Estudio de espectros de una protuberancia solar en extremo ultravioleta

Fil: Rovira, Marta G.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina

Deposition of composite materials using a wire-bar coater for achieving processability and air-stability in Organic Field-Effect Transistors (OFETs)

Organic thin films based on composite materials of semiconducting dibenzo-tetrathiafulvalene (DB-TTF) and insulating styrenic matrices (Polystyrene (PS10k) and Poly-alpha methylstyrene (PAMS10k) ) have been fabricated by the wire-bar coating technique in ambient conditions (air, light, humidity) and contrasted with the ones prepared by thermally evaporating the organic semiconductor. The transistors fabricated with DB-TTF:PS10k composites show a clear fieldeffect behavior with p-type characteristics, exhibiting charge carriers mobilities in the range of 0.01 cm2/Vs, fully comparable with the films obtained by thermal evaporation. However, while the thermally evaporated films show poor stability in air, the wire-bar coated composites films and devices are highly reproducible and exhibit lower threshold voltage values. Thus, we demonstrate the suitability of the wire-bar technique for manufacturing large area devices.The authors thank the ERC StG 2012-306826 e-GAMES project, the Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), the DGI (Spain) with project BE-WELL CTQ2013-40480-R, and the Generalitat de Catalunya (2014-SGR-17). F. G. D. P. thanks Universidad Técnica de Ambato and Secretaría de Educación Superior, Ciencia, Tecnología e Innovación for funding through a doctoral scholarship “Convocatoria abierta 2010”.Peer Reviewe

Single Crystal-Like Performance in Solution-Coated Thin-Film Organic Field-Effect Transistors

In electronics, the fi eld-effect transistor (FET) is a crucial cornerstone and successful integration of this semiconductor device into circuit applications requires stable and ideal electrical characteristics over a wide range of temperatures and environments. Solution processing, using printing or coating techniques, has been explored to manufacture organic fi eld-effect transistors (OFET) on fl exible carriers, enabling radically novel electronics applications. Ideal electrical characteristics, in organic materials, are typically only found in single crystals. Tiresome growth and manipulation of these hamper practical production of fl exible OFETs circuits. To date, neither devices nor any circuits, based on solution-processed OFETs, has exhibited an ideal set of characteristics similar or better than today’s FET technology based on amorphous silicon. Here, bar-assisted meniscus shearing of dibenzo-tetrathiafulvalene to coat-process self-organized crystalline organic semiconducting domains with high reproducibility is reported. Including these coatings as the channel in OFETs, electric fi eld and temperature-independent charge carrier mobility and no bias stress effects are observed. Furthermore, record-high gain in OFET inverters and exceptional operational stability in both air and water are measured.The authors thank the ERC StG 2012-306826 e-GAMES project, the Networking Research Center on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), the DGI (Spain) project BE-WELL CTQ2013-40480-R, and the Generalitat de Catalunya (2014-SGR- 17). Research in Sweden was fi nancially supported by the Advanced Functional Materials Center at Linköping University, the Önnesjö Foundation, the Knut and Alice Wallenberg Foundation (Power Paper project, scholars), the Swedish Foundation for Strategic Research (SSF, Synergi project). F.G.D.P. thanks Universidad Técnica de Ambato and Secretaría de Educación Superior, Ciencia, Tecnología e Innovación for funding through a doctoral scholarship “Convocatoria abierta 2010.” The authors also thank Witold Tatkiewicz for his help with the ImageJ software.Peer reviewe

Properties of fast submillimeter time structures during a large solar flare

We report properties of fast varying submillimeter emission during one of the strongest solar radio flares of solar cycle 23. Emission was obtained by the Solar Submillimeter-Wave Telescope at 212 and 405 GHz and compared with hard X-ray and γ-ray counts up to few tens of MeV photon energy ranges. We employ different methods to detect and characterize flux density variations and find that during the impulsive phase of the event, the closer in time to the peak flare, the higher the occurrence of the fastest and brightest time structures. The good comparison with hard X-ray and γ-ray count rates indicates that fast submillimeter pulses are the signatures of primary energetic injections. The characteristics of the fast spikes at 212 and 405 GHz, such as their flux density and localization, compared to those of the underlying slower impulsive component, also suggest that their nature is different.Fil: Raulin, Jean Pierre. Universidade Presbiteriana Mackenzie; BrasilFil: Kaufmann, Pierre. Universidade Estadual de Campinas; Brasil. Universidade Presbiteriana Mackenzie; BrasilFil: de Castro, Carlos G. Giménez. Universidade Presbiteriana Mackenzie; BrasilFil: Pacini, Alessandra A.. Universidade Presbiteriana Mackenzie; BrasilFil: Makhmutov, Vladimir S.. Russian Academy Of Sciences; RusiaFil: Levato, Orlando Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "El Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "El Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "El Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "El Leoncito"; ArgentinaFil: Rovira, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; Argentin

Rapid Submillimeter Brightenings Associated with a Large Solar Flare

We present high time resolution observations of Active Region 8910 obtained simultaneously at 212 and 405 GHz during a large Hα flare, which produced a soft X-ray class X1.1 event. Data were obtained with the new solar submillimeter telescope recently installed at the El Leoncito Observatory to explore this poorly known part of the solar emission spectrum. A small slow submillimeter enhancement (≤300 sfu) was associated to bulk emissions at X-rays, Hα, and microwaves. The event exhibited numerous submillimeter-wave 100-300 ms duration spikes, the larger ones with fluxes on the order of 220 and 500 sfu (±20%) at 212 and 405 GHz, respectively. A dramatic increase in the incidence rate of submillimeter spikes sets in as a new large loop system appears in AR 8910, and X-ray emission increases nearly 1 hr before the large flare. The brightening incidence rate (~20 per minute) correlates well with the large flare light curves at X-rays and Hα. The submillimeter spikes may be associated to microflares, waves, or quakes in flaring active regions.Facultad de Ciencias Astronómicas y Geofísica

Rapid Submillimeter Brightenings Associated with a Large Solar Flare

We present high time resolution observations of Active Region 8910 obtained simultaneously at 212 and 405 GHz during a large Hα flare, which produced a soft X-ray class X1.1 event. Data were obtained with the new solar submillimeter telescope recently installed at the El Leoncito Observatory to explore this poorly known part of the solar emission spectrum. A small slow submillimeter enhancement (≤300 sfu) was associated to bulk emissions at X-rays, Hα, and microwaves. The event exhibited numerous submillimeter-wave 100-300 ms duration spikes, the larger ones with fluxes on the order of 220 and 500 sfu (±20%) at 212 and 405 GHz, respectively. A dramatic increase in the incidence rate of submillimeter spikes sets in as a new large loop system appears in AR 8910, and X-ray emission increases nearly 1 hr before the large flare. The brightening incidence rate (~20 per minute) correlates well with the large flare light curves at X-rays and Hα. The submillimeter spikes may be associated to microflares, waves, or quakes in flaring active regions.Fil: Kaufmann, Pierre. Universidade Presbiteriana Mackenzie; BrasilFil: Raulin, J. P. Universidade Presbiteriana Mackenzie; BrasilFil: Correia, E.. Universidade Presbiteriana Mackenzie; BrasilFil: Costa, J. E. R.. Universidade Presbiteriana Mackenzie; BrasilFil: Giménez de Castro, C. G.. Universidade Presbiteriana Mackenzie; BrasilFil: Silva, A. V. R.. Universidade Presbiteriana Mackenzie; BrasilFil: Levato, Orlando Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "el Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "el Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "el Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "el Leoncito"; ArgentinaFil: Rovira, Marta Graciela. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Mandrini, Cristina Hemilse. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Fernández Borda, R.. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Bauer, O. H.. Max PlanckInstitut fur extraterrestrische Physik,; Alemani

FISH and immunohistochemical status of the hepatocyte growth factor receptor (c-Met) in 184 invasive breast tumors

Grants PI05/0961 and PI06/1513 from Ministerio de Sanidad y Consumo ISCIII and RTICC 06/0020/1

Acute Graft-vs.-Host Disease-Associated Endothelial Activation in vitro Is Prevented by Defibrotide

Altres ajuts: This study was supported in part by Jazz Pharmaceuticals Plc (IST-16-10355), German Jose Carreras Leukaemia Foundation (11R/2016 and 03R/2019).Angiogenesis and endothelial activation and dysfunction have been associated with acute graft-vs.-host disease (aGVHD), pointing to the endothelium as a potential target for pharmacological intervention. Defibrotide (DF) is a drug with an endothelium-protective effect that has been approved for the treatment of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation. Clinical data suggest that DF also reduces the incidence of aGVHD; however, the mechanisms of DF-mediated aGVHD regulation have not been examined. To investigate possible DF-mediated prophylactic and therapeutic mechanisms in aGVHD, we performed in vitro studies using endothelial cell (EC) lines. We found that DF significantly and dose-dependently suppressed EC proliferation and notably reduced their ability to form vascular tubes in Matrigel. To explore whether DF administered prophylactically or therapeutically has a significant effect on aGVHD endothelial dysfunction, ECs were exposed to media containing sera from patients with aGVHD (n = 22) in the absence or presence of DF and from patients that did not develop aGVHD (n = 13). ECs upregulated adhesion molecules (vascular cell adhesion molecule 1, intercellular adhesion molecule 1), the adherence junction protein VE-cadherin, von Willebrand factor (VWF), and Akt phosphorylation in response to aGVHD sera. These responses were suppressed upon treatment with DF. In summary, DF inhibits vascular angiogenesis and endothelial activation induced by sera from aGVHD patients. Our results support the view that DF has notable positive effects on endothelial biology during aGVHD

Carba-Cyclophellitols are Neutral Retaining Glucosidase Inhibitors

The conformational analysis of glycosidases affords a route to their specific inhibition through transition-state mimicry. Inspired by the rapid reaction rates of cyclophellitol and cyclophellitol aziridineboth covalent retaining β-glucosidase inhibitorswe postulated that the corresponding carba “cyclopropyl” analogue would be a potent retaining β-glucosidase inhibitor for those enzymes reacting through the ⁴H₃ transition-state conformation. <i>Ab initio</i> metadynamics simulations of the conformational free energy landscape for the cyclopropyl inhibitors show a strong bias for the ⁴H₃ conformation, and carba-cyclophellitol, with an <i>N</i>-(4-azidobutyl)­carboxamide moiety, proved to be a potent inhibitor (<i>K</i>_i = 8.2 nM) of the <i>Thermotoga maritima</i> <i>Tm</i>GH1 β-glucosidase. 3-D structural analysis and comparison with unreacted epoxides show that this compound indeed binds in the ⁴H₃ conformation, suggesting that conformational strain induced through a cyclopropyl unit may add to the armory of tight-binding inhibitor designs

The avoidance of G-CSF and the addition of prophylactic corticosteroids after autologous stem cell transplantation for multiple myeloma patients appeal for the at-home setting to reduce readmission for neutropenic fever

Background Autologous stem cell transplantation (ASCT) remains the standard of care for young multiple myeloma (MM) patients; indeed, at-home ASCT has been positioned as an appropriate therapeutic strategy. However, despite the use of prophylactic antibiotics, neutropenic fever (NF) and hospital readmissions continue to pose as the most important limitations in the outpatient setting. It is possible that the febrile episodes may have a non-infectious etiology, and engraftment syndrome could play a more significant role. The aim of this study was to analyze the impact of both G-CSF withdrawal and the addition of primary prophylaxis with corticosteroids after ASCT. Methods Between January 2002 and August 2018, 111 MM patients conditioned with melphalan were managed at-home beginning +1 day after ASCT. Three groups were established: Group A (n = 33) received standard G-CSF post-ASCT; group B (n = 32) avoided G-CSF post-ASCT; group C (n = 46) avoided G-CSF yet added corticosteroid prophylaxis post-ASCT. Results The incidence of NF among the groups was reduced (64%, 44%, and 24%; P2 (OR 6.1; P = 0.002) and G-CSF avoidance plus corticosteroids (OR 0.1; P60 years (OR 14.6; P = 0.04) and G-CSF avoidance plus corticosteroids (OR 0.07; P = 0.05). Conclusions G-CSF avoidance and corticosteroid prophylaxis post ASCT minimize the incidence of NF in MM patients undergoing at-home ASCT. This approach should be explored in a prospective randomized clinical trial