectral synthesis of iron absorption
lines. For each MDF, we determine maximum likelihood fits for Leaky Box,
Pre-Enriched, and Extra Gas (wherein the gas supply available for star
formation increases before it decreases to zero) analytic models of chemical
evolution. Although the models are too simplistic to describe any MDF in
detail, a Leaky Box starting from zero metallicity gas fits none of the
galaxies except Canes Venatici I well. The MDFs of some galaxies, particularly
the more luminous ones, strongly prefer the Extra Gas Model to the other
models. Only for Canes Venatici I does the Pre-Enriched Model fit significantly
better than the Extra Gas Model. The best-fit effective yields of the less
luminous half of our galaxy sample do not exceed 0.02 Z_sun, indicating that
gas outflow is important in the chemical evolution of the less luminous
galaxies. We surmise that the ratio of the importance of gas infall to gas
outflow increases with galaxy luminosity. Strong correlations of average [Fe/H]
and metallicity spread with luminosity support this hypothesis.Comment: 17 pages, 5 figures; accepted for publication in ApJ; minor
corrections in v3; corrected typographical errors in Tables 1 and 3 in v
Biomarker Testing to Estimate Under-Reported Heavy Alcohol Consumption by Persons with HIV Initiating ART in Uganda
Alcohol affects the transmission and treatment of HIV, yet may be under-reported in resource-limited settings. We compared self-reported alcohol consumption with levels of plasma carbohydrate-deficient transferrin (%CDT), a biomarker of heavy alcohol consumption, in persons initiating antiretroviral therapy in Uganda. Almost seven percent (6.7%) of persons reporting abstaining and 10% reporting consuming 1–40 drinks in the prior month tested positive for %CDT, and actual under-report may be higher due to low sensitivity of %CDT. These results suggest likely under-report in those reporting abstaining and current drinking. Improved identification of heavy alcohol consumption is needed for research and clinical purposes
Feedback control architecture and the bacterial chemotaxis network.
PMCID: PMC3088647This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Bacteria move towards favourable and away from toxic environments by changing their swimming pattern. This response is regulated by the chemotaxis signalling pathway, which has an important feature: it uses feedback to 'reset' (adapt) the bacterial sensing ability, which allows the bacteria to sense a range of background environmental changes. The role of this feedback has been studied extensively in the simple chemotaxis pathway of Escherichia coli. However it has been recently found that the majority of bacteria have multiple chemotaxis homologues of the E. coli proteins, resulting in more complex pathways. In this paper we investigate the configuration and role of feedback in Rhodobacter sphaeroides, a bacterium containing multiple homologues of the chemotaxis proteins found in E. coli. Multiple proteins could produce different possible feedback configurations, each having different chemotactic performance qualities and levels of robustness to variations and uncertainties in biological parameters and to intracellular noise. We develop four models corresponding to different feedback configurations. Using a series of carefully designed experiments we discriminate between these models and invalidate three of them. When these models are examined in terms of robustness to noise and parametric uncertainties, we find that the non-invalidated model is superior to the others. Moreover, it has a 'cascade control' feedback architecture which is used extensively in engineering to improve system performance, including robustness. Given that the majority of bacteria are known to have multiple chemotaxis pathways, in this paper we show that some feedback architectures allow them to have better performance than others. In particular, cascade control may be an important feature in achieving robust functionality in more complex signalling pathways and in improving their performance
Abundance Analysis of HE2148-1247, A Star With Extremely Enhanced Neutron Capture Elements
Abundances for 27 elements in the very metal poor dwarf star HE2148-1247 are
presented, including many of the neutron capture elements. We establish that
HE2148-1247 is a very highly s-process enhanced star with anomalously high Eu
as well, Eu/H about half Solar, demonstrating the large addition of heavy
nuclei at [Fe/H] = -2.3 dex. Ba and La are enhanced by a somewhat larger factor
and reach the solar abundance, while Pb significantly exceeds it. Ba/Eu is ten
times the solar r-process ratio but much less than that of the s-process,
indicating a substantial r-process addition as well. C and N are also very
highly enhanced. We have found that HE2148-1247 is a radial velocity variable.
The C, N and the s-process element enhancements thus presumably were produced
through mass transfer from a former AGB binary companion. The large enhancement
of heavy r-nuclides also requires an additional source as this is far above any
inventory in the ISM at such low [Fe/H]. We further hypothesize that accretion
onto the white dwarf from the envelope of the star caused accretion induced
collapse of the white dwarf, forming a neutron star, which then produced heavy
r-nuclides and again contaminated its companion. (abridged)Comment: Accepted by the Astrophysical Journal. Companion paper by Qian and
Wasserburg follow
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