Cosmological scaling solutions of minimally coupled scalar fields in three dimensions

We examine Friedmann-Robertson-Walker models in three spacetime dimensions. The matter content of the models is composed of a perfect fluid, with a $\gamma$-law equation of state, and a homogeneous scalar field minimally coupled to gravity with a self-interacting potential whose energy density red-shifts as $a^{-2 \nu}$, where a denotes the scale factor. Cosmological solutions are presented for different range of values of $\gamma$ and $\nu$. The potential required to agree with the above red-shift for the scalar field energy density is also calculated.Comment: LaTeX2e, 11 pages, 4 figures. To be published in Classical and Quantum Gravit

SOCIAL DAMAGE AND THE NEED FOR THE FIGURE OF THE SOCIAL ACTOR

The acts of corruption of public officials in Peru generate damages to supra-individual interests, because the right to "social welfare" of the citizens is violated (art. 44 of the Constitution) which the State guarantees, and therefore the obligation to compensate arises (art. 35 of the United Nations Convention Against Corruption), and to determine who would intervene as a legitimate subject would be the anti-corruption public prosecutor, in such a way that the violated interest that only has a diffuse existence and not in the individuality of the persons is guaranteed

Compression system for the phonocardiographic signal

An FPGA-based approach is proposed for implementing a compression system developed specifically for the signal of phonocardiogram. The compression method offers better rate and distorsion than standard audio compression techniques. Both the algorithm and the details on the solutions adopted for its implementation are presented in this paper.This work has been supported by Ministerio de Ciencia y Tecnología of Spain, under grant TIN2006-15460-C04-04

Estimating the longitudinal magnetic field in the chromosphere of quiet-Sun magnetic concentrations

Details of the magnetic field in the quiet Sun chromosphere are key to our understanding of essential aspects of the solar atmosphere. We aim to determine the longitudinal magnetic field component (B_lon) of quiet Sun regions depending on their size. We estimated B_lon by applying the weak-field approximation (WFA) to high-spatial-resolution Ca II 854.2 nm data taken with the Swedish 1m Solar Telescope. Specifically, we analyzed the estimates inferred for different spectral ranges using the data at the original cadence and temporally integrated signals. The longitudinal magnetic field in each considered plasma structure correlates with its size. Using a spectral range restricted to the line core leads to chromospheric longitudinal fields varying from 50 G at the edges to 150-500 G at the center of the structure. These values increase as the spectral range widens due to the photospheric contribution. However, the difference between this contribution and the chromospheric one is not uniform for all structures. Small and medium-sized concentrations show a steeper height gradient in B_lon compared to their chromospheric values, so estimates for wider ranges are less trustworthy. Signal addition does not alleviate this situation as the height gradients in B_lon are consistent with time. Finally, despite the amplified noise levels that deconvolving processes may cause, data restored with the destretching technique show similar results, though are affected by smearing. We obtained B_lon estimates similar to those previously found, except for large concentrations and wide spectral ranges. In addition, we report a correlation between the height variation of B_lon compared to the chromospheric estimates and the concentration size. This correlation affects the difference between the photospheric and chromospheric magnetic flux values and the reliability of the estimates for wider spectral ranges.Comment: 14 pages, 14 figures. Accepted for publication in Astronomy & Astrophysics; abstract has been abridge

Randomized phase II study of fulvestrant plus palbociclib or placebo in endocrine-sensitive, hormone receptor-positive/HER2–advanced breast cancer: GEICAM/2014–12 (FLIPPER)

Background The potential benefit of adding palbociclib to fulvestrant as first-line treatment in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative endocrine-sensitive advanced breast cancer (ABC) patients remains uncharacterized. Patients and methods In this randomized (1:1), double-blind, phase II study, postmenopausal women with HR-positive, HER2-negative ABC with de novo metastatic disease or those who relapsed after >12 months of adjuvant endocrine therapy received palbociclib/fulvestrant or placebo/fulvestrant. Stratification was based on recurrent versus de novo metastatic disease and visceral involvement. The primary objective was one-year progression-free survival (PFS-1y) rate. The sample size was 190 patients. The two-sided alpha of 0.2, 80% of power to detect a difference between the arms, assuming PFS rates of 0.695 and 0.545 for palbociclib/fulvestrant and placebo/fulvestrant, respectively. Results In total, 189 patients were randomized to palbociclib/fulvestrant ([n = 94] or placebo/fulvestrant [n = 95]). 45.5% and 60.3% of patients had de novo metastatic disease and visceral involvement, respectively. PFS-1y rates were 83.5% and 71.9% in the palbociclib/fulvestrant and placebo/fulvestrant arms, (HR 0.55, 80% CI 0.36–0.83, P = 0.064). The median PFS were 31.8 and 22.0 months for the palbociclib/fulvestrant and placebo/fulvestrant arms (aHR 0.48, 80% CI 0.37–0.64, P = 0.001). The most frequent grade 3–4 adverse events were neutropenia (68.1% vs. 0%), leucopenia (26.6% vs. 0%), anemia (3.2% vs. 0%), and lymphopenia (14.9% vs. 2.1%) for the palbociclib/fulvestrant and placebo/fulvestrant, respectively. The most frequent non-hematologic grade 3–4 adverse event was fatigue (4.3% vs. 0%). Conclusions Palbociclib/fulvestrant demonstrated better PFS-1y rates and median PFS than placebo/fulvestrant in HR-positive/HER2-negative endocrine-sensitive ABC patients

Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation

Simian Virus 40 (SV40) large T antigen (T Ag) is a multifunctional viral oncoprotein that regulates viral and cellular transcriptional activity. However, the mechanisms by which such regulation occurs remain unclear. Here we show that T antigen represses CBP-mediated transcriptional activity. This repression is concomitant with histone H3 deacetylation and is TSA sensitive. Moreover, our results demonstrate that T antigen interacts with HDAC1 in vitro in an Rb-independent manner. In addition, the overexpression of HDAC1 cooperates with T antigen to antagonize CBP transactivation function and correlates with chromatin deacetylation of the TK promoter. Finally, decreasing HDAC1 levels with small interfering RNA (siRNA) partially abolishes T antigen-induced repression. These findings highlight the importance of the histone acetylation/deacetylation balance in the cellular transformation mediated by oncoviral proteins

Larval Development in Tropical Gar (Atractosteus tropicus) Is Dependent on the Embryonic Thermal Regime: Ecological Implications under a Climate Change Context

In ectotherm species, environmental temperature plays a key role in development, growth, and survival. Thus, determining how temperature affects fish populations is of utmost importance to accurately predict the risk of climate change over fisheries and aquaculture, critical to warrant nutrition and food security in the coming years. Here, the potential effects of abnormal thermal regimes (24, 28 and 32 C; TR24, TR28, and TR32, respectively) exclusively applied during embryogenesis in tropical gar (Atractosteus tropicus) has been explored to decipher the potential consequences on hatching and growth from fertilization to 16 days post-fertilization (dpf), while effects on skeletal development and body morphology were explored at fertilization and 16 dpf. Egg incubation at higher temperatures induced an early hatching and mouth opening. A higher hatching rate was obtained in eggs incubated at 28 C when compared to those at 24 C. No differences were found in fish survival at 16 dpf, with values ranging from 84.89 to 88.86%, but increased wet body weight and standard length were found in larvae from TR24 and TR32 groups. Thermal regime during embryogenesis also altered the rate at which the skeletal development occurs. Larvae from the TR32 group showed an advanced skeletal development, with a higher development of cartilaginous structures at hatching but reduced at 16 dpf when compared with the TR24 and TR28 groups. Furthermore, this advanced skeletal development seemed to determine the fish body morphology. Based on biometric measures, a principal component analysis showed how along development, larvae from each thermal regime were clustered together, but with each population remaining clearly separated from each other. The current study shows how changes in temperature may induce craniofacial and morphological alterations in fish during early stages and contribute to understanding the possible effects of global warming in early development of fish and its ecological implications.Versión del edito

COPLA, a taxonomic classifier of plasmids

Background: Plasmids are mobile genetic elements, key in the dissemination of antibiotic resistance, virulence determinants and other adaptive traits in bacteria. Obtaining a robust method for plasmid classification is necessary to better understand the genetics and epidemiology of many pathogens. Until now, plasmid classification systems focused on specific traits, which limited their precision and universality. The definition of plasmid taxonomic units (PTUs), based on average nucleotide identity metrics, allows the generation of a universal plasmid classification scheme, applicable to all bacterial taxa. Here we present COPLA, a software able to assign plasmids to known and novel PTUs, based on their genomic sequence. Results: We implemented an automated pipeline able to assign a given plasmid DNA sequence to its cognate PTU, and assessed its performance using a sample of 1000 unclassified plasmids. Overall, 41% of the samples could be assigned to a previously defined PTU, a number that reached 63% in well-known taxa such as the Enterobacterales order. The remaining plasmids represent novel PTUs, indicating that a large fraction of plasmid backbones is still uncharacterized. Conclusions: COPLA is a bioinformatic tool for universal, species-independent, plasmid classification. Offered both as an automatable pipeline and an open web service, COPLA will help bacterial geneticists and clinical microbiologists to quickly classify plasmids.This work was supported by the Spanish Ministry of Science and Innovation [PID2020-117923GB-I00 to FdlC]; the Spanish Ministry of Economy, Industry and Competitiveness [DI-17-09164 to SR-S]; and USA Centers for Disease Control and Prevention [200-2019-06679 to FdlC]. The funders had no role in the design of the study, nor in the collection, analysis, and interpretation of data, nor in writing the manuscript included in this submission

El índice Ka: un nuevo algoritmo para analizar los componentes de la superficie terrestre en imágenes de satélite

El cambio del paisaje de la superficie terrestre, su composición y estructura, ocurrido por causas di- versas, ha estado en la mira de toda la humanidad. Se han desarrollado diversas formas para entender- los y la sensoría remota es lo más reciente y nove- doso para tener un conocimiento rápido de gran- des extensiones. En este estudio se ha desarrollado un nuevo algoritmo para medir estos cambios, así como para identificar valores espectrales de espe- cies de coníferas, utilizando imágenes del satélite Landsat7 ETM+. Los resultados muestran un gran potencial del índice Ka para detectar los diferentes componentes superficiales y su variabilidad debi- do a efectos naturales o antropológicos, etc. The change in the landscape of the terrestrial surface, its composition, and its structure, caused by many factors, has been in the aim of all humanity. Diverse forms have been developed in order to understand them, the sensory remote being the most recent and novel thing in acquiring fast knowledge of large extensions. In this study a new algorithm has been developed to measure these changes, as well as to identify ghastly values of coniferous species using images of the satellite Landsat7 ETM+. The results show a great potential of the Ka index in detecting the different superfi- cial components and its variability due to natural effects or due to man