Assessment of dental caries among children and adults inhabiting Starorypin (11th–12th c.) compared to other Early Medieval populations from Poland

Dental caries testing provides information about diet, hygiene and eating habits. This information can be useful in reconstructing the living conditions of historical populations. The aim of this study was to determine the frequency of dental caries in adults and children in the Early Middle Ages population from Starorypin (Poland) and compare the results with other early medieval populations from Poland.A total of 346 adult permanent teeth and 131 deciduous teeth were included in the study. Both the macroscopic method and imaging methods (X-ray and a light-induced fluorescence technique) were applied in the study.Dental caries were recorded in 33% (115/346) of the permanent teeth and in 10% (13/131) of the deciduous teeth. In permanent teeth, dental caries were diagnosed on the approximal surface, while dental caries in deciduous teeth are most often diagnosed on the occlusal surface. Early childhood caries (ECC) were mainly diagnosed on the teeth of individuals within the 3.0–5.5 years age group.The frequency of dental caries seemed to be high compared to other early medieval populations. The obtained results may have been influenced by ‘broadband’ odontological research methods, not limited to the macroscopic method alone. However, it can be also argued that the frequency of dental caries observed in this study might have been influenced by a highly varied diet, as indicated by archaeozoological and archaeobotanical studies. The surfaces affected by dental caries correspond to findings of other studies showing that in adults, these were the approximal surfaces, while they were the labial/occlusion surfaces on the deciduous teeth

The influence of warm ischemia elimination on kidney injury during transplantation - Clinical and molecular study

Kidney surface cooling was used during implantation to assess the effect of warm ischemia elimination on allograft function, histological changes and immune-related gene expression. 23 recipients were randomly assigned to a group operated on with kidney surface cooling during implantation (ice bag technique, IBT group), and the other 23 recipients receiving the contralateral kidney from the same donor were operated on with a standard technique. Three consecutive kidney core biopsies were obtained during the transplantation procedure: after organ recovery, after cold ischemia and after reperfusion. Gene expression levels were determined using low-density arrays (Format 32, TaqMan). The IBT group showed a significantly lower rate of detrimental events (delayed graft function and/or acute rejection, p = 0.015) as well as higher glomerular filtration rate on day 14 (p = 0.026). A greater decrease of MMP9 and LCN2 gene expression was seen in the IBT group during total ischemia (p = 0.003 and p = 0.018). Elimination of second warm ischemia reduced the number of detrimental events after kidney transplantation, and thus had influence on the short-term but not long-term allograft function. Surface cooling of the kidney during vascular anastomosis may reduce some detrimental effects of immune activation resulting from both brain death and ischemia-reperfusion injury

The Spectrum of FANCM Protein Truncating Variants in European Breast Cancer Cases

Germline protein truncating variants (PTVs) in the FANCM gene have been associated with a 2–4-fold increased breast cancer risk in case-control studies conducted in different European populations. However, the distribution and the frequency of FANCM PTVs in Europe have never been investigated. In the present study, we collected the data of 114 European female breast cancer cases with FANCM PTVs ascertained in 20 centers from 13 European countries. We identified 27 different FANCM PTVs. The p.Gln1701* PTV is the most common PTV in Northern Europe with a maximum frequency in Finland and a lower relative frequency in Southern Europe. On the contrary, p.Arg1931* seems to be the most common PTV in Southern Europe. We also showed that p.Arg658*, the third most common PTV, is more frequent in Central Europe, and p.Gln498Thrfs*7 is probably a founder variant from Lithuania. Of the 23 rare or unique FANCM PTVs, 15 have not been previously reported. We provide here the initial spectrum of FANCM PTVs in European breast cancer cases

Do you feel excluded? : an explorative study of who the perceived typical shopping mall consumer is and if this consumer feels excluded from city centers

As the retail apocalypse is increasing, it is common to face stores without consumers in citycenters. E-commerce is one of the factors that has had a negative impact on physical stores,both in city centers and in shopping malls. It has been easier for shopping malls than forcity centers to fight the increased competition.The purpose of this thesis was to explore who the typical shopping mall consumer was andif this consumer felt excluded from city centers. Four concepts were investigated; consumerstereotype, place image, shopping experience and place attractiveness. A qualitative,method and an exploratory approach were applied, and the data was collected through anonline focus group and interviews.The findings showed that the perceived typical shopping mall consumer had seven traits;social, fun, curious, open, flexible, time thrifty, calm and patient, and four characteristics;young, families with children, females and formal styles/ fashion oriented. Furthermore,this consumer felt excluded as a shopper because of the limited supply and divided citycenter.The implication of this study was to understand who the typical shopping mall consumeris and, if and why he/she felt excluded. Hence, this can provide retailers in city centers withunderstanding of what factors affect the perceived typical shopping mall consumer’s choiceand thus will enable them to make their stores more welcoming also to the typical shoppingmall customer.The original value of this study is an understanding of the perceived typical shopping mallconsumer and if this consumer feels excluded from city centers, which has previously notbeen explored

Osteoarthritis – a problematic skeletal trait in past human populations. Osteoarthritic changes vs. entheseal changes in the late medieval and early modern population form Łekno

According to medical knowledge, physical activity plays a role in osteoarthritic changes formation. The impact of occupation on osteoarthritic changes development in past human populations is not clear enough, causing problems with interpretation. The aim of the current study is to examine the relationship between osteoarthritis and entheseal changes. Skeletal material comes from the late medieval, early modern population from Łekno (Poland). The sample consists of 110 males and 56 females (adults only). Osteophytes, porosity and eburnation were analyzed in the shoulder, elbow, wrist, hip, knee, and ankle. Entheses on the humerus, radius, femur, and tibia were examined. Standard ranked categorical scoring systems were used for the osteoarthritic and entheseal changes examination