Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis

Galectin (Gal)-1, an endogenous lectin found at sites of immune privilege, plays a critical role in the regulation of the immune response. Therapeutic administration of Gal-1 or its genetic delivery suppresses chronic inflammation in experimental models of autoimmunity. The purpose of this work was to investigate the occurrence of circulating anti-Gal-1 antibodies in patients with autoimmune and infectious uveitis as potential determinant factors of disease progression.Fil: Romero, Marta D.. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación Ver; Argentina. Laboratorio Inmunopatología Investigación y Docencia LIIDO; ArgentinaFil: Muiño, Juan Carlos. Universidad Nacional de Córdoba; Argentina. Fundación Ver; ArgentinaFil: Bianco, German Ariel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ferrero, Mercedes. Laboratorio Inmunopatología Investigación y Docencia LIIDO; Argentina. Fundación Ver; ArgentinaFil: Juarez, Claudio P.. Fundación Ver; ArgentinaFil: Luna, José Domingo. Fundación Ver; ArgentinaFil: Rabinovich, Gabriel A.. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Keys to Unlocking Creative Potential: The Expressive Path to Personal Growth

An experiential journey into personal growth and creative expression is, by nature, transformational. Undertaken in a public platform using social media (Twitter and blogging) it reveals powerful potential as a teaching and mentoring tool for inspiring creative action around the world. This project was designed to blend my joys and passions for tweeting positive inspiration and encouragement, sharing my readings and research related to creativity, exploring expressive art, activating creative potential with joy, collecting and sharing quotes, coaching positive change and creative action, and raising awareness of everyday creativity into a learning pathway which could be accessed by anyone using the internet. My intents were to trigger interest in exploring personal creative potential by offering daily insights, inspiration, prompts and encouragement which could lead to increased creative action, joy and positive change experiences. This project was also a vehicle for building social media marketing skills to generate dramatic increases in audience, followers, and visits to my websites. As a creativity educator, it is critical to attend to my own creative process as a way of informing my growth as a creativity catalyst and creative change leader. I believe teaching creativity creatively has the power to positively change lives and our collective future. As a result of this project, I am prepared to take creativity training mainstream with the world as my classroom

OPTIONS FOR ANALYZING UNBALANCED SPLIT-PLOT EXPERIMENTS: A CASE STUDY

Unbalanced split-plot experiments present many analysis problems. This paper discusses some of the difficulties by comparing the results of the analysis recommended by Milliken and Johnson (1984) to a set of minimal sufficient statistics using a small experiment from Milliken and Johnson as a case study. The estimators used by Milliken and Johnson are not necessarily the best (smallest variance) estimators. A set of minimal sufficient statistics is used to show that the whole plot error term suggested by Milliken and Johnson does not have a distribution that is proportional to an exact chi-square distribution and is not always independent of parameter function estimators. Other options for analyzing unbalanced split-plot experiments and unbalanced repeated measures experiments in which the repeated measures satisfy the Huyhn-Feldt (1970) conditions are proposed

Addition of a dairy fraction rich in milk fat globule membrane to a high-saturated fat meal reduces the postprandial insulinaemic and inflammatory response in overweight and obese adults.

Meals high in SFA, particularly palmitate, are associated with postprandial inflammation and insulin resistance. Milk fat globule membrane (MFGM) has anti-inflammatory properties that may attenuate the negative effects of SFA-rich meals. Our objective was to examine the postprandial metabolic and inflammatory response to a high-fat meal composed of palm oil (PO) compared with PO with an added dairy fraction rich in MFGM (PO+MFGM) in overweight and obese men and women (n 36) in a randomised, double-blinded, cross-over trial. Participants consumed two isoenergetic high-fat meals composed of a smoothie enriched with PO with v. without a cream-derived complex milk lipid fraction ( dairy fraction rich in MFGM) separated by a washout of 1-2 weeks. Serum cytokines, adhesion molecules, cortisol and markers of inflammation were measured at fasting, and at 1, 3 and 6 h postprandially. Glucose, insulin and lipid profiles were analysed in plasma. Consumption of the PO + MFGM v. PO meal resulted in lower total cholesterol (P = 0·021), LDL-cholesterol (P = 0·046), soluble intracellular adhesion molecule (P = 0·005) and insulin (P = 0·005) incremental AUC, and increased IL-10 (P = 0·013). Individuals with high baseline C-reactive protein (CRP) concentrations (≥3 mg/l, n 17) had higher (P = 0·030) insulin at 1 h after the PO meal than individuals with CRP concentrations <3 mg/l (n 19). The addition of MFGM attenuated this difference between CRP groups. The addition of a dairy fraction rich in MFGM attenuated the negative effects of a high-SFA meal by reducing postprandial cholesterol, inflammatory markers and insulin response in overweight and obese individuals, particularly in those with elevated CRP

Goods Booking System in WIJAYA Printing Company

In an age of globalization era is the all sophisticated and modern developments in science and technology are advancing rapidly. One of progress is the use of computers that have been widely used the entrepreneur as a tool for their business activities. Starting from mid-level businessmen to top-level businessmen. By using the computer all transactions will sale items stored neatly and orderly. System sales are currently running on the company often have difficulty in doing data collection of goods sold, and the calculated result of booking and reservation sales to make his report.For that need to be made at the company's computerized system, where the data will be easily processed into accurately and quickly. Checking goods obtained accurate results and the calculation of bookings will be stored properly

Consumption of a high-fat meal containing cheese compared with a vegan alternative lowers postprandial C-reactive protein in overweight and obese individuals with metabolic abnormalities: a randomised controlled cross-over study.

Dietary recommendations suggest decreased consumption of SFA to minimise CVD risk; however, not all foods rich in SFA are equivalent. To evaluate the effects of SFA in a dairy food matrix, as Cheddar cheese, v. SFA from a vegan-alternative test meal on postprandial inflammatory markers, a randomised controlled cross-over trial was conducted in twenty overweight or obese adults with metabolic abnormalities. Individuals consumed two isoenergetic high-fat mixed meals separated by a 1- to 2-week washout period. Serum was collected at baseline, and at 1, 3 and 6 h postprandially and analysed for inflammatory markers (IL-6, IL-8, IL-10, IL-17, IL-18, TNFα, monocyte chemotactic protein-1 (MCP-1)), acute-phase proteins C-reactive protein (CRP) and serum amyloid-A (SAA), cellular adhesion molecules and blood lipids, glucose and insulin. Following both high-fat test meals, postprandial TAG concentrations rose steadily (P < 0·05) without a decrease by 6 h. The incremental AUC (iAUC) for CRP was significantly lower (P < 0·05) in response to the cheese compared with the vegan-alternative test meal. A treatment effect was not observed for any other inflammatory markers; however, for both test meals, multiple markers significantly changed from baseline over the 6 h postprandial period (IL-6, IL-8, IL-18, TNFα, MCP-1, SAA). Saturated fat in the form of a cheese matrix reduced the iAUC for CRP compared with a vegan-alternative test meal during the postprandial 6 h period. The study is registered at clinicaltrials.gov under NCT01803633

Photoproduction of the Hypertriton

In the framework of the impulse approximation we study the photoproduction of the hypertriton $^3_{\Lambda}$H by using realistic $^3$He wave functions obtained as solutions of Faddeev equations with the Reid soft-core potential for different $^3_{\Lambda}$H wave functions. We obtain relatively small cross sections of the order of 1 nb. We also find that the influence of Fermi motion is important, while the effect of different off-shell assumptions on the cross section is not too significant.Comment: 6 pages in Latex. Talk given at the 15th International Conference on Few-Body Problems in Physics, Groningen, Netherlands, 22-26 July 1997. To be published in Nucl. Phys.

Heavy hole states in Germanium hut wires

Hole spins have gained considerable interest in the past few years due to their potential for fast electrically controlled qubits. Here, we study holes confined in Ge hut wires, a so far unexplored type of nanostructure. Low temperature magnetotransport measurements reveal a large anisotropy between the in-plane and out-of-plane g-factors of up to 18. Numerical simulations verify that this large anisotropy originates from a confined wave function which is of heavy hole character. A light hole admixture of less than 1% is estimated for the states of lowest energy, leading to a surprisingly large reduction of the out-of-plane g-factors. However, this tiny light hole contribution does not influence the spin lifetimes, which are expected to be very long, even in non isotopically purified samples